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Caution About Early Intubation and Mechanical Ventilation in COVID-19

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Caution About Early Intubation and Mechanical Ventilation in COVID-19 Tobin et al. Ann. Intensive Care (2020) 10:78 https://doi.org/10.1186/s13613-020-00692-6 REVIEW Open Access Caution about early intubation and mechanical ventilation in COVID-19 Martin J. Tobin*, Franco Laghi and Amal Jubran A fear of ventilator shortage with COVID-19 panicked patients. Carteaux et al. [7] concluded that high tidal vol- politicians into demanding automakers to branch into ume predicted need for endotracheal intubation. Patients ventilator manufacture. ultimately intubated were signifcantly sicker than non- Some experts have argued that mechanical ventilation intubated patients: more frequent immunosuppres- should be employed early in order to prevent COVID-19 sion (37.5% v 6.7%), higher SAPS II (41 v 30), and lower patients progressing from mild disease to more severe PaO2/FiO2 (122 v 177). Need for intubation was more lung injury. Tis viewpoint has been expressed most likely precipitated by severity of underlying illness than forcefully by Marini and Gattinoni in a JAMA Editorial tidal-volume size (which was found to be a marginal pre- [1], where they attest that vigorous spontaneous inspira- dictor). Tidal volumes in these two studies do not consti- tory eforts can rapidly lead to patient self-induced lung tute a sound scientifc basis for occurrence of P-SILI in injury (P-SILI). patients with COVID-19. P-SILI is thought to parallel ventilator-induced lung Based on the P-SILI hypothesis, Gattinoni and coau- injury (VILI), an entity supported by decades of experi- thors advocate radical changes to ventilator management mentation and randomized trials [2]. In contrast, P-SILI of patients with COVID-19. Tey claim that noninvasive has surfaced only in the past 4–5 years [3]. Two research options are of “questionable” value [5], “intubation should studies are commonly cited by authors warning about be prioritized”, [4] and delayed intubation will cause a P-SILI [1, 3–5]. P-SILI vortex that induces more severe ARDS [1]. To induce hyperventilation, Mascheroni et al. [6] Tey view heightened respiratory drive in COVID-19 infused salicylate into the brainstem of spontaneously patients as maladaptive, and recommend deliberate low- breathing sheep. Te authors claim that the conse- ering of respiratory drive in these patients [1]. Tey claim quent ~ threefold increase in minute ventilation produced that “near normal compliance … explains why some of lung injury, and this was prevented by mechanical venti- the patients present without dyspnea” [5]. If a COVID- lation. Tidal volume (the focus of authors warning about 19 patient is severely hypoxic, normal lung compliance P-SILI) [1, 3–5] increased from 178 to 235 ml. Te pro- will not prevent dyspnea. Concurrently some COVID-19 portional tidal volume in healthy humans would be patients are free of dyspnea despite substantial hypox- 502 ml—much less than experienced by healthy pregnant emia (dubbed “silent-happy hypoxia”) [8]. Tis arises women. because the level of hypoxemia per se is not sufciently In a non-blinded, observational study, patients with low to induce increased respiratory motor output and acute respiratory failure who failed noninvasive ventila- accompanying PaCO2 levels blunt the hypoxic response tion had higher tidal volume than successfully managed [2, 9]. To assess patient efort, Gattinoni and coauthors rec- ommend inserting an esophageal balloon as a “crucial” *Correspondence: [email protected] step [5]. Tey specify that when esophageal-pressure Division of Pulmonary and Critical Care Medicine, Hines Veterans Afairs swings increase above 15 cmH2O, “the risk of lung injury Hospital and Loyola University of Chicago Stritch School of Medicine, Hines, IL 60141, USA increases and therefore intubation should be performed © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/. Tobin et al. Ann. Intensive Care (2020) 10:78 Page 2 of 3 as soon as possible” [5]. No experimental data exists to radical approach to mechanical ventilation in the time of justify this assertion. Expressing vague and ill-defned the COVID-19 pandemic. concepts in mathematical terms gives them a specious air Te true impact of mechanical ventilation in COVID- of respectability that cloaks lack of knowledge and per- 19 will never be known. It depends on whether intubated petuates confusion. Equally important, manipulations of patients truly required mechanical ventilation or whether the upper airway while inserting an esophageal balloon they could have been sustained with oxygen supplied by in a dyspneic COVID-19 patient will escalate the risk for less drastic methods [8]. It is difcult to determine how endotracheal intubation. many physicians have been infuenced by P-SILI as a jus- We are not recommending a desultory approach to tifcation for preemptive mechanical ventilation as a pre- instituting mechanical ventilation or saying that numbers ventive measure. are not important. When we learn that a patient is acutely Even if high tidal volume and P-SILI play some role and persistently hypoxemic despite supplemental oxy- in the progression of respiratory failure in COVID-19 gen, we immediately consider steps to institute assisted patients—for which there is no convincing evidence— ventilation. But it is not possible to pick an oxygen satu- this would not provide justifcation for liberal use of ration breakpoint at which the benefts of mechanical endotracheal intubation, for which there are decades of ventilation will decidedly outweigh its hazards across all research documenting fatal complications. patients [2]. To recommend instituting mechanical ven- tilation based on esophageal-pressure swings above 15 Abbreviations cmH2O [5] amounts to playing with fre. VILI: Ventilator-induced lung injury; P-SILI: Patient self-induced lung injury; Mechanical ventilation is lifesaving in severe respira- SAPS II: Simplifed Acute Physiology Score II. tory failure, and few medical therapies equal its power Acknowledgements [2]. While some COVID-19 patients can be managed Not applicable. with supplemental oxygen, patients with the most severe Authors’ contributions respiratory failure demand insertion of an endotracheal All authors contributed equally to the drafting of the manuscript and provided tube [8]. An endotracheal tube facilitates control over an critical revision for important intellectual content. All authors read and unstable airway and enables precise regulation of oxy- approved the fnal manuscript. gen, pressure and volume [10]. But the endotracheal tube Funding brings in its wake a slew of complications [2]. Each day of National Institute of Nursing Research (RO1-NR016055) and Merit Review mechanical ventilation exposes patients to complications Award, Veterans Administration Research (1 I01 RX002803-01A1). and increases mortality [2]. Availability of data and materials Recommendations based on P-SILI for discontinuation Not applicable. of mechanical ventilation in COVID-19 patients are par- Ethics approval and consent to participate ticularly radical. Marini and Gattinoni recommend that Not applicable. “weaning should be undertaken cautiously” [1]. Numer- ous studies demonstrate that physicians are unnecessar- Consent for publication Not applicable. ily cautious in assessing patients for weaning [2, 10]. To advocate “spontaneous trials only at the very end of the Competing interests weaning process” [1] is a formula to increase mortality in MJT receives royalties for two books on critical care published by McGraw-Hill, Inc., New York. COVID-19 patients—especially when an insufcient sup- ply of ventilators is feared and some authorities recom- Received: 22 May 2020 Accepted: 30 May 2020 mend connecting four patients to a single ventilator. Te process of transforming thoughts about a new biological entity into material things (reifcation) takes years. Once existence of a new entity is corroborated References 1. Marini JJ, Gattinoni L. Management of COVID-19 respiratory distress. through additional research, it acquires substance and JAMA. 2020. https ://doi.org/10.1001/jama.2020.6825. is gradually accepted as approximating truth. History 2. Tobin MJ. Principles and practice of mechanical ventilation. 3rd ed. New is replete with entities once viewed as real, now consid- York: McGraw Hill; 2013. p. 3–1516. 3. Brochard L, Slutsky A, Pesenti A. Mechanical ventilation to minimize pro- ered fction (status lymphaticus, visceroptosis). At this gression of lung injury in acute respiratory failure. Am J Respir Crit Care time, the existence of P-SILI is based only on the shakiest Med. 2017;195(4):438–42. of circumstantial evidence and has yet to be exposed to 4. Gattinoni L, Coppola S, Cressoni M, Busana M, Rossi S, Chiumello D. Covid-19 does not lead to a “typical” acute respiratory distress syndrome. the acid-wash of experimental testing by difering scien- Am J Respir Crit Care Med. 2020. https ://doi.org/10.1164/rccm.20200 tists. Yet P-SILI is being promoted as a raison d’etre for a 3-0817L E. Tobin et al. Ann. Intensive Care (2020) 10:78 Page 3 of 3 5. Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L, 9. Tobin MJ, Gardner WN. Monitoring of the control of ventilation. In: Tobin Camporota L. COVID-19 pneumonia: diferent respiratory treatments for MJ, editor. Principles and practice of intensive care monitoring. New York: diferent phenotypes? Intensive Care Med.
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