Variation in the Heritability of Educational Attainment: an International Meta-Analysis
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The Genetics of Tobacco Use: Methods, Findings and Policy Implications W Hall, P Madden, M Lynskey
119 Tob Control: first published as 10.1136/tc.11.2.119 on 1 June 2002. Downloaded from REVIEW The genetics of tobacco use: methods, findings and policy implications W Hall, P Madden, M Lynskey ............................................................................................................................. Tobacco Control 2002;11:119–124 Research on the genetics of smoking has increased our Specific study designs—adoption, twin, and link- understanding of nicotine dependence, and it is likely to age designs—are needed to separate the effects of genes from those of the environment. illuminate the mechanisms by which cigarette smoking adversely effects the health of smokers. Given recent Adoption studies advances in molecular biology, including the completion In the adoption design we compare the similarity in smoking between adoptive children and their of the draft sequence of the human genome, interest has biological parents with the similarity between now turned to identifying gene markers that predict a adopted children and their adoptive parents or heightened risk of using tobacco and developing between adoptive sibling pairs and biological sib- ling pairs. If smoking is largely or wholly geneti- nicotine dependence cally determined, then there should be greater .......................................................................... similarity between children and their biological parents and siblings than between adopted hanks to RA Fisher, genetics has been linked children and their adoptive parents or siblings. to scepticism about a causal relation between One early adoption study found an association cigarette smoking and lung cancer.12 Fisher3 between the smoking of foster children and their T biological siblings but not their adoptive argued that the association between smoking and 5 6 lung cancer was explained by shared genes that siblings. -
Nurture Might Be Nature: Cautionary Tales and Proposed Solutions Sara
Nurture might be nature: Cautionary tales and proposed solutions Sara A. Hart* Department of Psychology and Florida Center for Reading Research Florida State University, USA Callie Little Department of Psychology University of New England, Australia Florida Center for Reading Research Florida State University, USA Elsje van Bergen Department of Biological Psychology Vrije Universiteit Amsterdam, the Netherlands *Corresponding author: Sara A. Hart, 1107 W. Call Street, Tallahassee, FL, 32308. [email protected], ORCID: 0000-0001-9793-0420 FINAL IN PRESS CITATION: Hart, S.A., Little, C., & van Bergen, E. (in press). Nurture might be nature: Cautionary tales and proposed solutions. npj Science of Learning. 1 Abstract Across a wide range of studies, researchers often conclude that the home environment and children’s outcomes are causally linked. In contrast, behavioral genetic studies show that parents influence their children by providing them with both environment and genes, meaning the environment that parents provide should not be considered in the absence of genetic influences, because that can lead to erroneous conclusions on causation. This article seeks to provide behavioral scientists with a synopsis of numerous methods to estimate the direct effect of the environment, controlling for the potential of genetic confounding. Ideally, using genetically- sensitive designs can fully disentangle this genetic confound, but these require specialized samples. In the near future, researchers will likely have access to measured DNA variants (summarized in a polygenic scores), which could serve as a partial genetic control, but that is currently not an option that is ideal or widely available. We also propose a work around for when genetically sensitive data are not readily available: the Familial Control Method. -
Thomas F. Oltmanns Department of Psychological and Brain Sciences / Somers Hall / Campus Box 1125 One Brookings Drive / Washington University, St
Thomas F. Oltmanns Department of Psychological and Brain Sciences / Somers Hall / Campus Box 1125 One Brookings Drive / Washington University, St. Louis, MO 63130-4899 April 1, 2020 PERSONAL: Telephone: Office: (314) 935-6595 FAX: (314) 935-7588 Cell: (314) 712-0151 E-mail Address: [email protected] Lab Website: psychnet.wustl.edu/SPANLAB/ EDUCATION AND TRAINING: University of Wisconsin - Madison: B.A. (with honors), Psychology, 1972 Stony Brook University: Ph.D., Clinical Psychology, 1976 Psychological Center, Stony Brook University / Farmingville Community Mental Health Center: Clinical Internship (APA Approved, Captive Internship Program at SBU) 1975-76. PROFESSIONAL EXPERIENCE: Edgar James Swift Professor of Psychology in Arts and Sciences, and Professor of Psychiatry, Washington University, 2003-present Director of Clinical Training in Psychology, Washington University, 2004-2016 Professor of Psychology, University of Virginia, 1986-2003 Director of Clinical Training in Psychology, University of Virginia, 1987-93, 2002-2003 Professor of Psychiatric Medicine, University of Virginia, 1986-2003 Professor of Psychology, Indiana University, 1985-86 Adjunct Professor of Clinical Psychology, Department of Psychiatry, Indiana University School of Medicine, 1985-86 Associate Professor of Psychology, Indiana University, l98l-85 Assistant Professor of Psychology, Indiana University, l976-81 AWARDS, HONORS, AND ELECTED OFFICES: President, Academy of Psychological Clinical Science, 2014-2016 Walter G. Klopfer Award for Distinguished Contributions -
Curriculum Vitae
Updated 8/29/2019 CURRICULUM VITAE PERSONAL INFORMATION Name: Brian Matthew D’Onofrio Office: Department of Psychological and Brain Sciences Indiana University 1101 E. 10th St. Bloomington, IN 47405 Phone: 812-856-0843 [email protected] www.indiana.edu/~devpsych ACADEMIC POSITIONS Department of Psychological and Brain Sciences / Indiana University - Bloomington, IN 2014 - Present Full Professor & Director of Clinical Training (Clinical Science Program) 2011 - 2014 Associate Professor 2005 - 2011 Assistant Professor Department of Medical Epidemiology and Biostatistics / Karolinska Institutet - Stockholm, Sweden 2016 – Present Visiting Professor EDUCATION 2004-2005 Harvard Medical School / Children’s’ Hospital Boston – Boston, MA APA-Accredited Predoctoral Clinical Internship Training in Clinical and Pediatric Psychology 1999-2005 University of Virginia - Charlottesville, VA Doctoral Student in APA-Accredited Clinical Psychology Program PhD in Clinical Psychology August 2005 MA in Psychology received May 2002 Dissertation: Causation versus selection: A genetically informed study of marital instability and its consequences for young adult offspring. (June 2004) Major Advisors: Eric Turkheimer, Ph.D. & Robert Emery, Ph.D. 1997-1999 Virginia Commonwealth University - Richmond, VA Graduate Courses in Statistics and Behavior Genetics Major Advisor: Lindon Eaves, Ph.D. & Judy Silberg, Ph.D. 1993-1997 University of Virginia (UVA) - Charlottesville, VA Bachelor of Arts in Distinguished Majors Psychology Program, minor in Religious Studies - -
Nature Vs. Nurture Results in a Draw, According to Twins Meta-Study 19 May 2015
Nature vs. nurture results in a draw, according to twins meta-study 19 May 2015 said. Although the contribution of genetic and environmental factors was balanced for most of the traits studied, the research showed there could be significant differences in individual traits. For example, risk for bipolar disorder was about 70 per cent due to genetics and 30 per cent due to environmental factors. "When visiting the nature versus nurture debate, there is overwhelming evidence that both genetic and environmental factors can influence traits and The research drew on data from almost every twin study diseases," Dr Benyamin said. across the world from the past 50 years. "What is comforting is that, on average, about 50 per cent of individual differences are genetic and 50 per cent are environmental. One of the great tussles of science – whether our health is governed by nature or nurture – has been "The findings show that we need to look at settled, and it is effectively a draw. ourselves outside of a view of nature versus nurture , and instead look at it as nature and nurture." University of Queensland researcher Dr Beben Benyamin from the Queensland Brain Institute In 69 per cent of cases, the study also revealed that collaborated with researchers at VU University of individual traits were the product of the cumulative Amsterdam to review almost every twin study effect of genetic differences. across the world from the past 50 years, involving more than 14.5 million twin pairs. "This means that there are good reasons to study the biology of human traits, and that the combined The findings, published in Nature Genetics, reveal effect of many genes on a trait is simply the sum of on average the variation for human traits and the effect of each individual gene," Dr Benyamin diseases is 49 per cent genetic, and 51 per cent said. -
Genetic and Environmental Influences on Human Behavioral Differences
Annu. Rev. Neurosci. 1998. 21:1–24 Copyright c 1998 by Annual Reviews Inc. All rights reserved GENETIC AND ENVIRONMENTAL INFLUENCES ON HUMAN BEHAVIORAL DIFFERENCES Matt McGue and Thomas J. Bouchard, Jr Department of Psychology and Institute of Human Genetics, 75 East River Road, University of Minnesota, Minneapolis, Minnesota 55455; e-mail: [email protected] KEY WORDS: heritability, gene-environment interaction and correlation, nonshared environ- ment, psychiatric genetics ABSTRACT Human behavioral genetic research aimed at characterizing the existence and nature of genetic and environmental influences on individual differences in cog- nitive ability, personality and interests, and psychopathology is reviewed. Twin and adoption studies indicate that most behavioral characteristics are heritable. Nonetheless, efforts to identify the genes influencing behavior have produced a limited number of confirmed linkages or associations. Behavioral genetic re- search also documents the importance of environmental factors, but contrary to the expectations of many behavioral scientists, the relevant environmental factors appear to be those that are not shared by reared together relatives. The observation of genotype-environment correlational processes and the hypothesized existence of genotype-environment interaction effects serve to distinguish behavioral traits from the medical and physiological phenotypes studied by human geneticists. Be- havioral genetic research supports the heritability, not the genetic determination, of behavior. INTRODUCTION One of the longest, and at times most contentious, debates in Westernintellectual history concerns the relative influence of genetic and environmental factors on human behavioral differences, the so-called nature-nurture debate (Degler 1991). Remarkably, the past generation of behavioral genetic research has led 1 0147-006X/98/0301-0001$08.00 2 McGUE & BOUCHARD many to conclude that it may now be time to retire this debate in favor of a perspective that more strongly emphasizes the joint influence of genes and the environment. -
Nitive Skills in Academic Achievement in Identical and Fraternal Twins
Volume 9 Issue 1 (2020) AP Research Twin Study A Comparison of Nature Vs. Nurture on Cog- nitive Skills in Academic Achievement in Identical and Fraternal Twins Amina Dada1 1Lapeer High School, Lapeer, MI, USA ABSTRACT This research study is looking at the academic achievement levels in identical and fraternal twins at the high school level through a measurable cognitive perspective. The purpose is to see if the data collected agrees with past research on how much academic achievement is due to genetics or environmental influences (nature vs nurture). Twins were asked to take three online cognitive tests and score differences were computed to determine statistical significance. I then drew connections on how much the scores were due to genetics while accounting for confounding variables in the environmental influence’s aspect. Therefore, the study concludes that the majority of academic achievement is due to genetics in both identical and fraternal twin sets. This indicates my research supports past research that shows genetics plays the majority factor in academic achievement whether twins are younger or older in age. This study is purely correlational and analyzes data with the twin method which means it in no way proves anything but rather shows a connection between academic achievement and genetics. This research adds more support to the current body of knowledge, but also brings up an important point of how future research can study environmental influences in- depth to see how it influences academic achievement beyond what can be measured in the classroom. Introduction Twin studies are a very important tool that psychologists and scientists use to analyze a certain trait, and look to see how much of it is due to genetics or other environmental influences. -
Genetic Epidemiology of Epilepsy: a Twin Study
Original Article Genetic epidemiology of epilepsy: A twin study Krishan Sharma Department of Anthropology, Panjab University, Chandigarh - 160 014, India. The study explored the genetic susceptibility and prevalence diseases/disorders having epileptic seizure as phenotypic ex- of epilepsy in twins. The data on epilepsy were retrieved pression. In fact, disorders associated with more than 10 hu- [3,4] from the health records of 199 pairs of twins. Proband con- man chromosomes are linked with epilepsy. A genetic mis- cordance rate in monozygotic (MZ) twins was four times more sense mutation has also been associated with autosomal domi- than that in dizygotic (DZ) twins (0.67 vs. 0.17). Three of 15 nant nocturnal frontal lobe epilepsy.[5] Certain genetic mark- (20%) affected twin kinships had epileptic first-degree rela- ers have also been linked with epilepsy. For example, juvenile tives. These findings indicated significant underlying genetic myoclonic epilepsy has been linked to the HLA loci on Chrho- susceptibility to epilepsy with the Holzinger’s heritability es- mosome 6.[6] timate being 0.45. The prevalence of epilepsy was similar in Besides genetic factors, a large number of pre- and peri- MZ (45.45), DZ (45.11) twins, and their non-twin siblings natal factors, such as obstetric trauma, cerebral palsy, pre- (47.60). In the general population from various nationalities, maturity and neurological damage are widely believed to be the mean prevalence rate of epilepsy varied from 5 to 17 important causes of epilepsy.[7-10] Human twins have to face a per 1000. The appreciably higher prevalence rate in twin high frequency of such adverse perinatal events. -
Twin Studies of Political Behavior: Untenable Assumptions?
| | ⅜ Comment Twin Studies of Political Behavior: Untenable Assumptions? Jon Beckwith and Corey A. Morris Using the “classical twin method,” political scientists John Alford, Carolyn Funk, and John Hibbing conclude that political ideol- ogies are significantly influenced by genetics, an assertion that has garnered considerable media attention. Researchers have long used human twins in attempts to assess the degree of genetic influence on various behavioral traits.Today, this methodology has been largely replaced in favor of contemporary molecular genetic techniques, and thus heritability studies have seen a diminishing role in behavioral genetic research of the twenty-first century. One important reason the twin method has been superseded is that it depends upon several questionable assumptions, the most significant of which is known as the equal environments assumption. Alford, Funk, and Hibbing argue that this crucial assumption, and thus their conclusion, holds up under empirical scrutiny. They point to several studies in support of this assumption. Here, we review the evidence presented and conclude that these attempts to test the equal environments assumption are weak, suffering significant methodological and inherent design flaws. Furthermore, much of the empirical evidence provided by these studies actually argues that, contrary to the interpretation, trait-relevant equal environments assumptions have been violated. We conclude that the equal environments assumption remains untenable, and as such, twin studies are an insufficient method -
Environment Interaction in the National Merit Twin Study
Behav Genet (2009) 39:165–169 DOI 10.1007/s10519-008-9253-9 BRIEF COMMUNICATION The Effect of Assumptions About Parental Assortative Mating and Genotype–Income Correlation on Estimates of Genotype– Environment Interaction in the National Merit Twin Study John C. Loehlin Æ K. Paige Harden Æ Eric Turkheimer Received: 21 July 2008 / Accepted: 12 December 2008 / Published online: 27 December 2008 Ó Springer Science+Business Media, LLC 2008 Abstract In a previous paper (Harden et al. in Behav Gen Introduction 37:273–283, 2007) models of genotype–environment inter- action were fitted to data from the National Merit Twin In a previous paper (Harden et al. 2007), we found a sta- Study, resulting in evidence for an interaction: the herita- tistically significant interactive effect of income on the bility of National Merit Qualifying Test scores increased at heritability of scores on the National Merit Scholarship higher levels of family income. The present paper investi- Qualifying Test (NMSQT). This served to generalize an gates two assumptions made in the previous modeling. earlier finding of an interactive effect of income on the These were a lack of resemblance between parents for cog- heritability of IQ in low-income 7-year-old children nitive skill, and possible correlations between family income (Turkheimer et al. 2003) to a different part of the age and and a child’s genes because of the contribution of parental ability ranges. In both cases, the heritability of cognitive genes to both. The assumptions were found not to seriously skills increased with income. affect estimates of the interaction effect—heritability still In fitting models to the National Merit data, certain increased with income—but they did make a difference for latent variables were assumed to be independent of one other parameter estimates from the modeling. -
Ethical Considerations of the Germeval20 Task 1. IQ Assessment
Ethical considerations of the GermEval20 Task 1. IQ assessment with natural language processing: Forbidden research or gain of knowledge? Dirk Johannßen Chris Biemann David Scheffer MIN Faculty, MIN Faculty, Faculty of Economics Dept. of Computer Science Dept. of Computer Science NORDAKADEMIE Universitat¨ Hamburg Universitat¨ Hamburg 25337 Elmshorn, Germany & Nordakademie 22527 Hamburg, Germany http://lt:informatik:uni-hamburg:de/ fbiemann, [email protected] [email protected] Abstract is what the intelligence test measures’ suggests (Maas et al., 2014), whilst most definitions at least The use of Intelligence Quotient (IQ) testing as a measure for intellectual ability is controver- agree that intelligence is always connected to suc- sial. Even though IQ testing is considered to cessfully overcoming challenges of everyday life be among the most valid measures of psychol- situations (Rost, 2009). ogy, findings and current research sparked a Since those aspects already are concerns, any debate over racial or socioeconomic biases, as work that involves automation by the use of NLP well as the label of ‘pseudoscience’ for many techniques and IQ testing information based on situations that involve IQ testing. The Ger- natural language texts understandably raises con- mEval20 Task 1 asked researchers to inves- tigate NLP approaches for approximating the cerns. In case of the GermEval20 Task 1, the re- ranking based on IQ and high school scores search has caused more than just concerns, but a from so-called implicit motive texts. Quickly, so-called shitstorm on the social platform Twitter1. a vivid discourse on whether the shared task should be viewed as unethical and forbidden was held within the NLP community. -
Nature Versus Nurture Grade Level
Assignment Discovery Online Curriculum Lesson title: Nature Versus Nurture Grade level: 9-12, with adaptation for younger students Subject area: Human Body Contemporary Studies Behavioral Science Duration: Two class periods Objectives: Students will 1. learn that environment can influence some personality traits, while others are genetic; 2. understand that the most effective way to study the concept of nature versus nurture is by conducting research with identical and fraternal twins reared separately and together; and 3. discover that the issues of nature versus nurture are still debated in the scientific community. Materials: - Computer with Internet access - Copies of Classroom Activity Sheet: Analyzing Twin Studies - Printouts of three twin studies from these Web sites: § http://www.mugu.com/cgi-bin/Upstream/Issues/psychology/IQ/bouchard-twins.html § http://www.thetimes.co.uk/article/0,,2-96428,00.html § http://www.ncbi.nlm.nih.gov/htbin- post/Entrez/query?db=m&form=6&uid=10808236&dopt=r - Copies of Take-Home Activity Sheet: What Do You Think? Procedures: 1. Begin the lesson by asking students what they think determines their likes, dislikes, and personality characteristics. Is it their genetic makeup or their environment? Discuss their ideas. 2. Explain that researchers have been debating this question for centuries. This debate is referred to as “nature versus nurture.” Researchers have studied identical and fraternal twins to try to determine whether genetics (nature) or environment (nurture) has a greater effect on personality development. Identical twins, or monozygotic twins, come from the same fertilized egg. In the earliest stages of development, the egg splits into two zygotes, creating two individuals with the same genetic code.