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Deep Brain Stimulation Leads Safe? an Updated Assessment of Stimulation Safety

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Where Science Meets Innovation A Joint Meeting of NANS & NIC euromod n N u a la ic t r io e n m S A o c h i t e r t y o N • est 1994 • June 25–29, 2016 Baltimore, MD Sheraton Inner Harbor Jointly provided by the Congress of Neurological Surgeons, North American Neuromodulation Society, and Neural Interfaces Conference. TABLE OF CONTENTS Chronic High Density Longitudinal Intrafascicular Electrode Arrays for Peripheral Nerves ........................................................................................................................ 14 John Burns, member technical staff; Julianne Grainger, MSBE; John Lachapelle, MSEE; Edward Keefer, PhD; Jonathan Cheng, MD FACS Closed-Loop Control of a Virtual Prosthetic Hand by a Human Subject After Prior Amputation ..................................................................................................... 15 David Kluger, BS; David Page, BS; Suzanne Wendelken, MS; Tyler Davis, MD PhD; Douglas Hutchinson, MD; David Warren, PhD; Gregory Clark PhD Demonstration of NCA/MCMB Chemistry and 3mAh Microcell for Implantable Medical Device Applications Involving Neurostimulation ...................................... 16 Som Mohanty A Platform Development Strategy for Implantable Neurostimulator Devices ................................................ 17 Andrew Kelly Noninvasive Treatment of Postoperative Cauda Equina Syndrome Pelvic Pain and Urinary Incontinence: A Case Series ................................................................... 18 Yuriy Ivanov; Anna Lasak, MD; Roshni Durgam MD Motor Decoding and Sensory Stimulation for Upper-limb Prostheses Using Implanted Neural and Muscular Electrode Arrays ............................................................. 19 Suzanne Wendelken; David Page, BS; David Kluger, BS; Tyler Davis, MD PhD; David Warren, PhD; Christopher Duncan, MD; Douglas Hutchinson, MD; Gregory Clark, PhD Harnessing Normal Tissue Response to Create a Stable Neural Interface ................................................... 20 Amitabha Lahiri; Ignacio Delgado-Martinez, MD; Ng Kian Ann, PhD; Shih-Cheng Yen, PhD; Nitish Thakor, director Six-Year Follow-up on Implanted Neuroprostheses for Upright Mobility after Paralysis ............................... 22 Ronald Triolo, PhD; Stephanie Bailey; Michael Miller, MS; Kevin Foglyano, BSE; Lisa Lombardo, MPT; Rudi Kobetic, MS Center of Pressure Feedback Control of Task-Dependent Postures with an Implanted Standing Neuroprosthesis .......................................................................................................................................... 23 Brooke Odle; Alexander Hunt, PhD; Lisa Lombardo, MPT; Musa Audu, PhD; Ronald Triolo, PhD Chronic Implantation of PDMS-Based Optical Waveguides for Powering Wireless Microelectrode Array ..................................................................................................... 24 Ali Ersen; Mesut Sahin, PhD A Biophysical Model to Predict Electrical Stimulation–Evoked Response in Cortical and Subcortical Brain Regions .................................................................................... 25 Ishita Basu; Kara Farnes, BA; Deborah Vallejo-Lopez, MSc; Britni Crocker, MS; Angelique Paulk, PhD; Sydney Cash, MD PhD; Mark Kramer, PhD; Alik Widge, MD PhD Low-Cost, Compact Current Source for Chronic Stimulation of Rat Retin ..................................................... 26 Sahar Elyahoodayan; James Weiland, professor Peripheral Nerve Stimulator Implant for Postherpetic Trigeminal Neuralgia ................................................. 28 Arpit Patel, DO; Devang Padalia, MD; Corey Reeves, MD; Ankur Patel, MS2; Neal Shah, MD Quantification of Dorsal Column Fiber Responses in a Model of Kilohertz-Frequency Spinal Cord Stimulation ............................................................................................... 29 Leonel Medina, MSc; Nathan Crosby, PhD; John Janik, PhD; Warren Grill, PhD Evaluation of Focused Multipolar Stimulation for Cochlear Implants in Acute and Long-Term Deafened Animals ................................................................................................. 30 Shefin George, ME; James Fallon, PhD; Mohit Shivdasani, PhD; Andrew Wise; Rob Shepherd Composition of Tears Induced by Electrical Stimulation of the Anterior Ethmoid Nerve ................................ 31 Mark Brinton; Andrea Kossler, MD; Zara Patel, MD; Manfred Franke, PhD; Jim Loudin, PhD; Christopher Ta, MD; Daniel Palanker, PhD 2 | A Joint Meeting of NANS & NIC | June 25–29, 2016 TABLE OF CONTENTS Are Directional Deep Brain Stimulation Leads Safe? An Updated Assessment of Stimulation Safety .............................................................................................................. 32 Ashley Kapron; Daniel Merrill; Christopher Butson, PhD Incorporating Initial Polarization for Accurate Modeling of Extracellular Neural Stimulation................................................................................................................... 33 Boshuo Wang, PhD; Aman Aberra; Warren Grill, PhD; Angel Peterchev, PhD Interactions of Prosthetic and Natural Vision in Animals With Local Retinal Degeneration .................................................................................................................. 34 Henri Lorach; Xin Lei; Ludwig Galambos, BS/MS Eng; Theodore (Ted) Kamins, PhD; Keith Mathieson; Roopa Dalal, MSc; James Harris, PhD; Daniel Palanker, PhD Predicted Effect of Electrode Position on the Amplitude of Recorded Neural Signals Using Cufflike Technologies ................................................................................. 36 Iian Black; James Abbas, PhD; Ranu Jung, PhD Cerebral Vasculature and Heterogeneity Outside the Brain Impact Predictions in Models of Deep Brain Stimulation .............................................................................. 37 Bryan Howell; Cameron McIntyre, PhD Phasic Activation of the External Urethral Sphincter Increases Voiding Efficiency in Rat and Cat ................................................................................................................. 38 Warren Grill, PhD; Christopher Langdale, MS Evaluating Sexual Arousal in a Female Rat Model With Pudendal and Tibial Nerve Stimulation ........................................................................................................ 39 Lauren Zimmerman; Indie Rice, BSE in progress; Mitchell Berger, MD PhD; Tim Bruns, PhD Laser Pyrolyzed Carbon-based Electrodes for Neural Interfaces .................................................................. 40 Ana Oliveira; Juan Ordonez, PhD; Danesh Ashouri Vajari, MSc; Max Eickenscheid, PhD; Thomas Stieglitz Functional Organization of Motoneuronal Pools in the Lumbar Spinal Cord of Monkeys: Intraspinal Microstimulation Targets ..................................................................... 41 Amirali Toossi; Dirk Everaert, PhD; Steve Perlmutter, PhD; Vivian Mushahwar, PhD Computational Evidence of Saphenous Nerve Recruitment During Percutaneous Tibial Nerve Stimulation for Overactive Bladder.......................................................... 42 Christopher Elder; Paul Yoo, PhD Paired Electrical Stimulation to Alter Low-Frequency Brain Oscillation Synchrony in Fear Circuits .......................................................................................................... 43 Meng-Chen Lo; Alik Widge, MD PhD 17T Diffusion Tensor Imaging Elucidates Targets of Deep Brain Stimulation ................................................ 44 Katie Warthen; Justin Hilliard, MD; Kelly Foote, MD; Christopher Butson, PhD Mapping Threshold Response of Cortical Neurons to Pulsed Uniform Electric Field ..................................... 45 Aman Aberra; Boshuo Wang, PhD; Angel Peterchev, PhD; Warren Grill, PhD Novel Predictive Spinal Cord Stimulation Algorithm for Chronic Pain ........................................................... 46 Haigreeva Yedla; Brandon Swan, BSE; Shivandan Lad; Warren Grill, PhD Implantable Neural Recording and Stimulation Technologies for In-Vivo Electrophysiology for Rodents .............................................................................. 47 James Morizio, Vinson Go Microneurography as a Tool for Testing Limb Prosthetics ............................................................................ 48 Changqing Kao, MD; Peter Konrad, MD PhD; André Diedrich, MD PhD; Laura Diedrich, MD; Michael Goldfarb, PhD 3 | A Joint Meeting of NANS & NIC | June 25–29, 2016 TABLE OF CONTENTS An Adaptable Intraspinal Microstimulation Controller to Restore Walking after a Hemisection Spinal Cord Injury ............................................................................... 49 Ashley Dalrymple; Dirk Everaert, PhD; Vivian Mushahwar, PhD EMG-Bridge for Motor Function Rebuilding of Paralyzed Limbs ................................................................... 50 Zhi-Gong Wang Dr-Ing; Xiao-Ying Lü Dr; Hai-Peng Wang, Master; Yu-Xuan Zhou, Master; Xue-Liang Bao, PhD MEA-based Quantitative Measurement of Electrophysiological State of Quiescent Neuronal Networks ........................................................................................................ 51 Xiao-Ying Lü; Zhi-Gong Wang Dr-Ing; Shuai An, PhD, candidate in translation Suppression of Scarring in Peripheral Nerve Implants by Drug Elution ......................................................... 52 James Fitzgerald, MA BM BCh FRCS(SN) PhD Dual Purpose Carbon Fiber Electrode Array for the Detection of Electrophysiological
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