Genomes comparisons: predicted signal peptides (SignalP prob. > 0.75) - unnormalized #ORFs 1400

1200 #ORFs p >= 0.75

1000

800

600

400

200

0 subtilis Aquifex aeolicus Xylella fastidiosa Buchnera sp. APS Bacillus halodurans Yersinia pestis KIM Treponema pallidum Thermotoga maritima Chlamydia muridarum Chlamydia pneumoniae Chlorobium tepidum TLS Helicobacter pylori 26695 Rickettsia conorii Malish 7 Rd innocua Clip11262 Nostoc sp. PCC 7120 DNA Sinorhizobium meliloti 1021 Yersinia pestis strain CO92 Salmonella typhimurium LT2 Pasteurella multocida PM70 genitalium G37 Mesorhizobium loti strain MA Synechocystis sp. PCC 6803 Helicobacter pylori, strain J99 perfringens str. 13 Caulobacter crescentus CB15 Streptomyces coelicolor A3(2) K-12 MG1655 pneumoniae R6 Pirellula sp. strain 1 (reduced3) M129 Mycobacterium leprae strain TN Pseudomonas aeruginosa PA01 Chlamydophila pneumoniae J138 Chlamydophila pneumoniae AR39 Salmonella enterica serovar Typhi Ralstonia solanacearum GMI1000 Escherichia coli O157:H7 EDL933 TIGR4 Mycobacterium tuberculosis H37Rv strain EGD MGAS315 Rickettsia prowazekii strain Madrid E Clostridium acetobutylicum ATCC824 Mycobacterium tuberculosis CDC1551 Mycoplasma pulmonis (strain UAB CTIP) Corynebacterium glutamicum ATCC 13032 Streptococcus pyogenes strain MGAS8232 subsp. MW2 Staphylococcus aureus subsp. N315 Staphylococcus aureus subsp. Mu50 Lactococcus lactis subsp. strain IL1403 Campylobacter jejuni subsp. NCTC 11168 Streptococcus pyogenes M1 GAS strain SF370 Neisseria meningitidis serogroup B strain MC58 Neisseria meningitidis serogroup A strain Z2491 Thermoanaerobacter tengcongensis strain MB4T Buchnera aphidicola str. Sg (Schizaphis graminum) Xanthomonas axonopodis pv. citri str. 306, complet Escherichia coli O157:H7 substrain RIMD 0509952 Brucella melitensis strain 16M chromosome I and II Xanthomonas campestris pv. str. ATCC 33 Fusobacterium nucleatum subsp. ATCC 2558 Vibrio cholerae chromosome I and II, complete Deinococcus radiodurans R1 complete chromosome 1 and 2 Agrobacterium tumefaciens strain C58 circular and linear chromosome Genomes comparisons: predicted signal peptides (SignalP prob. > 0.75) - normalized #ORFs/Mbp 250

#ORFs/Mbp p >= 0.75 200

150

100

50

0 Bacillus subtilis Aquifex aeolicus Xylella fastidiosa Buchnera sp. APS Borrelia burgdorferi Bacillus halodurans Yersinia pestis KIM Treponema pallidum Thermotoga maritima Chlamydia muridarum Chlamydia trachomatis Chlamydia pneumoniae Ureaplasma urealyticum Chlorobium tepidum TLS Helicobacter pylori 26695 Rickettsia conorii Malish 7 Haemophilus influenzae Rd Listeria innocua Clip11262 Nostoc sp. PCC 7120 DNA Sinorhizobium meliloti 1021 Yersinia pestis strain CO92 Salmonella typhimurium LT2 Pasteurella multocida PM70 Mycoplasma genitalium G37 Mesorhizobium loti strain MA Synechocystis sp. PCC 6803 Helicobacter pylori, strain J99 str. 13 Caulobacter crescentus CB15 Streptomyces coelicolor A3(2) Escherichia coli K-12 MG1655 Streptococcus pneumoniae R6 Pirellula sp. strain 1 (reduced3) Mycoplasma pneumoniae M129 Mycobacterium leprae strain TN Pseudomonas aeruginosa PA01 Chlamydophila pneumoniae J138 Chlamydophila pneumoniae AR39 Salmonella enterica serovar Typhi Ralstonia solanacearum GMI1000 Escherichia coli O157:H7 EDL933 Streptococcus pneumoniae TIGR4 Mycobacterium tuberculosis H37Rv Listeria monocytogenes strain EGD Streptococcus pyogenes MGAS315 Rickettsia prowazekii strain Madrid E Clostridium acetobutylicum ATCC824 Mycobacterium tuberculosis CDC1551 Mycoplasma pulmonis (strain UAB CTIP) Corynebacterium glutamicum ATCC 13032 Streptococcus pyogenes strain MGAS8232 Staphylococcus aureus subsp. MW2 Staphylococcus aureus subsp. N315 Staphylococcus aureus subsp. Mu50 Lactococcus lactis subsp. strain IL1403 Campylobacter jejuni subsp. NCTC 11168 Streptococcus pyogenes M1 GAS strain SF370 Neisseria meningitidis serogroup B strain MC58 Neisseria meningitidis serogroup A strain Z2491 Thermoanaerobacter tengcongensis strain MB4T Buchnera aphidicola str. Sg (Schizaphis graminum) Xanthomonas axonopodis pv. citri str. 306, complet Escherichia coli O157:H7 substrain RIMD 0509952 Brucella melitensis strain 16M chromosome I and II Xanthomonas campestris pv. str. ATCC 33 Fusobacterium nucleatum subsp. ATCC 2558 Vibrio cholerae chromosome I and II, complete Deinococcus radiodurans R1 complete chromosome 1 and 2 Agrobacterium tumefaciens strain C58 circular and linear chromosome Organism