nd Annual 22 Albert B. Sabin Gold

Award Ceremony

MedalPresented to Roger I. Glass, M.D., Ph.D.

for his many contributions toward improving children’s health worldwide, including novel scientific research for the prevention of gastroenteritis from rotaviruses and noroviruses

Tuesday, April 14, 2015 Bethesda North Marriott Hotel & Conference Center North Bethesda, MD Ceremony Program

5:30 PM REGISTRATION & REFRESHMENTS

6:30 PM WELCOME Peter J. Hotez, M.D., Ph.D. President, Sabin Institute; Director, Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development; Dean, National School of Tropical Medicine at Baylor College of Medicine

INTRODUCTION & PRESENTATION OF THE ALBERT B. SABIN GOLD MEDAL Walter A. Orenstein, M.D. Professor of Medicine and Pediatrics, Emory University; Associate Director, Emory Vaccine Center

Mathuram Santosham, M.D., M.P.H. Professor of Pediatrics and International Health Director, Center for American Indian Health Johns Hopkins University

ACCEPTANCE Roger I. Glass, M.D., Ph.D. Director, Fogarty International Center Associate Director for International Research National Institutes of Health

7:30 PM RECEPTION

About Sabin Vaccine Institute

The Sabin Vaccine Institute (Sabin) is a non-profit, 501(c)(3) organization of scientists, researchers and advocates dedicated to reducing needless human suffering from vaccine-preventable and neglected tropical diseases (NTDs). Since its founding in 1993 in honor of Dr. Albert B. Sabin, the developer of the oral , Sabin has been at the forefront of global efforts to eliminate, prevent, and cure infectious and neglected tropical diseases.

Sabin develops new , advocates for increased use of existing vaccines and promotes expanded access to affordable medical treatments in collaboration with governments, academic institutions, scientists, medical professionals and other non-profit organizations. About Dr. Albert B. Sabin

After receiving his medical degree in 1931, Dr. Sabin began research on poliomyelitis (polio), which at the time had reached epidemic proportions around the globe. At the Children’s Hospital Research Foundation in Cincinnati, Ohio, he was able to prove that polio was an of the alimentary tract, indicating that polio might be prevented by an oral vaccine.

Dr. Sabin’s early research was Dr. Sabin administers his oral vaccine to interrupted by World War two Cincinnati children - 1960s II. He joined the U.S. Army Epidemiological Board’s Virus Committee in 1941 and accepted assignments abroad, where he worked on vaccines for encephalitis, visceral leishmaniasis and dengue fever. At the end of World War II, Dr. Sabin returned to Cincinnati and resumed his research.

He focused on isolating a mutant form of the polio virus incapable of producing the disease and thereby safe for introduction to the human body. The avirulent virus reproduced rapidly in the intestines, displacing lethal forms of the polio virus and providing protection from the disease.

The oral vaccine was first tested outside the United States from 1957 to 1959 and introduced in the American public in 1959. Since then, Dr. Sabin’s vaccine has been used to eliminate polio in countries throughout the world.

Dr. Sabin dedicated his entire professional career to the elimination of human suffering though his groundbreaking medical advances, while also waging a lifelong campaign against poverty and the resulting health inequities.

It was in this spirit of commitment and dedication that his longtime friends and colleagues - led by Heloisa Sabin, his widow, and the late Dr. H.R. Shepherd, Sabin’s Founding Chairman - established the Sabin Vaccine Institute in 1993 following Dr. Sabin’s death.

Dr. Sabin in his laboratory - 1955 Dr. Sabin - 1980s

Images of Dr. Sabin courtesy of Winkler Center for the Health Professions, University of Cincinnati About Roger I. Glass, M.D., Ph.D

Dr. Roger Glass, the Director of the Fogarty International Center at the National Institutes of Health, is internationally known for his lifelong contributions to understand and control rotavirus diarrhea through the use of vaccines. For more than three decades, he has pioneered research that has documented the epidemiology and enormous burden of rotavirus diarrhea throughout the world and worked to prevent this disease through the development and use of vaccines. These vaccines, including several that he has helped to develop, are now in use in the national immunization programs in more than 70 countries. They have already made a major impact to reduce both deaths and diarrheal hospitalizations, and improve the health of millions of children worldwide.

As a young epidemiologist at the Centers for Disease Control and Prevention, Dr. Glass became engaged in research on enteric diseases and spent four years as a Scientist at the International Center for Diarrheal Disease Research in Bangladesh. This experience made him appreciate that diarrhea was one of the most important causes of death among children under 5 years and that rotavirus was the most common cause of both hospitalizations and deaths. After completing his Ph.D. on cholera with Prof. Jan Holmgren at the University of Gothenburg, Sweden, he joined the Laboratory of Infectious Diseases at NIH with Dr. Albert Kapikian to work on molecular and laboratory studies related to the first rotavirus vaccine. In 1986, he returned to CDC as Chief of the Viral Gastroenteritis Section where he spent two decades leading research on enteric . His group helped establish sentinel hospital surveillance of rotavirus, now ongoing in more than 60 countries around the world, which has resulted in data Dr. Glass with members of the Viral Gastroenteritis detailing the enormous Section, CDC - 2006 burden of this disease. This evidence established rotavirus as a global priority, and a prime target for vaccine development. His team also trained a cohort of epidemiologists and laboratory scientists who have become part of a global network monitoring the prevalence of disease, distribution of strains, and the impact of vaccines to improve child health. In 1995, he spent a year in the Global Program for Immunizations at WHO, where he developed a global strategy for surveillance of rotavirus hospitalizations that remains active to this day.

Because of his concern that rotavirus vaccines produced by major manufacturers might be unaffordable for use in low-income countries, Dr. Glass worked in India for more than 20 years in partnership with Drs. M.K. Bhan, Harry Greenberg, and Krishna Ella and others to develop a novel vaccine that could be marketed to the public sector for $1.00 per dose, a fraction of the cost of the existing vaccines. This vaccine was just licensed in India and launched to the public by the Prime Minister of India, Narendra Modi. A similar effort has led to the development of a vaccine now licensed in Vietnam. Dr. Glass continues to work to improve the efficacy of live oral vaccines through research on a next generation of inactivated vaccines that would be administered by intramuscular or intradermal routes.

Dr. Glass graduated from Harvard University, magna cum laude, in the History of Science and was awarded a Fulbright Fellowship to study at the University of Buenos Aires. He then received his M.D. from Harvard Medical School and Dr. Glass with Dr. M.K. Bhan at ROTAVAC® his M.P.H. from the Harvard School launch in Delhi - 2015 of Public Health. After clinical training in internal medicine at Mt. Sinai Hospital in New York City, and a year working at Oxford University and the Sysin Institute in Moscow, he joined the Epidemic Intelligence Service at CDC.

Dr. Glass has received numerous awards, including the Charles C. Shepard Lifetime Scientific Achievement Award from CDC, the Dr. Charles Merieux Award from the National Foundation for Infectious Diseases, the Louis Pasteur Award from the Children’s Vaccine Initiative, and the Child Health Award from the Programme for Global Paediatric Research. He has served on the editorial board of Science and many other journals and on numerous advisory committees of the WHO, IOM and PAHO. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and delivered the 2014 John F. Enders Lecture at the Infectious Diseases Society of America’s annual meeting. He has co-authored more than 600 research papers and chapters and has lectured in five languages. He is married to Barbara J. Stoll, M.D., the George Brumley, Jr. Professor and Chair of the Department of Pediatrics at Emory University School of Medicine and Director of the Pediatric Center of Emory and Children’s Healthcare of Atlanta. He and his wife have three children. About the Albert B. Sabin Gold Medal Award

Awarded annually since 1994, the Albert B. Sabin Gold Medal Award recognizes a researcher who has made extraordinary contributions in the field of vaccinology or a complementary field.

This year marks the 22nd year that Sabin has bestowed the award. We applaud all of our past winners on their contributions to improving health worldwide.

Albert B. Sabin Gold Medal Award Recipients (2015-1994)

2015 2014 2013 2012 Roger I. Mathuram Anne A. F. Marc Glass, Santosham, Gershon, LaForce, M.D., Ph.D. M.D., M.P.H. M.D. M.D. 2011 2011 2010 2009 Douglas R. John T. John D. Rino Lowy, M.D. Schiller, Clemens, Rappuoli, Ph.D. M.D. Ph.D.

2008 2007 2006 2005 Ruth S. Hilary William Albert Z. Nussenz- Koprowski, H. Foege, Kapikian, weig, M.D. M.D., M.D. M.D., Ph.D. (d. 2013) M.P.H. (d. 2014)

2004 2003 2002 2001 William S. Samuel L. Stanley A. John B. Jordan, Jr., Katz, M.D., Plotkin, Robbins, M.D. D.Sc. M.D. M.D. (d. 2008) 2000 1999 1998 1998 Ciro A. de Maj. Gen. Allen C. Myron M. Quadros, Philip K. Steere, Levine, M.D., M.P.H. Russell, M.D. M.D., (d. 2014) M.D. D.T.P.H. (USA Ret.)

1997 1996 1995 1994 Maurice R. Joseph L. Robert M. Donald A. Hilleman, Melnick, Chanock, Henderson, Ph.D., D.Sc. Ph.D. M.D. M.D., M.P.H. (d. 2005) (d. 2001) (d. 2010) The Sabin Vaccine Institute gratefully acknowledges those who helped make the 2015 Albert B. Sabin Gold Medal Award Ceremony possible.

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