On the Origins and Diagnosis of Asperger Syndrome a Clinical, Neuroimaging and Genetic Study
ON THE ORIGINS AND DIAGNOSIS OF ASPERGER SYNDROME A CLINICAL, NEUROIMAGING AND GENETIC STUDY Taina Nieminen-von Wendt ACADEMIC DISSERTATION To be presented, with the permission of the Medical Faculty of the University of Helsinki, for public examination in Lecture Hall 3 of Biomedicum Helsinki, Haartmaninkatu 8, on 3 December 2004, at 12 noon Supervised by: Lennart von Wendt MD, PhD, Professor Department of Child Neurology, University of Helsinki Helsinki, Finland Raija Vanhala MD, PhD Department of Child Neurology, University of Helsinki Helsinki, Finland Reviewed by: Matti Iivanainen MD, PhD, Professor Department of Child Neurology, University of Helsinki Helsinki, Finland Jari Tiihonen MD, PhD, Professor Department of Forensic Psychiatry, University of Kuopio Niuvanniemi-Hospital Kuopio, Finland Department of Psychiatry, University of Helsinki Helsinki, Finland Official examiner at the dissertation appointed by the Faculty of Medicine, University of Helsinki: Ola Skjeldal MD, PhD, Professor Department of Pediatrics, University of Oslo Rikshospitalet Oslo, Norway ISBN 952-91-7800-X (nid.) ISBN 952-10-2079-2 (PDF) Yliopistopaino Helsinki 2004 CONTENTS 1. LIST OF ORIGINAL PUBLICATIONS 5 2. ABBREVIATIONS 6 3. ABSTRACT 7 4. INTRODUCTION 8 5. REVIEW OF THE LITERATURE 10 5.1 HISTORY 10 5.2 EPIDEMIOLOGY 11 5.3 DIAGNOSIS 13 5.3.1 INTERNATIONAL CLASSIFICATION OF DISEASES (10TH ED) (ICD-10) AND DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS (4TH ED) (DSM-IV) 13 5.3.2 FORMER DIAGNOSTIC CRITERIA 19 5.3.3 SCREENING INSTRUMENTS 21 5.3.4 OTHER DIAGNOSTIC TOOLS 21 5.4 DIFFERENTIAL DIAGNOSTICS AND CO-MORBIDITY 22 5.4.1 HIGH FUNCTIONING AUTISM 22 5.4.2 SCHIZOPHRENIA, SCHIZOID- AND SCHIZOTYPAL PERSONALITY DISORDER 25 5.4.3 ATTENTION - DEFICIT HYPERACTIVITY DISORDER 29 5.4.4 TICS and TOURETTE SYNDROME 30 5.4.5 EATING DISORDERS 30 5.4.6 ALEXITHYMIA 31 5.4.7 OBSESSIVE-COMPULSIVE DISORDER 31 5.4.8 MUTISM 32 5.5 NEUROIMAGING 32 5.5.1 MRI 32 5.5.2 SPECT, PET, fMRI, and NMR 34 5.6 GENETICS 36 6.
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