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CURRICULUM VITAE William C. L. Stewart, Ph.D

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CURRICULUM VITAE William C. L. Stewart, Ph.D CURRICULUM VITAE William C. L. Stewart, Ph.D. PRESENT TITLE AND AFFILIATION DUAL/JOINT APPOINTMENT Assistant Professor Department of Pediatrics The Ohio State University College of Medicine Columbus, Ohio Assistant Professor Department of Statistics (zero salary joint appointment) The Ohio State University College of Medicine Columbus, Ohio Principal Investigator Battelle Center for Mathematical Medicine The Research Institute of Nationwide Children's Hospital Columbus, Ohio CITIZENSHIP AND VISA STATUS U.S. Citizen OFFICE ADDRESS Battelle Center for Mathematical Medicine The Research Institute 575 Children’s Crossroad, Columbus, OH 43215 P: (614) 355 – 6674 F: (614) 355 – 5898 [email protected] EDUCATION UNDERGRADUATE EDUCATION 05/99 San Francisco State University B.A. San Francisco, CA Mathematics 1 GRADUATE EDUCATION 05/02 University of Washington M.S. Seattle, WA Statistics 11/05 University of Washington Ph.D. Seattle, WA Statistics POST-GRADUATE EDUCATION & TRAINING 1999 Genentech Summer Intern San Francisco, CA Pre-clinical Biostatistics 06/08 University of Michigan Postdoctoral Research Ann Arbor, MI Statistical Genetics ACADEMIC APPOINTMENTS 2008 – 2012 Assistant Professor of Biostatistics Columbia University New York, NY 2012 – Present Assistant Professor of Pediatrics The Ohio State University Columbus, OH 2012 – Present Assistant Professor of Statistics (zero salary joint appointment) The Ohio State University Columbus, OH SERVICE ACADEMIC ADMINISTRATIVE RESPONSIBILITIES 2012 Recruitment Advisory Committee, Member Columbia University New York, NY 2 2009 – 2012 Steering Committee of Mailman School of Public Health, Member Columbia University New York, NY 2012 – 2014 Research Information Technology Advisory Committee, Member The Research Institute Columbus, OH 2013 – 2014 Battelle Center for Mathematical Medicine Website Committee, Member The Research Institute Columbus, OH 2016 – 2017 Research Retreat Planning Committee The Research Institute Columbus, OH 2016 – Present BCMM Departmental Seminar “Nerd Hour” The Research Institute Columbus, OH INSTITUTIONAL/LOCAL ACTIVITIES 2011 Invited Panelist: Meet the Methodologist: Genomics in Public Health Mailman School of Public Health, Columbia University 2014 Hard Work, Youth & Discipline: What Can Applied Math Do for Me? Young Scientists Seminar Series Nationwide Children's Hospital 2015 Hard Work, Youth & Discipline: A Crossroad between Mathematics and Science Young Scientists Seminar Series Nationwide Children's Hospital 2016 Invited Panelist: Mechanisms of Human Health and Disease Nationwide Children's Hospital 2017 Invited Panelist: Mechanisms of Human Health and Disease Nationwide Children's Hospital NATIONAL ACTIVITIES MILITARY OR OTHER GOVERNMENT SERVICE 1988 – 1990 Cadet United States Air Force Academy 3 Colorado Springs, CO HONORS AND AWARDS 2015 Service from the Heart Teamwork Award Nationwide Children's Hospital Columbus, OH 2016 Merit Award Summer Poster Competition Nationwide Children's Hospital Columbus, OH 2017 FASEB Travel Award Federation of American Societies for Experimental Biology Bethesda, MD 2018 Distinguished Presentation Award World Gene Conference Singapore RESEARCH SUPPORT ONGOING RESEARCH Peer Reviewed R01AI143740-01 Das (PI) 04/01/19 – 03/31/24 National Institute of Allergy and Infectious Disease Developing a predictive in silico toolkit for modeling NK cell responses against RNA virus infections the genetic architecture The purpose of this grant is to create new mathematical models to better understand the signaling kinetics of NK cell response initiated by the inoculation of various RNA viral strains. Ideally, we would like to develop a collection of math models that can be used, as needed, to understand the viral lode kinetics and cell signaling cascades of categorically different types of infections. 4 R56AI146581 Das (PI) 08/01/19 – 07/30/20 National Institute of Allergy and Infectious Disease Modeling Antibody-induced Immune Responses by NK Cells in Mice and Humans The purpose of this grant is to create new mathematical models to better understand the signaling kinetics of NK cell response initiated by antibody-induction. Here, we propose to use sophisticated techniques in mathematics, statistics, and computer science to better understand and model the cell signaling cascades of NK cells in mice and humans. Non – Peer Reviewed COMPLETED RESEARCH Peer Reviewed R25HD086885 Buhimschi (PI) 04/01/16 – 03/31/19 Futures Matter: Transformative Transdisciplinary Summer Research Program The goal of this project is to expose talented and under-represented high school students to cutting-edge research by pairing students and principal investigators (PIs) with shared interests through an active research project in the PI’s laboratory. CHEST Foundation Hayes (PI) 09/01/16 – 08/31/19 Improving the LAS with Geospatial Lung Allocation Simulation Software The goal of this project is to improve the health-related outcomes of lung transplant patients by allocating donor lungs to recipients more efficiently nationwide. The software that we propose to develop will ensure that allocation policies are flexible and adaptive. MARCH of DIMES Buhimschi (PI) 01/01/18 – 07/01/18 Identifying the Genes for Extreme Gestational Term Length The primary goal of this project is to scan the genomes of affected families ascertained for extreme gestational term length from a large national registry to find genetic loci and/or genes influencing pre- and post-term birth. R01DK031775 Greenberg (PI) 04/01/03 – 02/28/07 National Institute of Diabetes and Digestive and Kidney Diseases Two-Locus Models of Epistasis and Heterogeneity The goal of this research is to explore a wide range of two-locus models via customized simulation software to determine which models are most likely contributing to complex common disease. R01DK031813 Hodge (PI) 09/01/88 – 08/31/10 National Institute of Diabetes and Digestive and Kidney Diseases Linkage and Segregation in Complex Genetic Diseases 5 The goal of this research is to develop methods for detecting gene-gene and gene-environment interaction in common complex diseases using extensions to standard approaches in linkage and segregation analysis. R01CA138750 Kandel (PI) 07/01/09 – 06/30/10 National Institute on Drug Abuse Genetic Factors and Nicotine Dependence in Adolescents The goal of this research is to identify genetic risk factors for nicotine dependence in a multi- ethnic longitudinal cohort of adolescents. R01 MH048858 Gambel (PI) 09/01/10 – 08/31/11 National Institute of Environmental Health Sciences Biomarkers for Arsenic Toxicity The goal of this research is to identify biomarkers that are predictive of early-stage skin lesions in individuals with elevated exposure to arsenic. R21NS070323 Greenberg (PI) 10/01/09 – 09/30/11 National Institute of Neurological Disorders and Stroke The Role of Genome Encoded ME2 in Epilepsy The goal of this research is to uncover that portion of the genetic mechanism governing the presentation of idiopathic generalized epilepsy that relates specifically to genetic variation observed in the ME2 gene. R01MH048858 (subcontract) Stewart (PI) 09/01/10 – 08/31/11 Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate The goal of this research is to better understand the complex interplay between genetic factors associated with arsenic-induced skin lesions and the presence/absence of folate. Non – Peer Reviewed Rackham Graduate School Boehnke (PI) 06/01/06 – 05/31/08 University of Michigan Rackham Interdisciplinary Workshop The purpose of this grant is to establish a monthly multidisciplinary seminar series at the University of Michigan. Professional Schools Fund Stewart (PI) 07/01/08 – 06/30/09 Columbia University A Flexible Method for Deletion Discovery from High-Throughput Genotype Data with Applications to Bipolar Disorder The goal of this research is to develop an ultra-sensitive deletion detection method by modeling the multivariate inheritance of allele single intensity data, and to apply this method to an existing bipolar disorder data set. Calderone Prize Stewart (PI) 11/01/09 – 10/31/10 Columbia University 6 Subsampling Increases Power to Find Disease Genes The purpose of this research is to develop new linkage methods to extract the maximum amount of information from dense SNP linkage scans, and to apply the proposed methodology to a hypertension and end-stage renal disease study. PENDING RESEARCH SUPPORT R01AI146581 Das (PI) 08/01/20 – 06/30/24 National Institute of Allergy and Infectious Disease Modeling Antibody-induced Immune Responses by NK Cells in Mice and Humans The purpose of this grant is to create new mathematical models to better understand the signaling kinetics of NK cell response initiated by antibody-induction. Here, we propose to use sophisticated techniques in mathematics, statistics, and computer science to better understand and model the cell signaling cascades of NK cells in mice and humans. PUBLICATIONS ARTICLES IN PEER REVIEWED JOURNALS 1. George AW, Basu S, Li N, Rothstein J, Sieberts SK, Stewart W, Wijsman E, Thompson EA (2003). Approaches to mapping genetically correlated complex traits. BMC Genetics 4 (Suppl 1): S71. 2. Sieh W, Basu S, Fu A, Rothstein J, Scheet P, Stewart W, Sung Y, Thompson E, Wijsman E (2005). Comparison of marker types and map assumptions using MCMC- based linkage analysis of COGA data. BMC Genetics 6 (Suppl 1): S11. 3. Stewart WCL, and Thompson EA (2006). Improving estimates of genetic maps: A maximum likelihood approach.
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