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Evidence Review D7 National Institute for Health and Care Excellence Draft for consultation Neonatal parenteral nutrition [D7] Ratio of non-nitrogen energy to nitrogen NICE guideline tbc Evidence reviews September 2019 Draft for consultation These evidence reviews were developed by the National Guideline Alliance which is part of the Royal College of Obstetricians and Gynaecologists DRAFT FOR CONSULTATION Error! No text of specified style in document. Disclaimer The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian. Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties. NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the Welsh Government, Scottish Government, and Northern Ireland Executive. All NICE guidance is subject to regular review and may be updated or withdrawn. Copyright © NICE 2019. All rights reserved. Subject to Notice of Rights. ISBN: DRAFT FOR CONSULTATION Ratio of non-nitrogen energy to nitrogen Contents What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? .......................................................................................... 6 Review question ............................................................................................................. 6 Introduction ........................................................................................................... 6 Summary of the protocol ....................................................................................... 6 Clinical evidence ................................................................................................... 7 Summary of clinical studies included in the evidence review ................................. 7 Quality assessment of clinical outcomes included in the evidence review ............. 8 Economic evidence ............................................................................................... 8 Summary of studies included in the economic evidence review ............................. 8 Economic model .................................................................................................... 9 Evidence statements ............................................................................................. 9 Research recommendation ................................................................................. 11 The committee’s discussion of the evidence ........................................................ 11 References .......................................................................................................... 13 Appendices ........................................................................................................................ 14 Appendix A – Review protocols .................................................................................... 14 Review protocol for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ...................................................................................................... 14 Appendix B – Literature search strategies .................................................................... 20 Literature search strategies for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ............................................................................................ 20 Appendix C – Clinical evidence study selection ............................................................ 33 Clinical study selection for: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? .................. 33 Appendix D – Clinical evidence tables .......................................................................... 34 Clinical evidence tables for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ............................................................................................ 34 Appendix E – Forest plots............................................................................................. 39 Forest plots for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? .............. 39 Appendix F – GRADE tables ........................................................................................ 40 GRADE tables for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ...................................................................................................... 40 Appendix G – Economic evidence study selection ........................................................ 46 Economic evidence study selection for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ..................................................................................... 46 4 DRAFT FOR CONSULTATION Ratio of non-nitrogen energy to nitrogen Appendix H – Economic evidence tables ...................................................................... 46 Economic evidence tables for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ............................................................................................ 46 Appendix I – Economic evidence profiles ..................................................................... 47 Economic evidence profiles for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ............................................................................................ 47 Appendix J – Economic analysis .................................................................................. 48 Economic analysis for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ...................................................................................................... 48 Appendix K – Excluded studies .................................................................................... 49 Excluded studies for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ...................................................................................................... 49 Appendix L – Research recommendations ................................................................... 61 Research recommendations for review question: What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting and target dose)? ............................................................................................ 61 5 DRAFT FOR CONSULTATION Ratio of non-nitrogen energy to nitrogen 1 What are the most effective relative 2 amounts of nitrogen and non-nitrogen 3 energy (starting and target dose)? 4 Review question 5 What are the most effective relative amounts of nitrogen and non-nitrogen energy (starting 6 and target dose)? 7 Introduction 8 Babies require energy in order to meet resting energy requirements, energy expenditure and 9 to facilitate growth through new tissue formation. Nitrogen (amino acids or protein) is 10 required for new tissue formation. If insufficient non-nitrogen energy (carbohydrates and 11 lipids) is given then nitrogen is used for non-growth purposes and is not available to generate 12 new tissues. An excess of non-nitrogen energy can lead to increased adiposity and may 13 cause hyperglycaemia or hypertriglyceridemia. If an excess of nitrogen is given this results in 14 oxidation of amino acids resulting in high levels of blood urea. 15 Summary of the protocol 16 Please see Table 1 for a summary of the Population, Intervention, Comparison and Outcome 17 (PICO) characteristics of this review. 18 Table 1: Summary of the protocol (PICO table) Population Babies born preterm, up to 28 days after their due birth date (preterm babies) Babies born at term, up to 28 days after their birth (term babies) Intervention Ratio of nitrogen and non-nitrogen energy Comparison Other ratios of nitrogen and non-nitrogen energy Outcomes Critical Neurodevelopmental
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