Hivep3 (NM 010657) Mouse Untagged Clone – MC225284 | Origene

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for MC225284

Hivep3 (NM_010657) Mouse Untagged Clone Product data:

Product Type: Expression Plasmids Product Name: Hivep3 (NM_010657) Mouse Untagged Clone Tag: Tag Free Symbol: Hivep3 Synonyms: 2900056N03Rik; A130075N07; AI848000; E030045D18Rik; KBP-1; KBP1; Krc; Rc; Schnurri-3; Shn3 Vector: pCMV6-Entry (PS100001) E. coli Selection: Kanamycin (25 ug/mL) Cell Selection: Neomycin Fully Sequenced ORF: >MC225284 representing NM_010657 Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC

ATGGATCCTGACCAAAGCATCAAGGGCACCAAGAAGGCTGATGGAAGTCCCCGGAAGCGGCTGACCAAAG GAGAGGCCATTCAGACGAGTGTTTCTTCCAGTGCTCCATACCCAGGCAGCGGCACTACTGCTCCCTCAGA GAGTGCCACCCAGGAGCTCCTAGCCACGCAGCCTTTCTCAGGCCCCTCTCAGGAGAAAACGGGCCAGCAG CAGAAGCCTGCCCGGAGGCCTTCCATCGAGGCCTCGGTCCACATCTCTCAGCTTCCGCAGCACCCTCTGA CACCAGCATTCATGTCCCCGGGCAAGCCAGAGCATCTCCTCGAGGGGTCCACGTGGCAGCTGGTTGACCC CATGAGACCTGGACCCTCGGGCTCCTTTGTGGCCCCCGGGCTGCATCCGCAGAGCCAGCTCCTCCCATCC CATGCTTCTATCCTTCCTCCTGAGGAGCTGCCTGGCATCCCTAAGGTCTTTGTGCCTCGTCCCTCACAGG TCTCCCTGAAACCTGCAGAAGAGGCACACAAGAAAGAGAGGAAACCGCAGAAGCCAGGCAAGTATATATG TCAATACTGCAGCCGACCCTGCGCCAAGCCCAGTGTGCTCCAGAAACACATTCGCTCACACACAGGTGAG AGGCCCTACCCCTGCGGCCCCTGCGGCTTCTCCTTCAAGACCAAGAGTAACCTCTACAAGCACAGGAAGT CCCATGCCCACCGTATCAAAGCTGGCCTGGCCTCGGGCTCCAGCAGTGAGATGTACCCCCCTGGGCTGGA GATGGAGAGGATCCCCGGGGAAGAGTTTGAGGAACCCACCGAGGGAGAAAGCACAGACTCTGAGGAGGAA ACGGGTGCCGCATCAGGTCCCTCCACAGATGTTCTCCCCAAACCCAAGCACCCCCTGCTCTCAAGTAGTT TGTACAGCTCCGGGAGCCACGGTTCCAGCCAGGAACGCTGCTCCCTCTCCCAGTCAAGCACTGGCCCATC ACTAGAGGACCCCGCCCCATTTGCAGAAGCCTCATCGGAACATCCCCTGAGCCATAAACCGGAAGACACG CACACCATCAAGCAGAAGCTGGCACTCCGCCTGAGTGAGAGGAAGAAGCTGATCGAAGAGCAGACATTCC TGAGCCCAGGGAGCAAAGGCAGCACAGAGTCCGGGTACTTCTCACGCTCTGAGAGCGCTGAGCAGCAGGT CAGCCCCCCCAACACCAACGCAAAGTCCTACGCAGAGATCATCTTCGGCAAGTGTGGACGGATTGGGCAG CGGACCTCCATGCTGGCATCCACCTCTACCCAGCCCCTACTGCCTCTATCCTCGGAAGACAAGCCCAGCT TGGTACCTTTGTCTGTGCCCAGGACACAAGTGATCGAACATATCACCAAGCTCATCACCATCAATGAAGC CGTGGTGGACACCAGTGAGATCGACAGTGTGAAGCCCAGGAGGAGCTCTCTAACCAGGCGCAGCAGCGTG

This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 4 Hivep3 (NM_010657) Mouse Untagged Clone – MC225284

GAGTCCCCGAAGTCCAGCCTCTACCGGGACTCACTATCGTCCCATGGGGAGAAGACTAAGCAGGAGCAAT CACTGCTGAGCCTCCAGCACCCACCCAGCTCCACGCACCCTGTGCCTCTCCTGAGAAGTCACTCAATGCC TTCTGCCGCCTGCACCATCAGCACCCACCACCACACCTTCCGTGGTAGCTACTCCTTTGATGACCACGTC GCTGACCCCGAGGTCCCCAGCCGCAACACTCCCGTGTTTACCTCCCACCCACGGATGCTAAAGCGCCAGC CAGCCATTGAATTACCTTTGGGGGGTGAGTACAGTTCCGAGGAGCCTGGACCGAGCAGCAAGGACCCCAC CTCCAAGCCCTCCGATGAACCAGAACCCAAGGAAAGCGACCTTACCAAAAAGACCAAGAAGGGGTTCAAA ACAAAAGGCGCGAACTATGAATGTACCATCTGCGGTGCTCGGTACAAAAAGAGAGATAATTACGAAGCTC ATAAGAAGTACTACTGCTCTGAGCTCCAGATCACAAAAGCCCACTCTGTAGGTGCTCATGAAGTGGAAAA GACTCAGGCTGAGCCTGAGCCTTGGTCCCAGATGATGCATTATAAACTGGGGGCCACCTTGGAACTCACT CCGCTGAGAAAAAGACGGAAAGAAAAGAGCCTTGGAGATGAGGAAGAGCCACCTGCCTTTGGCAGCCCAG GCCCTTCAGAAACAGCTCATAACCGTCCCCTGGGGTCCACCAAGTCACCAGCAGAAGCAAGCAAATCAGC GCCCTCTCTAGAGGGACCCACGAGCTTCCAGCCCAGGACTCCCAAGCCAGGAGCTGGGTCAGAACCAGGG AAGGAGAGGAGAACAATGTCCAAAGAAATTTCCGTCATCCAGCACACCAGCTCCTTTGAGAAGTCTGACC CACCGGAGCAGCCCAGTGGCCTGGAGGAAGACAAGCCCCCGGCCCAGTTCTCATCCCCACCACCTGCCCC GCACGGACGCTCCGCTCACTCCCTGCAGCCAAGGTTGGTCCGGCAGCCCAACATTCAGGTTCCAGAGATC CTCGTGACAGAAGAACCGGACAGGCCTGACACAGAGCCTGAGCCGCCCCCCAAGGAGCCTGAGAAGACAG AAGAATTCCAGTGGCCCCAGCGCAGCCAGACACTGGCACAACTCCCAGCGGAGAAGCTGCCACCCAAGAA AAAGAGACTCCGCCTGGCTGAGATGGCGCAGTCCTCGGGGGAGTCCAGCTTTGAGTCCTCCGTGCCTCTG TCTCGAAGCCCAAGCCAGGAGAGCAGCATTTCTCTGAGTGGCTCCAGCCGCTCGGCTTCATTCGACAGGG AAGACCATGGAAAAGCTGAGGCCCCTGGACCCTTCTCAGACACACGCTCCAAAACCTTGGGCTCCCACAT GCTGACTGTCCCCAGCCACCACCCACATGCCCGAGAGATGAGACGGTCAGCCTCAGAGCAGAGCCCCAAT GTGCCCCATTCCTCACACATGACTGAGACCCGAAGCAAATCCTTTGACTACGGCAGCTTGTCCCCTACAG GACCATCCTTAGCAGTGCCTGCTGCTCCGCCACCCCCAGCCGCCCCGCCAGAAAGAAGAAAATGCTTTCT GGTACGTCAGGCCTCCCTGAACAGACCTCCAGAAGCCGAGCTGGAGGCTGTGCCCAAGGGAAAACAAGAG AGCAGTGAGGAGCCCGCAGCCAGCAAGCCTTCCACAAAAAGCTCTGTGCCCCAGATCTCTGTGGGCACTA CGCAAGGTGGGCCTTCAGGGGGCAAAAGCCAGATGCAGGACAGGCCCCCACTGGGATCCAGCCCACCCTA CACAGAAGCTCTGCAAGTGTTCCAACCTCTCGGCACCCAGCTGCCCCCTCCAGCCTCTCTCTTCTCCTTG CAACAGCTCTTGCCTCAGGAGCAAGAACAATCCTCTGAGTTCTTCCCCACACAAGCAATGGCCGGCCTCC TCTCCTCCCCATACTCCATGCCCCCGCTCCCACCTTCCTTGTTCCAAGCCCCACCACTTCCTCTACAGCC TACTGTGCTACACCCCAGCCAGCTCCATCTCCCCCAGCTCCTGCCTCACGCTGCAGATATCCCCTTCCAG CAGCCCCCTTCCTTTCTCCCCATGCCATGCCCTGCCCCTTCAACCCTCTCCGGATATTTCCTCCCTCTGC AATCCCAGTTTGCACTGCAGCTCCCTGGTGAAATAGAAAGCCACTTGCCCCCAGTCAAAACCAGCCTGCC CCCTCTGGCCACAGGACCTCCTGGCCCCTCCAGCAGCACAGAATACAGCAGTGACATCCAGCTGCCTCCT GTGACTCCCCAAGCCACCTCCCCAGCTCCCACATCAGCCCCACCACTGGCCCTTCCTGCCTGTCCAGATG CCATGGTGTCACTGGTTGTTCCTGTCCGAATCCAGACCCATATGCCATCCTATGGAAGTGCCATGTACAC CACTTTGTCTCAGATCTTGGTCACACAGTCTCCGGGTAGCCCAGCAAGCACGGCCCTTACCAAGTACGAG GAACCCTCCTCCAAAAGTATGACTGTTTGTGAGGCTGATGTATATGAGGCTGAGCCTGGGCCATCGAGCA TAAGCAAGGAACAAAACAGAGGTTACCAGACACCATATCTGAGAGTACCTGAAAGGAAAGGCACTTCACT GTCTTCTGAGGGTATCCTGAGCCTGGAGGGGTGCTCATCCACAGCCAGTGGAAGCAAGCGCGTCCTTTCC CCAGCTGGCAGTCTTGAACTTACCATGGAAACCCAGCAGCAGAAAAGGGTAAAGGAGGAAGAAGCTTCCA AGGCAGATGAAAAACTGGAGCTTGTGAGTACCTGTAGTGTCGTGCTGACAAGTACAGAGGATAGGAAGAA GACAGAGAAACCCCATGTGGGTGGCCAGGGCCGGAGCAGGAGGGAGGCAGAAACACTGTCCAGCTTGTCT TCAGATGTATCCGACCCAAAAGAACTTTCTCCCCTCTCTCATTCCACATTGTCCCATGGGACAGCCCCAG GCTCAGAAGCTTTGAAGGAATATGCCCAACCATCTAGCAAAGCTCACCGAAGAGGTCTGCCTCCAATGAG TGTAAAGAAAGAAGATCCAAAGGAACAGACTGACCTCCCTCCCCTGGCACCCCCTAGTTCTCTGCCTCTG TCAGATACTTCCCCTAAACCAGCCAAATTGCAAGAAGGTACGGACTCAAAGAAGGTACTGCAGTTCCCCA GCCTCCACACAACCACTAATGTCAGTTGGTGCTATTTAAACTACATTAAGCCAAATCACATCCAGCATGC AGATAGGAGGTCCTCTGTTTACGCTGGTTGGTGCATAAGTTTGTACAACCCCAACCTTCCAGGGGTTTCC ACTAAAGCTGCTTTGTCCCTCCTGCGATCTAAGCAGAAGGTGAGCAAAGAGACATATACCATGGCCACAG CTCCGCATCCTGAGGCAGGAAGGCTGGTTCCATCCAACTCCCGAAAGCCCCGCATGACAGAGGTGCACCT CCCGTCGCTGGTTTCCCCAGAGAGCCAGAAAGACCCAGCTAGAGTGGAAAAGGAAGAAAAGCAAGGGAAG GCGGAGGAAGGTACTCCCACTTCCAAGAGAGGCGAGCCGGCGAGGGTCAAGATCTTCGAAGGAGGGTACA

This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 4 Hivep3 (NM_010657) Mouse Untagged Clone – MC225284

AATCAAACGAAGAGTATATATATGTGCGAGGCCGCGGCCGAGGGAGATATGTTTGTGAGGAATGTGGAAT TCGCTGCAAGAAGCCCAGCATGCTGAAGAAACACATCCGCACCCACACTGACGTCCGGCCCTATGTGTGC AAGCACTGTCACTTTGCTTTTAAAACCAAAGGGAATCTGACTAAGCACATGAAGTCGAAAGCCCACAGCA AAAAGTGCCAAGAGACGGGGGTGCTGGAGGAGCTGGAAGCCGAAGAAGGAACCAGTGATGACCTGCACCA GGACTCAGAGGGGCAAGAGGGCGCCGAGGCTGTGGAGGAGCACCAGTTCTCAGACCTGGAGGACTCTGAC TCAGACTCAGACCTGGATGAAGATGAGGAGGAGGAAGAGGAGGAGGAAGAGAGCCAGGATGAGCTGTCTG GGCCATGCTCGGAGGCAGCTCCGCCTTGCCTGCCCCCCACACTACAGGAGAACTCCTCACCCGTTGAGGG CCCTCAGGCTCCAGATAGCACTTCTGACGAGGTCCCGCAAGGCAGCTCCATCTCAGAAGCCACGCATTTG ACCGCCAGCAGTTGTTCCACACCTAGCCGGGGTACCCAAGGCCTTCCCAGGCTGGGACTGGCCCCACTGG AGAAGGACATGAGCTCAGCCCCGAGTCCCAAGGCCACGTCCCCTAGGAGGCCGTGGTCCCCAAGCAAAGA AGCAGGCAGCCGCCCCTCACTCACTCGCAAACATTCACTCACCAAAAATGACTCGTCTCCCCAGCAATGT TCACCGGCCCGAGAAGCTCAGGCCTCAGTAACGAGCACACCTGGTCCCCAGATGGGCCCAGGAAGGGACC TGGGCCCTCACCTTTGTGGGTCTCCAAGACTGGAGCTGTCCTGTCTCACTCCCTACCCCATAGGAAGAGA AGCGCCCGCTGGACTCGAGCGTGCCACAGACACAGGCACCCCCAGATATTCACCCACCAGGAGATGGTCT CTGGGTCAGGCCGAGTCACCGCCACAGACAGTGCTGCCAGGGAAATGGGCCCTGGCTGGGCCCTGCAGCC CCTCAGCGGACAAGAGTGGCCTGGGCTTGGGGCCGGTTCCACGGGCCCTCCTCCAGCCCGTGCCTCTACC TCACACACTTCTCAGCAGAAGCCCTGAAACGTGCACCTCTGCATGGCGGAAGACTGAGTCCCGAAGTCCA TCAGCTGGCCCTGCTCCTCTCTTCCCCCGACCATTCTCCGCCCCTCATGACTTCCATGGCCACCTCCCTA GCCGAAGTGAGGAGAACCTCTTCAGCCACCTGCCTCTGCATTCCCAGCTCCTGAGCCGCGCCCCCTGCCC CCTCATTCCCATCGGTGGGATCCAGATGGTACAGGCCCGGCCAGGAGCCCAGCCCACCGTGCTTCCTGGA CCCTGCGCGGCCTGGGTCAGTGGCTTCTCAGGGGGCGGCAGTGACCTAACTGGGGCCCGAGAGGCCCAGG AGCGCAGCCGCTGGAGTCCCACAGAGAGCCCTTCAGCATCGGTGTCCCCTGTGGCCAAGGTCTCCAAGTT TACACTCTCGTCAGAGCTGGAAGAGGAAAGGACCGGCAGAGGCCCAGGAAGACCTCCTGACTGGGAACCT CACAGGGCTGAAGCCCCTCCAGGACCCATGGGCACACACAGCCCCTGCTCCCCACAGCTGCCCCAAGGCC ACCAGGTGGCACCTTCCTGGAGGGGCCTCTTGGGGTCACCACACACACTGGCCAACCTAAAGGCCTCAAG CTTCCCACCACTGGATCGCAGCAGCTCCATGGACTGCCTGGCAGAGACCTCCACTTACTCTCCACCCCGG AGCAGGAACCTCTCTGGAGAACCCAGGACCCGTCAAGGCTCCCCTGAGCTCTTAGGTAGAGGGGAGCTCA GGACACCTCTATTCCTGCCCAAGGGTAGTGGCCCCCCAAGCATCTAG

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Restriction Sites: SgfI-MluI ACCN: NM_010657 Insert Size: 7047 bp OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). RefSeq: NM_010657.3, NP_034787.2 RefSeq Size: 9021 bp RefSeq ORF: 7047 bp Locus ID: 16656 UniProt ID: A2A884

This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 3 / 4 Hivep3 (NM_010657) Mouse Untagged Clone – MC225284

Gene Summary: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N- terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.[UniProtKB/Swiss-Prot Function]