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Download Press ILC 2019 TM MEDIA KIT THE INTERNATIONAL LIVER CONGRESS™ VIENNA, AUSTRIA | 10-14 APRIL, 2019 1 CONTENTS About EASL 3 About ILC 4 Press Conference Programme 5 EASL Press Releases: Wednesday, 10 April 6 EASL Press Releases: Thursday, 11 April 8 EASL Press Releases: Friday, 12 April 20 EASL Press Releases: Saturday, 13 April 32 Media Release 55 (Coalition launches Global Scientific Strategy to Cure Hepatitis B) Background Information 58 2 ABOUT EASL The European Association for the Welcome Message Study of the Liver (EASL) is a not-for- From The EASL profit medical association dedicated to Secretary General: pursuing excellence in liver research, Prof. Tom clinical practice of liver disorders, and Hemming Karlsen in providing education to all those interested in hepatology. Whilst the roots of the association were founded in Europe in 1966, EASL On behalf of EASL, I welcome continues to engage globally with all you to the International Liver stakeholders in the liver field wherever CongressTM (ILC) 2019 and they are based. Our aim is to spread thank you for your support of Europe’s knowledge, expertise and best practice as leading organisation dedicated to well as the latest scientific breakthroughs in advancing the scientific, medical and hepatology and the International Liver public understanding of the liver. Congress™ is our annual platform for achieving this aim. Since its foundation in 1966, EASL has evolved into a driving force by supporting EASL’s mission is to be the Home of the education of healthcare professionals, Hepatology so that all who are involved promoting research in the field of liver with treating liver disease can realise their disease and fostering policy changes to full potential to cure and prevent it. support liver health. The role that our media partners play in helping us to achieve these The purpose of the association is to goals cannot be under-estimated and, as promote communication between an organisation, we are most grateful for European scientists, academics and your ongoing support in reporting on stakeholders interested in the liver and its and communicating the latest science disorders. In particular, the association presented at our annual congress. shall: I hope that you will find this year’s ILC • Promote research concerning the liver scientific programme both informative and • Promote education of physicians, valuable and should you require any further scientists as well as public awareness information or support then please do not of liver diseases and their management hesitate to contact our media team. • Act as an advisor to European and national health authorities concerning Thank you again for your support and I liver diseases, the provision of clinical wish you a stimulating congress and a services and the need for research pleasant stay in Vienna. funding • Foster European multicentre controlled trials • Facilitate scientific exchange • Facilitate participation of Young Investigators at its meetings 3 ABOUT THE INTERNATIONAL LIVER CONGRESS™ This annual congress is the biggest event in the EASL calendar, attracting scientific and medical experts from around the world to learn about the latest in liver research. Attending specialists present, share, debate and conclude on the latest science and research in hepatology, working to enhance the treatment and management of liver disease in clinical practice. The International Liver Congress™ 2019 takes place from 10-14 April 2019 at the Reed Messe Wien Congress and Exhibition Center, Vienna, Austria. 10-14 April, 2019 Vienna, Austria International The latest in liver Delegates research CONTACT The ILC 2019 Press Team look forward to welcoming you in the press room. Luke Paskins e: [email protected] Hannah Murray t: +44 (0) 1444 811099 Justin Wilkes For further information you can also speak to: Karen Mazzoli, EASL Head of Marketing and Communications 4 PRESS CONFERENCE PROGRAMME Date Schedule Theme Chair Abstract Title/Conference Details Presenters Peter Revill A Global Anna Lok Wednesday Scientific The International Coalition to Eliminate HBV (ICE-HBV) will launch 11.00-13.00 Peter Revill Mark Bulterys 10.04.2019 Strategy to Cure a Global Scientific Strategy to Cure Hepatitis B Su Wang Hepatitis B Markus Cornberg THU-299 Increased risk of mortality with liver disease progression in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis patients: An analysis of French national hospital care Public health Professor Thursday PS-062 The increasing importance of non-alcoholic fatty liver Jerome Boursier 9.30-10.30 crisis of fatty liver Philip N. 11.04.2019 disease in human deficiency virus (HIV) positive patients Zobair Younossi disease Newsome GS-06 Positive results from REGENERATE: A phase 3 international, randomized, placebo-controlled study evaluating obeticholic acid treatment for NASH GS-13 Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of bulevirtide (Myrcludex B) in with PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infection PS-074 A first-in-class orally available HBV cccDNA destabilizer ccc_R08 achieved sustainable HBsAg and HBV DNA suppression in the HBV circle mouse model through elimination of cccDNA-like molecules in the mouse liver Heiner Wedemeyer New Professor Lu Gao Friday 10.30-11.30 therapeutic Markus PS-087 Fecal microbiota capsules are safe and effective in Jasmohan S Bajaj 12.04.2019 approaches Cornberg patients with recurrent hepatic encephalopathy: A randomized, Joost PH Drenth Vienna, Austria blinded, placebo-controlled trial Manisha Balwani PS-192 Lanreotide reduces liver growth in autosomal dominant polycystic kidney disease: Data from a 120-week randomized clinical trial GS-14 ENVISION, a phase 3 study to evaluate efficacy and safety of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1, in acute hepatic porphyria patients The EASL International Liver Foundation (EILF), in collaboration with the US Centers for Disease Prevention and Control will The latest in liver officially launch the first ever Centre of Excellence in Viral Hepatitis Massimo Colombo Elimination to showcase leading efforts to eliminate viral hepatitis Saturday Viral Hepatitis Jeffrey V. Lazarus 10.00-12.00 TBC and to fuel other countries to kick-start or expand and enhance research 13.04.2019 Elimination David Sergeenko their programmes. Minister Davit Sergeenko of the Ministry of Francisco Averhoff Internally Displaced Persons from the Occupied Territories, Labour, Health and Social Affairs of Georgia will be present to accept the award on behalf of the Georgian HCV elimination programme LB-02 Elafibranor, a peroxisome proliferator-activated receptor alpha and delta agonist demonstrates favourable efficacy and Velimir Luketic safety in patients with primary biliary cholangitis and inadequate response to ursodeoxycholic acid treatment LB-03 Tenofovir treatment has lower risk of hepatocellular carcinoma than entecavir treatment in patients with chronic Terry CF Yip hepatitis B Best of late Professor Saturday 14.30-15.30 breaking Francesco LB-06 Interim safety and efficacy results of the ABI-H0731 phase 13.04.2019 2a program exploring the combination of ABI-H0731 with Nuc abstracts Negro Jacob Lalezari therapy in treatment-naive and treatment-suppressed chronic hepatitis B patients PS-178 Simplified monitoring for hepatitis C virus treatment Gregory Dore with glecaprevir plus pibrentasvir: the SMART-C study Multicenter, Double-blind, Placebo-controlled, Randomized Trial Guadalupe of Emricasan in Subjects with NASH Cirrhosis and Severe Portal Garcia-Tsao Hypertension (PH) 5 EMBARGO: 00.01 Wednesday, 10 April, 2019 ‘Real-world’ experience confirms effectiveness of sofosbuvir/velpatasvir/voxilaprevir in people with chronic hepatitis C (HCV) infection failing direct-acting antivirals (DAAs) ILC 2019: Real-world’ studies in Germany VEL/VOX ± ribavirin (RBV) due to virological and the USA confirm high rates of sustained failure up to February 2019 (N=110; HCV GT1 virological response with sofosbuvir/ [71%], GT3 [34%], and GT4 [5%]; median age velpatasvir/voxilaprevir (SOF/VEL/VOX) in 54 years; 86% male; 27% with cirrhosis). Prior individuals with chronic HCV infection failing DAA regimens included paritaprevir/ritonavir/ DAAs ombitasvir ± dasabuvir ± RBV (PrO ± D ± RBV [n=30]), ledipasvir/sofosbuvir ± RBV (LDV/SOF ± EUROPEAN ASSOCIATION FOR THE STUDY RBV [n=35]), SOF/velpatasvir ± RBV (SOF/VEL OF THE LIVER (EASL) ± RBV [n=18]), daclatasvir + SOF ± RBV (DCV + SOF ± RBV [n=13]), elbasvir/grazoprevir (EBR/ 11 April 2019, Vienna, Austria: GZR [n=8]), SOF + RBV (n=2), and simeprevir ‘Real-world’ studies conducted in Germany and + SOF + RBV (n=1). Four patients had received the USA have confirmed the effectiveness and SOF/VEL/VOX + RBV (HCV GT1b [n=2], GT3a tolerability of sofosbuvir/velpatasvir/voxilaprevir [n=2]). (SOF/VEL/VOX) when used to treat individuals with chronic hepatitis C (HCV) infection who According to investigator Dr Johannes had previously failed direct-acting antivirals Vermehren from the Goethe University Hospital (DAAs). The two studies presented today at in Frankfurt, Germany, with SVR data available The International Liver Congress™ 2019 in from 74 patients as of February 2019, sustained Vienna, Austria, reported sustained virological virologic response was 100%. SOF/VEL/VOX response rates (SVR) of 93–100%, confirming was well tolerated, with fatigue (14%) and the effectiveness of this treatment in clinical headaches
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