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IL17A Antibody Rabbit Polyclonal Antibody Catalog # ALS14963
Specification
IL17A Antibody - Product Information
Application WB Primary Accession Q16552 Reactivity Human Host Rabbit Clonality Polyclonal Calculated MW 18kDa KDa
IL17A Antibody - Additional Information
Gene ID 3605
Other Names Interleukin-17A, IL-17, IL-17A, Cytotoxic Western Blot (non-reducing) of IL-17 T-lymphocyte-associated antigen 8, CTLA-8, antibody ALS14963 IL17A, CTLA8, IL17
Target/Specificity Human IL-17A
Reconstitution & Storage Store Lyophilized at room temperature up to 1 month; Reconstituted for up to two weeks at 2-8°C. Aliquot and freeze at -20°C for long term storage. Avoid freeze/thaw cycles.
Precautions IL17A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. Western Blot (reducing) of IL-17 antibody ALS14963 IL17A Antibody - Protein Information
Name IL17A IL17A Antibody - Background
Synonyms CTLA8, IL17 Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Function Enhances the surface expression of Effector cytokine of innate and adaptive ICAM1/intracellular adhesion molecule 1 in immune system involved in antimicrobial fibroblasts. host defense and maintenance of tissue integrity (PubMed: Page 1/3 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 target="_blank">24120361
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Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122). Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms (By similarity). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus- specific IgM antibodies at first line of host defense (By similarity).
Cellular Location Secreted
Tissue Location Expressed in memory Th17 cells (at protein level).
IL17A Antibody - Protocols
Provided below are standard protocols that you may find useful for product applications.
• Western Blot • Blocking Peptides • Dot Blot • Immunohistochemistry • Immunofluorescence • Immunoprecipitation • Flow Cytomety • Cell Culture
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