Student Drug and Alcohol Abuse Prevention Program
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Hormone Testing Summary
Accession # 00280399 Female Sample Report 123 A Street Sometown , CA 90266 Last Menstrual Period: Ordering Physician: DOB: 1953-10-10 Collection Times: Precision Analytical Age: 63 2016-10-02 06:00AM 2016-10-02 08:00AM Gender: Female 2016-10-01 06:00PM 2016-10-01 10:00PM 2016-10-02 02:00AM Hormone Testing Summary Key (how to read the results): Sex Hormones See Pages 2 and 3 for a thorough breakdown of sex hormone metabolites opausa n l R e a m n e g 1.8 4.5 6.0 2.3 14.0 r 5.1 2.8 1.5 P e patient low limit high limit 20.0 result 0.2-0.7 0.3-2.0 Postmenopausal range Estradiol(E2) Progesterone Testosterone (Serum Equivalent, ng/mL) Progesterone Serum Equivalent is a calculated value based on urine pregnanediol. Adrenal Hormones See pages 4 and 5 for a more complete breakdown of adrenal hormones Total DHEA Production 300 500 3000 Age Range 2516 Daily Free Cortisol Pattern 20-39 1300-3000 240 40-60 750-2000 (ng/mg) >60 500-1200 Total DHEA Production (DHEAS + Etiocholanolone + Androsterone) 180 High Range Limit 120Cortisol 80 52 2750 5930 60 230 6500 Patient Values Low Range Limit 24hr Free Cortisol cortisol Metabolized Cortisol (THF+THE) 0 (A+B+C+D) metabolism (Total Cortisol Production) Waking (A) Morning (B) Afternoon (C) Night (D) Free cortisol best reflects tissue levels. Metabolized cortisol best reflects total cortisol production. The following videos (which can also be found on the website under the listed names along with others) may aid your understanding: DUTCH Complete Overview Estrogen Tutorial Female Androgen Tutorial Cortisol Tutorial PLEASE BE SURE TO READ BELOW FOR A NY SPECIFIC LA B COMMENTS. -
Pediatric Pharmacotherapy
Pediatric Pharmacotherapy A Monthly Review for Health Care Professionals of the Children's Medical Center Volume 1, Number 10, October 1995 DIURETICS IN CHILDREN • Overview • Loop Diuretics • Thiazide Diuretics • Metolazone • Potassium Sparing Diuretics • Diuretic Dosages • Efficacy of Diuretics in Chronic Pulmonary Disease • Summary • References Pharmacology Literature Reviews • Ibuprofen Overdosage • Predicting Creatinine Clearance Formulary Update Diuretics are used for a wide variety of conditions in infancy and childhood, including the management of pulmonary diseases such as respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD)(1 -5). Both RDS and BPD are often associated with underlying pulmonary edema and clinical improvement has been documented with diuretic use.6 Diuretics also play a major role in the management of congestive heart failure (CHF), which is frequently the result of congenital heart disease (7). Other indications, include hypertension due to the presence of cardiac or renal dysfunction. Hypertension in children is often resistant to therapy, requiring the use of multidrug regimens for optimal blood pressure control (8). Control of fluid and electrolyte status in the pediatric population remains a therapeutic challenge due to the profound effects of age and development on renal function. Although diuretics have been used extensively in infants and children, few controlled studies have been conducted to define the pharmacokinetics and pharmacodynamics of diuretics in this population. Nonetheless, diuretic therapy has become an important part of the management of critically ill infants and children. This issue will review the mechanisms of action, monitoring parameters, and indications for use of diuretics in the pediatric population (1-5). Loop Diuretics Loop diuretics are the most potent of the available diuretics (4). -
Primary Structure and Functional Expression of a Cdna Encoding the Thiazide-Sensitive, Electroneutral Sodium-Chloride Cotransporter GERARDO GAMBA*, SAMUEL N
Proc. Natl. Acad. Sci. USA Vol. 90, pp. 2749-2753, April 1993 Physiology Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter GERARDO GAMBA*, SAMUEL N. SALTZBERG*t, MICHAEL LOMBARDI*, AKIHIKO MIYANOSHITA*, JONATHAN LYTTON*, MATTHIAS A. HEDIGER*, BARRY M. BRENNER*, AND STEVEN C. HEBERT*t§ *Laboratory of Molecular Physiology and Biophysics, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Center for Study of Kidney Disease, Harvard Medical School, 75 Francis Street, Boston, MA 02115; and tMount Desert Island Biological Laboratory, Salsbury Cave, ME 04672 Communicated by Robert W. Berliner, December 17, 1992 ABSTRACT Electroneutral Na+:Cl- cotransport systems et al. (15) have identified a protein band of 185 kDa obtained are involved in a number of important physiological processes from membranes of rabbit renal cortex exposed to [3H]me- including salt absorption and secretion by epithelia and cell tolazone that may be a component of the thiazide-sensitive volume regulation. One group of Na+:Cl- cotransporters is Na+:Cl- cotransporter. specifically inhibited by the benzothiadiazine (thiazide) class of In this report we describe the sequence, functional and diuretic agents and can be distinguished from Na+:K+:2ClI pharmacological characterization, and tissue-specific expres- cotransporters based on a lack of K+ requirement and insen- sion of a cDNA clone (TSCil) encoding the electroneutral sitivity to sulfamoylbenzoic acid diuretics like bumetanide. We thiazide-sensitive Na+ :C1- cotransporter, isolated by a func- report here the isolation of a cDNA encoding a thiazide- tional expression strategy from the urinary bladder of the sensitive, electroneutral sodium-chloride cotransporter from euryhaline teleost P. -
The Steroid Metabolome in Men with Mood and Anxiety Disorders
Physiol. Res. 64 (Suppl. 2): S275-S282, 2015 https://doi.org/10.33549/physiolres.933067 The Steroid Metabolome in Men With Mood and Anxiety Disorders M. DUŠKOVÁ1, M. HILL1, M. BIČÍKOVÁ1, M. ŠRÁMKOVÁ1, D. ŘÍPOVÁ2, P. MOHR2, L. STÁRKA1 1Institute of Endocrinology, Prague, Czech Republic, 2National Institute of Mental Health, Klecany, Czech Republic Received May 5, 2015 Accepted May 20, 2015 Summary many other hormones and various factors have been The mood and behavior of individuals result from an orchestra of identified as modulators of mood and behavior in such many factors. Among them steroids play an important role; disorders. Recent studies have described the role of brain- however, only several common hormones have been investigated derived neurotrophic factor (BDNF) (Pluchino et al. in this respect. It has been demonstrated that some steroid 2013, Numakawa et al. 2014), thyroid hormones (Duntas metabolites long considered merely the products of steroid and Mails 2013), inflammation (Halaris 2013), immunity hormone metabolism in fact possess considerable activity in the (Pitychoutis and Papadopoulou-Daifoti 2010), melatonin CNS. For this reason we studied the steroid metabolome (Boyce and Hopwood 2013), oxytocin and vasopressin including 50 analytes in 20 men with depression, 20 men with (Scantamburlo et al. 2009, Matsuzaki et al. 2012), the anxiety and 30 healthy controls. Significant differences were renin-angiotensin-aldosterone system (Franklin et al. found not only between controls and men with either depression 2012, Murck et al. 2012), the cannabinoid system or anxiety, but also between men with depression and anxiety. (Martykánová 2010, Gorzalka and Hill 2011, Smaga et Particularly striking were those steroids until now not generally al. -
Increased and Mistimed Sex Hormone Production in Night Shift Workers
Published OnlineFirst March 3, 2015; DOI: 10.1158/1055-9965.EPI-14-1271 Research Article Cancer Epidemiology, Biomarkers Increased and Mistimed Sex Hormone Production & Prevention in Night Shift Workers Kyriaki Papantoniou1,2,3,4, Oscar J. Pozo2, Ana Espinosa1,2,3,4, Josep Marcos2,3, Gemma Castano-Vinyals~ 1,2,3,4, Xavier Basagana~ 1,2,3,4, Elena Juanola Pages 5, Joan Mirabent6,7, Jordi Martín8, Patricia Such Faro9, Amparo Gasco Aparici10, Benita Middleton11, Debra J. Skene11, and Manolis Kogevinas1,2,3,4,12 Abstract Background: Night shift work has been associated with Results: Night workers had higher levels of total progestagens an increased risk for breast and prostate cancer. The effect [geometric mean ratio (GMR) 1.65; 95% confidence intervals of circadian disruption on sex steroid production is a pos- (CI), 1.17–2.32] and androgens (GMR: 1.44; 95% CI, 1.03–2.00), sible underlying mechanism, underinvestigated in hum- compared with day workers, after adjusting for potential con- ans. We have assessed daily rhythms of sex hormones founders. The increased sex hormone levels among night and melatonin in night and day shift workers of both shift workers were not related to the observed suppression of sexes. 6-sulfatoxymelatonin. Peak time of androgens was significantly Methods: We recruited 75 night and 42 day workers, ages later among night workers, compared with day workers (testos- 22 to 64 years, in different working settings. Participants terone: 12:14 hours; 10:06-14:48 vs. 08:35 hours; 06:52-10:46). collected urine samples from all voids over 24 hours on a Conclusions: We found increased levels of progestagens and working day. -
Studies on Steroid Fever II. Pyrogenic and Anti-Pyrogenic Activity in Vitro of Some Endogenous Steroids of Man
Studies on steroid fever II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man G. M. Dillard, Phyllis Bodel J Clin Invest. 1970;49(12):2418-2426. https://doi.org/10.1172/JCI106461. Research Article The pyrogenic properties of some C-19 and C-21 steroids were examined by in vitro incubation of human blood leukocytes with serum-buffer solutions of the steroids and injection of the 18-hr supernatants into rabbits. In previous studies this method demonstrated release of leukocyte endogenous pyrogen by etiocholanolone. With two exceptions, steroids known to cause fever in man, such as 11β-OH etiocholanolone and 3α-hydroxy-5β-pregnane-20-one were also pyrogenic in vitro. All steroids tested which are nonpyrogenic in man, such as androsterone, 3β-OH etiocholanolone, and 3α, 17α-dihydroxy-5β-pregnan-20-one were also nonpyrogenic in vitro. Solubility in aqueous solution did not correlate with pyrogenic capacity. Inhibition of pyrogen release from human leukocytes in vitro by hydrocortisone and estradiol was demonstrated. Hydrocortisone-treated leukocytes released less pyrogen than did normal leukocytes when stimulated either by etiocholanolone or by phagocytosis of heat-killed staphylococci. On the other hand, estradiol-treated blood leukocytes and mononuclear cells showed significant suppression of pyrogen release when phagocytosis, but not etiocholanolone, was used as the stimulus. When blood cells were incubated with progesterone, greater than normal amounts of pyrogen were released following phagocytosis, and the inhibiting effect of estradiol could be partially reversed. Neither estradiol nor hydrocortisone appeared to act on rabbit leukocytes. These studies indicate that a variety of naturally-occurring steroids may alter pyrogen release from leukocytes. -
UWM Performance Enhancing Substance Statement
UWM SPORTS MEDICINE POSITION STATEMENT ON PERFORMANCE ENHANCING SUBSTANCES & NON-THERAPEUTIC DRUGS Each year student-athletes and coaches look for the “edge” over their opponents. At times, student-athletes make decisions to take a performance enhancing substance based on information read about or hear from others. Examples may include injectable substances, pills, powders, and/or drink mixtures purchased from other people, through the mail, or at retail “nutrition” stores. These are marketed to the public or sold on the internet as “performance enhancing” but research in the area of enhancing performance has shown doubtable improved overall performance. Some examples of these include but not limited to: protein powders/pills, creatine, amino acid supplements, alcohol, amphetamines, barbiturates, caffeine, ephedrine, cocaine, LSD, PCP, Marijuana or synthetic marijuana, tobacco products, nitric oxide, beta blockers, diuretics, Beta-2 agonists, and anabolic-androgenic steroids & precursors, like: testosterone epitestosterone human growth hormone EPO androstenedione DHEA, and herbal substances, like: ma huang ephedra kava (aka: ava, ava peper, awa, kava root, Kawa, rauschpfeffer, sakau, tonga, yangona gensing gotu kola bitter orange (aka: citrus aurantium amara, zhi shi) UWM and the NCAA Committee on Competitive Safeguards and Medical Aspects of Sports understands athletes are searching for safe, legal, and effective ways to improve their athletic performance. Many of these are banned by the NCAA, UWM, professional sports, national sport organizations, and are illegal. Furthermore, many of them may cause or trigger other health issues like heart conditions, liver disease, and muscle injuries. Some of these items are combined, or “stacked”, in the same product, which may have, at the minimum, an additive effect or even a multiplying effect of the action/reaction to/of the body. -
The Bumetanide-Sensitive Na-K-2Cl Cotransporter NKCC1 As a Potential Target of a Novel Mechanism-Based Treatment Strategy for Neonatal Seizures
Neurosurg Focus 25 (3):E22, 2008 The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures KRISTOPHER T. KAHLE, M.D., PH.D.,1 AND KEVIN J. STALEY, M.D.2 1Department of Neurosurgery and 2Division of Pediatric Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Seizures that occur during the neonatal period do so with a greater frequency than at any other age, have profound con- sequences for cognitive and motor development, and are difficult to treat with the existing series of antiepileptic drugs. During development, ␥-aminobutyric acid (GABA)ergic neurotransmission undergoes a switch from excitatory to – – inhibitory due to a reversal of neuronal chloride (Cl ) gradients. The intracellular level of chloride ([Cl ]i) in immature neonatal neurons, compared with mature adult neurons, is about 20-40 mM higher due to robust activity of the chlo- ride-importing Na-K-2Cl cotransporter NKCC1, such that the binding of GABA to ligand-gated GABAA receptor- associated Cl– channels triggers Cl– efflux and depolarizing excitation. In adults, NKCC1 expression decreases and the – expression of the genetically related chloride-extruding K-Cl cotransporter KCC2 increases, lowering [Cl ]i to a level – such that activation of GABAA receptors triggers Cl influx and inhibitory hyperpolarization. The excitatory action of GABA in neonates, while playing an important role in neuronal development and synaptogenesis, accounts for the decreased seizure threshold, increased seizure propensity, and poor efficacy of GABAergic anticonvulsants in this age group. Bumetanide, a furosemide-related diuretic already used to treat volume overload in neonates, is a specific inhibitor of NKCC1 at low doses, can switch the GABA equilibrium potential of immature neurons from depolarizing to hyperpolarizing, and has recently been shown to inhibit epileptic activity in vitro and in vivo in animal models of neonatal seizures. -
NCAA Division III
Form 11-3f Academic Year 2011-12 Drug-Testing Consent NCAA Division III For: Student-athletes. Action: Sign and return to your director of athletics. Due date: Before your institution's first competition. Required by: NCAA Constitution 3.2.4.6 and NCAA Bylaw 14.1.4. Purpose: To assist in certifying eligibility. Effective date: This consent from shall be in effect from the date this document is signed and shall remain in effect until a subsequent Drug-Testing Consent Form is executed. Requirement to Sign Drug-Testing Consent Form. Name of your institution: _________________________________________________________ You must sign this form prior to competition in intercollegiate athletics per NCAA Constitution 3.2.4.6 and Bylaw 14.1.4. If you have any questions, you should discuss them with your director of athletics. Consent to Testing. You agree to allow the NCAA to test you in relation to any participation by you in any NCAA championship or in any postseason football game certified by the NCAA for the banned drugs listed in Bylaw 31.2.3 (attached). Consequences for a Positive Drug Test. By signing this form, you affirm that you are aware of the NCAA drug-testing program, which provides: 1. A student-athlete who tests positive shall be withheld from competition in all sports for a minimum of 365 days from the drug-test collection date and shall lose a year of eligibility; 2. A student-athlete who tests positive has an opportunity to appeal the positive drug test; 3. A student-athlete who tests positive a second time for the use of any drug other than a "street drug" shall lose all remaining regular-season and postseason eligibility in all sports. -
Ncaa Drug-Testing Program | 2021-22
NCAA DRUG-TESTING PROGRAM | 2021-22 BANNED SUBSTANCES: NCAA NUTRITIONAL/DIETARY • Stimulants • Cannabinoids SUPPLEMENTS WARNING: • Anabolic Agents • Peptide Hormones, • Nutritional/dietary supplements, including vitamins and • Alcohol and Beta Growth Factors, Blockers Related Substances and minerals, are not well regulated and may cause a positive (banned for rifle only) Mimetics drug test result. • Diuretics/ • Hormone and Masking Agents Metabolic Modulators • Student-athletes have tested positive and lost their eligibility using nutritional/dietary supplements. • Narcotics • Beta-2 Agonists Go to ncaa.org/drugtesting • Many nutritional/dietary supplements are contaminated for examples* under each class. with banned drugs not listed on the label. *Any substance that is chemically/ • Any product containing a nutritional/dietary supplement pharmacologically related to any of the classes above, even if it is not listed as an example, also ingredient is taken at your own risk! is banned! QUESTIONS ABOUT MEDICINES AND SUPPLEMENTS? 816-474-7321 or dfsaxis.com (password ncaa1, ncaa2 or ncaa3) Contents Chapter I — NCAA Banned Substances ....................................................................................................... 2 Chapter II — Medical Exceptions Procedures ............................................................................................ 3 Chapter III — Drug Education Guidelines .................................................................................................... 4 Chapter IV — NCAA Drug-Testing -
Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures
Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Cleary, Ryan T., Hongyu Sun, Thanhthao Huynh, Simon M. Manning, Yijun Li, Alexander Rotenberg, Delia M. Talos, et al. 2013. Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. PLoS ONE 8(3): e57148. Published Version doi:10.1371/journal.pone.0057148 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:10658064 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures Ryan T. Cleary1, Hongyu Sun1, Thanhthao Huynh1, Simon M. Manning1,3, Yijun Li2, Alexander Rotenberg1, Delia M. Talos1, Kristopher T. Kahle5, Michele Jackson1, Sanjay N. Rakhade1, Gerard Berry2, Frances E. Jensen1,4* 1 Department of Neurology, Children’s Hospital Boston, Boston, Massachusetts, United States of America, 2 Division of Genetics and Metabolism, Children’s Hospital Boston, Boston, Massachusetts, United States of America, 3 Division of Newborn Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 4 Program in Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America, 5 Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America Abstract Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl2 cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA receptors in the perinatal period. -
AOD Biennial Review
Introduction The Drug-Free Schools and Communities Act and Part 86 of the Education Department General Administrative Regulations (EDGAR) require each institution of higher education participating in Title IV student financial assistance to certify that it has developed and implemented a program to prevent the unlawful possession, use, and distribution of drugs and alcohol on campus and at institution-recognized events and activities. Annually, the institution must distribute to current students and employees written information about its drug and alcohol abuse prevention program, including information about related sanctions. The distribution plan must include provisions for sharing this information with new students and employees who join the institution at later points in the year as well. In addition, on a biennial basis, the institution must conduct a review to determine the effectiveness of its programs and prepare a report of the review’s findings. The report must be retained and made available to the US Department of Education upon request. Notre Dame of Maryland University (“NDMU” or “the University”) acknowledges these responsibilities, including the timely review of and reporting on the effectiveness of its prevention programs. NDMU is a private, Catholic university established in 1895 with the mission to educate leaders to transform the world. NDMU is a comprehensive university that is home to Maryland's only women's college and offers a wide variety of full and part-time undergraduate, graduate, doctoral, and certificate programs to women and men. The University enrolls approximately 2300 students and has Schools of Arts, Sciences, and Business; Education; Nursing; and Pharmacy. Additionally, the University offers programs for adult students fully online and at several locations throughout the State.