Sodium Nitrite

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SODIUM NITRITE Prepared at the 44th JECFA (1995), published in FNP 52 Add 3 (1995) superseding specifications prepared at the 17th JECFA (1973), published in FNP 4 (1978) and in FNP 52 (1992). Metals and arsenic specifications revised at the 63rd JECFA (2004). An ADI of 0-0.06 mg/kg bw was established at 44th JECFA (1995). Nitrite should not be used for infants below 3 months SYNONYMS INS No. 250 DEFINITION Chemical names Sodium nitrite C.A.S. number 7632-00-0 Chemical formula NaNO2 Formula weight 69.00 Assay Not less than 97.0% on the dried basis DESCRIPTION White or slightly yellow, hygroscopic and deliquescent granules, powder, or opaque, fused masses of sticks FUNCTIONAL USES Antimicrobial preservative, colour fixative CHARACTERISTICS IDENTIFICATION Solubility (Vol. 4) Freely soluble in water, sparingly soluble in ethanol Test for sodium (Vol. 4) Passes test Test for nitrite (Vol. 4) Passes test PURITY Loss on drying (Vol. 4) Not more than 0.25% (over silica gel, 4 h) Lead (Vol. 4) Not more than 2 mg/kg Determine using an atomic absorption technique appropriate to the specified level. The selection of sample size and method of sample preparation may be based on the principles of the method described in Volume 4, “Instrumental Methods.” METHOD OF Weigh, to the nearest mg, 1 g of the dried sample. Transfer to a 100 ml ASSAY volumetric flask and dissolve in water diluting to the mark. Pipette 10.0 ml of this solution into a mixture of 50.0 ml of 0.1N potassium permanganate, 100 ml of water and 5 ml of sulfuric acid, keeping the tip of the pipette well below the surface of the liquid. Warm the solution to 40o, allow it to stand for 5 min, and add 25.0 ml of 0.1N oxalic acid. Heat the mixture to about 80o and titrate with 0.1N potassium permanganate. where X = ml of 0.1N potassium permanganate used for titration W = weight (in grams) of the sample .

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