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EXPERIENCE THE NATIONAL INSTITUTES OF HEALTH 6th NIH National Graduate Student Research Conference October 16–18, 2011 NATCHER CONFERENCE CENTER | BETHESDA, MARYLAND CONTENTS AGENDA ..................................................................................................................................1 THE NATIONAL INSTITUTES OF HEALTH CAMPUS MAP ......................................................4 THE NATCHER CENTER CONFERENCE FLOOR PLAN- P2 LEVEL ............................................5 NIH INSTITUTES & CENTERS ...................................................................................................6 BIOGRAPHICAL SKETCHES ...................................................................................................11 POSTER SESSION OVERVIEW ...............................................................................................17 POSTER SESSION 1 ...............................................................................................................19 ABSTRACTS - SESSION 1 ......................................................................................................25 POSTER SESSION 2 ...............................................................................................................67 ABSTRACTS - SESSION 2 ......................................................................................................71 ORGANIZING COMMITTEE CONTACT INFORMATION ......................................................111 SPEAKER CONTACT INFORMATION ...................................................................................113 PARTICIPANT CONTACT INFORMATION ............................................................................115 PARTICIPANT INDEX ...........................................................................................................121 EXIT SURVEY .......................................................................................................................123 AGENDA Sunday, October 16, 2011: Hyatt Regency Bethesda 3:00 – 9:00 PM Check In and Registration 5:15 – 5:30 PM Welcome and Opening Remarks Jackie A. Lavigne, PhD, MPH, Co-Chair, NGSRC Organizing Committee 5:30 – 6:15 PM NIH 101 What is the NIH, how is it organized, and how does it work? Sharon L. Milgram, PhD, Director, NIH Office of Intramural Training & Education 6:15 – 9:00 PM DineArounds* (organized by the NIH Fellows Committee) Monday, October 17, 2011: Natcher Conference Center, Bethesda 7:30 – 8:00 AM Registration Outer Lobby 8:00 – 9:00 AM Light Refreshments with the NIH Institute/Center Training Directors Lower Level Lobby 9:00 – 9:45 AM Concurrent ScientificS essions (presenters are senior postdoctoral fellows) Session I Balcony A • Transitions in Chromatin Structure Require Multiple Chromatin Remodeling Systems Stephanie A. Morris, PhD National Cancer Institute • Study of the Gut Microbiome: From Translational Research to Evaluation of Cancer Risk Roberto Flores, PhD, MPH National Cancer Institute Session II Balcony B • Interactions between SPATE Family Proteins and Mammalian Cells Matt Wenham, DPhil National Institute of Diabetes and Digestive and Kidney Diseases • RecQ Helicases in DNA Repair Marie Rossi, PhD National Institute on Aging 9:45 – 10:00 AM Morning Break 10:00 – 11:30 AM Poster Session I – Upper Level Atrium; details to be provided 6th National Graduate Student Research Conference Program Guide 1 11:30 – 12:30 PM Lunch with NIH Postdoctoral Fellows and NIH Investigators Lower Level Lobby Participants will have an opportunity to interact with current NIH trainees and investigators. 12:30 – 2:00 PM Poster Session II – Upper Level Atrium; details to be provided 2:00 – 3:00 PM Career Workshop I: Advancing Your Career at the NIH Lower Level, Room E1/E2 Lori M. Conlan, PhD Director, Office of Postdoctoral Services, OITE 3:00- 3:15 PM Afternoon Break 3:15 – 4:00 PM** Keynote Scientific Presentation Lower Level, Room E1/E2 How to Build a Dog: Genetics of Complex Traits in the Canine Elaine A. Ostrander, PhD National Human Genome Research Institute 4:00 – 5:00 PM Career Workshop II Lower Level, Room E1/E2 NIH Postdoctoral Fellows who recently transitioned to a variety of scientific jobs, including tenure-track academic positions and positions as science policy analysts, will share advice on critical job search skills, their own job searches, and their current positions. • Bobbie Ann Austin, PhD Assistant Director, Association for Research in Vision and Ophthalmology • Sydella Blatch, PhD Assistant Professor, Department of Biology, Stevenson University • Sandeep Dayal, PhD Science Policy Analyst, Office of Science Policy Analysis National Institute of Diabetes and Digestive and Kidney Diseases, NIH • Britta Hahn, PhD Assistant Professor, Department of Psychiatry University of Maryland School of Medicine • Orlando Lopez, PhD Commissioner’s Fellow, Food and Drug Administration • Marci Scidmore, PhD Associate Professor, Department of Microbiology and Immunology Cornell University 5:00 – 5:30 PM** Closing Remarks, Festival Evaluation, Raffle Lower Level, E1/E2 Michael M. Gottesman, MD Deputy Director for Intramural Research, NIH 6:00 PM FelCom Networking Event; Dinner on Your Own 2 National Institutes of Health Tuesday: Bethesda and Other Campuses Breakfast on Your Own Meetings with NIH scientists * Reservations will be made for groups of 10 at a selection of Bethesda restaurants. Conference participants can sign up to “dine” at the restaurant that interests them most. Each group will be “hosted” by a current NIH postdoc. Diners will cover the cost of their own dinners. ** Event will be held jointly with Resident Research Career Day at the NIH. 6th National Graduate Student Research Conference Program Guide 3 Updated 6/30/09 NIH Visitor Map Street Address: National Institutes of Health 9000 Rockville Pike Bethesda, MD 20892 THE NATIONAL INSTITUTES OF HEALTH CAMPUS MAP Main Entrance: NIH Gateway Drive Rockville Pike & NIH Gateway Drive NIH Gateway Center Vehicle Inspection: 5am – 10pm, Monday-Friday After 10pm on weekdays, all day weekends and holidays, all visitor (patients, commercial, non- commercial) vehicles, motorcycles and bicycles must enter campus at the CVIF Pedestrians: 24 hours, 7 days a week West Gateway Center (Pedestrians Only) Near Old Georgetown Rd & South Dr 6am - 12pm Monday - Friday Patient and Patient Visitor Entrance Cedar Lane & West Drive Valet Parking at Clinical Center Main Entrance Weekdays: Inbound Traffic Only: 7am - 7pm Weekends & Holidays: Closed Commercial Vehicle Inspection Facility (CVIF) Building 67: Commercial Vehicles Only Rockville Pike - between North Dr. and Wilson Dr. Open 24 hours a day, 7 days a week 4 National Institutes of Health On weekends and holidays, all visitor vehicles must use the CVIF to enter campus To learn more about visitor and security issues at the NIH, visit: http://www.nih.gov/about/visitor/index.htm. For questions about campus access, please contact the ORS Information Line at [email protected] or 301-594-6677, TTY - 301-435-1908. THE NATCHER CENTER CONFERENCE FLOOR PLAN- P2 LEVEL This diagram depicts the P2 Level of the Natcher Conference Center. Upstairs on the Atrium (Lobby) Level of the Natcher Conference Center you will find the entrance to Balconies A, B and C, and poster presentations. 6th National Graduate Student Research Conference Program Guide 5 NIH INSTITUTES & CENTERS The Office of the Director (OD) The Office of the Director is the central office at NIH for its 27 Institutes and Centers. The OD is responsible for setting policy for NIH and for planning, managing, and coordinating the programs and activities of all the NIH components. OD’s program offices include the Office of AIDS Research and the Office of Research on Women’s Health, among others. National Cancer Institute (NCI) - Established in 1937 NCI leads a national effort to eliminate the suffering and death due to cancer. Through basic and clinical biomedical research and training, NCI conducts and supports research that will lead to a future in which we can prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases. National Eye Institute (NEI) - Established in 1968 NEI conducts and supports research that helps prevent and treat eye diseases and other disorders of vision. This research leads to sight-saving treatments, reduces visual impairment and blindness, and improves the quality of life for people of all ages. NEI-supported research has advanced our knowledge of how the eye functions in health and disease. National Heart, Lung, and Blood Institute (NHLBI) - Established in 1948 NHLBI provides leadership for a national program in diseases of the heart, blood vessels, lung, and blood; blood resources; and sleep disorders. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Women’s Health Initiative. The Institute plans, conducts, fosters, and supports an integrated and coordinated program of basic research, clinical investigations and trials, observational studies, and demonstration and education projects. National Human Genome Research Institute (NHGRI) - Established in 1989 NHGRI supports the NIH component of the Human Genome Project, a worldwide research effort designed to analyze the structure of human DNA and determine the location of the estimated 30,000 to 40,000 human genes. The