Phytochemical Analysis of Tabernaemontana Divaricata
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Effect of Various Extracts of Tabernaemontana Divaricata on Haloperidol Induced Catalepsy in Rats
Raj et al., International Current Pharmaceutical Journal, February 2014, 3(3): 240-242 International Current http://www.icpjonline.com/documents/Vol3Issue3/02.pdf Pharmaceutical Journal ORIGINAL RESEARCH ARTICLE OPEN ACCESS Effect of various extracts of Tabernaemontana divaricata on haloperidol induced catalepsy in rats *Chanchal N. Raj1, A. Balasubramaniam2, Sayyed Nadeem2 1Department of Pharmacy, Karpagam University,Coimbatore, Tamilnadu, – 641021, India 2Technocrats Institute of Technology- Pharmacy, Bhopal, M.P.-462021, India ABSTRACT Parkinson’s disease (PD) is one of the neurodegenerative diseases with selective loss of dopamine neurons of the substantia n igra pars compacta. In the present study, anti-cataleptic activity of Tabernaemontana divaricata leaves extracts viz. aqueous and ethanolic at different doses (50, 100 and 150 mg/kg i.p.) were studied using haloperidol (1 mg/kg, i.p.) induced catalepsy in rats which is a useful animal model for screening drugs for Parkinson’s disease. Both the extracts were found to reduce catalepsy significantly (P<0.001) as compared to the haloperidol treated rats showing greater effect at 150 mg/kg i.p. dose. Thus the present study reveals the anti- cataleptic activity of Tabernaemontana divaricata evaluating the traditional folklore medicinal use of the plant. Key Words: Tabernaemontana divaricata, Parkinson’s disease (PD), catalepsy, haloperidol, bar test. INTRODUCTIONINTRODUCTION by the increase of the lipid peroxidation product, Neurological disorders include brain injuries, neuro- malonaldehyde. -
Alkaloids with Anti-Onchocercal Activity from Voacanga Africana Stapf (Apocynaceae): Identification and Molecular Modeling
molecules Article Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling Smith B. Babiaka 1,2,*, Conrad V. Simoben 3 , Kennedy O. Abuga 4, James A. Mbah 1, Rajshekhar Karpoormath 5 , Dennis Ongarora 4 , Hannington Mugo 4, Elvis Monya 6, Fidelis Cho-Ngwa 6, Wolfgang Sippl 3 , Edric Joel Loveridge 7,* and Fidele Ntie-Kang 1,3,8,* 1 Department of Chemistry, Faculty of Science, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon; [email protected] 2 AgroEco Health Platform, International Institute of Tropical Agriculture, Cotonou, Abomey-Calavi BEN-00229, Benin 3 Institute for Pharmacy, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle, Germany; [email protected] (C.V.S.); [email protected] (W.S.) 4 Department of Pharmaceutical Chemistry, School of Pharmacy, University of Nairobi, Nairobi P.O. Box 19676–00202, Kenya; [email protected] (K.O.A.); [email protected] (D.O.); [email protected] (H.M.) 5 Department of Pharmaceutical Chemistry, School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa; [email protected] 6 ANDI Centre of Excellence for Onchocerciasis Drug Research, Biotechnology Unit, Faculty of Science, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon; [email protected] (E.M.); fi[email protected] (F.C.-N.) 7 Department of Chemistry, Swansea University, Singleton Park, Swansea SA2 8PP, UK 8 Institute of Botany, Technical University of Dresden, 01217 Dresden, Germany * Correspondence: [email protected] or [email protected] (S.B.B.); Citation: Babiaka, S.B.; Simoben, C.V.; [email protected] (E.J.L.); ntiekfi[email protected] or fi[email protected] (F.N.-K.) Abuga, K.O.; Mbah, J.A.; Karpoormath, R.; Ongarora, D.; Abstract: A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A (1), along with Mugo, H.; Monya, E.; Cho-Ngwa, F.; eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), iboxy- Sippl, W.; et al. -
A Review on Tabernaemontana Spp.: Multipotential Medicinal Plant
Online - 2455-3891 Vol 11, Issue 5, 2018 Print - 0974-2441 Review Article A REVIEW ON TABERNAEMONTANA SPP.: MULTIPOTENTIAL MEDICINAL PLANT ANAN ATHIPORNCHAI* Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Bangsaen, Chonburi 20131 Thailand. Email: [email protected] Received: 01 March 2016, Revised and Accepted: 29 January 2018 ABSTRACT Plants in the genus Tabernaemontana have been using in Thai and Chinese traditional medicine for the treatment several diseases. The great majority constituents of Tabernaemontana species have already been subjected to isolation and identification of monoterpene indole alkaloids present in their several parts. Many of monoterpene indole alkaloids exhibited a wide array of several activities. The biogenesis, classification, and biological activities of these alkaloids which found in Tabernaemontana plants were discussed in this review and its brings the research up-to-date on the bioactive compounds produced by Tabernaemontana species, directly or indirectly related to human health. Keywords: Tabernaemontana plants, Phytochemistry, Biogenesis, Terpene indole alkaloids, Biological activities. © 2018 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4. 0/) DOI: http://dx.doi.org/10.22159/ajpcr.2018.v11i5.11478 INTRODUCTION alkaloids are investigated. All monoterpene indole alkaloids are derived from aromatic amino acid tryptophan and the iridoid terpene Several already drugs were discovered from the natural products. secologanin (Scheme 1). Tryptophan converts to tryptamine using Especially, the treatments of infectious diseases and oncology have tryptophan decarboxylase which is a pyridoxal-dependent enzyme. benefited from numerous drugs which were found in natural product The specific iridoid precursor was subsequently identified as sources. -
UPS-QT11443.Pdf
UNIVERSIDAD POLITÉCNICA SALESIANA SEDE QUITO CARRERA: INGENIERÍA EN BIOTECNOLOGÍA DE LOS RECURSOS NATURALES Trabajo de titulación previo a la obtención del título de: INGENIERA EN BIOTECNOLOGÍA DE LOS RECURSOS NATURALES TEMA: INHIBICIÓN DE LA ACTIVIDAD HEMOLÍTICA DEL VENENO DE Bothrops atrox POR LOS EXTRACTOS DE Tabernaemontana sananho Ruiz & Pav. Y Mucuna cf. elliptica (Ruiz&Pav.) DC. AUTORA: JENNY VERÓNICA CUEVA PUNGACHO TUTOR: WILSON FABIÁN TAPIA HERNÁNDEZ Quito, marzo 2017 Dedicatoria Mi tesis la dedico con todo mi amor a Dios por haberme dado la vida y permitirme haber llegado hasta este momento tan importante de mi formación profesional. A mis padres Cecilia e Iván, a mis hermanos Lorena e Iván Cueva y mi Sobrinita Amelia por ser el pilar más importante en mi vida, demostrándome siempre su cariño, apoyo incondicional y sobre todo su confianza para culminar esta etapa de mi vida. A la compañera de toda la vida Birkha que fue quien en las noches frías de angustia siempre estuvo demostrándome su lealtad y cariño hasta su último suspiro. Agradecimiento Sin duda alguna mi profundo agradecimiento a la UNIVERSIDAD POLITÉCNICA SALESIANA que me dio la oportunidad de realizar mis sueños en la formación profesional con la ayuda de los maestros formadores de jóvenes con inspiraciones para un mañana lleno de sueños y formar un futuro de promesas para una vida mejor. Este proyecto es el resultado del esfuerzo conjunto de todos los que formamos el grupo de trabajo. De manera especial mi agradecimiento a mi tutor Químico Farmacéutico Wilson Tapia quien con su esfuerzo, dedicación y sobretodo con su profesionalismo que nos impartió sus conocimientos e hizo posible la culminación del proyecto. -
Gastroprotective Effect of Tabernaemontana Divaricata (Linn.) R.Br
British Journal of Pharmaceutical Research 1(3): 88-98, 2011 SCIENCEDOMAIN international www.sciencedomain.org Gastroprotective Effect of Tabernaemontana divaricata (Linn.) R.Br. Flower Methanolic Extract in Wistar Rats Mohammed Safwan Ali Khan1,2&3* 1Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Selangor Darul Ehsan, Malaysia. 2Department of Pharmacognosy, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad 500001, Andhra Pradesh, India. 3Department of Pharmaceutical Sciences, Nims University, Shobha Nagar, Delhi Highway, Jaipur - 303 121, Rajasthan, India. Received 24th April 2011 Accepted 2nd June 2011 Research Article Online Ready 6th June 2011 ABSTRACT Tabernaemontana divaricata (L.) R.Br belonging to Apocynaceae family is traditionally used by people in many parts of the world to treat various disorders. The present study was undertaken to investigate anti-ulcer property of Tabernaemontana divaricata flower methanolic extract (TDFME 500 mg/kg, p.o) by pyloric ligation induced gastric ulceration model using Omeprazole (8mg/kg, p.o) as a standard drug in wistar rats. Five parameters i.e., volume of gastric juice, pH, free & total acidities and ulcer index were assessed. The test extract significantly (p< 0.01) decreased volume of gastric juice, free & total acidities and ulcer index. Like standard, it also raised pH of gastric acid. The observed percentage protection for standard and test were 89.84% and 79.53%, respectively. Thus, TDFME 500 mg/kg had a positive effect on all the parameters under study and the results were similar to that of standard. From the above results, it can be concluded that TDFME exhibits remarkable gastroprotective effect. -
The Iboga Alkaloids
The Iboga Alkaloids Catherine Lavaud and Georges Massiot Contents 1 Introduction ................................................................................. 90 2 Biosynthesis ................................................................................. 92 3 Structural Elucidation and Reactivity ...................................................... 93 4 New Molecules .............................................................................. 97 4.1 Monomers ............................................................................. 99 4.1.1 Ibogamine and Coronaridine Derivatives .................................... 99 4.1.2 3-Alkyl- or 3-Oxo-ibogamine/-coronaridine Derivatives . 102 4.1.3 5- and/or 6-Oxo-ibogamine/-coronaridine Derivatives ...................... 104 4.1.4 Rearranged Ibogamine/Coronaridine Alkaloids .. ........................... 105 4.1.5 Catharanthine and Pseudoeburnamonine Derivatives .. .. .. ... .. ... .. .. ... .. 106 4.1.6 Miscellaneous Representatives and Another Enigma . ..................... 107 4.2 Dimers ................................................................................. 108 4.2.1 Bisindoles with an Ibogamine Moiety ....................................... 110 4.2.2 Bisindoles with a Voacangine (10-Methoxy-coronaridine) Moiety ........ 111 4.2.3 Bisindoles with an Isovoacangine (11-Methoxy-coronaridine) Moiety . 111 4.2.4 Bisindoles with an Iboga-Indolenine or Rearranged Moiety ................ 116 4.2.5 Bisindoles with a Chippiine Moiety ... ..................................... -
Biosynthesis by in Situ Hybridization (ISH)
Localization of monoterpenoid indole alkaloid (MIA) biosynthesis by in situ hybridization (ISH) By Elizabeth Edmunds, Hons. B.Sc. A Thesis Submitted to the Department of Biotechnology In partial fulfillment of the requirements For the degree of Masters of Science August, 2012 Brock University St. Catha rines, Ontario ©Elizabeth Edmunds, 2012 ii Acknowledgments First and foremost I would like to thank Dr. Vincenzo Deluca for the opportunity to work in his laboratory under his mentorship. I have appreciated the helpful insight that has guided me through the course of this project. I have gained a valuable experience being able to learn from such an established and knowledgeable researcher. Secondly, I would like to thank my committee members Dr. Jeffrey Atkinson and Dr. Heather Gordon for their support and advice and their time to serve on my advisory committee. Thirdly, I would like to thank my colleagues and co-workers for their patience and helpful advice throughout my project. Particular mention must be given to Dr. Carlone's lab for their assistance and insight into in situ hybridization techniques. Finally, I would like to express my sincerest gratitude and appreciation towards my family and friends for their support. I would not be where I am today without the support and love from my mother and father, as well as Craig Easton. iii Abstract Monoterpenoid indole alkaloids (MIA) are among the largest and most complex group of nitrogen containing secondary metabolites that are characteristic of the Apocynaceae plant family including the most notable Catharanthus roseus. These compounds have demonstrated activity as successful drugs for treating various cancers, neurological disorders and cardiovascular conditions. -
Brisbane Native Plants by Suburb
INDEX - BRISBANE SUBURBS SPECIES LIST Acacia Ridge. ...........15 Chelmer ...................14 Hamilton. .................10 Mayne. .................25 Pullenvale............... 22 Toowong ....................46 Albion .......................25 Chermside West .11 Hawthorne................. 7 McDowall. ..............6 Torwood .....................47 Alderley ....................45 Clayfield ..................14 Heathwood.... 34. Meeandah.............. 2 Queensport ............32 Trinder Park ...............32 Algester.................... 15 Coopers Plains........32 Hemmant. .................32 Merthyr .................7 Annerley ...................32 Coorparoo ................3 Hendra. .................10 Middle Park .........19 Rainworth. ..............47 Underwood. ................41 Anstead ....................17 Corinda. ..................14 Herston ....................5 Milton ...................46 Ransome. ................32 Upper Brookfield .......23 Archerfield ...............32 Highgate Hill. ........43 Mitchelton ...........45 Red Hill.................... 43 Upper Mt gravatt. .......15 Ascot. .......................36 Darra .......................33 Hill End ..................45 Moggill. .................20 Richlands ................34 Ashgrove. ................26 Deagon ....................2 Holland Park........... 3 Moorooka. ............32 River Hills................ 19 Virginia ........................31 Aspley ......................31 Doboy ......................2 Morningside. .........3 Robertson ................42 Auchenflower -
NJ Native Plants - USDA
NJ Native Plants - USDA Scientific Name Common Name N/I Family Category National Wetland Indicator Status Thermopsis villosa Aaron's rod N Fabaceae Dicot Rubus depavitus Aberdeen dewberry N Rosaceae Dicot Artemisia absinthium absinthium I Asteraceae Dicot Aplectrum hyemale Adam and Eve N Orchidaceae Monocot FAC-, FACW Yucca filamentosa Adam's needle N Agavaceae Monocot Gentianella quinquefolia agueweed N Gentianaceae Dicot FAC, FACW- Rhamnus alnifolia alderleaf buckthorn N Rhamnaceae Dicot FACU, OBL Medicago sativa alfalfa I Fabaceae Dicot Ranunculus cymbalaria alkali buttercup N Ranunculaceae Dicot OBL Rubus allegheniensis Allegheny blackberry N Rosaceae Dicot UPL, FACW Hieracium paniculatum Allegheny hawkweed N Asteraceae Dicot Mimulus ringens Allegheny monkeyflower N Scrophulariaceae Dicot OBL Ranunculus allegheniensis Allegheny Mountain buttercup N Ranunculaceae Dicot FACU, FAC Prunus alleghaniensis Allegheny plum N Rosaceae Dicot UPL, NI Amelanchier laevis Allegheny serviceberry N Rosaceae Dicot Hylotelephium telephioides Allegheny stonecrop N Crassulaceae Dicot Adlumia fungosa allegheny vine N Fumariaceae Dicot Centaurea transalpina alpine knapweed N Asteraceae Dicot Potamogeton alpinus alpine pondweed N Potamogetonaceae Monocot OBL Viola labradorica alpine violet N Violaceae Dicot FAC Trifolium hybridum alsike clover I Fabaceae Dicot FACU-, FAC Cornus alternifolia alternateleaf dogwood N Cornaceae Dicot Strophostyles helvola amberique-bean N Fabaceae Dicot Puccinellia americana American alkaligrass N Poaceae Monocot Heuchera americana -
Uses of Voaca Nga Species
USES OF VOACA NGA SPECIES N.G.BISSET PharmacognosyResearch Laboratories, Department of Pharmacy, Chelsea College, Universityof London, Manresa Road, London SW36LX Received4-II-198 5 Dateo fPublicatio n 16-VIII-1985 INTRODUCTION None of the species of the genus has attained any widespread application and evenV. afriLa, the one with the greatest distribution range and the one to which most of the uses described apply, has rather tainted localu e..A few ofti e medicinalapplication s appear to reflect theactivxt.e so fth ealkaloid spre - luntoriEnte (cf. Phytochemistry,Sectio n 3).Th efollowin g paragraphsgiv e aSoutline ox the uses which have been reported in the literature and as annotations on specimenskep ti nth eherbari a listedo np .00 . 1. THE PLANTS 1.1. V.AFRICANA (ANGUSTIFOLIA ?,LUTESCENS, PUBERULA) West Africa: The latex is said to be a rubber adul^t^dU i^put into acariou s tooth (Dalziel, 1937).Th e plant xs reported tob euse dm treatin g scabies (Janot and Goutarel, 1955).Senegal :Th e^amnk a (or Serere^) eat the fruit; theytrea t woundswit hth elatex .Th eplan tx sals oco n^ *obea pan a cea - the leafy branches are put into baths morning and ev«J^d a ^. prepared from them is given to people affected ^r^^S^ss. tierx of the leaves isdrun k as a tonic and against fatigue due^ obr«h^n Inth eCasamanc ea decoctio n ofth eroot stake nthre etime sdad y« . ecomme ed for women to counteract the effects of premature and rapid birth it » a 19 giveninternall y for hernial pain (Kerharo and Adam, ^' ^^hoca; Theleave shav esevera luses :A decoctio ni sapplie da sa wash •aganistduur t , it is put into baths against generalized oedema; it xs, utxhzea a fnction in a drink in the treatment of leprosy; a lotion is ^^^^ (possibly in children; and the juice is placed in the nostrlis oca^.^ Zernal v0 through confusion with other Apocynaceae- *«"* ™""£ °ossibly used -—^(Bouquetand^^ l for adulterating rubber (F. -
Tabernaemotana Divaricata
Imperial Journal of Interdisciplinary Research (IJIR) Vol-2, Issue-10, 2016 ISSN: 2454-1362, http://www.onlinejournal.in Quantification of Phytochemicals and HPTLC Finger Printing of Stem and Leaf Extracts of Tabernaemotana divaricata. Dr. Anubha Arora, Dr. Yashwant Rai & Dr. Sunder Pal Department of Botany, V.M.K (P.G) College, Mangalore, Green Planet Welfare Association Meerut, Uttar Pradesh, Department of Chemistry, D.N. (P.G) College, Meerut Abstract: - HPTLC is an analytical technique used It is an evergreen glabrous and dichotomously for the qualitative and quantitative evalution of branched about 2-3 m high shrub and commonly polyherbal formulations. Tabernaemotana called Pinwheel flower, Crape jasmine , East India divaricata an important medicinal plant wide rose bay and Nero’s crown (Dasturet.al 1962). medicinal value is frequently used in a large no of Ethnobotanically have been known to possess traditional herbal preparations. For HPTLC antimicrobial , anthelmintic, antioxidant , curative statinory phase was silica gel 60 F254 plate. The properties against nervous disorders, skin mobile phase consisted of Toluene: Ethylacetate: problems, respiratory and eyeailments,veneral Formic acd (7:2:0.5). In the present study the diseases, diabetes , chronic bronchitis , snake bite Preliminary Phytochemical screening of and cardiotonic ailments.(Ignacimutu et.al 2006 Tabernaemotana divaricata stem and leaf and Sathishkumar et.al 2012). Rootsare extraction has been done to dentify the chemical emmenagogue aphrodisiac tonic ,puragative , constituents and HPTLC fingerprinting of astrigent to the bowels and tonic to the brains , Tabernaemotana divaricata stem and leaf tracts lever and spleen , and useful in paralysis. has been performed which may be used as marks for quality evaluation and standardization of the Rahmanet.al (2011) observed the antibacterial drug. -
Isohtion of Alkaloids and Structural Identification of Two Dimers
Indole Alkaloids from Ervatamia ouientaiis. I Isohtion of Alkaloids and Structural Identification of Two Dimers ., John R. Knox and Jacob Slobbe I 9 1;:’ ,di Department of Organic Chemistry, University of Western Australia, ,;,, ,A>.i I Nedlands, W.A. 6009. Abstract Ethanol extracts of Eruafamia orientalis have yielded the following known alkaloids: ibogaine, iboxygaine, voacristine, vobasine, dregamine, tabernaemontanine, apparicine, voacamine and 16-demethoxycarbonylvoacamine. In addition, two new dimeric alkaloids of the voacamine group and the novel 2-acylindoles ervatamine, 2O-epiervatamine and 19-dehydroervatamine have been isolated from the extracts. The two new dimeric compounds have been identified by physical and chemical methods as lddemethoxycarbonyldihydrovoacamine and 16-demethoxycarbonyl-20’-epi- dihydrovoacamine. Plants classified in the Tabernaemontaneaetribe (Apocynaceae) have proved to be a rich source of indole alkaloids. ’ The tribe is the sole plant source of the iboga type alkaloids (with one exception’), the related voacamine group of dimeric alkaloids and the vobtusine group of dimeric alkaloids; it is also an important source of the 2-acylindole class and has afforded miscellaneousother types of indole alkaloids.1*3r4 The second largest of the 20 genera in the tribe is Eruatamia’ but rela- tively few of the 92-95 species in the genus have been examined for alkaloids. Iboga- type alkaloids have been obtained from E. dichotoma (coronaridine,6 heyneanine,’ voacristine hydroxyindolenine’), E. coronaria (coronaridine, voacangine’) and E. pandacaqui (coronaridine”), 2-acylindoles from E. coronaria (dregamine, tabernae- montanine’), E. divaricata (tabernaemontanine”) and E. pandacaqui (tabernae- montanine”) and aspidospermine types from E. dichotoma (tabersonine”) and E. dioaricafa (lochnericine, voaphylline”). E. pandacaqui has also afforded 20-epilochneridine and three dimeric alkaloids (ervafoline, ervafolidine, isoerva- r Hegnauer, R., ‘Chemotaxonomie der Pflanzen’ Vol.