PENN Fall 2007 Psychiatry Perspective

Exciting New Initiatives in the Department of Psychiatry

In This Issue utstanding facilities, programs, and people separate top-notch organizations from Otheir peers. Penn’s Department of Psychiatry, in partnership with PENN Medi- cine, is investing heavily in all three to enhance the Department’s position among the COVER STORY nation’s top psychiatry departments and bolster the Department’s regional, national, Exciting New Initiatives ...... 1 and international stature. Current academic and clinical programs are receiving a sig- CHAIRMAN’S REPORT ...... 2 nificant part of the investment, while other support is directed toward new initiatives. PROGRAM HIGHLIGHTS Penn Psychiatry Perspective will detail each of these new initiatives in future issues, but Stunkard Program ...... 3 for now we briefly highlight their key features. Mobile Clinical Trials Unit . . . .6 OUR DISTINGUISHED FACULTY FACILITIES Awards and Honors ...... 8 News & Goings-On ...... 10 New and Upgraded Inpatient Facilities at Pennsylvania Hospital – The University of Research News ...... 13 Pennsylvania Health System (UPHS) will build a new state-of-the-art psychiatric inpa- Research Grants ...... 15 tient unit at Pennsylvania Hospital and upgrade the Department’s current unit there. Faculty in the News ...... 17 Construction is scheduled for completion in June 2008. As part of this plan, the New Faculty ...... 18 Department’s inpatient service at the Hospital of the University of Pennsylvania CORNERSTONES (HUP) will be consolidated with these new services at Pennsylvania Hospital. Faculty Spotlight ...... 19 Voluntary Faculty Profile . . . . .22 ROGRAMS Employee Snapshot ...... 24 P

EDUCATIONAL HIGHLIGHTS As part of this physical expansion and transition, the Department will create six new, Resident Class of 2011 ...... 26 innovative, and inter-related academic and clinical programs throughout the UPHS: Residents’ Corner ...... 27 • Penn Comprehensive Depression Center – Based at HUP, Penn Presbyterian Med- ical Center, and Pennsylvania Hospital, including the new inpatient unit at Penn- sylvania Hospital, this center will treat patients with depression and bipolar illness, develop and implement new approaches to detect and treat depression and bipolar disorders, and study the neurobiology of mood disorders. The Department has been invited to become an Inaugural Member of the National Network of Depres- sion Centers, and the Department’s center will be unique in the region, and one of Up-to-date information on the first in the country. Departmental Events are available on the • Penn Women’s Mental Health and Wellness Program – Located at both HUP and Department’s website Pennsylvania Hospital, this program will focus on the specialty needs of women by (www.mail.upenn.edu/psych) treating and studying psychiatric disorders such as depression and anxiety occur- ring over the female life cycle. The program will build on and expand the excel- lence of existing collaborations among Penn’s Departments of Psychiatry and Obstetrics and Gynecology. This will be a full academic program, unprecedented in the region, and one of only a few such programs in the country. • Penn Psychosomatic Medicine Program – This program, based at HUP, will pro- vide enhanced consultative services to the medical and surgical services at HUP Department of Psychiatry and will feature a Psychosomatic Medicine Fellowship Training Program. and Penn Behavioral Health University of Pennsylvania Continued on page 21 PAGE 2 PENN PSYCHIATRY PERSPECTIVE FALL 2007

Chairman’s Report

ne of the feature stories this issue depicts a very visible whether the treatments them- Oeffort by the Department to expand its involvement with selves are effective in communi- the local community. The Mobile Clinical Trials Unit, designed ty settings. and operated by the Department’s HIV/AIDS Prevention For almost four decades, the Research Division (David Metzger, PhD), is a major departmen- Center for Studies of Addiction tal initiative to increase the enrollment of hard-to-reach popula- (CSA) (Charles O’Brien, MD, tions in clinical trials, with potential long-term research and PhD) has pioneered new treat- clinical benefits. ments for addictive disorders. This endeavor is just one of the Department’s many communi- While each of CSA’s six divi- ty-oriented programs, and I would like to cite a few of these sions conducts research relevant activities to illustrate the scope of our commitment to our to addiction treatment in the neighbors. community, the work of two units stands out in this regard. Our participation in the community starts with patient care. The Novel Interventions in Penn Behavioral Health clinicians treat patients from any- Criminal Justice Populations where, but our facilities are especially accessible to those near- Division (James Cornish, MD) develops and tests new treat- by. ments to improve outcomes for people involved in the criminal University City and West Philadelphia residents are well- justice system. Currently, the division is the lead site in a multi- served by the Department’s general and specialized psychiatric site trial of depot (injectable) naltrexone treatments for opiate- services located at the Hospital of the University of Pennsylva- dependent patients who are on probation or parole. The CSA’s nia (HUP) and Penn Presbyterian Medical Center (PPMC). Center on the Continuum of Care in the Addictions (James HUP provides a wide range of psychiatric inpatient, outpatient, McKay, PhD) investigates how therapies should be modified and emergency services, while PPMC is particularly known for over the long term as patients’ conditions change. The goal is its focused addiction treatment programs. At our affiliated hos- to foster sustained participation in treatment, regardless of pitals adjacent to the Penn campus, the Department of Child modality or setting. and Adolescent Psychiatry at Children’s Hospital of Philadel- Department faculty are also heavily involved in reducing dis- phia offers psychiatric services for young patients, and the parities in medical care experienced by certain segments of our Philadelphia Veterans Administration Medical Center provides population, particularly African Americans. The CMHPSR psychiatric care to military veterans. conducts research on treatment disparities for severely mental- Located in Center City Philadelphia, Pennsylvania Hospital ly ill African Americans. The Center for Community Health Psychiatry is recognized for its community-oriented programs, and Health Disparities (Chanita Hughes-Halbert, PhD), sup- including its Hall-Mercer Community Mental Health and Men- ported by the National Center on Minority Health and Health tal Retardation Center, Homeless Outreach Services, the South- Disparities, similarly focuses on understanding why minority east Asian Program, and the city-funded Crisis Response Cen- populations in America often receive inferior health care and ter. demonstrate higher incidences of specific diseases. Research is also one of our core missions, and here, too, the Coupled with these clinical and research efforts, Department community is an essential participant. Therapies developed faculty are also active in educating mental health professionals, under tightly controlled conditions in academic environments policy makers, legislators, and the general public about mental may not transfer easily to other venues, and Department facul- health disorders and the delivery of mental health care in ty are partnering with local institutions to adapt these treat- America. Of note is the Annenberg Adolescent Mental Health ments to community settings. Community residents are the Initiative (AMHI), a Department-led effort to inform both pro- ultimate beneficiaries of treatments shown to work in the “real fessionals and the public about the treatment and prevention of world.” mental health disorders in adolescents. While nationally orient- ed, the AMHI is no less relevant to our local community. With over two decades of experience, the Center for Mental Health Policy and Services Research (CMHPSR) (Trevor Through these and many other community-oriented initiatives, Hadley, PhD) works closely with Philadelphia community Penn’s Department of Psychiatry demonstrates daily its com- mental health care agencies to assess the effectiveness of mental mitment to serve our neighbors. As Chairman, I pledge to con- health interventions in local surroundings. The CMHPSR also tinue to fulfill this public responsibility. helps state and local agencies increase patient access to psychi- atric treatments, recognizing that potentially efficacious treat- ments have little value if they are not available to those who need them. The Center for Psychotherapy Research (CPR) (Paul Crits- Christoph, PhD) has a related focus in investigating whether Dwight L. Evans, MD academically proven treatments for depression also work when Ruth Meltzer Professor and Chair delivered by community-based providers. The CPR is now Professor of Psychiatry, Medicine and Neuroscience exploring why some patients leave treatment early and

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Program Highlights

ALBERT J. STUNKARD WEIGHT MANAGEMENT PROGRAM irst, the dry definitions: treatments for obesity and other cholesterol are used. Widely F eating disorders, and have treated acclaimed for his pathbreaking patients suffering from these con- work, which continues to this day, According to the Centers for ditions. Dr. Stunkard is honored by having Disease Control and Prevention, his name associated with the new “overweight and obesity are In October, the Center ramped up program. “I am surprised and both labels for ranges of weight its efforts to treat over- that are greater than what is weight and obese individ- generally considered healthy for uals by opening the a given weight.” Overweight Albert J. Stunkard Weight indicates that a person weighs Management Program. too much for his or her given Named after Albert J. height. Obesity goes a step fur- (“Mickey”) Stunkard, ther, signifying that an individ- MD, one of the world’s ual has both excessive weight leading investigators of and too much body fat as well. obesity and eating disor- ders, the new program Now the frightening facts: emphasizes the impor- According to the National Cen- tance of basing clinical ter for Health Statistics, two out therapies on solid of every three adult Americans research. are overweight and one out of Dr. Stunkard, a member three is obese. And this situation Thomas A. Wadden, PhD (l) and of the Department of Psychiatry Albert J. Stunkard, MD (r) has become progressively worse for most of the past fifty years, at the Stunkard Program’s official launch, over the last half century. October 3, 2007 is credited with many significant By any measure, Americans are firsts. Among them, he was the having problems controlling their first to: delighted with this new program weight, and there is cause for con- that will allow our group to trans- • describe night eating syndrome cern. Obesity is associated with late some of our research findings and develop a treatment for it; serious medical conditions, includ- into practice,” he says. ing diabetes, high blood pressure, • describe binge eating disorder; The Stunkard Weight Management high cholesterol, sleep apnea, and • establish the strong relationship Program treats overweight and joint problems. It increases health between obesity and social obese adults. Thomas A. Wadden, care expenses and generates addi- class; PhD, Professor of Psychology in tional costs for the economy due to Psychiatry, Director of the CWED, absenteeism from work and school • introduce the long-term use of and Executive Director of the and reduced productivity. The group behavior modification to Stunkard Program, says that the American Obesity Association says help patients lose weight and new program “is open to all indi- that obesity is the second leading maintain their weight loss; and viduals who struggle with their cause of unnecessary deaths in • describe the contribution of excess weight, starting with those America. genetics to body weight. with a body mass index [a meas- For almost five decades, faculty in ure relating height and weight] of He also recognized that weight the Department’s Center for at least 27 kg/m2.” loss medications should be used Weight and Eating Disorders on a long-term basis, in the same The Stunkard Program primarily (CWED) have conducted pioneer- manner that medications for high offers care through group pro- ing research on the causes of and blood pressure, type 2 diabetes, or grams, in which peer support is Continued on page 4

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Continued from page 3 critical to helping patients main- losses than traditional Sometimes, lifestyle modifica- tain motivation and overcome lifestyle approaches. tion alone is not enough to obstacles. Individual counseling achieve sufficient weight loss, • Penn Start is a 14-week is available. But irrespective of and more radical interventions lifestyle intervention the therapeutic setting or treat- are employed. Weight loss med- designed to promote slow ment, the program’s guiding ications help facilitate long-term and steady weight loss. Par- principles remain the same. weight control and the Stunkard ticipants consume a diet of Overweight individuals are Program medical staff is highly conventional foods and lose treated compassionately and experienced in their appropriate weight by reducing calories professionally and weight loss uses. Dr. Wadden says that and increasing physical programs are tailored to individ- “probably 30 percent of the U.S. activity. Weekly group ses- ual needs and circumstances. population qualifies for the use sions address grocery shop- The causes of weight gain are of weight loss medications. They ping, label reading, dining viewed as complex, often are for persons with a BMI of 30 out, and other topics in involving genetics, illness, poor or more, or 27 or more in the lifestyle modification. eating and exercise habits, and presence of co-morbid condi- emotional distress, and treat- Achieving initial weight loss is tions. They are also very useful ments are equally comprehen- not sufficient! Sustaining the for maintaining lost weight.” sive and sophisticated. activities that led to weight The Stunkard Program team reduction is essential. The Encore The Stunkard works closely with the Bariatric Program offers Surgery Program at the Univer- two basic “The Stunkard Program provides an unparalleled sity of Pennsylvania Health Sys- patient pro- level of care for overweight and obese individu- tem. “Bariatric surgery is appro- grams. Both are als,” says Dr. Sarwer. “All of the Program’s staff priate for the 5 percent of Amer- designed to pro- members have trained at the Center for Weight icans who have extreme obesity, mote weight and Eating Disorders under the supervision of rec- defined by a BMI of 40 or more loss through ognized experts. As a result, they know that the – about 100 pounds over- lifestyle modifi- treatment of weight disorders must be guided by weight,” says David B. Sarwer, cations which two overriding principles -- compassion for PhD, Associate Professor of Psy- incorporate patients who suffer from these conditions and a chology in Psychiatry and Direc- heart-healthy commitment to scientific research in selecting the tor of Clinical Services at the nutrition and most appropriate treatments.” Center for Weight and Eating increased physi- Disorders. “Persons with a BMI cal activity. The of 35 or more, who have devel- Program teaches skills needed to programs are staffed by a multi- oped health complications of keep off lost weight by empha- disciplinary team consisting of obesity, also may be candidates sizing the importance of main- nutritionists, physicians, psy- for surgery.“ Choosing bariatric taining changes in diet and chologists, and other health care surgery is a major decision, and activity. Nutrition classes and professionals. program staff work closely with exercise instruction are central patients before the operation to • The Health First Program is features of the program. Group guide their decision-making and specifically designed for sessions are held every other afterward to assist with the individuals with a significant week and provide a structured dietary and behavioral changes amount of weight to lose. and supportive environment to necessary for the most success- This program is medically learn the skills needed for ful postoperative result, says Dr. supervised and targeted at weight maintenance through Sarwer, who will serve as Direc- achieving maximum reduc- reversing small weight gains as tor of the Stunkard Program. tions in weight and improve- they occur, increasing lifestyle ments in cardiovascular activity, and improving the Before beginning any therapy, health. It is designed to image individuals have of their each patient meets with mem- induce larger initial weight own bodies. bers of the treatment team for an Continued on page 5 www.med.upenn.edu/psych www.med.upenn.edu/psych PAGE 5

Continued from page 4 initial assessment. Before their turning on a computer and tap- under the supervision of recog- appointment, patients complete ping on a keyboard. That’s quite nized experts. As a result, they a questionnaire concerning their a change from Jefferson’s agrari- know that the treatment of weight and dieting histories, eat- an society in which most Ameri- weight disorders must be guid- ing and activity habits, and life can’s expended hundreds of ed by two overriding principles stressors. Most -- compassion for patients patients also have a who suffer from these con- medical evaluation to ditions and a commitment ensure that the weight to scientific research in loss program address- selecting the most appro- es their individual priate treatments.” health and wellness And what can patients goals. Patients’ person- expect when they come to al physicians are con- the Stunkard Weight Man- sulted to facilitate agement Program? Perhaps comprehensive care. the best clue is provided by Stunkard Program Executive Director Wadden staff help patients in how he describes his select the weight loss mentor. program that best l to r: Dwight L. Evans, MD, Albert J. Stunkard, MD, “Mickey Stunkard has been meets their needs. David B. Sarwer, PhD, and Thomas A. Wadden, PhD an inspiration to me and to Decisions are based on hundreds of other scientists whether patients require a con- calories a day working on their and clinicians who work in the ventional or more accelerated farms.” fields of obesity research and weight loss program, the level of weight management. He has an medical supervision needed, the Even recreation today requires infectious enthusiasm for structure desired (e.g., no meals less physical energy. “As a result research that I could not escape or all meals provided), and the of video games,” Dr. Wadden as a postdoctoral fellow back in length of program (14-week ver- continues, “we now have a gen- 1981. I cannot imagine having a sus longer). eration of children who excel at more caring and gifted mentor playing basketball and football Unfortunately, the factors pro- than Mickey Stunkard. He is a without ever venturing outside. ducing the current obesity epi- consummate scientist, clinician, Fortunately, we are starting to demic are well-entrenched and and educator. And he is a gener- see serious efforts to change not likely to disappear soon. Dr. ous and devoted friend.” both the eating and activity Wadden says that “the obesity environments, as parents, educa- Research-oriented, caring, gifted, epidemic is a result of our tors, and public health officials generous. It’s an apt description ancient genes. They protected us start to realize how serious the of Dr. Stunkard, and sets the bar from starvation in times of obesity crisis is.” high for the clinicians entrusted famine, but we now live in a with helping patients in the pro- land in which food is plentiful, There are many weight loss cen- gram that bears his name. cheap, and marketed to con- ters and programs in the region, sumers around the clock. Eating but the Stunkard Weight Man- has become a recreational pas- agement Program stands out. For additional information about time that often has little to do “The Stunkard Program pro- the Albert J. Stunkard Weight Man- with satisfying hunger or vides an unparalleled level of agement Program, please call 215- obtaining needed nutrition. At care for overweight and obese 746-4100. Additional information is the same time, we have become individuals,” says Dr. Sarwer. also available on the Program’s an increasingly sedentary nation “All of the Program’s staff mem- website (www.med.upenn.edu/ in which work, for many Ameri- bers have trained at the Center weightloss). cans, consists of little more than for Weight and Eating Disorders

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A NEW WAY TO REACH OUT: THE HIV/AIDS MOBILE CLINICAL TRIALS UNIT

here’s a new neighbor on the block. lead many members of our target populations to T view medical professionals, service providers, researchers, and their associated institutions with This Fall, a new approach to clinical trials a significant level of distrust and suspicion. Over- research will make its first appearance on the coming these barriers to research participation streets of West Philadelphia. It’s called a Mobile requires researchers to develop creative methods Clinical Trials Unit (MCTU) and is intended to to engage potential participants.” facilitate the completion of randomized clinical trials testing of HIV vaccines and other preven- One approach has been to locate research facili- tion interventions that may someday prevent the ties in areas where high-risk individuals reside. spread of HIV infection. The Division, for instance, has used a storefront building in North Philadelphia for the past ten This new MCTU, operated by the Department of years as a base for conducting studies. Psychiatry’s HIV/AIDS Prevention Research Division, is designed to address a central prob- A more promising course has been to create a lem for all clinical researchers – how to recruit mobile transport system capable of going wher- eligible individuals to participate in clinical trials ever potential study and ensure that they com- enrollees live. In 1998, plete the studies. the Division convert- Without the con- ed a second-hand sistent coopera- Winnebago into a tion of study sub- Mobile Assessment jects, even the Unit (MAU) to pre- best-designed screen volunteers for innovative trials study eligibility, and are destined to fail. added a second and larger used Win- Since 1988, the nebago in 2002. The HIV/AIDS Preven- Division also main- tion Research Divi- tains a mini-van to sion has enrolled transport participants to office visits and a over 5000 individu- Toyota automobile for specimen pick-up, deliv- als in various clinical studies. Despite this suc- ery, and other logistical activities. cess, attracting and retaining prospective study participants has been a continuing challenge. The MAUs are made available to others if they pay for the driver's time and fuel. Several com- David S. Metzger, PhD, Director of the Division munity-based organizations and the Philadelphia and Associate Professor of Psychology in Psychi- Department of Health have used these vehicles atry, explains that “in Philadelphia and other for health promotion activities. Dr. Metzger says urban areas in the United States, these [high-risk that sharing use of the MAUs helps “build and hard-to-reach] populations are likely to rep- stronger relationships with the community.” resent segments of the African American and Latino populations struggling with a host of While the MAUs have been valuable for pre- social issues and economic disadvantages. These screening potential subjects, they do not have the factors, coupled with a long history of abuse and capacity to carry out full screenings, which are maltreatment by the health care establishment, much more medically intensive and include a full

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physical and related blood work. Until now, full To facilitate rapid communications with remote screenings have been conducted at the Division’s sites, the MCTU has a cellular broadband antenna clinical offices. “If people are eligible for the study and is equipped with a computer with access to and willing to participate,” says Dr. Metzger, the study participant database, the Internet, and “they are then invited to our campus offices for with faxing capabilities. A cell phone is on the unit participation in the study.” The problem, Dr. Met- at all times. zger says, is that “nearly 50 percent of those who The MCTU was purchased with strong support appeared eligible and willing when pre-screened from the Dean of the School of Medicine, Arthur in their home communities on our MAUs did not Rubenstein, MBBCh, and the Chairman of Psychi- complete scheduled appointments at our Universi- atry, Dwight Evans, MD. In addition, the National ty-based clinical offices where protocol-specific Institute of Allergy and Infectious Diseases study visits are conduct- (NIAID) HIV Vaccine Trial ed.” Network (HVTN) is provid- Losing half the potential ing financial support for enrollees between the equipment. Operating costs, pre-screening and study including expenses for staff, participation stages cre- supplies, and fuel costs, will ates significant obstacles be no greater than those for to implementing the tri- the current campus-based als. Over the past five clinical office. “If we are years alone, Division successful in enrolling the researchers have pre- trials faster,” says Dr. Met- screened over 4,000 zger, “a strong argument potential subjects, can be made that the mobile screened nearly 1500 unit will actually be cost subjects, and enrolled effective.” over 800 participants Dr. Metzger emphasizes into clinical trials of The MCTU -- A look inside that the MCTU will be the behavioral, vaccine, and “first unit designed to conduct an entire clinical microbicide interventions. The sequential drop-off trial on a mobile unit in the community. All eyes in numbers from each phase to the next has been will be upon our site as we begin implementa- troubling. tion.” The aim is to increase the number of eligible The new MCTU represents a possible solution to potential participants who complete trials. The retaining potential enrollees unable or unwilling HIV/AIDS Prevention Research Division has to journey to Penn. The MCTU is an all-in-one earned a reputation for employing mobile units to mobile site for pre-screening, screening, and full enroll and retain high-risk participants in clinical study participation, eliminating the need for study trials, but “with this unit,” says Dr. Metzger, “I participants to ever leave their neighborhoods. believe we will engage and enroll significantly The 300 square foot vehicle is fully equipped with more of these individuals.” a powered chair lift, three refrigerators, and emer- Informing the community about the MCTU is crit- gency supplies, and provides lighting, heating, air ical to its success. “We have a group of recruit- conditioning, and running water, all powered by a ment, ethnographic, and community education main generator. Interior space includes a recep- staff dedicated to getting the word out to mem- tion and waiting area, two fully equipped private bers of the communities we target,” says Dr. Met- examination rooms, specimen processing and zger. “We always try to get community permission phlebotomy areas, an area for private consulta- before parking the MCTU at a local site. We have tions, a bathroom with a flush toilet, and storage worked in many of the neighborhoods where HIV space. is most prevalent for over 15 years and have

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Our Distinguished Faculty

AWARDS & HONORS

Penn Honors term loyalty to the Department and excellence in teaching and/or supervising. Upon receiving the award, Dr. Cohen The Albert Stunkard Faculty Recognition Award is given remarked, “It is very important that we be good teachers. annually to faculty members who are outstanding teach- Our goal as teachers should always be that those we teach ers and mentors. The graduating resident class selects should be better than we are.” award winners who have significantly influenced their education and training. Named for Albert J. Stunkard, Charles Dackis, MD was appointed Medical Director of MD, Emeritus Professor of Psychiatry and former Chair of Psychiatric Clinical Services for the Hospital of the Uni- the Department, this award recognizes Dr. Stunkard's versity of Pennsylvania (HUP) and the Clinical Practices enormous contribution to the education, training, and of the University of Pennsylvania (CPUP). This appoint- support of Department housestaff. Alexandra Mclean, ment is in addition to his role as Medical Director of Psy- MD, Sarah DeMichele, MD, David Weiss, MD, John chiatric Clinical Services at Penn Presbyterian Medical O'Reardon, MD, Claudia Baldassano, MD, E. Cabrina Center. In his new role, Dr. Dackis will have responsibility Campbell, MD, and Jeffrey Staab, MD received this for the Psychiatric Clinical Services under CPUP, which honor in 2007. include clinical services in individual programs through- out the Department, as well as the general outpatient and The 2007 PGY-3 & 4 Teaching Award was awarded to resident clinics. He will also be responsible for the inpa- David Weiss, MD and the 2007 PGY-1 & 2 Teaching tient, emergency, and consult services at HUP. Award was also awarded to David Weiss, MD. These awards honor those individuals whom the residents Joseph T. English, MD received the believe were the most effective teachers of the academic 2007 Edward A. Strecker Award from year and exemplary in shaping their overall education. Pennsylvania Hospital and the Univer- sity of Pennsylvania Health System for Claudia Baldassano, MD was awarded the 2007 Martin P. outstanding contributions to the field Szuba Award for Excellence in Clinical Teaching and of clinical psychiatry. Research. This award is presented annually to a Depart- ment faculty member with outstanding teaching abilities, Deborah Kim, MD received the 2007 Emily B. Hartshorne ongoing clinical research, and a focus on translating Mudd Award. This award is offered yearly in honor of Dr. research concepts into clinically useful teaching, all of Emily Mudd, Professor Emeritus of Family Studies in which Dr. Szuba embodied in his work. Psychiatry and founder of the Marriage Council of Philadelphia. It is presented to an individual who has Aaron T. Beck, MD received an honorary degree from the contributed substantially to the field of family health. University of Pennsylvania at the 2007 Commencement in May. He also received the 2007 William Osler Patient Ori- Eva Loeb, MD was the 2007 recipient of the Earl Bond ented Research Award from the School of Medicine in Award. Initiated by the efforts of Dr. William Peltz, this recognition of his achievements in conducting research annual award is given to a Department member who has with human subjects. distinguished himself/herself for teaching at the medical student, resident, and/or graduate levels. Rhonda Boyd, PhD was selected as a Macy Foundation Faculty Scholar by the James R. McKay, PhD has been elected Center of Excellence for Diversity in to a two-year term on the Senate Execu- Health Education and Research at the tive Committee of the University of Penn School of Medicine. The award is Pennsylvania Faculty Senate and the Uni- funded by a grant from the Josiah Macy, Jr. versity Council. He will serve as repre- Foundation and is intended to support the sentative of Faculty Constituency #24, career development of minority faculty. which includes the Departments of Der- matology, Family Medicine and Commu- Kenneth D. Cohen, MD received the 2007 Clinical Facul- nity Health, Ophthalmology, Orthopaedic Surgery, ty Award from the Department of Psychiatry. This award, Otorhinolaryngology: Head and Neck Surgery, and Psy- funded by a clinical faculty member, is given to a volun- chiatry. teer clinical faculty member who has demonstrated long-

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Continued from page 8 Thomas A. Wadden, PhD received the 2007 Arthur K. ter for comprehensive, interdisciplinary pain medicine Asbury Outstanding Faculty Mentor Award from the practice, teaching, research and policy development at the School of Medicine. This award “recognizes a faculty University of Pennsylvania." The award honors Dr. Oak- member who has fostered the professional development ley, a world-renowned expert in pain medicine and of other faculty members by providing inspiring and founding board member of the National Pain Foundation, effective counsel and opportunities for achievement.” who was killed in a plane crash in 2006.

Namni Goel, PhD was selected as Pres- Regional, National & International Honors ident-Elect of the Society for Light Treatment and Biological Rhythms, an Aaron T. Beck, MD was elected a Fellow of the American international society, in June 2007. In Academy of Arts and Sciences. April, she was chosen to serve on the Rhonda Boyd, PhD was selected to serve on the Ethical Editorial Board of SLEEP and, in Conduct Committee for the Society for Research in Child August, was appointed to the Editorial Development. Board of Chronobiology International.

Edward S. Brodkin, MD was listed in Philadelphia Maga- Christian Kohler, MD was selected by the Association of zine’s “Top Doctors” 2007 survey for expertise in autism Academic Psychiatry as the recipient of the Regional spectrum disorders. Teaching Award for Region III, based on his teaching of PGY-II residents and medical students who rotate on the In April, Gregory K. Brown, PhD received the Edwin neuropsychiatry team on 11 Founders at HUP. The award Shneidman Award from the American Association of Sui- was presented in September at the AAP's annual meeting cidology for outstanding contributions in suicidology in Boston. research. Caryn Lerman PhD has been selected to receive The James C. Coyne, PhD was granted an Alton Ochsner Award Relating Smoking and Health from appointment as a Visiting Honorary the American College of Chest Physicians. The award is Professor in Health Psychology at the "for outstanding and exemplary original scientific investi- University of Groningen, the Nether- gations that relate tobacco consumption and health." She lands. He will visit Groningen regularly will receive the award in October at the College's annual and facilitate exchanges of doctoral stu- convention in Chicago. Dr. Lerman also will receive the dents, fellows, and junior faculty, build- Cancer Control Award from the American Cancer Society ing on an existing relationship between in October for her outstanding contributions to cancer the University of Pennsylvania and University of Gronin- prevention and control research. gen. He also gave the Inaugural Lecture for that universi- ty’s SHARE (Public Health) Graduate Program, “The David S. Metzger, PhD received the Seduction of Death: Rethinking the Goals of Health Psy- 2007 International Program Award of chology.” Excellence in International Leadership from the National Institute on Drug David F. Dinges, PhD received the NASA Distinguished Abuse. He was recognized for his Public Service Medal in May. This recognition is the high- “global efforts to prevent HIV trans- est honor NASA awards to a non-Government employee mission by reducing drug use and and is granted to individuals whose distinguished accom- associated risk behaviors.” The award plishments contributed substantially to the NASA mis- “recognizes U.S. or non-U.S. drug abuse researchers who sion. According to NASA criteria, "the contribution must have made significant contributions to international col- be so extraordinary that other forms of recognition would laborative research and/or capacity building outside the be inadequate." United States. The awardees serve as exemplars to their colleagues through superior efforts to develop the human Dwight L Evans, MD and Lee Fleisher, MD (Anesthesi- resources necessary to improve scientific understanding ology and Critical Care) will receive the John C. Oakley of drug abuse and addiction and develop and implement Pioneers in Pain Medicine Award from the National Pain science-based prevention and treatment programs.” Foundation at its Triumph Dinner event in Philadelphia in October. This is the second year that the award has David B. Sarwer, PhD was a Visiting Fellow at the Uni- been given. The NPF is recognizing Drs. Evans and versity of the West of England’s Centre for Appearance Fleisher "for their administrative vision and leadership in Research. facilitating the development of an interdepartmental cen-

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NEWS & GOINGS ON

Kelly C. Allison, PhD Pennsylvania State Senator Vincent keynote address to the Couples will be the a keynote Hughes. Coping Conference, at the Universi- speaker this fall at her ty of Vancouver, British Columbia, graduate school alma Gregory K. Brown, PhD gave the “Being in a Couple, Health and mater, Miami Universi- Keynote Speaker Address, “Cogni- Well-Being: Some New Issues and ty, during the dedica- tive Therapy for Suicide Prevention: Old Issues Redefined.” He also gave tion of the university’s Application in Community Set- paper presentations at the annual new Psychology building. tings,” at the Delaware Suicide Pre- meetings of the Royal College of vention Conference (Newark, Psychiatrists (Edinburgh, Scotland); Ellen Berman, MD serves as Chair Delaware) in April. He gave a Ple- the International Psycho-Oncology of the Group for the Advancement nary Address, “Cognitive Therapy Society (London, England); and the of Psychiatry (GAP) Committee on for Suicide Prevention: A Public European Health Psychology Soci- the Family. The Committee is lead- Health Approach,” at the Interna- ety (Maastricht, the Netherlands). ing efforts to transform family train- tional Association for Suicide Pre- ing in residency programs so that vention, (Killarney, Ireland) in David F. Dinges, PhD gave lectures the primary focus is on support and August. He also delivered an invit- in the spring and summer on differ- psychoeducation for all families of ed address, “Cognitive Therapy for ent topics at various venues, includ- psychiatric patients, with Suicide Prevention,” to the Suicide ing "Sleep Deprivation Effects on couple/family therapy as an option Prevention Action Network (Wash- Cognition: Strategies for Mitigation" for those who need it. The Commit- ington, DC) in July. (U.S. Naval Academy, Annapolis tee's first paper, "Family Skills for and also the Center for Translation- General Psychiatry Residents: al Neuroscience, Department of Meeting ACGME Core Competen- In August, the Center for Studies of Neurobiology & Developmental cy Requirements," was published Addiction hosted nine Iranian psychiatrists Sciences, College of Medicine, Uni- in Academic Psychiatry in 2006. as part of the US State Department’s Inter- versity of Arkansas for Medical Sci- Their second paper, "Family-Ori- national Visitor Leadership Program. The ences, Little Rock); "Optimizing ented Patient Care Through the International Visitors Council of Philadelphia Neurobehavioral Performance Residency Training Cycle," was escorted the Iranian physicians and their through Biology and Technology" recently accepted for publication three interpreters during the visit to the CSA. (JASON Program, McLean, Vir- in the same journal. The Commit- The scientific exchange consisted of presen- ginia); "Optical Computer Recogni- tee has also presented this work at tations by Penn investigators, informal dis- tion of Behavioral Stress in Space the Association of Academic Psy- cussion, and a presentation by one of the Flight" and "Countermeasures to chiatry and the American Associa- Iranian scientists. Neurobehavioral Deficits From tion of Directors of Psychiatric Cumulative Sleep Deprivation Dur- Residency Training (AADPRT). In ing Space Flight: Dose-response addition, Dr. Berman serves as Pres- James C. Coyne, PhD gave an invit- Effects of Recovery Sleep Opportu- ident of the Association of Family ed lecture, “The Challenge of Pro- nities" (16th Annual International Psychiatrists (AFP). Among other viding Effective and Acceptable Academy of Astronautics Humans activities, the AFP is a reviewer of Psychosocial Services to Cancer in Space Symposium, Beijing, APA documents such as practice Patients,” at the Edinburgh Cancer China); "Sleep and Waking in guidelines, ensuring that family Centre (Edinburgh, Scotland) and to Deployment and Critical Settings: issues are included in everyday the Ontario Cancer Coalition Performance, Biology, Technology" practice. She is a co-author of the (Toronto, Canada). He also gave an (U.S. Public Health Service Scientific chapter “Couples Therapy,” in Tas- invited talk to the National Cancer and Training Symposium, Cincin- man A, Kay J, Lieberman J. Psychia- Institute, “Psychosocial and Behav- nati, Ohio); and "Optimizing Neu- try, 3rd ed, vol 2, currently in press. ioral Outcomes Associated with Dis- robehavioral Performance through closure of Genetic Information.” He Biology and Technology" (Commit- Rhonda Boyd, PhD is serving on gave an invited talk to the Sixth tee on Military and Intelligence the planning committee for the Meeting of the European Alliance Methodology for Emergent Neuro- Breaking the Silence conference, Against Depression, “Dissemination physiological and Cognitive/Neural which focuses on behavioral health and the Achievement of Sustainabil- Science Research in the Next Two in the African American community. ity in the Expansion of the EAAD” Decades, National Academies, The conference is sponsored by (Leipzig, Germany). He gave a Washington, DC). In May 2007, Dr.

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Dinges was a panelist at the Inter- Depression” and “Circadian telephone to provide ongoing coun- national Space Medicine Summit at Rhythm Profiles in Night Eating seling and support to patients with Rice University in Houston, TX. Syndrome” at the Society for Light substance use disorders who have Treatment and Biological Rhythms completed an initial phase of care. In August, Dwight L. Evans, MD in Copenhagen, Denmark. In May, Dr. McKay gave an invited presented and chaired a panel in lecture on "Implementing the Dublin, Ireland on "Promising Daniel D. Langleben, MD spoke in Chronic Care Model" to the County Treatments and Interventions for Berlin in May at the 11th Berlin Col- Alcohol and Drug Program Admin- Youth," sponsored by the American loquium sponsored by the Konrad istrators Association of California. Foundation for Suicide Prevention Adenauer and the Gottlieb Daimler Also in May, he delivered a lecture and the Irish National Office for and Karl Benz Foundations on the on "New Developments in Continu- Suicide Prevention. The title of the topic of "Mind Reading.” In Sep- ing Care in the Addictions" to the program was "Youth Suicide: New tember 2007, he also was one of the Integrated Substance Abuse Pro- Knowledge for a New Generation." invited lecturers at The Oxford grams of the Semel Institute for Autumn School for Neuroscience in Neuroscience and Human Behavior Since 2000, Rollin Gallagher, MD Oxford, United Kingdom and lec- at UCLA. has served as Founding Editor-in- tured on the use of fMRI for lie Chief of Pain Medicine, official jour- detection. Cory F. Newman, PhD delivered nal of the American Academy of invited lectures (along with playing Pain Medicine. In 2007, the journal Stephen E. Levick, a piano recital of the music of increased to 8 issues yearly and MD is the faculty Chopin) at the Psychotherapy became the official journal of the advisor for the School & CBT Centre (Szkola Psy- International Spine Intervention newly formed Uni- choterapii Poznawczo-Behawioral- Society and the Faculty of Pain versity of Pennsyl- nej) in Warsaw, Poland in May. In Medicine of the Australia New vania chapter of the July, he presented a keynote address Zealand College of Anesthetists. In Student Society for entitled "Power Supervision: Train- August, Dr. Gallagher briefed the Stem Cell Research (SSSCR). SSSCR ing the Next Generation of CBT U.S. Senate Health, Education, educates students and others about Clinicians to Excel in Both Technical Labor, and Pensions Committee on stem cells and their therapeutic Merit and Artistic Impression" at the "Transition from Acute to potential, and advocates for stem the World Congress of Behavioral Chronic Pain: Considerations of cell research and the new field of and Cognitive Therapy in Pain, Addiction, and Mental Health regenerative medicine. Barcelona, Spain. Dr. Newman also Co-Morbidity." He delivered several gave his 12th annual piano recital in national presentations during 2007 Louis Littman, MD, PhD spoke on June at Dunlop Auditorium, featur- including: "Treatment of Injured "Careers in Psychiatry" for the ing the works of Bach, Beethoven, Soldiers: Transition from Acute to National Youth Leadership Forum Chopin, and Brahms. Chronic Pain With/Without Co- on Medicine at Villanova University morbidities" (Annual Meeting of the in August. In April, he delivered a Charles P. O'Brien, MD, PhD and American Pain Society, Washington, lecture on "More than Sadness: A. Thomas McLellan, PhD deliv- DC); "Complex Regional Pain Syn- Major Depression and Bipolar Dis- ered lectures on the treatment of drome: Continuum of Care" (Cleve- order" for the Depression and Bipo- addiction to a workshop of journal- land Clinic Annual Conference on lar Support Alliance of New Jersey. ists held prior to the meeting of the Pain, Orlando); and Managing Dr. Littman also serves on the Med- College on Problems of Drug Chronic and Breakthrough Pain ical Advisory Board of that organi- Dependence in Quebec City, Cana- with Opioid Analgesics" (Texas zation. da in June. At the meeting, investi- Medical Society Annual Conference, gators from the Center for Studies Dallas). James R. McKay, PhD is participat- of Addiction displayed posters and ing in a small workgroup that is made presentations on addiction- In June 2007, Namni Goel, PhD revising and updating the substance related topics. Also in June, Dr. delivered a lecture on “Phenotyping abuse treatment practice guidelines O’Brien delivered the Plenary Lec- Neurobehavioral and Cognitive for the Department of Veterans ture on “New Treatments for Addic- Responses to Partial Sleep Depriva- Affairs treatment system. Dr. tive Disorders” at an international tion” at the School of Medicine’s McKay is working with the states of meeting of the Addiction Research Center for Sleep and Respiratory Delaware and Rhode Island to Congress in Paris. Neurobiology. She also spoke on implement and evaluate Penn- “Light Treatment for Chronic developed protocols that use the Paul M. Robins, PhD gave a talk Continued on page 12

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Continued from page 11 on "The Experience of Secondary trol Program Seminar Series at The Traumatic Stress" to the Cardiac Ohio State University Comprehen- Mobile Clinical Trials Unit Transplant Program at The Chil- sive Cancer Center. He gave anoth- Continued from page 7 dren's Hospital of Philadelphia er invited lecture at the Focus on (CHOP) in May. In June, he dis- Head and Neck Cancers Conference strong ties to these places. We will cussed "Training in Providing Psy- in Philadelphia, titled: "Advancing use all methods at our disposal to chology Services Within Pediatric our Understanding of Prevention of Primary Care" in the Psychology Head and Neck Cancer." inform the target areas of our cur- Seminar Series at CHOP. Dr. Robins rent studies. We have done radio also attended the Education Leader- This fall, Jack L. Solomon, MD is interviews and talk shows in the ship Conference of the American scheduled to chair a Site Visit from past, but our best method is word Psychological Association and met the Board of Professional Standards of mouth.” with U.S. Senators and Representa- of the American Psychoanalytic tives in Washington, DC on Septem- Association to the Psychoanalytic HIV vaccine studies are the ber 11 to advocate for reauthoriza- Institute of the Department of Psy- MCTU’s primary projects at the tion of the Substance Abuse & Men- chiatry and Behavioral Science of moment, but the unit can be used tal Health Services Administration the Emory University School of for any clinical trials requiring (SAMHSA) work force and campus Medicine. enrollees from the community. The suicide programs. unit will be used for a Center for Paul Root Wolpe, Studies of Addiction study evaluat- Richard J. Ross, MD, PhD led a PhD gave a talk in ing the efficacy of delivering Meet the Professors session on April to the Society modafinil to cocaine users at high “Posttraumatic Stress Disorder and for Experimental risk of HIV infection. In the future, Sleep” at the annual meeting of the Biology on the Associated Professional Sleep Soci- ethics of pharma- the unit may also be a resource for eties in June in Minneapolis. cogenomics at the other studies in the Department Society's annual and University. David B. Sarwer, PhD delivered meeting. In May, he spoke at the Nothing before compares to the lectures in San Diego in June at the Aerospace Medicine Annual Meet- Annual Meeting of the American ing on Bioethics in Long Duration MCTU. Dr. Metzger says “many Society for Bariatric Surgery on the Space Flight. In June, he spoke at places have mobile medical units to following topics: "Psychological Sta- the London School of Economics deliver care to people in hard-to- tus in Adolescents Undergoing and Political Science on security reach places, or to reach people Bariatric Surgery"; "Does Preopera- issues and neuroethics, and at who never come to medical facili- tive Weight Loss Make a Differ- Oxford and Cambridge on brain ties. Often these are specialty-spe- ence?"; "Preoperative Psychological enhancement ethics. In July, he cific, such as dental care, eye care, Assessment: Essential Elements"; spoke at a conference on reforming or prenatal care facilities.” and "Medical and Psychological health care in Pennsylvania at Jeffer- Rescue for the Post-operative son Medical School, and in August In a real sense, the MCTU is really Bariatric Surgery Patient with he spoke at the "SMART ART" con- a unique experiment to learn how Weight Gain.” In New York in April, ference on artificial reproductive clinical experiments can be more Dr. Sarwer spoke on "Society's Beau- technologies in Baltimore. effectively conducted. “Our ty Ideal and the Pursuit of Cosmetic hypothesis,” says Dr. Metzger,” is Surgery" at the Second Annual George E. Woody, MD presented that we can enroll a cohort of study Women Plastic Surgeons' Luncheon data from a study of buprenorphine of the American Society of Aesthetic for opioid-dependent adolescents participants who are at highest risk Plastic Surgeons. and young adults at one interna- of HIV infection using this new tional and two national meetings. unit. We will evaluate the degree Robert A. Schnoll, PhD delivered He also chaired a symposium at a to which participants like the unit, an invited lecture in April titled June meeting of the College on the speed of trial enrollment, and "Evaluating Treatments for Nicotine Problems of Drug Dependence that our retention rates. I am optimistic Dependence: Studies with Cancer highlighted National Institute on that we will see success in each of Patients, New Agents, and Recruit- Drug Abuse contributions to inter- these areas, but we have to do the ment Methods" for the Cancer Con- national addiction research. trial first!”

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RESEARCH NEWS

Edward S. Brodkin, MD is starting a new research project, funded by an R01 grant from the National Institute The Center for Weight and Eating Disorders of Mental Health, titled "Neurobiolo- has begun a new study titled “Improvements in Repro- gy of Sociability in a Mouse Model ductive Status Following Bariatric Surgery,” with partic- System Relevant to Autism." The ipating investigators David B. Sarwer, PhD, Kelly C. study will use a mouse model system Allison, PhD, Samantha Butts, MD, MSCE (Obstetrics to test the relationships between social and Gynecology), Christos Coutifaris, MD, PhD behaviors and specific brain abnormalities relevant to (Obstetrics and Gynecology), and Noel Williams, MD autism. This mouse model system also will test the (Surgery). This study will prospectively compare the effect of genes and environmental factors on these social reproductive endocrine status of women with obesity behaviors and brain traits. The goal is to elucidate the and irregular menses in two groups – women undergo- neurobiology and genetics of sociability disruptions in ing bariatric surgery and women attempting weight loss autism, and to identify promising directions for future with caloric restriction. It is expected that the sizable basic and clinical research on autism. weight loss imparted by bariatric surgery will produce Monica E. Calkins, PhD is the Principal Investigator on improvements in reproductive status above and an NIH K08 research grant titled “A Prospective Study beyond those achieved by more conservative weight of Endophenotypes in At-Risk Youths and Their Sib- loss treatments. lings.” The project period runs from August 2007 through May 2012. Bruce Turetsky MD and Raquel E. Gur, MD, PhD serve as mentors on the grant. Depression and Bipolar Disorder, New York, McGraw-Hill, In a paper published in the May issue of the Psychologi- 2006). He was also a co-author of a book targeted for cal Bulletin, co-authors James C. Coyne, PhD, Michael adolescent readers describing a teenager's personal Stefanek, PhD (American Cancer Society), and Steven experience with depression (Irwin C, Evans DL, C. Palmer, PhD reviewed all available evidence con- Andrews LW. Monochrome Days: A Firsthand Account of cerning the view widely held by cancer patients and One Teenager's Experience with Depression, New York, professionals alike that being in psychotherapy or a Oxford University Press, 2007). This volume is a prod- support group prolonged the life of cancer patients. uct of the Adolescent Mental Health Initiative (AMHI) They found numerous methodological and analytic supported by the Annenberg Foundation Trust at Sun- problems in even the widely cited classic studies and nylands. concluded that no credible evidence existed for a benefit Martin E. Franklin, PhD is the Penn for survival. The findings of the review were reported in Principal Investigator on a recently fund- numerous media sources including Reuters, and inter- ed National Institute of Mental Health views appeared with Dr. Coyne on NPR and Canadian multi-site five-year grant titled “Family- National Public Radio. Drs. Coyne and Palmer also based Treatment of Pediatric OCD wrote an invited follow up article for The European [Obsessive-Compulsive Disorder].” The Health Psychologist, “Does Anyone Read the Classic R01 grant also involves Brown Universi- Studies They Cite?” Dr. Coyne also published two ty (J. Freeman, PI) and Duke University (J. March, PI). papers with Dr. Joan Cook (formerly Assistant Professor The study will examine treatments for children ages 5-8 in the Department and now at Yale University) in the who suffer from OCD. Journal of General Internal Medicine in March and August on the perspectives of primary care physicians and Teresa R. Franklin, PhD and her colleagues wrote two older patients on the difficulties encountered in tapering papers related to brain imaging of nicotine craving or discontinuing chronic use of benzodiazepines. The (Franklin, T.R., Ehrman, R., Wang, Z., Wang, J.J., Sciorti- articles were covered in stories in Reuters and other no. N., Harper, D., Li, Y., Kampman, K., O’Brien, C.P., media. Detre, J., Childress, A.R. Limbic activation to cigarette smoking cues, independent of withdrawal: A perfusion Dwight L. Evans, MD was a co-editor of the first com- fMRI study. Neuropsychopharmacology, Mar 21 2007 AOP; prehensive edited volume addressing the relationship Franklin, T.R., Ehrman, R., Lynch, K., Harper, D., Sciorti- between depression and chronic medical illness (Evans no, N., O’Brien, C.P., Childress, A.R. Menstrual cycle DL, Charney DS, and Lewis L [Eds]. Physician's Guide to phase effects on smoking status in an NRT treatment Continued on page 14

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study: Preliminary Findings. Journal of Women’s Health, rate the 10th anniversary of the "Dolly" experiment in press). She also received a research grant from Pfizer (From Xenopus to Oedipus: “Dolly,” Human Cloning, titled “Measurement of the Effects of Varenicline on and Psychological and Social “Clone-ness,” 2007, 9[1]: Brain Activation to Smoking Reminders and Subse- 33-39). In his introductory editorial, Ian Wilmut, the quent Smoking Behaviors: A Perfusion fMRI Study.” chief editor of the journal and leader of the research Among other objectives, these studies will investigate team that cloned "Dolly," referred to Dr. Levick's paper the effects of varenicline on resting brain activation and as "an extremely important essay." how it modulates the characteristic response to smok- Richard J. Ross, MD, PhD and Samuel Kuna, MD, ing reminders in limbic brain regions activated during Director of the VA’s Stars & Stripes Network (VISN 4) smoking cue exposure. Regional Sleep Center at the Philadelphia VA Medical Marina Goldman, MD received a research grant from Center and Associate Professor of Medicine at Penn, the National Alliance for Research on Schizophrenia received a Parkinson's Disease Research, Education and Depression on "Brain Substrates Associated with and Clinical Center pilot project grant titled "Develop- Vulnerability to Substance Abuse in Adolescents with ment of a Validated Questionnaire for Dream Enact- Conduct Disorder." ment Behavior (DEB).” Stephen E. Levick, MD contributed an invited essay to a special issue of Cloning and Stem Cells to commemo-

The Center for Studies of Addiction received a notice of grant award for the com- peting renewal of its P60 comprehensive NIH center for five more years to year 25 (June 30, 2012). Charles P. O’Brien, MD, PhD is the Principal Investigator of this grant titled “Center for Research on Improving the Treatment of Drug Abuse.” The center has received continuous NIH funding since 1973. In addition, researchers at the CSA started several new studies in the spring: • Based at Reading Hospital, one study focuses on primary care patients started on an opioid analgesic for chronic non-malignant pain to determine the risk for addic- tion in the treatment of pain (P.I. – Martin D. Cheatle, PhD, with Charles P. O'Brien, MD, PhD, David W. Oslin, MD, James McKay, PhD, Rollin Gallagher, MD, and A. Thomas McLellan, PhD). • Another study centers on cocaine addiction in women in West Philadelphia who trade sex for drugs by comparing the effects of modafinil versus a placebo on cocaine use and high-risk sexual behavior. The study will be conducted from a mobile clinic van, along with ongoing HIV vaccine studies. (P.I. – Charles Dackis, MD, with David S. Metzger, PhD, David W. Oslin, MD, and Charles P. O'Brien, MD, PhD). • A six-site collaborative study focuses on the prevention of relapse to heroin addic- tion in parolees and probationers using depot (injectable) naltrexone. The study is led by Penn (P.I. – Charles O'Brien, MD, PhD, with James W.Cornish, MD) and includes investigators at Columbia University, New York University, Virginia Com- monwealth University, Brown University, and the Social Research Center of Friends Research Institute (Baltimore). • Another study focuses on the treatment of opioid addiction with a buprenorphine implant (P.I. – George E. Woody, MD and Kyle M. Kampman, MD).

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RESEARCH GRANTS The following sponsored research funding was received by the Department during the period April 1, 2007 through September 30, 2007

New NIH Awards (includes New and Competing Renewals)

Name Sponsor Project Title

BRODKIN, EDWARD NIH NEUROBIOLOGY OF SOCIABILITY IN A MOUSE MODEL SYSTEM RELEVENT TO AUTISM

CALKINS, MONICA NIH A PROSPECTIVE STUDY OF ENDOPHENOTYPES IN AT-RISK YOUTHS

FRANKLIN, MARTIN NIH FAMILY BASED TREATMENT OF EARLY CHILDHOOD OCD HOT FLASHES AND ANXIETY SENSITIVITY AMONG BREAST CANCER SUR- HANISCH, LAURA NIH VIVORS HUGHES-HALBERT, CHANITA NIH AFRICAN AMERICAN PARTICIPATION IN CANCER GENETICS RESEARCH

LANGLEBEN, DANIEL NIH FUNCTIONAL MRI OF ANTI-TOBACCO PUBLIC SERVICE ANNOUNCEMENTS

LYNCH, KEVIN NIH MEDIATION METHODS IN ALCOHOL CONTINUTING CARE RESEARCH MANDELL, DAVID NIH INTERSTATE VARIATION IN HEALTHCARE UTILIZATION AMONG CHILDREN WITH ASD

METZGER, DAVID NIH PENN PREVENTION CLINICAL TRIALS UNIT

O'BRIEN, CHARLES NIH CENTER FOR RESEARCH ON IMPROVING TREATMENT OF DRUG ABUSE PALMER, STEVEN NIH HEALTH BEHAVIORS IN TESTICULAR CANCER SURVIVORS

STIRMAN, SHANNON NIH INFLUENCES ON THE SUSTAINABILITY OF EVIDENCE-BASED PSYCHOTHER- APIES

THASE, MICHAEL NIH GENETIC DETERMINANTS OF BIPOLAR DISORDER

THASE, MICHAEL NIH PROPHYLACTIC COGNITIVE THERAPY FOR DEPRESSION

Other Federal Agencies Name Sponsor Project Title BLANK, MICHAEL CDC PS07-005 MULTI-SITE RAPID HIV TESTING IN URBAN COMMUNITY MENTAL HEALTH SETTINGS

DINGES, DAVID NATIONAL SPACE BIOMEDICAL SLEEP-WAKE MEDICATIONS IN SPACE FLIGHT: REVIEW OF BEST PRACTICES RESEARCH INSTITUTE

DINGES, DAVID US AIR FORCE OPTIMIZING PERFORMANCE THROUGH SLEEP-WAKE HOMEOSTASIS: INTE- GRATING PHYSIOLOGICAL AND NEUROBEHAVIORAL DATA VIA AMBULATORY ACQUISITION IN LABORATORY AND FIELD ENVIRONMENTS

DINGES, DAVID NATIONAL SPACE BIOMEDICAL READINESS TO PERFORM IN A SPACE ANALOG ENVIRONMENT RESEARCH INSTITUTE

OVERALL, KAREN DEFENSE ADVANCED DEVELOPING DOGS FOR THE WAR FIGHTER AND OTHER RELATED CON- RESEARCH PROJECTS AGENCY TEXTS: IDENTIFYING DOGS WHO CAN WORK USING AUDITORY SIGNALS

ROSS, RICHARD DEPARTMENT OF VETERANS IPA AFFAIRS

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Other Agencies and Organizations

Name Sponsor Project Title

AUDRAIN-MCGOVERN, COMMONWEALTH OF PENN- PRIMARY CARE NETWORK FOR ADOLESCENT SMOKING CESSATION JANET SYLVANIA

BECK, AARON COMMUNITY BEHAVIORAL DISSEMINATION OF COGNITIVE THERAPY TO COMMUNITY MENTAL HEALTH HEALTH CENTERS

BROWN, GREGORY AMERICAN FOUNDATION FOR PILOT PROJECT FOR THE DEVELOPMENT OF A SUICIDE ATTEMPT REG- SUICIDE PREVENTION ISTRY AND CLASSIFICATION OF SUICIDAL BEHAVIOR FOR ADULTS

GUR, RUBEN NATIONAL ALLIANCE FOR BRIDGING HUMAN NEUROPSYCHOLOGY WITH MOUSE BEHAVIOR RESEARCH ON SCHIZOPHRE- THROUGH FUNCTIONAL IMAGING OF SANDY MICE AND HUMANS WITH HAP- NIA AND DEPRESSION LOTYPES THAT MAY AFFECT GLUTAMATE SYNAPSES KOHLER, CHRISTIAN NATIONAL ALLIANCE FOR EMOTION RECOGNITION AND EXPRESSION IN STABLE SCHIZOPHRENIA RESEARCH ON SCHIZOPHRE- NIA AND DEPRESSION METZGER, DAVID FAMILY HEALTH INTERNATION- HPTN 035: PHASE II/IIIb SAFETY AND EFFECTIVENESS STUDY OF THE VAGI- AL NAL MICROBICIDES BUFFER GEL AND 0.5% PRO 2000/5 GEL (P) FOR THE PREVENTION OF HIV INFECTION IN WOMEN METZGER, DAVID FAMILY HEALTH INTERNATION- EVALUATE EFFICACY OF HIV/OPIATE DEPENDENT INJECTORS AL

PRICE, R. ARLEN ELI LILLY AND COMPANY CANDIDATE REGIONS ASSOCIATED WITH LEAN AND OBESE PHENOTYPES IN HUMANS

Clinical Trials

Name Sponsor Project Title

KAMPMAN, KYLE TITAN PHARMACEUTICALS PRO-805: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTI- CENTER STUDY/STUDIES OF PROBUPHINE IN PATIENTS WITH OPIOID DEPENDENCE TS WITH BIPOLAR I DISORDER WITH A RECENT MANIC OR MIXED EPISODE

O'REARDON, JOHN P SANOFI-SYNTHELABO, INC A MULTI-CENTER, DOUBLE-BLIND, PARAELLEL GOUP, FIXED DOSE, 4-ARM, PLACEBO AND PAROXETINE CONTROLLED EIGHT WEEK EFFICACY STUDY OF 2 ORAL DOSES OF SR58611A (175MG OR 350 MG, B.I.D.) IN ADULT OUT- PATIENTS WITH MAJOR DEPRESSIVE DISORDER

O'REARDON, JOHN P NEURONETICS A COMPASSIONATE USE TREATMENT PROTOCOL FOR PATIENTS WITH MAJOR DEPRESSION PREVIOUSLY RESPONSIVE TO RTMS TREATMENT WITH THE NEURONETICS MODEL 2100 CRS REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) SYSTEM

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FACULTY IN THE NEWS

Kelly C. Allison, PhD was interviewed by Judith A. Coché, PhD, ABPP was reporter Sara Selis for a March 29, 2007 story in the focus of an article by Laurie on-line magazine ConsultantLive: Consultations in Abraham for the cover story of the Primary Care. (www.consultantlive.com). The story August 12, 2007 issue of The New was titled "Binge Eating Disorder: Surprisingly York Times Magazine - "Can this Common, Seriously Undertreated." She was also Marriage Be Saved?" Dr. Coché interviewed by reporter Tiffany McGee for a Sep- provided the journalist live, ongo- tember 24, 2007 story in People magazine, "A Dan- ing access to her couples group gerous New 'Diet': Insulin Abuse." therapy sessions, and commented extensively on her work with couples. She also appeared on Judith S. Beck, PhD was inter- NBC's Today Show and on NPR's On Point, on viewed by many publications August 14. Both appearances focused on interven- (including The New York Times, tions targeted on increasing marital satisfaction Newsweek, Prevention, Health, throughout the life of the couple. Dr. Coché wel- Good Housekeeping, and Psychi- comes comments and questions about her work atric News) and appeared on and can be reached at [email protected]. multiple national and regional radio (including NPR Morning David Dinges, PhD was interviewed by various Edition and CNN Radio) and tel- media outlets, including New Scientist, BBC Radio, evisions shows (including the Today Show on UPI, and Chron.com, about studies conducted by NBC-TV) to speak about her new books - The Beck the Division of Sleep and Chronobiology and the Diet Solution (published in April) and The Beck Diet Unit for Experimental Psychiatry on astronauts Solution Weight Loss Workbook (published in Sep- during NEEMO (NASA Extreme Environment tember), which present a cognitive therapy Mission Operations) missions under the ocean in approach to weight loss and maintenance. Her the Aquarius facility. He was also interviewed by recommendations are also found on numerous the Providence Journal on the need for sleep. His websites and blogs. recent reports on sleep time in 47,000 respondents from the American Time Use Survey were high- Rhonda Boyd, PhD was interviewed by WTXF- lighted in USA Today, Time on-line, and UPS on- TV in Philadelphia on May 22, 2007. The inter- line. view, shown on the Fox 29 Ten O’Clock News and Good Day Philadelphia, concerned a local case of Namni Goel, PhD was interviewed for an article maternal infanticide in which postpartum stress in Science, published on September 14, 2007. The and depression may have played a role. story, by Yudhijit Bhattacharjee, discussed major issues surrounding circadian rhythms, light thera- Gregory K. Brown, PhD appeared on the “Second py and psychiatric illness, and new findings indi- Opinion” television series as an expert panelist in cating the presence of circadian rhythm distur- suicide prevention on WXXI Public Broadcasting bances in Night Eating Syndrome. (Rochester, New York) that was taped for broad- cast on June 23. He was also a suicide expert pan- Daniel D. Langleben, MD was featured in a July elist on the “Barbershop Talk Radio Show” on 2, 2007 story in The New Yorker (“Duped”) by Mar- WURD in Philadelphia on September 6. garet Talbot on the use of fMRI for lie detection.

Anna Rose Childress, PhD and Charles P. Stephen E. Levick, MD was quoted in “Duplicat- O’Brien, MD, PhD were interviewed for an article ed Dolly: The Cloning Story 10 Years After” which on the treatment of addiction for Business Week. was posted on May 31, 2007 in the Whyfiles, an Continued on page 18

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Continued from page 17 on-line science magazine from the University of lions of Women Hate the Way They Look" (Fitness Wisconsin. The article presented his thoughts on Magazine); "10 Things Your Plastic Surgeon Won't the likely psychological consequences of human Tell You" (Smartmoney Magazine); "Way to Go, Grad! reproductive cloning. Here's a Check for a New Nose" and "Diet Pill's Icky Side Effects Keep Users Honest" (msnbc.com); Charles P. O’Brien, MD, PhD was interviewed in "Plastic Splurgery" (Philadelphia Magazine); "Breast French by a journalist from Science et Vie for an arti- Implants Linked to Suicide Risk" (Los Angeles cle on neuroscience. Times); "Study Suggests that a Need for Physical Perfection May Reveal Emotional Flaws" (The New David B. Sarwer, PhD was interviewed for stories York Times). across a range of topics. These included: "Why Mil-

NEW FACULTY Gregory C. Carlson, PhD

regory C. Carlson, PhD joined the Department faculty in GFebruary 2007 as an Assistant Professor in the Tenure Track. A basic scientist, Dr. Carlson studies how the wiring of the brain – called neuronal circuitry – may affect how we think and behave. He asks a simple question – to what extent can changes in neuronal circuit function explain mental and behavioral disorders? To do this, he has developed a reper- toire of traditional electrophysiological and state-of–the-art in vitro imaging techniques. His current focus is on understand- ing the relationship between abnormal circuitry and behavior in developmental disorders, such as autism, Rett syndrome and schizophrenia. Rett syndrome is a genetic disorder found almost exclusively in girls that produces a constellation of abnormalities, including motor and breathing irregularities, as well as autism and epilepsy. With in vitro imaging tech- niques utilizing mouse models of Rett syndrome, Dr. Carlson has found large differences in neu- ronal circuit function. It is hoped that the findings and concepts developed in his investigations may help spur research on additional disorders and other brain components, and through understanding the role of circuit changes in disease, define the role of neuronal circuit function in normal brain activity and behavior. Although on the faculty only a short time, he has already developed collabo- rations with Steven E. Arnold, MD and Thomas N. Ferarro, PhD, in Psychiatry. Dr. Carlson earned a BS in 1993 from The Evergreen State College in Olympia, Washington and a PhD in Anatomy and Neurobiology from the University of Maryland School of Medicine in 2000. He was a post-doctoral fellow in the Department of Physiology at Maryland until 2002, when he accepted a post-doctoral fellowship in Neurology at the Children’s Hospital of Philadelphia. He continued in that position until his appointment to the Psychiatry faculty in February.

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Cornerstones Recognizing the significant achievements of our faculty and staff

or thirty-three years, Raquel E. “Ruben and I planned our career Michigan State where Raquel complet- Gur, MD, PhD has been affiliated paths together,” she says. “He was a ed her PhD in Psychology in 1974. F year ahead of me and we decided that with Penn’s Department of Psychiatry, 1974 was a decision year, and the as he pursued graduate school I first as a fellow, and then assistant Gurs chose Penn’s Department of Psy- would transfer as an undergraduate. professor, medical student, resident, chiatry for postdoctoral supervised At that time, a faculty member from associate professor, professor and, clinical training. “Penn was the best Michigan State University was on sab- since 2002, The Karl and Linda Rickels option for both of Professor of Psy- us,” Dr. Raquel Gur chiatry. recalls. She trained at It’s not the usual FACULTY SPOTLIGHT Philadelphia General sequence for a Hospital where career in academic she gained clin- medicine, but it’s ical experience the route that this distin- Raquel E. Gur, MD, PhD in schizophre- guished neuroscientist nia and also chose. And it’s only one rotated through of the uncommon journeys that Dr. the VA Medical Center where Joseph Gur has taken to reach the pinnacle of DiGiacomo, MD was one of her prin- her profession. cipal mentors. A native Israeli, Dr. Gur served in the At this point, Dr. Ruben Gur moved Israeli Defense Forces during the 1967 forward in his academic career with War, fulfilling her mandatory military appointment as Assistant Professor, obligation. Following her service, she and later Associate Professor and Pro- entered Hebrew University in 1968, fessor of Psychology in Psychiatry in taking an interest in Arabic and Mid- the Departments of Psychiatry and dle Eastern Studies. “Inspired by [for- Psychology. Meanwhile, Dr. Raquel mer Prime Minister] Golda Meir,” she Gur was appointed Assistant Profes- says, “I wanted to bring peace to the sor in the Department of Psychiatry in region and took Arabic as a second 1975. Raquel’s and Ruben’s paths had language, [but] I quickly learned that, been in close parallel for some years as a woman, my options would be now, but now Raquel took a different limited and decided to pursue science. batical at the Hebrew University and turn. Psychology, especially the biological encouraged us to apply to Michigan State.” Before they left, Raquel and In 1977, Dr. Raquel Gur became a basis of behavior, was an exciting medical student at Penn, eventually developing discipline.” Ruben were married in Israel and, after Ruben finished his BA at Hebrew earning her MD in 1980. She explains Life experience soon reinforced her University in 1970, both came to the that “the clinical experience with intellectual leanings. “As an under- United States, beginning a series of schizophrenia convinced me that it is graduate, I interned in a mental hospi- interconnected career moves. a brain disorder and the graduate tal in Jerusalem, providing compan- seminars in the School of Medicine, ionship to people with schizophre- It was a journey that led to a new per- which I took and enjoyed, affected my nia,” she says. “I became captivated manent home and two stellar academ- decision to pursue medical school.” by this disorder and decided to pur- ic careers. Raquel completed her She published her first paper on schiz- sue its understanding.“ It became a undergraduate degree at Michigan ophrenia in 1977 as a first year med- lifelong interest, though not her only State, earning a BS (Psychology) in ical student. one. 1971 and an MA the next year. Mean- while, Ruben earned his PhD in Psy- Pursuing her interest in schizophrenia, Dr. Gur’s relationship with Ruben chology in 1973. She and Ruben then Dr. Gur took two residencies, first in Gur, her future husband, began in went to Stanford, he on a postdoctoral Neurology and later in Psychiatry. Israel and soon developed into both a fellowship and she on a pre-doctoral This extensive training continued personal and professional connection. fellowship, before both returned to until 1986. Why did she do her Neu- Continued on page 20

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Continued from page 19 rology training first? “I was interested Research on the causes of and treat- and 1998, were that schizophrenia in the neural basis of behavior,” she ments for schizophrenia has remained affects both brain anatomy and physi- says. “Neurology offered a solid back- a mainstay of her academic career, but ology, as indicated by structural and ground in understanding central nerv- she has added other lines of inquiry to functional neuroimaging (2). ous system (CNS) pathology and this core interest. With the increased behavioral manifestations associated availability and sophistication of with diverse brain disorders. I wanted imaging technology for research pur- this background before delving into poses, she and Dr. Ruben Gur have psychiatry and pursuing schizophre- initiated explorations on how brain nia.” activity differs by gender, first in schizophrenia and later with respect Dr. Gur was in an unusual position – to other disorders and cognitive and she was already a member of the Psy- physiological phenomena, such as chiatry faculty while simultaneously a brain volume, memory, language, and medical student, and later a resident. cerebral blood flow. “As a woman in But there were no barriers as far as Department of Psychiatry academia,” she says, “I became acute- her fellow faculty were concerned. Annual Family Picnic ly aware of gender issues from the “My colleagues in Psychiatry were July 14, 2007 get-go. I am delighted that our initial supportive of my career path and (l to r): Dr. Dwight L. Evans and Jan Evans, observations on biological basis for Drs. Raquel and Ruben Gur shared my enthusiasm,” she remem- such differences have contributed to a bers. “George Ruff, MD, Associate rapidly growing literature on sex dif- Dean at that time, was wonderful in Well-known for her research, Dr. Gur ferences.” helping me pursue my goals, as were is also a dedicated teacher and clini- Karl Rickels, MD, [Aaron] Tim Beck, Today, Dr. Raquel Gur and her col- cian. She is the Principal Investigator MD, Lester Luborsky, PhD, Reuben leagues are extending their studies to on an NIH training grant in neuropsy- Kron, MD, and the late Paul Brady, adolescence with a focus on individu- chiatry aimed at integrating basic and MD.” als at risk for schizophrenia and at the clinical neuroscience research to inves- early prodromal phases of illness. tigate schizophrenia’s symptoms, With her residency training complet- Why this new interest? Dr. Gur pathophysiology, and causation. “I ed, Dr. Gur vaulted up the academic explains that “schizophrenia is a neu- view teaching and clinical care as ladder. She was appointed Associate rodevelopmental disorder and early important parts of the academic mis- identification and com- sion,” she says. “Training future pro- prehensive interventions fessionals is critical for the field.” Her “I have a deep commitment to individuals are important. This devotion to treating patients suffering work builds on our from schizophrenia carries back to her with schizophrenia and their families,” Dr. efforts in genetic studies undergraduate experiences with Gur emphasizes. “Working with them and the brain – behavior schizophrenic patients in the 1960s. “I strengthens my desire to make progress studies on cognition and have a deep commitment to individu- so they can be helped at the forefront.” emotion we have con- als with schizophrenia and their fami- ducted. The study of lies,” she emphasizes. “Working with emotions has gained them strengthens my desire to make momentum, as more progress so they can be helped at the Professor in 1987 (secondary appoint- methods are available to advance this forefront.” ment in Neurology), Professor in 1989 field. Advancing the understanding of (secondary appointments in Neurolo- Dr. Gur’s scholarly output has been the neural basis of emotion is critical gy and Radiology), and then named impressive. Her latest bibliography for neuropsychiatric disorders where Rickels Professor of Psychiatry in lists over 250 peer-reviewed papers; difficulties in emotion processing and 2002. Since 1984, she has served as 42 editorials, reviews, and chapters; 41 modulation are apparent.” Director of the Neuropsychiatry Sec- abstracts in the last three years alone; tion within the Department of Psychi- Dr. Gur cites two research findings as and two books. She has served on atry. In 2003, she was appointed Vice her major contributions to the schizo- numerous scientific committees and Chair of Research Development in the phrenia field. A paper published in advisory boards at the NIH, the Department, and in 2005 assumed a the Archives of General Psychiatry in National Institute of Mental Health, larger institutional role as Associate 1994 reported that neurocognitive and private associations and organiza- Director of the medical school’s Insti- deficits are evident in first-episode tions. She has also contributed in edi- tute for Translational Medicine and patients with schizophrenia (1). Other torial roles to the leading journals in Therapeutics. major conclusions, reported in 1995 her field, and has been the Principal Continued on page 21

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Continued from page 20 Investigator on numerous grants, including a Conte Center for Neuroscience of Mental Exciting New Initiatives Disorders. She has been recognized widely by her colleagues for the quality of her Continued from page 1 work, highlighted by her election to the • Penn Psychiatric Neuromodulation Program – Based at Institute of Medicine in 2001. both HUP and Pennsylvania Hospital, this program will Dr. Gur is a prodigious and well-respected offer novel treatments for depression such as transcranial researcher, educator, and physician. Can magnetic stimulation (TMS), vagal nerve stimulation there be any time for other pursuits? “In my (VNS), and, ultimately, deep brain stimulation (DBS). It ‘spare time’,” she says with a clear under- will be a national and regional center of excellence, and standing of how limited that is, “I enjoy will be developed in close collaboration with the Depart- sports as a participant – running and skiing – and cheering the Philadelphia teams.” She ment of Neurosurgery. travels, reads, and enjoys music and the the- • Penn Geriatric Psychiatry Program – Located at HUP, atre, “when there is a chance.” Penn Presbyterian Medical Center, and Pennsylvania Hos- Dr. Gur’s affiliation with Penn’s Department pital, including the new inpatient unit at Pennsylvania of Psychiatry now extends over three Hospital, this expanded program will build on the clinical, decades, and it has been a fruitful relation- educational, and research excellence of the current Geri- ship. She says that “Penn has enabled me to atric Psychiatry Program. It will launch new initiatives in fulfill my dreams and grow professionally. translational research and new treatment programs in The intellectual environment and opportuni- aging and resilience in collaboration with other depart- ties have been exciting.” ments and programs allied with the Penn Institute on But without taking anything away from Aging, including the Penn Memory Center, Geriatric Med- Penn, there’s a more enduring relationship icine, and the Penn Comprehensive Neuroscience Center. in Raquel Gur’s life. Throughout their careers, Drs. Raquel and Ruben Gur have • Mood Disorders Comprehensive Consultation Service – been an inseparable team, working together Located at 3535 Market Street, this consultation service and co-writing ever since Raquel’s second will provide comprehensive, state-of-the-art assessments published paper back in 1974. “As it turned and second opinions for individuals with mood and anxi- out,” she says, “we have been a great match ety disorders, including bipolar disorder, major depres- in both the personal and professional are- sion, dysthymia, mood disorders secondary to medical nas.” conditions, and anxiety disorders. It has worked out on the personal level, for sure, and most definitely at the professional PEOPLE level, where a generation of students, trainees, researchers, and patients have been Using modern facilities effectively and initiating and main- the welcome beneficiaries of their explo- taining highly acclaimed programs depends on recruiting rations on schizophrenia and the workings and retaining the best people. The Department of Psychiatry of the brain. is actively recruiting highly productive clinical and research faculty to augment its existing basic, translational, and clini- (1) Saykin AJ, Shtasel DL, Gur RE, Kester DB, cal programs and build high priority areas identified by Mozley LH, Stafiniak P, Gur RC. Neuropsycholog- PENN Medicine and the national scientific and medical com- ical deficits in neuroleptic naive, first episode schizophrenic patients. Archives of General Psychia- munities. try 1994, 51:124-131. The new academic and clinical initiatives noted above, cou- (2) Gur RE, Mozley PD, Resnick SM, Mozley LH, Shtasel DL, Gallacher F, Arnold SE, Karp JS, Alavi pled with continuing investment in the Department’s already A, Reivich M, Gur RC. Resting cerebral glucose successful programs, are designed to elevate the Depart- metabolism and clinical features of schizophrenia. ment’s position as one of the nation’s top-ranked academic Archives of General Psychiatry, 1995, 52, 657-667; psychiatry departments and contribute to the pre-eminence Gur RE, Maany V, Mozley D, Swanson C, Bilker W, Gur RC. Subcortical MRI volumes in neu- of the School of Medicine and PENN Medicine. We will keep roleptic-naive and treated patients with schizo- you informed about our new programs as they continue to phrenia. American Journal of Psychiatry 1998, evolve. 155:1711-1717.

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ess than four decades ago, foren- Wadsworth Veterans Hospital in Los U.S. Army Medical Corps at Walson Lsic psychiatry was a backwater Angeles and then to UCLA’s psychia- Army Hospital in Fort Dix, New Jer- within psychiatry. Today, forensic psy- try residency program where psychia- sey, where he was in charge of stock- chiatrists and psychologists appear try was oriented toward psychoanaly- ade and courts martial psychiatry. sis. “I was interested in how the mind regularly on national news broadcasts While at Fort Dix, Dr. Sadoff received works and how people thought about to analyze the psychological make-up permission to work at the old Fair- things philosophically,” Dr. Sadoff of criminal defendants, and the field is mount jail in Philadelphia every a fully recognized Wednesday and accredited sub- afternoon, where specialty. he began a fruit- It is no coincidence VOLUNTARY FACULTY PROFILE ful collaboration that the recent with Temple ascent of forensic psychoana- psychiatry in Amer- Robert L. Sadoff, MD lyst Melvin ica closely parallels the dis- Heller and tinguished career of the law profes- Department’s Robert L. Sad- sor Samuel off, MD. Polsky. He did research and wrote papers in the army “because I had the His interest in psychiatry, the law, and time, motivation, and the supervision ethics began early in life. Even as a from Mel and Sam. We did a little child, “I was interested in how the book on forensic psychiatry which mind works,” he says. “It was always never got published but it taught me more exciting to me than the body, how to write.” more of a challenge.” In 1965, after his military tenure, he Dr. Sadoff’s family nourished this began a one-year fellowship in foren- early fascination. His parents met in sic psychiatry with Heller and Polsky pharmacy school. “My father was a at Temple. A year later, as part of his pharmacist in a small store on a South responsibilities at Temple, Dr. Sadoff Minneapolis corner and everybody became the first Clinical Director of came to him for advice,” says Dr. Sad- the State Maximum Security Forensic off. “Everyone trusted him. My father Diagnostic Hospital at Holmesburg was a great ethicist. He lived the hon- Prison in Philadelphia. His main clini- est life of integrity,” he adds with con- cal responsibility was to evaluate peo- siderable pride. ple going to trial. The position provid- Dr. Sadoff’s mother’s mother was an ed good administrative experience, recalls. He also began to integrate the herbalist, and his mother’s sister “but I really liked the clinical work law into his intellectual orbit. became a lawyer in 1923, spurring his much better,” he says, and he left the position in 1968. mother’s own interest in the law. “My While forensic psychiatry in America mother and her sister were the only dates back to the work of Isaac Ray in In 1969, Dr. Sadoff entered the nation- ones to finish college in her family the nineteenth century, by the early al arena. At the request of Jonas and my father was the only one in his 1960’s, forensic psychiatry was not Rappeport from the University of family,” Dr. Sadoff emphasizes. Along viewed as one of psychiatry’s more Maryland, Mel Heller, Dr. Sadoff, and with much else, an appreciation for desirable subspecialties. Only a few five others traveled to Baltimore education was passed on to their son. places offered training in the disci- where they founded the American pline. Dr. Sadoff pursued his growing In 1952, at the age of 16, Dr. Sadoff Academy of Psychiatry and the Law interest in this nascent field with pur- enrolled in an accelerated pre-med (AAPL). The establishment of the pose. In an early step, he traveled program at the University of Minneso- AAPL marked the modern beginnings cross-town to study with Seymour ta, earning a BA, BS, and MD in seven of forensic psychiatry. Rappeport Pollack at USC, a pioneer in forensic years. He studied with a leading psy- served as President for the first two psychiatry. chopharmacologist, but remained years, and Dr. Sadoff served as the organization’s second President from intrigued by psychoanalysis, a limited His career in his chosen field now had 1971 to 1973. From the original eight area at Minnesota. To go farther in a clear path forward. Following his founders, the academy has grown to psychiatry, he would have to go else- psychiatry residency, he fulfilled his over 2000 members world-wide. where – west to an internship at two-year military commitment in the Continued on page 23

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Continued from page 22 Dr. Sadoff continued teaching at Tem- tency?” He has challenged his profes- ing to protest his innocence. Dr. Sad- ple’s law and medical schools until sion by citing studies showing that off was engaged by the prosecution in 1972, when he was lured to Penn by psychiatrists are so variable in their the Gary Heidnik case, who was con- lawyer and psychiatrist Jonas assessment of competency that their victed and executed for the rape, tor- Robitscher. Robitscher was leaving to opinions may be of limited value. ture, and/or murder of six women in take the Henry Luce Professorship at “Yet,” he says, ”the courts need us to a West Philadelphia basement in the Emory University, America’s first give opinions in certain matters. We 1980s. chair of law and medicine. He asked do this to a reasonable medical cer- Dr. Sadoff continues to teach after Dr. Sadoff to move to Penn to com- tainty.” almost four decades. “I love teach- plete the final year of his National Dr. Sadoff has examined over 9,000 ing,” he says. He’s now leading a Institute of Mental Health grant. individuals charged with crimes dur- seminar for two hours every Tuesday Dr. Sadoff was pleased with the offer, ing the past 40 years and has testified with residents and local forensic psy- but sought, and achieved, a more per- for both the prosecution and defense chiatrists and psychologists who manent position. In 1972, he was in criminal cases in about 20 states belong to the local branch of the appointed Clinical Assistant Professor and several federal jurisdictions. AAPL. of Psychiatry at Penn, Clinical Associ- Deciding which side to take may be a A man of many interests, Dr. Sadoff ate Professor the next year, then Clini- matter of who calls first, as it was enjoys reading and collecting books. cal Professor in 1978. when one prosecutor’s call came in “When I take my students, fellows, just after the defense’s. “You’re 20 The 1970’s were a great time. Dr. Sad- and residents with me on cases,” he minutes too late,” Dr. Sadoff told the off wrote grants, did research, and says, “we always find time to stop in disappointed court officer. began teaching forensic psychiatry to old bookstores. I had 4 or 5 1812 edi- medical students and residents. He Working for one side or the other tions of Rush’s Medical Inquiries and even initiated a forensic psychiatry does not affect Dr. Sadoff’s psychi- Observations Upon Diseases of the Mind, clinic where he would see clients on a atric evaluation. “If I work for prose- the first American textbook of psychi- pro bono basis. Evaluations cost a cution and I find insanity,” he says, atry.” On May 22, 2004, he donated all modest $35, but Dr. Sadoff remembers “sometimes the prosecution will agree of his books – some 4000 volumes – that “it became more of a hassle to file and push for time in a hospital, not to the College of Physicians of the paperwork, so we did the assess- jail. Prosecutors can be flexible and Philadelphia, establishing the Robert ments for free. If anyone asked, I paid the good ones are really interested in L. Sadoff Library of Legal Medicine the $35 to the clinic myself.” justice.” Sometimes, of course, they and Forensic Psychiatry. The follow- seek another opinion. ing year, he established a symposium As its profile has broadened, contem- at the College to attract speakers in porary forensic psychiatry has con- When working for the defense, “I the field. fronted more than a few challenges, could say that I don’t think it’s insani- Dr. Sadoff explains. For much of the ty here, it’s something else. I might Harkening back to the stellar example past century, majority opinion among suggest that they get an opinion from set by his father, Dr. Sadoff thinks psychiatrists was adequate to validate someone else.” If he is engaged by the seriously about ethical issues. He is opinions given in court. A recent legal defense, but not called to testify, the writing a book about the potential decision, however, established that prosecution cannot call him to the harm that a forensic examination can opinions from psychiatrists not sup- stand. However, the defense can call have upon the person examined. ported by scientific evidence are no him if he is employed by the prosecu- Children, adolescents, the elderly, the longer acceptable in court testimony. tion and does not take the stand. This incompetent, and the seriously men- critical distinction exists in the law, tally ill are particularly vulnerable. The emerging area of “neurolaw,” an Dr. Sadoff says, “because the prosecu- “Do these individuals really under- area of new interest in the Depart- tion is there to find justice. The stand the consequences if, for exam- ment, supports the need for neurosci- defense is there to zealously defend ple, the examiner is working for the entific evidence. Imaging technology its client.” prosecution in a death penalty case?” illustrating neural activity can identi- he asks. “Examiners have certain fy which sections of the brain control Dr. Sadoff has been involved in many powers we should not abuse,” he specific functions, and may help high-profile trials, including the Jef- emphasizes. explain behavior. frey MacDonald case for the defense, his first big case. In 1979, MacDonald Risks belong not only to examinees, Dr. Sadoff has taken special interest in was convicted of the 1970 murders of but to examiners as well. He relates a question increasingly asked by his pregnant wife and two daughters, two separate instances in which he lawyers – “are psychiatrists compe- and remains in prison while continu- was evaluating individuals with mul- tent to give an opinion about compe- Continued on page 24

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Continued from page 23 tiple personality disorders who lunged at him when their violent personalities came out. “Those who are disappointed with your testimony may also wish to harm you later on,” he adds. “I do take EMPLOYEE SNAPSHOT precautions when I’m in a prison.” Dr. Sadoff’s life – and career as well – continues to revolve around Fred Horner family, as it has since his early days in Minneapolis. “I take great pride and pleasure in my four chil- have a very busy day,” says Fred Horner, mail manager for the dren and 10 grandchildren,” he Department of Psychiatry. “A lot of what I carry is ‘same day says. “ My wife Joan and I try to “I visit them frequently.” delivery’ and the mail has to get to its location within hours.” Joan is not only Dr. Sadoff’s life This is not a complaint, mind you. partner, but she has teamed with After 27 years working for a card- him professionally as well. A for- board box manufacturer, Fred’s seven mer social worker, Joan Sadoff, years in the Department are a wel- MEd, MSW has produced two film come change. “I used to run the documentaries with Dr. Sadoff. machine that made the boxes,” he The latest, completed in 2002, is says. “I had three people beneath me the highly acclaimed Standing on to help set it up. When something My Sisters’ Shoulders, about the role went wrong, I was the one they came of women in the civil rights move- ment. They are now reviewing looking for. I was the one accountable. ideas for another short-film docu- I hated that job, but I was one of the mentary. highest paid there. That’s why I did it,” he says without regret. Looking to the future, Dr. Sadoff expresses optimism that the But, today, Fred says, “I go to work Department’s forensic psychiatry initiatives will prosper. “We’re with a smile on my face every day. I hoping that the program will grow enjoy being around people.” and proliferate and I’d like to work with some of the other units And each day he’s around many people at an exhausting number of at Penn, because I know that locations, as he picks up, sorts, and delivers incoming and outgoing [Penn] President Gutmann is very intramural and U.S. mail for the Department. His daily journey rivals interested in the integration of the that of a long-distance runner. various schools.” In 2006, Dr. Sadoff received the Fred begins Mondays at 7:00 am at the Center for Studies of Addiction Isaac Ray Award from the Ameri- (Treatment Research Center) at 39th and Chestnut Streets where he can Psychiatric Association, the drops off mail and picks up additional mail for delivery around cam- highest national award in forensic pus. Out by 7:30 am, Fred moves to the VA Medical Center where many psychiatry, an honor usually Department faculty run labs and clinics. reserved for judges and law pro- fessors. It’s a fitting capstone for Next is getting the mail in the Chairman’s Office in Blockley Hall. “The an illustrious career, not quite fin- mail is always loaded up there,” Fred says, “because it goes all over.” ished. “Joan and I have been lucky,” Dr. Sadoff says, “we’ve been fortunate. It’s been a lot of Fred’s next stops are in the Hospital of the University of Pennsylvania fun, it’s been a good ride. I’m 71 (HUP) on 10 Gates, where Neuropsychiatry is located, and at the Psy- now and you never know how chiatry inpatient unit on 11 Founders. He returns to HUP about two or much more time you have. You try three times a day. to make every day count.” Continued on page 25

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Continued from page 24

Then, Fred heads back to the Center for Studies of upon me for their mail. They appreciate receiving Addiction, mainly to deliver mail from the VA it in a timely fashion,” he says. there. Then it’s a long trek to the Department’s many offices and clinics at 3535 Market Street, Outside of work, Fred looks forward to deep-sea where he spends at least four hours every day. fishing at the Jersey shore. “I go to Brielle in north Jersey,” he says. “There are a lot of wrecks up Somehow, each day, he also fits in a trip to the there and the fish- Translational Research Laboratories (TRL) at 31st ing seems to be and Walnut and Penn Presbyterian Medical Center better.“ Sea bass at the campus’ northwestern edge. and bluefish are the main fare, with That’s a typical day. Then there are additional numerous varieties trips as circumstances require. “I’m in and out of of fish in the sum- the Dean’s office a lot to have items signed by the mer months. Dean,” Fred says. Every week, he also picks up mail at 30th and Market, travels to Ralston House, Fred has been and also hits Penn Tower. He makes two trips ocean fishing since each week to Presbyterian Medical Center at 39th he was 7 or 8 years and Market Streets. old. “My dad took me and my brother “I do special hand deliveries as needed,” says fishing,” he remembers. “I used to do freshwater Fred, and is on-call for pages from the Chairman’s fishing when I was a child, but it got boring, office when someone in the Department has a spe- because all day you might catch one fish and some cial hand-carry need. days you might not catch anything. I like to go out on a boat in the ocean. Even if you don’t catch Fred’s day ends around 3:00 pm. He sums it all up anything, you have a nice little boat ride.” pretty succinctly. “It’s a lot of walking, a lot of ter- ritory to cover,” he says. Laying on the beach and taking in some sun are also high up there on Fred’s spare time activities. But it’s not all about physical exercise for Fred. “I love to go swimming,” Fred adds, “[but] I pre- It’s really about the people along the way. “On my fer a pool over the ocean. The ocean has too much first job working in the Department I ran into a bacteria and sharks are starting to take a little bite couple of old friends I hadn’t seen since I was a out of you.” child,” he recalls as if it were yesterday. “They rec- ognized me and I recognized them.” On his daily Speaking of bites, Fred has another post-3:00 pm rounds, Fred sees his spiritual “brothers and sis- passion. “I love to cook,” he says. “I think I ters on campus, and I get to talk with them.” spoiled my wife – she doesn’t want to cook any more. She maybe cooks once or twice a week Fred especially values several frequent interac- now.” tions. “What really impressed me,” he says, “was that I got the chance to meet [Department] Chair- But whether it’s work, home, or play, people man Evans and Dr. Charles O’Brien. Both show a remain the focus. “I’ve learned to get along with lot of interest in me and are concerned about my everybody,” says Fred. “I get along with people. I health and welfare. I really appreciate the chance love people. I treat them with respect. They treat to talk with them a couple of times a week. They me with respect.” always treat me with respect and ask me how I’m doing.” “I just enjoy working for the Department,” Fred emphasizes more than once. And, one could add, Even in an age of electronic communications, he enjoys just about everything else he does, now moving snail mail in a timely way is critical for that cardboard boxes are but a distant memory. the Department’s functioning. “Everyone depends

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Educational Highlights

INTRODUCING THE RESIDENT CLASS OF 2011

he Department of Psychiatry welcomes the class of 2011 T(pictured below) to the residency-training program. The current class of interns in psychiatry was chosen from 553 applicants of whom 84 were actually ranked. These 10 individuals are extremely talented young doctors who were at the top of their medical school classes and who demon- strated a strong commitment to the field, as well as great leadership potential. They have shown themselves to be very fine house officers, eager to learn and dedicated to providing outstanding clinical care to their patients. This year's recruitment efforts began on September 1st and will continue until January 31, 2008.

Department of Psychiatry Rebecca Aspden, MD Andrea Bowen, MD Samuel Collier, MD Harvard Medical School Duke University Univ Texas - Houston Annual Family Picnic July 14, 2007

David Danish, MD Lauren Gendal, MD Jamey Levy, MD Case Western Reserve New York University New York University

Donovan Maust, MD Nadia McFarlane, MD Christopher Tjoa, MD Johns Hopkins University SUNY - Buffalo SUNY - Buffalo

Holly Valerio, MD University of Florida

www.med.upenn.edu/psych www.med.upenn.edu/psych PAGE 27 CORNER

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S --BY GLENDA L. WRENN, MD T (HUP INPATIENT CHIEF RESIDENT) N E he 2007-2008 Academic Year curriculum that addresses the role planned to facilitate discussion of residents as teachers and profes- around professionalism. D Twelcomes many new educa- I sionals. The monthly series begins tional initiatives, as well as an effort Other ongoing initiatives – Jessica

S with a session devoted to teaching to increase contact among inpatient Kovach, MD is developing new medical students that raises and E and outpatient residents. One of the opportunities for residents to major structural changes to the resi- discusses questions such as: ‘How

R explore community and addiction does one deal with an unmotivated dency program has been the consol- psychiatry, including working with student? How do you give and idation of PGY-1 and PGY-2 didac- Assertive Community Treatment receive feedback? How can I devel- tic sessions to Wednesday after- teams at Horizon House and the op my personal bedside teaching noons, which now follow the week- methadone clinic at the Philadel- style?’, and ‘What are effective ly resident business lunch meeting. phia VA Medical Center. Also, Juli- ways to structure formal didactics?’ The overall effect has been ette Galbraith, MD is working to In the next session, residents dis- enhanced cohesion among all class- expand the Group Therapy experi- cuss “professionalism” in the con- es of residents, with improved ence to include an outpatient group text of cases that highlight issues or seamless coverage of clinical servic- therapy elective. es and a distraction-free education- challenges they recently encoun- al experience for junior residents. tered. Midway through this series is Resident activities – Journal Club This is a great example of how resi- a Group Reflections session that remains popular with Regina Szucs, dent initiative, coupled with provides a forum for developing MD, PhD, Ben Pumphrey, MD, and administrative and clinical service residents’ interests and ability to Josh Blume, MD serving as active support, makes collaborative identify, reflect, and process diffi- coordinators. Movie Club is also in change effective and positive. cult issues that arise throughout the full swing with a diverse faculty of month or in the course of training. discussants and hosts. Michelle The Inpatient Morning Report Finally, residents meet at the end of Goldsmith, MD, Jin Joo, MD, and Series has also undergone restruc- their rotation to revisit their role as Lauren Kofod, MD are recent resi- turing with a new addition to the teachers. This session uses didactic dent coordinators of this event. existing Emergency Psychiatry, and interactive role play to further Process of Care, and Consulta- develop their skills as effective It has been an exciting summer for tion/Liaison series. Anthony Ros- teachers. In the future, interdisci- the residents and we are very much tain, MD, along with Benoit Dubé, plinary sessions with nurses and looking forward to a productive MD and myself, have organized a residents from other specialties are and enjoyable year!

American Psychiatric Association Annual Meeting 2007 San Diego

Dr. Michael E. Thase and his wife, Diane

l to r: Anthony L. Rostain, MD, MindGames 2007 -- “Jeopardy for Psychiatrists” Kari Groff, MD (Chief Resident, 2006-2007), Penn’s team finished second in this national competition for residents Matthew Hurford, MD (Former Chief Resident, 2005-2006), l to r: Richard F. Summers, MD, Dhwani Shah, MD , and Dhwani Shah, MD (Chief Resident, 2006-2007) Kari Groff, MD, Ben Smoak, MD, and Anthony L. Rostain, MD

PENN PSYCHIATRY PERSPECTIVE FALL 2007 Non-Profit Org. U.S. Postage PAID Permit No. 2563 Department of Psychiatry Phil., PA 19104 Office of the Chairman 3 Blockley Hall 423 Guardian Drive Philadelphia, PA 19104-6021 Telephone: (215) 662-2818 Fax: (215) 662-6911 URL: www.med.upenn.edu/psych

PENN PSYCHIATRY PERSPECTIVE URL: www.upenn.edu/psych/newsletter Editor: Rosellen Taraborrelli Telephone: (215) 662-2899 E-mail: [email protected] To make a gift to the Department of Psychiatry, please contact: Co-Editor: Paul Mischler Abigail Mason Woodworth PENN Medicine Development & Alumni Affairs Telephone: (215) 898-0602 3535 Market Street, Suite 750 Philadelphia, PA 19104-3309 E-mail: [email protected] Telephone: 215-898-0578 Writing and Design: Email: [email protected] Williams-Campbell Administrative Services, LLC URL: www.med.upenn.edu/psych/support