Author Manuscript Published OnlineFirst on April 8, 2019; DOI: 10.1158/1535-7163.MCT-18-0146 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Inhibition of Ubiquitin-specific protease 14 suppresses cell proliferation and synergizes with chemotherapeutic agents in neuroblastoma Yang Yu1,2, Yanling Zhao2, Yihui Fan2, Zhenghu Chen1, Hui Li2, Jiaxiong Lu2, Kevin Guo2, Sarah E. Woodfield1, Sanjeev A. Vasudevan1, Jianhua Yang2*, Jed G. Nuchtern1,2* 1Division of Pediatric Surgery, Texas Children’s Hospital Department of Surgery, Michael E. DeBakey Department of Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA 2Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA Running title: The role of USP14 in neuroblastoma Keywords: neuroblastoma, ubiquitin-specific protease 14, b-AP15, chemotherapy, synergy Corresponding authors: Dr. Jed G Nuchtern, 6701 Fannin St., Suite 1210, Houston, TX 77030, United States; phone: +1-832-822-3135; fax: +1-832-825-3141; Email:
[email protected], Dr. Jianhua Yang, 6701 Fannin St., Suite 1210, Houston, TX 77030, United States; phone: +1-832- 824-4572; fax: +1-832-825-1206; Email:
[email protected] The authors declare no conflicts of interest. Financial Information: This work was supported by NIH 1R21NS094654 to Dr. J. Yang. 1 Downloaded from mct.aacrjournals.org on September 29, 2021. © 2019 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 8, 2019; DOI: 10.1158/1535-7163.MCT-18-0146 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.