Indian Statistical Institute Applications of Mixed-Effects Models in Biostatistics Author(s): Robert D. Gibbons and Donald Hedeker Reviewed work(s): Source: Sankhyā: The Indian Journal of Statistics, Series B (1960-2002), Vol. 62, No. 1, Biostatistics (Apr., 2000), pp. 70-103 Published by: Springer on behalf of the Indian Statistical Institute Stable URL: http://www.jstor.org/stable/25053120 . Accessed: 31/05/2012 17:39 Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at . http://www.jstor.org/page/info/about/policies/terms.jsp JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact
[email protected]. Springer and Indian Statistical Institute are collaborating with JSTOR to digitize, preserve and extend access to Sankhy: The Indian Journal of Statistics, Series B (1960-2002). http://www.jstor.org Sankhy? : The Indian Journal of Statistics Special Issue on Biostatistics 2000, Volume 62, Series B, Pt. 1, pp. 70-103 APPLICATIONS OF MIXED-EFFECTS MODELS IN BIOSTATISTICS* By ROBERT D. GIBBONS and DONALD HEDEKER University of Illinois at Chicago SUMMARY. We present recent developments in mixed-effects models relevant to application in biostatistics. The major focus is on application of mixed-effects models to analysis of longitudinal data in general and longitudinal controlled clinical trials in detail. We present application of mixed-effects models to the case of unbalanced longitudinal data with complex residual error structures for continuous, binary and ordinal outcome measures for data with two and three levels of nesting (e.g., a multi-center longitudinal clinical trial).