DOCSLIB.ORG

D3K2 Supports Healthy Vitamin D Levels

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
D3K2 Supports Healthy Vitamin D Levels [email protected] www.biogenetix.com D3K2 Supports Healthy Vitamin D Levels Vitamin D has been shown in an ever-growing body of literature to support disease prevention and the maintenance of optimal health. Biogenetix D3K2 is a concentrated, synergistically blended Vitamin D/ Vitamin K formula for optimal absorption. Research suggests that if Vitamin D is to be dosed at therapeutic levels, Vitamin K is absolutely critical in proper application. Vitamin K has the all-important role of promoting proper Vitamin D utilization without causing calcification of muscles, arteries, or veins. Biogenetix uses natural Vitamin K2, called MK- 7, for optimal results. Use of Product: D3K2 provides a Supplement Facts Serving Size: 2 drops concentrated dosage of (0.08mL) Servings Per Container: 300 Vitamin D blended with Amount per Serving % Daily Value a complimentary balance Vitamin D (as cholecalciferol) 2000 IU 500% of Vitamin K2. Healthy Vitamin K2 (natural vitamin K2 as MK-7) 72mcg † vitamin D levels in the † Daily Value not established. body support numerous areas including: blood Other Ingredients: MCT oil (medium chain triglyceride oil from coconut/palm kernel oil), sugar metabolism, bone Sunflower Oil. health, immune health, cardiovascular health, DOES NOT CONTAIN: Sugar, wheat, casein, gluten, milk, autoimmune responses, neurodegenerative egg, yeast, preservatives, artificial flavorings, colorings, disorders, and many more. peanuts, tree nuts or fish. Formula Benefits: General Suggested Usage: Take as directed by your health care professional. • Support healthy vitamin D levels • Promote the dampening of arterial calcium build up • Promote proper blood sugar metabolism No Genetically and insulin receptor site sensitivity Engineered Ingredients • Support healthy immune system To be provided by health care professionals only. The dosage recommendations are only for your health care provider’s consideration. Please consult your health care provider for your individual dosing instructions. This product is for nutritional purposes only. It is not designed to diagnose, treat, reverse, cure, or prevent any disease. This product is not intended to replace or delay the use of prescrip- tion medication. These statements have not been evaluated by the FDA. All rights reserved © Biogenetix, LLC [email protected] www.biogenetix.com D3K2 References 1. Alti T, Gullu S, Usal AR, Erdogen G. The prevalence of vitamin D levels in the elderly of cancer mortality rates. Proceedings of the CIE symposium ’04; Light and Health: Turkish population. Arch Gerontol Geriatr 2005;40:53-60. non-visual effects, 30 Sept.-2 Oct. 2004. Commision International de L, Eclairage, 2. Atli T, Gullu S, Usal AR, Erdogan G. The prevalence of vitamin D deficiency and Vienna, Austria, 2004:174-177. effects of ultraviolet light on vitamin D levels in elderly Turkish population. Arch 28. Grant WB., Garland CF. A critical review of studies on vitamin D in relation to Gerontol Geriatr 2005;40:53-60. colorectal cancer. Nutr Cancer 2004;48:115-123. 3. Baker SB, Worthley LI, The essentials of calcium, magnesium and phosphate 29. Hanley DA, Davison KS. Vitamin D insufficiency in North America. J Nutr 2005; metabolism: part I. Physiology Department of Critical Care Medicine, Flinders 135:332-337. University of South Australia, Adelaide, South Australia (Crit Care Resusc. 2002 30. Hayas CE, Cantorna MT, DeLuca HF. Vitamin D and multiple sclerosis. Proc Soc Exp Dec;4(4):301-6.) Biol Medi 1997;216:21-27. 4. Bischoff-Ferrari HA, Conzelmann M, Dick W, et al. Effect of vitamin D on muscle 31. Hoick M. Vitamin D: importance in the prevention of cancers, type I diabetes, heart strength and relevance in regard to osteoporosis prevention. Z Rheumatol disease, and osteoporosis. Am J Clin Nutrition. 2004; 39:326-327. 2003;62:518-521. 32. Holick MF. Environment factors that influence the cutaneous production of vitamin D. 5. Campan P et al; Pilot study on n-3 polyunsaturated fatty acids in the treatment Am J Clin Nutr 1995;61:6838S-645S. of human experimental gingivitis. Departement de Chirurgie Buccale, Faculte de 33. Holick MF. Photosynthesis of vitamin D in the skin: effect of environmental and life- Chirurgie Dentaire de Toulouse, France. J Clin Periodontol. 1997 Dec;24(12):907- 13. style variables. Fed Proc 1987;46:1876-1882. 6. Cancer Chemoprevention and Cancer Treatment: is there a role for vitamin D, 34. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune 1alpha, 25(OH)2-vitamin D3, or new analogs (deltanois)? Bethesda, MD, November diseases, cancers, and cardiovascular diseases. Am J Clin Nutr 2004;80:1678S1688S. 17-19, 2004. Sponsored by the National Cancer Institute, NIH, The Vitamin D 35. Holick MF. Vitamin D deficiency: what pain it is. Mayo Clin Proc 2003;78:1457- 1459. Workshop, http://vitamined. ucr.edu/Cancer&CancerChemo.htm 36. Hypponen E, Laara E, Reunanen A, et al. Intake of vitamin D and risk of type I 7. Cantorna MT, Zhu Y, Froicu M, Whittke A. Vitamin D status, 1-25-dihydroxyvitamin diabetes: a birth-cohort study. Lancet 2001; 358:1500-1503. D3, and the immune system. Am J Clin Nutr 37. Hypponen E. Micronutrients and risk of type I diabetes: vitamin D, vitamin E, and 8. Carpenter TO et al “Effect of magnesium depletion on metabolism of 25- nicotinamide. Nutr Rev 2004; 62:340-347. hydroxyvitamin D in rats” 38. Hypponens E, Lara E, Reunanen A, et al. Intake of vitamin D and risk of type I 9. Chandra R and Sudhakaran L. Regulation of immune responses by Vitamin B6. NY diabetes: a birth-cohort study. Lancet 2001;358:1500-1503. Acad Sci 1990; 585:404-423. 39. Koutkia P, Lu Z, Chen TC, Holick MF. Treatment of vitamin D deficiency due to 10. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an Crohn’s disease with tanning bed ultraviolet B radiation. Gastroeneterology 2001; adult normal population. Osteoporosis Int 1997;7:439-443. 121:1485-1488. 11. Chiu K, et al. Hypovitaminosis D is associated with insulin resistance and beta cell 40. Koziol JA. Feng AC. Seasonal variations in exacerbations and MRI parameters in function. Am J Clin Nutrition. 2004; 79: 820-825. relapsing remitting multiple sclerosis. Neuroepidemiology 2004; 23:217-223. 12. Cox SE et al; Vitamin A supplementation increases ratios of proinflammatory to 41. Leklem JE. Vitamin B6. In: Shils ME, Olson JA, Shike M, Ross AC, ed. Modern antiinflammatory cytokine responses in pregnancy and lactation. Department of Nutrition in Health and Disease. 9th ed. Baltimore: Williams and Wilkins, 1999: Epidemiology and Population Health, London School of Hygiene and Tropical 413-421. Medicine (LSHTM), London, UK.Clin Exp Immunol. 2006 Jun;144(3):392-400. 42. Leyland DM and Beynon RJ. The expression of glycogen phosphorylase in normal 13. Cross D, et al. Phytoestrogens and vitamin D metabolism: A new concept for and dystrophic muscle. Biochem J 1991; 278:113-7. the prevention and therapy of colorectal, prostate, and mammary carcinomas. J 43. Liu HX et al; Promotion of intestinal drug absorption by milk fat globule membrane Nutrition. 2004; 134: 127-1212. 2 Danilenko M, et al. Carnosic acid and promotion Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University, of monocytic differentiation of HL60-G cells initiated by other agents. J Natl Cancer Japan Yakugaku Zasshi. 1991 Sep;111(9):510-4 Inst. 2001, 93(16): 1224-1233. 44. Luo XM, “Retinoic acid exerts dual regulatory actions on the expression and 14. Dayong Wu and Simin Nikbin Meydan ; “ n-3 Polyunsaturated fatty acids and nuclear localization of interferon regulatory factor-1” Department of Nutritional immune function” Nutritional Immunology Laboratory, Jean Mayer USDA Human Sciences, 126-S Henderson Building, University Park, PA 16802, USA, Exp Biol Med Nutrition Research Center on Aging at TUBS University,Boston, Proceedings of the (Maywood). 2006 May;231(5):619-31 Nutrition Society (1998), 57, 503-509 45. Lyakh LA, Sanford M, Chekol S, et al. TGF beta and vitamin D3 utilize distinct 15. DeLuca HF, Cantorna MT. Vitamin D:its role and uses in immunology. FASEB J pathways to suppress IL-12 production and modulate rapid differentiation of 2001;15:2579-2585. monocytes into CD83+ dendritic cells. J Immunol 2005;174:2061-2070. 16. Drugarin D. The pattern of Th1 cytokine in autoimmune thyroditis. Immunol Letts, 46. Mazur A et al, Magnesium and the inflammatory response: Potential 2000; 71: 73-77. physiopathological implications Equipe Stress Metabolique et Micronutriments, 17. Embroy AF, Snowdon LR, Vieth R. Vitamin D and seasonal fluctuations of gadolinium- Unite de Nutrition Humaine UMR 1019, Centre de Recherche en Nutrition Humaine enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol d’Auvergne, INRA, Theix, St. Genes Champanelle, France. Arch Biochem Biophys. 2000;48:271- 272. 2006 Apr 19 18. Embroy AF, Snowdon LR, Vieth R. Vitamin D and seasonal fluctuations of gadolinium- 47. Moore C, Murphy MM, Keast DR, Holick MF. Vitamin D intake in the United States. J enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol AM Diet Assoc 2004;104:980-983. 2000;48:271-271. 48. Moschakis T et al: Microstructural evolution of viscoelastic emulsions stabilised by 19. Embroy AF. Vitamin D supplementation in the fight against multiple sclerosis. J sodium caseinate and xanthan gum Procter Department of Food Science, University Orthomolecular Med 2004;19:27-38. of Leeds, Leeds LS2 9JT, UK J Colloid Interface Sci. 2005 Apr 15;284(2):714-28 20. Embry AF. Vitamin D supplementation in the fight against multiple sclerosis. J 49. Okada M, Ishikawa K, Watanabe K. Effect of vitamin B6 deficiency on glycogen Orthomolecular Med 2004; 19:27-38. metabolism in the skeletal muscle, heart, and liver of rats. J Nutr Sci Vitaminol 21. Ericksen EF, Glenrup H. Vitamin D deficiency and aging: implications for general (Tokyo) 1991; 37:349-57.
Load more

Recommended publications
  • Vitamin K: Double Bonds Beyond Coagulation Insights Into Differences Between Vitamin K1 and K2 in Health and Disease
    International Journal of Molecular Sciences Review Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease Maurice Halder 1,†, Ploingarm Petsophonsakul 2,†, Asim Cengiz Akbulut 2,†, Angelina Pavlic 2,† , Frode Bohan 3, Eric Anderson 3, Katarzyna Maresz 4, Rafael Kramann 1 and Leon Schurgers 1,2,* 1 Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany; [email protected] (M.H.); [email protected] (R.K.) 2 Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands; [email protected] (P.P.); [email protected] (A.C.A.); [email protected] (A.P.) 3 NattoPharma ASA, 0283 Oslo, Norway; [email protected] (F.B.); [email protected] (E.A.) 4 International Science & Health Foundation, 30-134 Krakow, Poland; [email protected] * Correspondence: [email protected]; Tel.: +31-43-3881680; Fax: +31-43-3884159 † These authors contributed equally to this work. Received: 24 January 2019; Accepted: 16 February 2019; Published: 19 February 2019 Abstract: Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K can be present in various isoforms, distinguishable by two main structures, namely, phylloquinone (K1) and menaquinones (K2). The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Although differing in structure, both act as cofactor for the enzyme gamma-glutamylcarboxylase, encompassing both hepatic and extrahepatic activity. Only carboxylated proteins are active and promote a health profile like hemostasis. Furthermore, vitamin K2 in the form of MK-7 has been shown to be a bioactive compound in regulating osteoporosis, atherosclerosis, cancer and inflammatory diseases without risk of negative side effects or overdosing.
    [Show full text]
  • Multicenter Randomized Controlled Trial of Vitamin K Antagonist
    CLINICAL RESEARCH www.jasn.org Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study An S. De Vriese ,1,2 Rogier Caluwé ,3 Lotte Pyfferoen,4 Dirk De Bacquer,5 Koen De Boeck,6 Joost Delanote,4 Didier De Surgeloose,7 Piet Van Hoenacker,8 Bruno Van Vlem,3 and Francis Verbeke 9 1Division of Nephrology and Infectious Diseases and 4Department of Medical Imaging, AZ Sint-Jan Brugge, Brugge, Belgium; Departments of 2Internal Medicine and 5Public Health, Ghent University, Ghent, Belgium; 3Division of Nephrology and 8Department of Medical Imaging, Onze Lieve Vrouw Hospital, Aalst, Belgium; 6Division of Nephrology and 7Department of Medical Imaging, ZNA Middelheim, Antwerp, Belgium; and 9Division of Nephrology, University Hospital, Ghent, Belgium ABSTRACT Background Vitamin K antagonists (VKAs), although commonly used to reduce thromboembolic risk in atrial fibrillation, have been incriminated as probable cause of accelerated vascular calcification (VC) in patients on hemodialysis. Functional vitamin K deficiency may further contribute to their susceptibility for VC. We investigated the effect of vitamin K status on VC progression in 132 patients on hemodialysis with atrial fibrillation treated with VKAs or qualifying for anticoagulation. Methods Patients were randomized to VKAs with target INR 2–3, rivaroxaban 10 mg daily, or rivaroxaban 10 mg daily plus vitamin K2 2000 mg thrice weekly during 18 months. Systemic dp-ucMGP levels were quantified to assess vascular vitamin K status. Cardiac and thoracic aorta calcium scores and pulse wave velocity were measured to evaluate VC progression. Results Baseline dp-ucMGP was severely elevated in all groups.
    [Show full text]
  • Randomised Controlled Trial of Nutritional Supplement on Bone Turnover Markers in Indian Premenopausal Women
    nutrients Article Randomised Controlled Trial of Nutritional Supplement on Bone Turnover Markers in Indian Premenopausal Women Pramod B. Umarji 1, Pankaj Verma 2, Vivek Garg 2, Marian Schini 3,* and Richard Eastell 3 1 Umarji Healthcare, Pune, Maharashtra 411045, India; [email protected] 2 Hindustan Unilever Limited R&D, Gurugram, Haryana 122002, India; [email protected] (P.V.); [email protected] (V.G.) 3 Academic Unit of Bone Metabolism, University of Sheffield, Sheffield S10 2NR, UK; r.eastell@sheffield.ac.uk * Correspondence: m.schini@sheffield.ac.uk; Tel.: +44-0114-215-9667 Abstract: Young Indian women may be at risk of poor bone health due to malnutrition. The aim of this study was to examine the effects on bone metabolism of a nutritional supplement in women aged 25 to 44. The nutritional supplement was a protein-rich beverage powder fortified with multi- micronutrients including calcium (600 mg), vitamin D (400 IU), and vitamin K (55 mcg) per daily serving, while a placebo supplement was low-protein non-fortified isocaloric beverage powder. This 6-month randomised, controlled trial showed favorable changes in bone turnover markers (decreased) and calcium homeostasis; such changes in older adults have been associated with slowing of bone loss and reduced fracture risk. For example, serum CTX decreased by about 30% and PINP by about 20% as a result of the increase in calcium intake. There were also changes in the ratio of carboxylated to undercarboxylated osteocalcin and such changes have been linked to a slowing of bone loss in older subjects. For example, the ratio increased by about 60% after 3 months as a result in the improvement in vitamin K status.
    [Show full text]
  • Vitamin K the “Forgotten” Vitamin
    Vitamin K The “Forgotten” Vitamin Ask anybody what vitamins they know about, and you’re likely to hear Vitamin C, Vitamin D, Vitamin E, and many people will even know that there are multiple vitamins called B. But if you ask about Vitamin K, a lot of people will say “is that really a thing?” Well, we’re here to tell you that not only is it a thing, but it’s as essential as any of the other vitamins you may have heard of. That’s why it’s one of the so-called “13 Essential Vitamins,” which are actually REQUIRED by our bodies in order to Function. Complicating matters even more is the fact that Vitamin K is actually a COMPLEX of vitamins, each with its own distinct properties. In order to understand Vitamin K, its importance in our diet, how to make sure we’re getting all the benefits of it, and how it interacts with other vitamins, we need to know what it is, what it does, what foods it can be found in, and what the different types are. Not Just One Vitamin Just as Vitamin B is actually a whole group of vitamins (B6, B12, Niacin, Riboflavin, etc.), Vitamin K is also a group of compounds, and not just one vitamin. The two most important of these are K1 and K2. There is also a synthetic form of Vitamin K known a K3, but as it can be toxic, it is not generally used in supplementation. Clean, Quiet, & Dark To make things even more complicated, there are two different forms of Vitamin K2 – MK4 and MK7.
    [Show full text]
  • Vitamin K2 Needs an RDI Separate from Vitamin K1
    nutrients Review Vitamin K2 Needs an RDI Separate from Vitamin K1 1, 1, 1, Asim Cengiz Akbulut y, Angelina Pavlic y , Ploingarm Petsophonsakul y , 2, 3 2 1,2, Maurice Halder y , Katarzyna Maresz , Rafael Kramann and Leon Schurgers * 1 Department of Biochemistry, Cardiovascular Research Institute Maastricht, 6200MD Maastricht, The Netherlands; [email protected] (A.C.A.); [email protected] (A.P.); [email protected] (P.P.) 2 Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany; [email protected] (M.H.); [email protected] (R.K.) 3 International Science & Health Foundation, 30-134 Krakow, Poland; [email protected] * Correspondence: [email protected]; Tel.: +31-43-3881680; Fax: +31-43-3884159 These authors contributed equally to this work. y Received: 25 May 2020; Accepted: 17 June 2020; Published: 21 June 2020 Abstract: Vitamin K and its essential role in coagulation (vitamin K [Koagulation]) have been well established and accepted the world over. Many countries have a Recommended Daily Intake (RDI) for vitamin K based on early research, and its necessary role in the activation of vitamin K-dependent coagulation proteins is known. In the past few decades, the role of vitamin K-dependent proteins in processes beyond coagulation has been discovered. Various isoforms of vitamin K have been identified, and vitamin K2 specifically has been highlighted for its long half-life and extrahepatic activity, whereas the dietary form vitamin K1 has a shorter half-life. In this review, we highlight the specific activity of vitamin K2 based upon proposed frameworks necessary for a bioactive substance to be recommended for an RDI.
    [Show full text]
  • Further Food Facts and Bones – Looking Beyond Calcium and Vitamin D
    Further Food Facts and Bones – looking beyond calcium and vitamin D Most people know that calcium and vitamin D are essential What is osteoporosis? for our bones, but these alone cannot keep them healthy and strong. Other nutrients are also needed. A healthy, mixed Osteoporosis occurs when the struts which make up the and well-balanced diet contains the variety of minerals and mesh-like structure within bones become thin causing vitamins, proteins and other nutrients that our bones need. them to become fragile and break easily, often following The ‘Eatwell Guide’ below shows the proportions of different a minor bump or fall. These broken bones are often food groups that make up well-balanced healthy eating. The referred to as ‘fragility fractures’. The terms ‘fracture’ and range of nutrients typically obtained from these groups is ‘broken bone’ mean the same thing. Although fractures also shown. can occur in different parts of the body, the wrists, hips and spine are most commonly affected. It is these broken A more detailed picture and explanation of the Eatwell Guide bones or fractures which can lead to the pain associated is in our booklet ‘All about osteoporosis and bone health’. with osteoporosis. Spinal fractures can also cause loss of This, and the central message on healthy eating for strong height and curvature of the spine. bones, is in Section 2 of the booklet and is also on our website. This fact sheet answers common questions about the role of specific nutrients in bone health and explains how to get these through healthy eating.
    [Show full text]
  • Vitamin K, an Example of Triage Theory: Is Micronutrient Inadequacy Linked to Diseases of Aging?1–3
    Perspective Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?1–3 Joyce C McCann and Bruce N Ames ABSTRACT selection, metabolic resources are preferentially allocated to The triage theory posits that some functions of micronutrients (the functions necessary for reproductive survival at the expense of ’40 essential vitamins, minerals, fatty acids, and amino acids) are those required for survival beyond reproductive age. The triage restricted during shortage and that functions required for short-term theory is unique in that it proposes a mechanistic trigger for the survival take precedence over those that are less essential. Insidious reallocation of micronutrient-dependent metabolic resources and Downloaded from changes accumulate as a consequence of restriction, which increases suggests that age-related disease is easily preventable by en- the risk of diseases of aging. For 16 known vitamin K–dependent suring an adequate supply of micronutrients. (VKD) proteins, we evaluated the relative lethality of 11 known If the theory is correct, the implications for public health are mouse knockout mutants to categorize essentiality. Results indicate enormous. Virtually every metabolic pathway includes one or that 5 VKD proteins that are required for coagulation had critical more enzymes that require essential micronutrients for activity. functions (knockouts were embryonic lethal), whereas the knockouts Micronutrient intake below recommended concentrations, but not www.ajcn.org of 5 less critical VKD proteins [osteocalcin, matrix Gla protein severe enough to cause overt clinical symptoms, is widespread (Mgp), growth arrest specific protein 6, transforming growth factor not only in poor countries but also in the United States (especially b–inducible protein (Tgfbi or big-h3), and periostin] survived at in the poor, children, adolescents, the obese, and the elderly), least through weaning.
    [Show full text]
  • VITAMINS D3 and K2 – Another Dynamic Duo!
    VITAMINS D3 AND K2 – Another Dynamic Duo! By Dr Nyjon K. Eccles BSc MBBS MRCP PhD Introduction In my last article “Vitamin D: An Underestimated Ally”, I summarised the science behind the many beneFits oF Vitamin D and how in the light oF this accumulating scientiFic support that no-one can aFFord to be deFicient in this important hormone. And yet evidence would indicate that as many as 70% oF us may be deFicient or have too low levels oF this God-given molecule. People are becoming aware oF this and although they may not have checked their blood levels, have taken it upon themselves to large doses oF vitamin D3. Whilst undoubtedly there are benefits to correcting your vitamin D deficiency, there lies a hidden danger in taking large doses oF Vitamin D3 without its sister vitamin, Vitamin K2. This article aims to clariFy the synergy between these two important molecules and explain why we need them both together For optimum bone and cardiovascular health. To reiterate, Vitamin D has been shown to inFluence dozens of conditions, including: Cancer, Hypertension, Heart Disease, Obesity, Rheumatoid Arthritis, Autism, Type 1 and Type 2 Diabetes, Osteoporosis, Multiple Sclerosis, Crohn’s and other InFlammatory Bowel disease, Flu, Tuberculosis, Dementia and Alzheimers, Eczema and Psoriasis, Muscle pain, Peridontal disease, Macular degeneration, Pre-eclampsia, InFertility, Asthma, Cystic Fibrosis, Migraines, Depression, Schizophrenia and Seizures. Some of these have been discussed in more detail in my previous article referenced above. The RDA for vitamin D remains at a measly 600 IUs. This is despite the overwhelming evidence showing that vitamin D is extremely important for a wide variety of health conditions besides bone health, and that most people may need about ten times this amount or more.
    [Show full text]
  • High-Dose Vitamins
    BREASTFEEDING MEDICINE c Volume 14, Number 5, 2019 LactMed Update ª Mary Ann Liebert, Inc. DOI: 10.1089/bfm.2019.0077 High-Dose Vitamins Jason B. Sauberan1,2 oncentrations of most vitamins in breast milk are creases milk concentrations by 30–70 mcg/L in both under- Cdependent on maternal diet.1 Daily vitamin supple- and well-nourished lactating mothers. mentation to achieve adequate dietary intake is thus a re- The highest supplemental dose studied has been 10 mg/day; commended intervention for lactating mothers who are milk concentrations increased from 200 mcg/L at baseline to undernourished, or for those with dietary restrictions. Even in 750 mcg/L after several months of supplementation.8 There mothers with no known dietary deficiency risks, the use of have been no reports of milk concentrations or breastfed in- prenatal vitamins during lactation is commonplace and is fant safety during maternal high-dose riboflavin therapy. considered safe for the breastfed infant (Table 1).2,3 Some Intravenous high-dose riboflavin has been safely used in lactating mothers may elect to consume high-dose or hyperbilirubinemic newborns as an adjunct to phototherapy. ‘‘megadose’’ vitamin therapy, beyond that required for ade- Riboflavin is considered to have a wide safety margin in quate daily intake. Commonly used vitamins taken in humans and there is no established upper limit of tolerability. megadoses are listed in Table 2. Depending on the vitamin, A common benign side effect of larger doses is bright yellow dosage, and the mother’s underlying vitamin status, this urine discoloration.6,9 Owing to a lack of data, other drugs for practice could potentially lead to vitamin concentrations in migraine prophylaxis with good safety records during milk that are harmful to the infant.
    [Show full text]
  • Brands and Types of Supplements We Recommend
    Brands and Types of Supplements We Recommend Magnesium glycinate http://amzn.to/2mdZC4W Bifido bacteria http://amzn.to/2mTG1UG l-carnitine http://amzn.to/2mdWw0O l-tyrosine http://amzn.to/2mTGeHs Estrovera http://amzn.to/2nCrxZs Kaprex http://amzn.to/2nCqjgG Ultraflora Spectrum http://amzn.to/2mG7sk6 D-HIST http://amzn.to/2mTJvH1 Lipotain http://amzn.to/2mD1sYz SAMe (Do not take with antidepressant) http://amzn.to/2oqcgxC Vitamin B-6 http://amzn.to/2o07Yd7 Magnesium L-Threonate http://amzn.to/2nZRSk4 Siberian Ginseng http://amzn.to/2mD80Gq GLYCINE http://amzn.to/2wRbYVR l-glutamine http://amzn.to/2ojMBop GELATIN http://amzn.to/2nxHzHK The Green can doesn’t gel up (Red can does, like jello) if you prefer that. http://amzn.to/2nxSocC Emu Oil http://amzn.to/2w9VGpn Kelp (for iodine) http://amzn.to/2n8CzYJ Estrofactors http://amzn.to/2mefc0x potassium http://amzn.to/2mGqd6K Heath Tip: There are a couple of prescription medicines that you’ve got to be aware of if you significantly increase your potassium intake, so if you’re on blood pressure medicines, talk to your doctor before you to take potassium. Vitamin D Make sure to take WITH FOOD and in the AM. Take 1000iu per 25 pounds you weigh. http://amzn.to/2mTQwYb Vitamin K2 http://amzn.to/2mTT34F Selenium http://amzn.to/2nk8YM6 7-KETO http://amzn.to/2nCKjjs Resveratrol: http://amzn.to/2nknDqD CURCUMIN: http://amzn.to/2mTJItt B-Complex http://amzn.to/2nxKDDO chromium (with cinnamon) http://amzn.to/2nCDzBT Choline http://amzn.to/2n8Io8t Zinc: http://amzn.to/2mTGyWP OsteoVantiv http://amzn.to/2mG5wIp Berberine http://amzn.to/2mG6XGC Ultra Potent Vitamin C http://amzn.to/2nCLwau HCL with Pepsin http://amzn.to/2oYA5dC Ashwagahnda http://amzn.to/2ogIRWP GUGGAL http://amzn.to/2mTRGTE CoQ10.
    [Show full text]
  • Vitamin K and Thrombosis
    Vitamin K and thrombosis Rithik Raina, Ayush Karnik, Prasad Shetye, Atul Laddu, On Behalf of the Georgia Thrombosis Forum The role of the fat soluble vitamin K (VK) in thrombosis is getting more clear every day. VK plays a major role in the coagulation cascade. VK deficiency can occur in any age group, but is encountered most often in infancy. The body needs VK to use calcium to build bone. Low levels of VK may be associated with a higher risk of osteoarthritis. VK improves bone health and reduces the risk of bone fractures, particularly in postmenopausal women who are at risk for osteoporosis. Our research in the physiology, role in thrombosis and uses of VK tell us that VK is one of the very important vitamins in life. Although use of warfarin is gradually going down due to the discovery of NOAC’s, warfarin is there to stay, and therefore we know that vitamin K is going to stay. Introduction Following the discovery of warfarin, a Vitamin K Antagonist (VKA), the importance of Vitamin K has become more apparent. The “K” in Vitamin K originated from the German word, "koagulation". Millions of patients who take warfarin for atrial fibrillation, DVT, PE, and prosthetic cardiac valves. The wide use of warfarin, an agent with a very narrow therapeutic index, has resulted in significant risk for major bleeding. Vitamin K serves as one of the major reversing agents for patients over- anticoagulated with warfarin. We at GTF took a challenge of researching the physiology of vitamin K and its role in thrombosis.
    [Show full text]
  • Association of Dietary Vitamin K and Risk of Coronary Heart Disease in Middle-­ Age Adults: the Hordaland Health Study Cohort
    Open access Original research BMJ Open: first published as 10.1136/bmjopen-2019-035953 on 21 May 2020. Downloaded from Association of dietary vitamin K and risk of coronary heart disease in middle- age adults: the Hordaland Health Study Cohort Teresa R Haugsgjerd ,1 Grace M Egeland,1,2 Ottar K Nygård,3,4 Kathrine J Vinknes,5 Gerhard Sulo,6,7 Vegard Lysne,4 Jannicke Igland,1 Grethe S Tell1,8 To cite: Haugsgjerd TR, ABSTRACT Strengths and limitations of this study Egeland GM, Nygård OK, Objective The role of vitamin K in the regulation of et al. Association of dietary vascular calcification is established. However, the ► The study had a long follow-up time with minimal vitamin K and risk of coronary association of dietary vitamins K1 and K2 with risk of heart disease in middle- age competing risk from other causes of death. coronary heart disease (CHD) is inconclusive. adults: the Hordaland Health ► Linkage to a nationwide database assured complete Design Prospective cohort study. Study Cohort. BMJ Open cohort follow- up. Setting We followed participants in the community- based 2020;10:e035953. doi:10.1136/ ► We had information on history of coronary heart dis- Hordaland Health Study from 1997 - 1999 through 2009 bmjopen-2019-035953 ease (CHD) at baseline which enabled us to evaluate to evaluate associations between intake of vitamin K and incident (new onset) CHD. ► Prepublication history and incident (new onset) CHD. Baseline diet was assessed by additional material for this ► The Food Frequency Questionnaire was not validat- a past- year food frequency questionnaire. Energy- adjusted paper are available online.
    [Show full text]