The Management of Diabetes Mellitus-Imperative Role of Natural
Bioorganic Chemistry 86 (2019) 305–315 Contents lists available at ScienceDirect Bioorganic Chemistry journal homepage: www.elsevier.com/locate/bioorg The management of diabetes mellitus-imperative role of natural products T against dipeptidyl peptidase-4, α-glucosidase and sodium-dependent glucose co-transporter 2 (SGLT2) ⁎ Ghulam Abbasa,b,c, , Ahmed Al Harrasic, Hidayat Hussainc,d, Ahmed Hamaedb, ⁎ Claudiu T. Supurana, a Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy b Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, P.O.Box 33, Nizwa 616, Oman c Natural and Medical Sciences Research Center, University of Nizwa, PC 616, Nizwa, Oman d Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle, (Salle), Germany ARTICLE INFO ABSTRACT Keywords: Diabetes mellitus is a chronic metabolic disorder which is rapidly spreading worldwide. It is characterized by Diabetes mellitus persistent elevated blood glucose level above normal values (hyperglycemia) due to defect in either insulin Antidiabetic agents secretion or in insulin action or both of them. Currently approved oral synthetic antidiabetic drugs such as Dipeptidyl peptidase-4 enzyme biguanides, thiazolidinediones, sulfonylureas, and meglitinides have shown undesirable side effects. Therefore, Alpha glucosidase enzyme newer approaches and targets for the management of diabetes mellitus are highly desirable. Dipeptidyl pepti- SGLT2 dase-4 enzyme, α-glucosidase enzyme and sodium-dependent glucose co-transporter 2 (SGLT2) have been re- Natural products Structure-activity relationship cognized as effective therapeutic targets for the management of diabetes mellitus while natural products are alternatives to oral synthetic hypoglycemic agents.
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