CURRICULUM VITAE William C. L. Stewart, Ph.D

CURRICULUM VITAE

William C. L. Stewart, Ph.D.

PRESENT TITLE AND AFFILIATION

DUAL/JOINT APPOINTMENT Assistant Professor Department of Pediatrics The Ohio State University College of Medicine Columbus, Ohio

Assistant Professor Department of Statistics (zero salary joint appointment) The Ohio State University College of Medicine Columbus, Ohio

Principal Investigator Battelle Center for Mathematical Medicine The Research Institute of Nationwide Children's Hospital Columbus, Ohio

CITIZENSHIP AND VISA STATUS

U.S. Citizen

OFFICE ADDRESS

Battelle Center for Mathematical Medicine The Research Institute 575 Children’s Crossroad, Columbus, OH 43215 P: (614) 355 – 6674 F: (614) 355 – 5898 [email protected]

EDUCATION

UNDERGRADUATE EDUCATION

05/99 San Francisco State University B.A. San Francisco, CA Mathematics

GRADUATE EDUCATION

05/02 University of Washington M.S. Seattle, WA Statistics

11/05 University of Washington Ph.D. Seattle, WA Statistics

POST-GRADUATE EDUCATION & TRAINING

1999 Genentech Summer Intern San Francisco, CA Pre-clinical Biostatistics

06/08 University of Michigan Postdoctoral Research Ann Arbor, MI Statistical Genetics

ACADEMIC APPOINTMENTS

2008 – 2012 Assistant Professor of Biostatistics Columbia University New York, NY

2012 – Present Assistant Professor of Pediatrics The Ohio State University Columbus, OH

2012 – Present Assistant Professor of Statistics (zero salary joint appointment) The Ohio State University Columbus, OH

SERVICE

ACADEMIC ADMINISTRATIVE RESPONSIBILITIES

2012 Recruitment Advisory Committee, Member Columbia University New York, NY

2009 – 2012 Steering Committee of Mailman School of Public Health, Member Columbia University New York, NY

2012 – 2014 Research Information Technology Advisory Committee, Member The Research Institute Columbus, OH

2013 – 2014 Battelle Center for Mathematical Medicine Website Committee, Member The Research Institute Columbus, OH

2016 – 2017 Research Retreat Planning Committee The Research Institute Columbus, OH

2016 – Present BCMM Departmental Seminar “Nerd Hour” The Research Institute Columbus, OH

INSTITUTIONAL/LOCAL ACTIVITIES

2011 Invited Panelist: Meet the Methodologist: Genomics in Public Health Mailman School of Public Health, Columbia University

2014 Hard Work, Youth & Discipline: What Can Applied Math Do for Me? Young Scientists Seminar Series Nationwide Children's Hospital

2015 Hard Work, Youth & Discipline: A Crossroad between Mathematics and Science Young Scientists Seminar Series Nationwide Children's Hospital

2016 Invited Panelist: Mechanisms of Human Health and Disease Nationwide Children's Hospital

2017 Invited Panelist: Mechanisms of Human Health and Disease Nationwide Children's Hospital

NATIONAL ACTIVITIES

MILITARY OR OTHER GOVERNMENT SERVICE

1988 – 1990 Cadet United States Air Force Academy

Colorado Springs, CO

HONORS AND AWARDS

2015 Service from the Heart Teamwork Award Nationwide Children's Hospital Columbus, OH

2016 Merit Award Summer Poster Competition Nationwide Children's Hospital Columbus, OH

2017 FASEB Travel Award Federation of American Societies for Experimental Biology Bethesda, MD

2018 Distinguished Presentation Award World Gene Conference Singapore

RESEARCH SUPPORT

ONGOING RESEARCH

Peer Reviewed

R01AI143740-01 Das (PI) 04/01/19 – 03/31/24

National Institute of Allergy and Infectious Disease Developing a predictive in silico toolkit for modeling NK cell responses against RNA virus infections the genetic architecture The purpose of this grant is to create new mathematical models to better understand the signaling kinetics of NK cell response initiated by the inoculation of various RNA viral strains. Ideally, we would like to develop a collection of math models that can be used, as needed, to understand the viral lode kinetics and cell signaling cascades of categorically different types of infections.

R56AI146581 Das (PI) 08/01/19 – 07/30/20

National Institute of Allergy and Infectious Disease Modeling Antibody-induced Immune Responses by NK Cells in Mice and Humans The purpose of this grant is to create new mathematical models to better understand the signaling kinetics of NK cell response initiated by antibody-induction. Here, we propose to use sophisticated techniques in mathematics, statistics, and computer science to better understand and model the cell signaling cascades of NK cells in mice and humans.

Non – Peer Reviewed

COMPLETED RESEARCH

Peer Reviewed

R25HD086885 Buhimschi (PI) 04/01/16 – 03/31/19 Futures Matter: Transformative Transdisciplinary Summer Research Program The goal of this project is to expose talented and under-represented high school students to cutting-edge research by pairing students and principal investigators (PIs) with shared interests through an active research project in the PI’s laboratory.

CHEST Foundation Hayes (PI) 09/01/16 – 08/31/19 Improving the LAS with Geospatial Lung Allocation Simulation Software The goal of this project is to improve the health-related outcomes of lung transplant patients by allocating donor lungs to recipients more efficiently nationwide. The software that we propose to develop will ensure that allocation policies are flexible and adaptive.

MARCH of DIMES Buhimschi (PI) 01/01/18 – 07/01/18 Identifying the Genes for Extreme Gestational Term Length The primary goal of this project is to scan the genomes of affected families ascertained for extreme gestational term length from a large national registry to find genetic loci and/or genes influencing pre- and post-term birth.

R01DK031775 Greenberg (PI) 04/01/03 – 02/28/07 National Institute of Diabetes and Digestive and Kidney Diseases Two-Locus Models of Epistasis and Heterogeneity The goal of this research is to explore a wide range of two-locus models via customized simulation software to determine which models are most likely contributing to complex common disease.

R01DK031813 Hodge (PI) 09/01/88 – 08/31/10 National Institute of Diabetes and Digestive and Kidney Diseases Linkage and Segregation in Complex Genetic Diseases

The goal of this research is to develop methods for detecting gene-gene and gene-environment interaction in common complex diseases using extensions to standard approaches in linkage and segregation analysis.

R01CA138750 Kandel (PI) 07/01/09 – 06/30/10 National Institute on Drug Abuse Genetic Factors and Nicotine Dependence in Adolescents The goal of this research is to identify genetic risk factors for nicotine dependence in a multi- ethnic longitudinal cohort of adolescents.

R01 MH048858 Gambel (PI) 09/01/10 – 08/31/11 National Institute of Environmental Health Sciences Biomarkers for Arsenic Toxicity The goal of this research is to identify biomarkers that are predictive of early-stage skin lesions in individuals with elevated exposure to arsenic.

R21NS070323 Greenberg (PI) 10/01/09 – 09/30/11 National Institute of Neurological Disorders and Stroke The Role of Genome Encoded ME2 in Epilepsy The goal of this research is to uncover that portion of the genetic mechanism governing the presentation of idiopathic generalized epilepsy that relates specifically to genetic variation observed in the ME2 gene.

R01MH048858 (subcontract) Stewart (PI) 09/01/10 – 08/31/11 Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate The goal of this research is to better understand the complex interplay between genetic factors associated with arsenic-induced skin lesions and the presence/absence of folate.

Non – Peer Reviewed

Rackham Graduate School Boehnke (PI) 06/01/06 – 05/31/08 University of Michigan Rackham Interdisciplinary Workshop The purpose of this grant is to establish a monthly multidisciplinary seminar series at the University of Michigan.

Professional Schools Fund Stewart (PI) 07/01/08 – 06/30/09 Columbia University A Flexible Method for Deletion Discovery from High-Throughput Genotype Data with Applications to Bipolar Disorder The goal of this research is to develop an ultra-sensitive deletion detection method by modeling the multivariate inheritance of allele single intensity data, and to apply this method to an existing bipolar disorder data set.

Calderone Prize Stewart (PI) 11/01/09 – 10/31/10 Columbia University

Subsampling Increases Power to Find Disease Genes The purpose of this research is to develop new linkage methods to extract the maximum amount of information from dense SNP linkage scans, and to apply the proposed methodology to a hypertension and end-stage renal disease study.

PENDING RESEARCH SUPPORT

R01AI146581 Das (PI) 08/01/20 – 06/30/24

PUBLICATIONS

ARTICLES IN PEER REVIEWED JOURNALS 1. George AW, Basu S, Li N, Rothstein J, Sieberts SK, Stewart W, Wijsman E, Thompson EA (2003). Approaches to mapping genetically correlated complex traits. BMC Genetics 4 (Suppl 1): S71.

2. Sieh W, Basu S, Fu A, Rothstein J, Scheet P, Stewart W, Sung Y, Thompson E, Wijsman E (2005). Comparison of marker types and map assumptions using MCMC- based linkage analysis of COGA data. BMC Genetics 6 (Suppl 1): S11.

3. Stewart WCL, and Thompson EA (2006). Improving estimates of genetic maps: A maximum likelihood approach. Biometrics 62: 728-734

4. Stewart WCL (2007) Improving estimates of genetic maps: A meta-analysis based approach. Genetic Epidemiology 31: 408-416

5. Matise TC, Chen F, Chen W, De La Vega FM, Hansen M, He C, Hyland F, Kennedy GC, Kong X, Murray S, Ziegle J, Stewart WCL, Buyske SG (2007). A Second-Generation Combined Linkage-Physical Map of the Human Genome. Genome Research 17: 1783- 1786

6. Zöllner S, Su G, Chen Y, Stewart WCL, McInnis MG, Burmeister M. (2009). Bayesian EM Algorithm for scoring polymorphic deletions from SNP data and application to a common CNV on 8q24. Genetic Epidemiology 33(4): 357-68

7. Stewart WCL, Peljto AL, Greenberg DA (2010). Multiple Subsampling of Dense SNP Data Localizes Disease Genes with Increased Precision. Human Heredity 69: 152-159

8. Rodriguez-Murillo* L, Subaran* R, Stewart* WCL, Sreemanta* P, Marathe S, Barst RJ, Chung WK, Greenberg DA (2010) Novel Loci Interacting Epistatically with Bone Morphogenetic Protein Receptor 2 Cause Familial Pulmonary Arterial Hypertension. Journal of Heart and Lung Transplantation, 29(2): 174-180.

9. He C, Weeks DE, Buyske S, Abecasis GR, Stewart WC, Matise TC, The Enhanced Map Consortium (2011). Enhanced genetic maps from family-based disease studies: population-specific comparisons, BMC Medical Genetics, 12(1):15.

10. Stewart WCL, Drill EN, Greenberg DA (2011). Finding disease genes: A fast and flexible approach for analyzing high-throughput data. European Journal of Human Genetics, 19(10): 1090-1094.

11. Stewart WCL, Subaran R (2012). Obtaining accurate p-values from a dense SNP linkage scan. Human Heredity, 74(1):12-16.

12. Lipner EM, Tomer Y, Noble JA, Monti MC, Lonsdale JT, Corso B, Stewart WCL, Greenberg DA (2013). HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. Human Immunology, 74(5):538-44.

13. Stewart WCL, Cerise J (2013). Increasing the Power of Association Studies with Affected Families, Unrelated Cases and Controls, Frontiers in Genetics. doi: 10.3389/fgene.2013.00200

14. Kambhampati S, Stewart C, Stewart WCL, Kelley J, and Ramnath R (2014). Managing Tiny Tasks for Efficient, Data-Parallel Subsampling. In The Second IEEE Conference on Cloud Engineering. March, 2014.

15. Heyer GL, Merison K, Rose SC, Perkins SQ, Lee EM, and Stewart WCL (2014). PedMIDAS-based scoring underestimates migraine disability on non-school days. Headache, 54(6):1048-53.

16. Stewart WCL, Huang Y, Greenberg DA, Vieland VJ (2014). Next-generation linkage and association methods applied to hypertension: A multifaceted approach to the analysis of sequence data. BMC Proceedings, 8(Suppl 1): S111

17. Subaran RL, Conte JM, Stewart WCL, Greenberg DA (2015). Pathogenic EFHC1 mutations are tolerated in healthy individuals dependent on reported ancestry. Epilepsia, Feb;56(2):188-94.

18. Stewart WCL, and Hager VR (2016). A powerful test of independent assortment that determines genome-wide significance quickly and accurately. Heredity, Jun:117:109-113.

19. Stewart WCL, and Bartlett CW (2016). Using High-Throughput Genotyping and Large Families to Reduce Sequencing Costs. Internal Medicine Review, Dec: 2(11).

20. Wang M, and Stewart WCL, (2017). A pragmatic test for detecting association between a dichotomous trait and the genotypes of affected families, controls and independent cases. Frontiers in Genetics, May: doi:10.3389/fgene.2017.00049.

21. Mukherjee S, Jensen H, Stewart WCL, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J (2017). In silico modeling identifies D45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Science Signaling 10(485).

22. Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J (2017). Connecting the dots across time: Reconstruction of single cell signaling trajectories using time-stamped data. Royal Society Open Science, 4(8): 170811.

23. Zhou X, Wang M, Zhang H, Stewart WCL, Lin S (2018). Logistic Bayesian lasso for detecting association combining family and case-control data. BMC Proceedings 12(Suppl 9):54.

24. Rumpf RW, Stewart WCL, Martinez SK, Gerrard CY, Adolphi NL, Thakkar R, Coleman A, Rajab A, Ray WC, Fabia R. (2018). Comparison of the Lund and Browder table to computed tomography scan three-dimensional surface area measurement for a pediatric cohort. Journal of Surgical Research, 221: 275–284.

25. Stewart WCL, Hodge SE. (2018). A Targeted Investigation into Clopper-Pearson Confidence Intervals. Internal Medicine Review. 4(4).

26. Pathak S, Miller J, Morris EC, Stewart WCL, Greenberg DA. (2018). DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians. Epilepsia 59(5):1011-1019

27. Doyle S, Tumin D, Stewart W, McConnell PI, Whitson BA, Tobias JD, Hayes D Jr. (2018). Predictive utility of lung allocation score for lung retransplantation outcomes. The Annals of Thoracic Surgery 106(5):1525-1532.

28. Trittmann J, Bartenshlag A, Zmuda E, Frick J, Gastier-Foster J, Stewart W, Klebanoff M, Nelin L (2018). Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia. Acta Paediatrica: Nurturing the Child 107(12):2158–2164.

29. Lakhani V, Li T, Mukherjee S, Stewart W, Sword W, Das J (2018). Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. Royal Society Open Science 5(11): 180810.

30. Li SS, Miller R, Tumin D, Stewart WCL, Tobias JD, Hayes D (2019). Lung allocation score thresholds prioritize survival after lung transplantation. CHEST 156(1):64-70.

31. Wang M, Greenberg DA, Stewart WCL (2019). Replication, Re-Analysis, and Gene Expression: ME2 and Genetic Generalized Epilepsy. Epilepsia 60(3):539-546.

32. Wang M, Greenberg DA, Stewart WCL (2019). In Response: ME2 association in adolescent-onset genetic generalized epilepsy. Epilepsia 60(9):2001-2002.

33. Wethington DS, Peeples M, Niewiesk S, Perelson A, Stewart W, Harder OE (2019). Mathematical Modeling Identifies the Role of Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton Rats. Journal of the Royal Society Interface Nov: doi.org/10.1098/rsif.2019.0389

34. Stewart WCL*, Gnona K*, White P, Kelly B, Klebanoof M, Buhimschi IA, Nelin LD (Accepted). Prediction of Short-Term Neonatal Complications in Preterm Infants Using Exome-Wide Genetic Variation and Gestational Age: A Pilot Study. Pediatric Research.

INVITED ARTICLES 1. Greenberg DA, Stewart WC (2012). How should we be searching for genes for common epilepsy? A critique and a prescription, Epilepsia 53 Suppl 4:72–80.

2. Wang M, Greenberg DA, Stewart WCL (2019). In Response: ME2 association analysis in adolescent-onset genetic generalized epilepsy. Epilepsia

EDITORIALS

1. Greenberg D. A., Stewart W. C. L., Rowland P. L. (2009). Paraoxonase Genes and Susceptibility to ALS. Neurology 73: 11-12

2. Stewart WCL. (2018). The Deteriorating State of Methods Development. Biostatistics and Biometrics Online Access Journal 5(5). 555675

ABSTRACTS

1. Stewart WCL, Thompson EA (2005). Marker Map Estimation Generalized. IGES Annual Meeting (poster presentation) Park City, UT

2. Stewart WCL, (2006). Using Meta-analysis to Combine Linkage Maps. ASHG Annual Meeting (poster presentation) New Orleans, LA

3. Stewart WCL, Abecasis G, Gateva V (2007). MERLIN: Modelling Genotyping Error in Standard Pedigree Analyses. IGES Annual Meeting (poster presentation) York, England

4. Stewart WCL, Burmeister M, McInnis M, Zoellner S (2007). Imputing Copy Number Variants from Family-Based Signal Intensity Data. ASHG Annual Meeting (poster presentation) San Diego, CA

5. Stewart WCL, Xiang N, Villafuerte S, Zoellner S, McInnis MG, Burmeister M (2008). HEMIZYG: Detects Novel SNP in Bipolar Linkage Region and Uncovers Evidence for Genetic Heterogeneity. ASHG Annual Meeting (poster presentation) Philadelphia, PA

6. Peljto AL, Stewart WCL, Greenberg A (2009). Multiple Subsampling of Dense SNP Data Localizes Disease Genes with Increased Precision. ASHG Annual Meeting (poster presentation) Honolulu, HI

7. Drill E, Stewart W (2010). Getting More from Your Dense SNP Data: EAGLET Increases Power and Precision. ASHG Annual Meeting (poster presentation) Washington D.C.

8. Stewart WCL, Subaran RL (2012). Obtaining Accurate P-values from a Dense SNP Linkage Scan. IGES Annual Meeting (poster presentation) Stevenson, WA

9. Stewart WCL, Cerise JE (2012). Combining Affected Families, Independent Cases and Controls to Increase the Power of Association Studies. ASHG Annual Meeting (poster presentation) San Diego, CA

10. Stewart WCL, Hodge SE, Greenberg DA (2013). Comparing Common Multipoint Linkage Methods: The Untold Story, IGES Annual Meeting (poster presentation) Chicago, IL

11. Stewart WCL, Monti MC (2013). Increasing the Power of Association: POPFAM+ Combines Arbitrary Affected Families, Unrelated Cases, Controls, and Reference Samples. ASHG Annual Meeting (poster presentation) Boston, MA

12. Stewart WCL, Bartlett CW (2014) Take Your Research to the Next Level with Secondary Data Analyses: Fine-mapping the SLI Gene. IGES Annual Meeting (poster presentation), Vienna, Austria

13. Wang M, Stewart WCL (2015) POPFAM+: A Powerful Test of Genetic Association for Independent Cases, Affected Families, and Controls. IGES Annual Meeting (oral presentation), Baltimore MD

14. Malhotra A, Bartlett CW, Greenberg DA, and Stewart WCL (2016) ME2 Expression is Associated with Epilepsy. Summer Poster Competition (poster presentation), Columbus, OH

15. Stewart WCL, Bartlett CW (2016). A statistically efficient gene-mapping method that reduces sequencing costs and better prioritizes candidate genes, IGES Annual Meeting (poster presentation) Toronto, CA

16. Stewart WCL, Wang M, Malhotra A, Greenberg DA (2017). ME2 gene influences susceptibility to genetic generalized epilepsy: The evidence from cosegregation, genetic

association, and gene expression studies is compelling, 32nd IEC (poster presentation) Barcelona, SP

17. Stewart WCL (2017). Leveraging large affected families and publicly available data to shrink confidence intervals of trait location, IGES Annual Meeting (poster presentation) Cambridge, UK

18. Doyle S, Tumin D, Stewart W, McConnell PI, Whitson BA, Tobias JD, Hayes D Jr (2017). Predictive utility of lung allocation score for lung retransplantation outcomes, CHEST 2017 (poster presentation) Toronto, CA

19. Gnona KM, Stewart WC, White P, Klebanoff M, Nelin LD, Buhimschi IA (2017). The SUPERBABY PROJECT: Genetic determinants of the favorable NICU course in premature newborns, ASHG Annual Meeting (poster presentation) Orlando, FL

20. Nelin L, Gnona K, Stewart W, White P, Klebanoff M, Buhimschi I (2018). Potential genetic determinants of resilience to the morbidities of prematurity, PAS (Pediatric Academic Societies) Meeting (poster presentation) Toronto, CA

21. Malhotra A, Buhimschi I, Stewart WCL (2018). Imputing HLA-A Genotypes in Kenyans: A Proof of Principle, 2018 Autumn Undergraduate Research Festival (oral presentation) Columbus, OH

22. Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King, Peeples M, Niewiesk S, Das J. (2018) Mathematical Modeling Identifies Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton Rats, 2018 RSV Symposium (poster presentation) Asheville, NC

23. Gnona MK, Stewart WCL, White P, Klebanoff M, Nelin LD, Buhimschi IA. (2019) Genetic Burden and Gestational Age Accurately Predict Complications in Preterm Infants, ASHG Annual Meeting (poster presentation) Houston, TX

BOOK CHAPTERS

1. Greenberg DA, Stewart WCL. Remind me again what disease we are studying? A population genetics, genetic analysis, and real data perspective on why progress on identifying genetic influences on common epilepsies has been so slow in genetic analysis of idiopathic epilepsies: challenges and strategies. In Progress and Brain Research. Steinlen, ed. Oxford: Elsevier 2014.

2. Stewart, WCL. The Fundamentals of Statistical Data Analysis. In Systems Immunology: An Introduction to Modeling for Scientists. Taylor & Francis 2016.

OTHER (Technical Reports & Computer Programs)

1. Stewart WCL, and George AW and Thompson EA (2002). Using Markov chain Monte Carlo for multipoint linkage analysis: Improved estimates of lod scores. Technical Report No. 412, Dept. of Statistics, Univ. of Washington.

2. GLASS+ (Software that simulates the allocation of donor lungs throughout the continental United States).

3. EAGLET (Efficient Genetic Analysis: Linkage, Estimation, and Testing – A software package for detecting and locating disease genes from the analysis of high-throughput genotype data; it’s distribution is worldwide).

4. POPFAM+ (Population and Family based association – A software program that pinpoints the location of disease genes from panels of densely spaced SNPs observed in affected families, independent cases, and controls).

5. GLOD (Gumbel distributed Lod Score – A software program that simulates rapid and accurate p-values for a powerful multipoint test of linkage; developed, maintained, and distributed worldwide).

6. HAPLODROP (A smaller auxiliary program that corrects for the inflation of type 1 error in the presence of linkage disequilibrium; it is distributed with EAGLET).

7. HEMIZYG (A smaller auxiliary program that detects extremely short deletions from SNP data; it is distributed with EAGLET).

8. METAMAP (A smaller auxiliary program that combines genetic maps from different populations; it was used to create the most widely used linkage map to date).

EDITORIALS AND REVIEW ACTIVITIES

EDITOR/SERVICE ON EDITORIAL BOARD(S)

2010 – Present Review Editor for Frontiers in Genetics: Statistical Genetics and Methodology

2019 – Present Editorial Board Member International Journal of Genetics and Genomics

JOURNAL REVIEWER

2004 – 2005 Ad Hoc Reviews for Journal of the Royal Statistical Society: Series B 2005 – Present Ad Hoc Reviews for Genetic Epidemiology 2006 – Present Ad Hoc Reviews for Human Heredity 2007 – 2009 Ad Hoc Reviews for American Journal of Human Genetics 2008 – 2009 Ad Hoc Reviews for Genome Research 2008 – Present Ad Hoc Reviews for BMC Genomics

2009 – Present Ad Hoc Reviews for Neurology 2010 – 2011 Ad Hoc Reviews for European Journal of Human Genetics 2010 – 2011 Ad Hoc Reviews for Diabetes 2010 – Present Ad Hoc Reviews for Epilepsia 2010 – Present Ad Hoc Reviews for Frontiers in Genetics 2010 – 2012 Ad Hoc Reviews for Behavior Genetics 2010 – 2011 Ad Hoc Reviews for Biometrics 2012 – 2013 Ad Hoc Reviews for Frontiers: Pharmacogenetics and Pharmacogenomics 2012 – 2013 Ad Hoc Reviews for Journal of the American Statistical Association 2012 – Present Ad Hoc Reviews for PLOS Genetics 2015 – Present Ad Hoc Reviews for Neuroscience Letters 2015 – Present Ad Hoc Reviews for G3: Genes Genomes Genetics 2016 – Present Ad Hoc Reviews for Computation and Mathematical Methods in Medicine 2017 – Present Ad Hoc Reviews for Statistical Science

TEACHING

COURSES TAUGHT

2015– 2018 Co-Instructor The Ohio State University Biophysics 6702

OTHER EDUCATIONAL PROGRAMS

06/2007 Mathematical and Theoretical Biology Workshop Arizona State University Tempe, AZ

08/2008 Methodology for Genetics Studies of Twins and Families Workshop Catholic University Leuven, Belgium

05/2015 Crash Course in Grant Writing Workshop The Research Institute Columbus, OH

2014 – Present Statistical Consulting at Nationwide Children's Hospital Heyer GL, MD Corsmeier D Trittman J, MD Muszynski J, MD MPH

TEACHING OUTSIDE OF CURRENT INSTITUTION

1999 – 2000 Instructor San Francisco State University Algebra I & II

2000 Instructor San Francisco State University Pre-Calculus

2008 – 2011 Instructor Columbia University P8175: Principles of Genetics for Biostatisticians

LECTURES/PRESENTATIONS National/International

2007 Detecting Short and Rare Copy Number Variants, Invited Speaker Statistics Department Seminar, Guelph University Guelph, Canada

2011 The Secondary Analysis of Existing Genetic Data, Invited Speaker Section of Medical Statistics and Epidemiology Seminar, Department of Health Sciences, University of Pavia Pavia, Italy

2017 Finding Genes for Human Diseases: A Statistician’s Sandbox, Invited Speaker Department of Mathematics, San Francisco State University

2017 Low Hanging Fruit Is Actually Much Higher Than We Think, Invited Speaker Department of Epidemiology, MD Anderson Cancer Center

2017 Leveraging 1000 Genomes to Improve Disease Gene Localization, Invited Speaker Symposium on Advances in Genomics, Epidemiology, and Statistics (SAGES) Perelman School of Medicine, University of Pennsylvania

2018 Approximate Importance Sampling and Its Implications for Mapping Disease-Genes, Invited Speaker Statistics Department Seminar National University of Singapore

2018 Approximate Importance Sampling and Its Impact on the Analysis of Sequence Data, Invited Speaker Department of Genetics, Genomics, and Informatics Seminar

University of Tennessee, Health Sciences Center

Local/Regional

2012 The Secondary Analysis of Existing Genetic Data with Applications to Association, Linkage, Bioinformatics, and Next-Gen Sequence Data, Invited Speaker Statistics Department Seminar, Ohio State University

2013 Combining Affected Families, Unrelated Cases & Controls: A More Powerful Test of Association, Invited Speaker StatGen Seminar Pennsylvania State University

Institutional

2009 Constructing High-Resolution, Candidate Gene Regions from Dense SNP Linkage Data: A Subsampling Based Approach. Invited Speaker American Statistical Association: New York State Psychiatric Institute Biostatistics Seminar Columbia University

2010 Increasing Power and Precision from Dense SNP Linkage Data, Invited Speaker Genetic Epidemiology Seminar Columbia University

2011 Meet the Methodologists: Genomics in Public Health, Panelist Mailman School of Public Health Columbia University

2014 Hard Work, Youth and Discipline: What can applied math do for me? Invited Speaker Young Scientists Seminar Series Nationwide Children's Hospital

2015 Hard Work, Youth and Discipline: A crossroad between mathematics and science, Invited Speaker Young Scientists Seminar Series Nationwide Children's Hospital

2017 There is a strong genetic contribution to GGE (aka IGE): So where are the genes?

Invited Speaker Grand Rounds Nationwide Children's Hospital

DIRECT SUPERVISION Undergraduate Students

2017 – 2018 Akanksha Malhotra Internship BA Ohio State University Columbus, OH

Graduate Students

2011 Esther Drill Genetic of Complex Disorders Training Grant DrPh Columbia University New York, NY

2017 – 2020 Komla Gnona SUPERBABY PROJECT PhD Ohio State University Columbus, OH

Summer Students

2010 Jodi-Ann Young Biostatistics Enrichment Summer Training BS Columbia, University

2011 Sundeep Kambhampati Computer Science Research Assistant MS Nationwide Children's Hospital/Ohio State University/The Ohio State University

2016 Akanksha Malhotra Futures Matter: Transformative Transdisciplinary Summer Research Program Undergraduate Ohio State University

Final Defense Participation

2009 Nicole Scott Jeff Long Human Genetics PhD University of Michigan Ann Arbor, MI

2010 Anna Peljto Ruth Ottman Genetic of Complex Disorders Training Grant DrPh Columbia University New York, NY

2011 Gilberto Levy Bruce Levin Biostatistics DrPh Columbia University New York, NY

Postdoctoral Research Fellows

2010 Yuan-Yuan Ho 2011 Jane Cerise 2012 Ryan Subaran 2015 – 2019 Meng Wang 2018 Shilpa Pathak

CONFERENCES AND SYMPOSIA

LOCAL/REGIONAL DISTINGUISHED ACTIVITIES

1. Present-Day Problems and Potentials for Precision Medicine Institute for Computational Biology, 09/22/2015, Invited Speaker Cleveland, OH

2. The 3rd International Conference on Mathematical and Computational Medicine Ohio State University, 05/16/2016, Conference Organizer, Chair, and Invited Speaker Columbus, OH

3. Mini-Conference to Celebrate Elizabeth Thompson’s Contributions to Statistics, Genetics and the University of Washington

University of Washington, 06/19/2018, Invited Speaker Seattle Washington

4. MBI: Family-Based Genomic Studies Workshop Ohio State University, 09/19/2018, Invited Speaker Columbus, OH

NATIONAL/INTERNATIONAL DISTINGUISHED ACTIVITIES

1. International Conference on Statistics, Probability, Operations Research, Computer Science and Allied Areas, 11/29/2009, Invited Speaker Visakhapatnam, India

2. 15th Grover Conference on Pulmonary Circulation, 09/06/2011, Invited Speaker Sedalia, Colorado

3. Joint Statistical Meetings, 07/20/2012, Session Organizer, Chair, and Invited Speaker San Diego, CA

4. Zing Conferences: Mathematical and Computational Medicine, 12/05/2012, Invited Speaker Cancun, Mexico

5. Zing Conferences: Mathematical and Computational Medicine, 12/05/2014, Invited Speaker Cancun, Mexico

6. 1st International Conference on Computational Genomics and Proteomics, 10/18/2016, Invited Speaker Guanacaste, Costa Rica

7. 2nd International Conference on Computational Genomics and Proteomics, 08/14/2017, Invited Speaker Playa Blanca-Farrallon, Panama

8. 2018 World Gene Conference, 11/13/2018, Invited Speaker Singapore

9. 4th International Conference on Mathematical and Computational Medicine, 12/03/2018, Conference Organizer, Chair, and Invited Speaker Cancun, Mexico

10. 32nd European Neurology Congress, 07/22/2019, Chair, and Invited Speaker

London, England

11. The First International Conference on Mathematical Multiscale Modeling in Biology, 10/21/2019, Invited Speaker Guanacaste, Costa Rica

PROFESSIONAL MEMBERSHIPS AND ACTIVITIES

2006 – 2018 Member, American Society of Human Genetics 2006 – 2018 Member, International Genetic Epidemiology Society 2006 – 2008 Member, Biometrics Society 2012 – 2016 Member, Aircraft Owners and Pilots Association 2012 – 2018 Member, United States Chess Federation 2012 – 2018 Member, American Epilepsy Society

I have reviewed the curriculum vitae for completeness and accuracy and agree with its content.

Signature ______

Date 02/04/20______