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(12) Patent Application Publication (10) Pub. No.: US 2016/0346339 A1 FINLEY Et Al

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(12) Patent Application Publication (10) Pub. No.: US 2016/0346339 A1 FINLEY Et Al US 2016.0346339A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0346339 A1 FINLEY et al. (43) Pub. Date: Dec. 1, 2016 (54) METHODS FOR PREPARATION OF Publication Classification CANNABS OL, EXTRACTS AND COMPOSITIONS (51) Int. Cl. A636/85 (2006.01) (71) Applicant: CONSTANCE THERAPEUTICS, A 6LX 3L/355 (2006.01) INC., Point Richmond, CA (US) (52) U.S. Cl. CPC ........... A61K 36/185 (2013.01); A61K 31/355 (72) Inventors: CONSTANCE FINLEY, Point (2013.01); A61 K 2.236/33 (2013.01); A61 K Richmond, CA (US); LUKE MCKEE, 2236/55 (2013.01) Aptos, CA (US); HALEY POOLE BESTWICK, Berkeley, CA (US); (57) ABSTRACT PAUL ROETHLE, Berkeley, CA (US) The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions (73) Assignee: CONSTANCE THERAPEUTICS, containing vitamin E, and methods for preparing the extracts INC., Point Richmond, CA (US) and compositions. In some embodiments, the present inven tion provides a method for preparing a cannabis oil extract (21) Appl. No.: 15/010,631 comprising eluting cannabinoids from cannabis plant mate rial with a solvent to produce an eluate, filtering the eluate (22) Filed: Jan. 29, 2016 with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions Sufficient to remove Related U.S. Application Data residual solvent, thereby preparing the extract. In some (60) Provisional application No. 61/996,993, filed on Jan. embodiments, the method further includes mixing a quantity 31, 2015, provisional application No. 62/259,539, of vitamin E with the extract to produce a cannabis oil filed on Nov. 24, 2015. composition. Patent Application Publication Dec. 1, 2016 Sheet 1 of 4 US 2016/0346339 A1 SE: ; - - - - SEs S. FS H EX; SSS $ 38S. FIG. 1A Patent Application Publication Dec. 1, 2016 Sheet 2 of 4 US 2016/0346339 A1 S SSS FIG. 1B Patent Application Publication Dec. 1, 2016 Sheet 3 of 4 US 2016/0346339 A1 WSSY. ANNAS is SN is sits FIG. 2 Patent Application Publication Dec. 1, 2016 Sheet 4 of 4 US 2016/0346339 A1 S$ 3 SSESSESS ES$$$$SESS...SSS Si38$838.388 Si:S SSSSSSR 88. FIG. 3 US 2016/0346339 A1 Dec. 1, 2016 METHODS FOR PREPARATION OF embodiments, the quantity of vitamin E is sufficient to CANNABS OIL EXTRACTS AND reduce the Viscosity of the composition to less than about COMPOSITIONS 3500 cp. In some embodiments, the method includes eluting cannabinoids and terpenes from cannabis plant material to CROSS-REFERENCES TO RELATED produce the eluate. In some embodiments, the method APPLICATIONS further includes mixing the extract with essential oils and/or 0001. This application claims priority to U.S. Provisional other ingredients. Patent Application No. 61/996,993, filed Jan. 31, 2015, and 0007. In certain aspects, the present invention provides a U.S. Provisional Patent Application No. 62/259,539, filed method for preparing a cannabis oil extract, the method Nov. 24, 2015, the disclosures of which are hereby incor comprising: porated by reference in their entirety for all purposes. 0008 eluting cannabinoids from cannabis plant mate rial with a solvent to produce an eluate; FIELD OF TECHNOLOGY 0009 filtering the eluate with a filter to produce a filtrate; 0002 This disclosure relates generally to cannabis oils 0.010 evaporating the solvent from the filtrate with a and cannabis oil formulations, including cannabis oil com distiller to produce a distillate; and positions with vitamin E, and methods of preparation 0.011 purging the distillate under conditions sufficient thereof. to remove residual solvent, thereby preparing the BACKGROUND OF THE INVENTION eXtract. 0012. In some embodiments, the method further com 0003. The medicinal use of oils and extracts derived from prises mixing a quantity of one or more ingredients selected cannabis plant material has been growing in popularity. For from the group consisting of vitamin E, an essential oil, an example, pharmacologically active compounds in cannabis herbal extract, a probiotic, a homeopathic remedy, a flower plant material including, but not limited to, delta-9-tetrahy essence, and a carrier oil with the extract to produce a drocannabinol (or THC) and cannabidiol (CBD) have been cannabis oil composition. shown to reduce the effects of nausea and Vomiting caused 0013. In particular embodiments, the method further by certain chemotherapy treatments. Research has also comprises mixing a quantity of vitamin E with the extract to shown the ability of cannabinoids and other compounds produce a cannabis oil composition. In some embodiments, found in cannabis to stimulate bone growth, relieve pain, aid the quantity of vitamin E is at least about 30% w/w based on sleep, inhibit bacterial cell growth, inhibit cancer cell the total weight of the composition. In some embodiments, growth, and alleviate or otherwise reduce the symptoms of the quantity of vitamin E is an amount Sufficient to reduce cancer, epilepsy, autoimmune disease, neurodegeneration, the viscosity of the composition to less than about 3500 cp. Alzheimer's disease, Lyme disease, post-traumatic stress In some embodiments, mixing the vitamin E with the extract disorder, and inflammation. Furthermore, extracts of canna comprises stirring the vitamin E into the extract until the bis plant material, whether ingested or inhaled, have also composition is homogenized. In some embodiments, the been shown to have therapeutic effects in patients with Vitamin E comprises a tocopherol, a tocotrienol, a salt glaucoma, dysmenorrhea, migraines, anxiety disorders, or a thereof, or a combination thereof. In some embodiments, the combination thereof. vitamin E is obtained from soybeans or sunflowers. As a 0004. However, cannabis oil is often highly viscous, non-limiting example, the vitamin E can be obtained from making it difficult to work with and load into new delivery non-genetically modified (non-GMO) soybeans or sunflow devices such as vaporizers and E-cigarettes. In addition, ers. In particular embodiments, the vitamin E includes Such oils, when vaporized or Smoked, are often rough on a C-tocopherol. patients throat and may induce coughing or gagging. 0014. In some embodiments, the cannabis plant material 0005. Therefore, a solution is needed in order to make consists essentially of cannabis buds. In some embodiments, Such extracts more conducive to today’s delivery devices the method further comprises solarizing the eluate before and make the inhalation/consumption of Such extracts more filtering the eluate. In some embodiments, the solvent is palatable for patients. In addition, Such a solution should ethanol. In some embodiments, the method further com also not have an adverse effect on the potency of the prises freezing the cannabis plant material and the solvent extracts active compounds and preserve the extract’s gus before eluting the cannabinoids from the cannabis plant tatory or aromatic qualities. material with the Solvent. In some embodiments, the can nabis plant material is a strain selected from the group BRIEF SUMMARY OF THE INVENTION consisting of a cannabis indica strain, a cannabis sativa, a 0006 Disclosed herein are cannabis oil extracts and hybrid strain, a high-CBD strain, and a high-THC strain. In compositions thereof, including cannabis oil compositions certain instances, the Strain is selected from the group containing vitamin E, and methods for preparing the extracts consisting of AC/DC, Blueberry, Cannatonic, Medihaze, and compositions. In particular, a method is disclosed herein Afghan Goo, and Prize Kush. In some embodiments, the for preparing a cannabis oil extract comprising eluting method further comprises purging the distillate under con cannabinoids from cannabis plant material with a solvent to ditions Sufficient to remove residual solvent comprises dehy produce an eluate, filtering the eluate with a filter to produce drating the distillate with a dehydrator. In certain instances, a filtrate, evaporating the solvent from the filtrate with a dehydrating the distillate includes dehydrating for at least distiller to produce a distillate, and dehydrating/purging the about 72 hours. distillate with a dehydrator or vacuum oven to prepare the 0015. In some embodiments, the method further com extract. In some embodiments, the method further includes prises heating the distillate to form a decarboxylated distil mixing a quantity of vitamin E with the extract. In some late. In some instances, the method further comprises purg US 2016/0346339 A1 Dec. 1, 2016 ing the decarboxylated distillate under conditions sufficient 0029 FIG. 1A shows a method of preparing a cannabis to remove residual solvent, thereby forming the extract. In oil composition according to one embodiment of the inven other instances, the method further comprises filtering the tion. decarboxylated distillate to form a decarboxylated filtrate. In 0030 FIG. 1B shows a method of preparing a cannabis Such instances, the method can further comprise purging the oil composition according to an embodiment of the inven decarboxylated filtrate under conditions to remove residual tion including optional decarboxylation and filtration steps. solvent, thereby forming the extract. 0031 FIG. 2 shows a graph depicting the viscosities of 0016. In other aspects, the present invention provides a cannabis oil compositions as a function of vitamin E per cannabis oil extract prepared by the method disclosed centages in the cannabis oil compositions. herein. 0032 FIG. 3 is a graph depicting THC and CBD per 0017. In particular embodiments, the cannabis oil extract centages in cannabis oil compositions made from various is prepared by a method comprising: strains of cannabis plant material. 0018 eluting cannabinoids from cannabis plant mate 0033. Other features of the present embodiments will be rial with a solvent to produce an eluate; apparent from the accompanying drawings and from the 0019 filtering the eluate with a filter to produce a detailed description that follows. filtrate; 0020 evaporating the solvent from the filtrate with a DETAILED DESCRIPTION OF THE distiller to produce a distillate; and INVENTION 0021 purging the distillate under conditions sufficient I.
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