Obesity and Infection
Review Obesity and infection Matthew E Falagas, Maria Kompoti Lancet Infect Dis 2006; 6: Obesity increases morbidity and mortality through its multiple eff ects on nearly every human system. However, the 438–46 various aspects of the association between obesity and infection have not been reviewed. Thus, we reviewed the relevant Alfa Institute of Biomedical literature focusing on clinical aspects of this association. Obesity has a clear but not yet precisely defi ned eff ect on the Sciences (AIBS), Athens, Greece immune response through a variety of immune mediators, which leads to susceptibility to infections. Data on the (M E Falagas MD, M Kompoti MD); Department of Medicine, incidence and outcome of specifi c infections, especially community-acquired infections, in obese people are so far Tufts University School of limited. The available data suggest that obese people are more likely than people of normal weight to develop infections Medicine, Boston, MA, USA of various types including postoperative infections and other nosocomial infections, as well to develop serious (M E Falagas), and Department complications of common infections. Large prospective studies are required to further defi ne the burden of infectious of Medicine, Henry Dunant Hospital, Athens (M E Falagas) morbidity and mortality conferred by obesity. Correspondence to: Dr Matthew E Falagas, Alfa Introduction including obesity-related mechanisms that lead to Institute of Biomedical Sciences The US National Institutes of Health and the WHO classify predisposition to infections, the epidemiology of (AIBS), 9 Neapoleos Street, people regarding their body weight according to the body nosocomial and community-acquired infections in the 151 23 Marousi, Greece.
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