Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized with Acute Myocardial Infarction: a Randomized Clinical Trial

Supplementary Online Content

O’Donoghue ML, Glaser R, Cavender MA, et al; LATITUDE-TIMI 60 Investigators. Effect of losmapimod on cardiovascular outcomes in patients hospitalized with acute myocardial infarction: a randomized clinical trial. JAMA . doi:10.1001/jama.2016.3609

eAppendix. LATITUDE-TIMI 60 Trial - Trial Leadership & Investigators

eTable. Secondary Endpoints in LATITUDE-TIMI 60

This supplementary material has been provided by the authors to give readers additional information about their work.

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eAppendix. LATITUDE-TIMI 60 Trial - Trial Leadership & Investigators

LATITUDE Executive Steering Committee members Chairman: Marc S. Sabatine, MD, MPH (TIMI Study Group, Brigham and Women’s Hospital, Boston, MA, US)

Global Principal Investigator: David A. Morrow, MD, MPH (TIMI Study Group, Brigham and Women’s Hospital, Boston, MA, US)

Members: Prof. Philip Aylward (Flinders Medical Centre, Adelaide, South Australia) Prof. Keith Fox (University of Edinburgh, Edinburgh, Scotland) Prof. José López-Sendón (Hospital Universitario La Paz, Madrid, Spain) Prof. P. Gabriel Steg (Hôpital Bichat-CI. Bernard, Paris, France) Prof. Pierre Theroux (Montreal Heart Institure, Montreal, Quebec, Canada)

GlaxoSmithKline members: Ian Laws (GlaxoSmithKline, London, UK) Ruchira Glaser (GlaxoSmithKline, King of Prussia, PA, US) Rich Davies (GlaxoSmithKline, King of Prussia, PA, US)

LATITUDE-TIMI 60 Steering Committee Members & National Lead Investigators Prof. Diego Ardissino (Azienda Ospedaliero-Universitaria di Parma, Parma, Italy) Prof. Dan Atar (Oslo University Hospital, Ullevål, Oslo, Norway) Prof. Andrzej Budaj (Grochowski Hospital, Warsaw, Poland) Prof. Ramón Corbalán (Pontificia Universidad Católica de Chile, Santiago, Chile) Dr. Anthony J. Dalby (Milpark Hospital, Johannesburg, South Africa) Prof. Mikael Dellborg (COR Pulmonale AB, Goteborg, Sweden) Dr. Rafael Diaz (Estudios Clínicos Latino America, Rosario, Argentina) Prof. Maria Dorobantu (Emergency Clinical Hospital of Bucharest, Bucharest, Romania) Prof. Assen R Goudev (Queen Giovanna University Hospital, Sofia, Bulgaria) Prof. Christian Hamm (The Kerchoff Heart Center, Bad Nauheim, Germany) Prof. Yong Huo (Peking University First Hospital, Biejing, China) Prof. Robert Kiss (State Health Center, Budapest, Hungary) Dr. Frantisek Kovar (University Hospital Martin, Martin, Slovakia)

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Prof. Basil Lewis (Lady Davis Carmel Medical Center, Haifa, Israel) Prof. Piera Merlini (Ospedale Niguarda Ca Granda, Milan, Italy) Prof. José C. Nicolau (Rua Aureliano Coutinho, São Paulo, BR) Dr. Ton Oude Ophuis (Canisius Wilhelmina Hospital, Nijmegan, Zetten, Netherlands) Prof. Alexander Parkhomenko (Institute of Cardiology, Kiev, Ukraine) Prof. Mikhail Ruda (Russian Cardiology Research and Prodaction Complex, Moscow, Russian Federation) Prof. Ki-Bae Seung (Kangnam St. Mary’s Hospital, Seoul, Korea) Prof. Peter Sinnaeve (University Hospitals Leuven, Leuven, Belgium) Prof. Jan Skov Jensen (Gentofte Hospital, Hellerup, Denmark) Prof. Jind řich Ŝpinar (University Hospital Brno, Brno, Czech Republic) Dr. Piyamitr Sritara (Ramathibodi Hospital, Mahidol University, Bangkok, Thailand) Prof. Jean-François Tanguay (Montreal Heart Institute, Montreal, QC, Canada) Prof. Dimitiros Tziakas (University General Hospital of Alexandroupolis, Alexandroupolis, Greece) Dr. Neal Uren (Royal Infirmary of Edinburgh, Edinburgh, United Kingdom) Prof. Harvey White (Auckland City Hospital, Auckland, New Zealand) Dr. Michelle O’Donoghue (Brigham and Women’s Hospital, Boston, MA, USA)

Independent Data Monitoring Committee members (IDMC): Chairman: Dr. Jeffrey L. Anderson (Intermountain Medical Center, Murray, UT, US) Statistician: Dr. Kerry L. Lee (Duke University School of Medicine, Durham, NC, US)

Additional Voting members: Dr. James de Lemos (UT Southwestern Medical Center, Dallas, TX, US) Prof. Freek W.A. Verheugt (Amsterdam, Netherlands) Dr. W. Douglas Weaver (Henry Ford Heart & Vascular Institute, Detroit, MI, US)

Clinical Endpoint Committee (CEC) Chairman – Stephen Wiviott, MD (TIMI Study Group, Brigham and Women's Hospital, Boston, MA, US) Director – Cheryl Lowe, RN (TIMI Study Group, Boston, MA, US) Manager –Jessica Lamp, BA (TIMI Study Group, Boston, MA, US)

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Team members: Mian Qasim Rehman, MD (Senior Medical Reviewer); Margarita Shimmer, MD (Medical Reviewer); Danielle Forni, RN (Senior Medical Reviewer), Ummi Khan, MD (Medical Reviewer); Arne Thompsen (CEC Coordinator)

CEC adjudicators – Cardiology Eric Awtry, MD (Boston Medical Center, Boston, MA, US) Clifford J. Berger, MD (Boston Medical Center, Boston, MA, US) Kevin Croce, MD, PhD (Brigham and Women’s Hospital, Boston, MA, US) Akshay Desai, MD, MPH (Brigham and Women’s Hospital, Boston, MA, US) Eli Gelfand, MD (Beth Israel Deaconess Medical Center, Boston, MA, US) Carolyn Ho, MD (Brigham and Women’s Hospital, Boston, MA, US) David E. Leeman, MD (Beth Israel Deaconess Medical Center, Boston, MA, US) Mark S. Link, MD (New England Medical Center, Boston, MA, US) Ashvin Pande, MD (Boston Medical Center, Boston, MA, US) Frederick Ruberg, MD (Boston Medical Center, Boston, MA, US)

CEC adjudicators – Neurology Andrew D. Norden, MD, MPH (Dana Farber Cancer Institute, Boston, MA, US) Natalia Rost, MD, MPH (Massachusetts General Hospital, Boston, MA, US) Scott Silverman, MD (Massachusetts General Hospital, Boston, MA, US) Aneesh Singhal, MD (Massachusetts General Hospital, Boston, MA, US)

CEC adjudicators – Hepatic Specialists Wolfram Goessling, MD, PhD (Brigham and Women’s Hospital, Boston, MA, US) Anna Rutherford, MD, MPH (Brigham and Women’s Hospital, Boston, MA, US)

Statistical Centers and involved statisticians: GlaxoSmitkKline Richard Davies, GlaxoSmithKline, Research Triangle Park, NC, US Jennifer Shannon, Parexel, Durham, NC, US Tim Rolfe, GlaxoSmithKline, Stockley Park, UK

TIMI Study Group Naveen Deenadayalu, TIMI Study Group, Boston, MA KyungAh Im, TIMI Study Group, Boston, MA

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Julia Kuder, TIMI Study Group, Boston, MA Sabina Murphy, TIMI Study Group, Boston, MA

Central laboratory Quest Diagnostics Clinical Laboratories, Inc. (Valencia, CA, US)

Data coordination: Data management: GlaxoSmithKline, R&D Projects Clinical Platforms & Sciences, King of Prussia, PA, US

Registration and Medication Ordering System [RAMOS] interactive voice response system: GlaxoSmithKline, R&D Platform Technology & Science, Upper Providence, PA, US

Web-based data capture vendor: Oracle Health Sciences, Boston, MA, US

LATITUDE-TIMI 60 Investigators by Country Listed are investigators who recruited at least 1 patient. Number of patients included is listed in brackets.

Argentina Alves de Lima, Alberto, Instituto Cardiovascular de Buenos Aires, Buenos Aires (12); Gomez Vilamajo, Oscar, Sanatorio San Martin S.A., Venado Tuerto, Sante Fe (3); Hrabar, Adrian, Sanatorio Modelo de Quilmes, Quilmes, Buenos Aires (1); Licheri, Alberto, Sanatorio Mayo S.A., Santa Fe, Santa Fe (4); Macin, Stella, Instituto de Cardiologia JF Cabral, Corrientes, Corrientes (15); Zapata, Gerardo, Instituto Cardiovascular de Rosario, Rosario, Santa Fe (7)

Australia Amerena, John, Barwon Health, Geelong, Victoria (4); Hammett, Christopher, Royal Brisbane Hospital, Herston, Queensland (27); Lehman, Sam, Flinders Medical Centre, Bedford Park (18); Muhlmann, Michael, Sir Charles Gairdner Hospital, Nedlands (6); Nguyen, Michael, Fiona Stanley Hospital, Murdoch (12); Poulter, Rohan, Nambour General Hospital, Nambourm Queensland (9); Raffel, Christopher, The Prince Charles Hospital, Brisbane, Queensland (12); Roberts-Thomson, Philip, Royal Hobart Hospital, Hobart, Tasmania (7); Stramer, Gregory, Cairns Base Hospital, Cairns, Queensland (27): Van Gaal, William, Northern Hospital, Epping, Victoria (8)

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Belgium Charlier, Filip, Imelda Ziekenhuis, Bonheiden (3); Cools, Frank, AZ Klina, Brasschaat (9); Dangoisse, Vincent, Cliniques Universitaires UCL de Mont Godinne, Yvoir (1); De Raedt, Herbert, Onze-Lieve-Vrouwziekenhuis - Campus Aalst, Aalst (8); Hermans, Kurt, AZ Sint-Lucas - Campus Sint-Lucas, Gent (6); Hoffer, Etienne, CHR La Citadelle, Liège (5); Missault, Luc, AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan, Brugge (6); Sinnaeve, Peter, UZ Leuven - Campus Gasthuisberg, Leuven (9); Verhaert, David, Ziekenhuis Oost-Limburg - Campus Sint- Jan, Namur (23); Vervoort, Geert, AZ Sint-Maarten - Campus Leopoldstraat, Mechelen (2)

Bulgaria Atzev, Borislav, MHAT "Puls", Blagoevgrad (14); Draganov, Todor, Second Miltiprofile Hospital for Active Treatment – Sofia, Sofia (12); Gelev, Valeri, MHAT "Tokuda Hospital Sofia", Sofia (8); Goudev, Assen, MHAT "Tsaritsa Yoanna", Sofia (8); Lazov, Petar, MHAT “Pazardjik", Pazardjik (13); Mihov, Atanas, MHAT "Sveta Ekaterina", Dimitrovgrad (10); Petrov, Ivo, City Clinic, Sofia (8)

Canada Billingsley, Ian, Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON (6); Cheung, Stephen, SMH Cardiology Clinical Trials Inc., Surrey, BC (9); Costa Vitali, Atilio, Health Sciences North (AMRIC), Sudbury, ON (14); Della Siega, Anthony, Victoria Heart Institute Foundation, Victoria, BC (4); Kassam, Saleem, Scarborough Cardiology Research Associates, Scarborough, ON (6); Nguyen, Michel, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC (4); Pearce, Murray, Murray Pearce Medicine Professional Corporation; Kitchener, ON (2); Tanguay, Jean-Francois, Montreal Heart Institute, Montreal, QC (13); Wong, Graham, Vancouver General Hospital, Vancouver, BC (8)

Chile Pérez Pino, Luis, Hospital Regional de Concepción Dr. Guillermo Grant Benavente, Concepción, Región Del Biobio (18); Pincetti, Christian, Hospital Regional de Temuco, Temuco, Región De La Araucania (3); Rodriguez Venegas, Manuel, Hospital Dr. Sotero del Rio, Santiago (6); Verdejo, Hugo, Hospital Clinico de la Pontificia Universidad Catolica de Chile, Santiago, Región Metro De Santiago (6)

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Czech Republic Coufal, Zdenek, Krajska nemocnice T. Bati a.s., Zlin (5); Gregor, Pavel, FNKV, Praha 10 (15); Homza, Miroslav, FN Ostrava, Ostrava (7); Horak, David, Nemocnice Liberec, Liberec (38); Matejka, Jan, Pardubicka krajska nemocnice, Pardubice (11); Sedlon, Pavel, UVN – Stresovice, Praha 6 (12); Smid, Ondrej, VFN - II. interni klinika, Praha 2 (5); Spacek, Radim, Krajska nemocnice Usti nad Labem, Usti nad Labem (4); Spinar, Jindrich, FN Brno-Bohunice, Brno (20); Stasek, Josef, FN Hradec Kralove, Hradec Kralove (10); Tousek, Frantisek, Nemocnice Ceske Budejovice, Ceske Budejovice (101)

Denmark Brønnum-Schou, Jens, Amager Hospital, København S (21); Nielsen, Henrik, Bispebjerg Hospital, København NV (9); Rasmussen, Soeren Lind, Hvidovre Hospital, Hvidovre (9); Skov Jensen, Jan, Amtssygehuset i Gentofte, Hellerup (12)

Estonia Hedman, Anu, East-Tallinn Central Hospital, Tallin (24); Reinmets, Julia, North Estonia Medical Centre, Tallinn (50); Soopold, Ullar, Tartu University Hospital, Tartu (25)

France Agraou, Benaissa, CH de Valenciennes - Hôpital Jean Bernard, Valenciennes Cedex (1); Cottin, Yves, Hopital du Bocage Centre de Cardiologie, Dijon Cedex (1); De Labriolle, Axel, Clinique du Pont de Chaume, Montauban cedex (17); Decoulx, Eric (FPI), CH de Tourcoing - Hôpital Gustave Dron, Tourcoing Cedex (1); Delarche, Nicolas, CH de Pau - Hôpital François Mitterrand, Pau (7); Elbaz, Meyer, CHU de Toulouse - Hôpital de Rangueil, Toulouse Cedex (2); Ohlmann, Patrick, HUS de Strasbourg - Nouvel Hôpital Civil, Strasbourg Cedex (33); Probst, Vincent, CHU de Nantes - Hôpital Nord Laënnec, Nantes Cedex (10); Schiele, François, CHU - Hôpital Jean Minjoz, Besançon Cedex (19); Steg, Gabriel, Hôpital Bichat Claude Bernard, Paris Cedex 18 (6)

Germany Appel, Karl-Friedrich, Ambulantes Herzzentrum Kassel, Kassel, Hessen (8); Bavendiek, Udo, Medizinische Hochschule Hannover, Hannover, Niedersachsen (3); Butter, Christian, Immanuel Klinikum Bernau, Bernau, Branderburg (8); Fuisting, Jan, St. Johannes-Hospital Dortmund, Dortmund, Nordrhein-Westfalen (28); Ghanem, Alexander, Asklepios Klinik St. Georg, Hamburg, Hamburg (6); Groenefeld, Gerian, Asklepios Klinik Barmbek, Hamburg, Hamburg

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(4); Hamm, Christian, Universitaetsklinikum Giessen, Giessen, Hessen (1); Hoffman, Ursula, Universitaetsklinikum Mannheim, Mannheim, Baden-Wuerttemberg (3); Kadel, Christoph, Klinikum Frankfurt Höchst gmbh, Frankfurt, Hessen (10); Karakas, Mahir, Universitaeres Herzzentrum Hamburg GmbH, Hamburg, Hamburg (2); Leschke, Matthias, Staedt. Kliniken Esslingen, Esslingen, Baden-Wuerttemberg (6); Mangner, Norman, Universitaet Leipzig Herzzentrum, Leipzig, Sachsen (5); Moellmann, Helge, Kerckhoff-Klinik GmbH, Bad Nauheim, Hessen (2); Olbrich, Hans-Georg, Asklepios Klinik Langen, Langen, Hessen (6); Reith, Sebastian, Universitaetsklinikum Aachen, Aachen, Nordrhein-Westfalen (14); Schwimmbeck, Peter, Klinikum Leverkusen, Leverkusen, Nordrhein-Westfalen (11); Sechtem, Udo, Robert Bosch Krankenhaus, Stuttgart, Baden-Wuerttemberg (14); Smettan, Jan, Universitaetsklinikum Leipzig, Stuttgart, Baden-Wuerttemberg (13); Stellbrink. Christoph, Staedt. Kliniken Bielefeld, Bielefeld, Nordrhein-Westfalen (14); vom Dahl, Juergen, Kliniken Maria Hilf GmbH, Moenchengladbach, Nordrhein-Westfalen (6); Vorpahl, Marc, Helios Klinikum Wuppertal Herzzentrum, Wuppertal, Nordrhein-Westfalen (5) Werner, Nikos, Universitaetsklinikum Bonn, Bonn, Nordrhein-Westfalen (3); Zeh, Wolfgang, Herzzentrum Bad Krozingen, Bad Krozingen, Baden-Wuerttemberg (4); Zirlik, Andreas, Universitaetsklinikum Freiburg, Freiburg, Baden- Wuerttemberg (16)

Greece Kanakakis, Ioannis, General Hospital of Athens "Alexandra", Athens (8); Kyriakides, Zenon, Red Cross Hospital, Athens (17); Mantas, Ioannis, General Hospital of Chalkida, Chalkida (8); Styliadis, Ioannis, Papageorgiou General Hospital, N. Efkarpia, Thessaloniki (3); Tziakas, Dimitrios, University General Hospital of Alexandroupolis, Alexandroupolis (21); Zarifis, Ioannis, G. Papanikolaou General Hospital of Thessaloniki, Thessaloniki (19)

Hong Kong Chan, Kwok Keung, Pamela Youde Nethersole Eastern Hospital, Chai Wan (8); Wong, Chi Yuen, Queen Elizabeth Hospital, Kowloon (5); Yan, Ping Yen Bryan, Prince of Wales Hospital, Satin, New Territories (1)

Hungary Benczúr, Béla, Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendel őintézet, Szolnok (8); Faluközy, József, Állami Szívkórház, Balatonfüred (13); Kiss, Róbert Gábor, MH Egészségügyi Központ, Budapest (22); Lupkovics, Géza, Zala Megyei Kórház, Zalaegerszeg (20); Merkely, Béla, Semmelweis Egyetem, Budapest (24)

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Israel Atar, Shaul, Western Galilee Hospital, Nahariya (12); Banai, Shmuel, Tel Aviv Sourasky Medical Center, Tel Aviv (9); Katz, Amos, Barzilai MC, Ashkelon (5); Meisel, Simcha, Hillel-Yaffe MC, Haddera (3); Mosseri, Morris, Meir MC, Kfar Saba (9)

Italy Ardissino, Diego, Azienda Ospedaliero-Universitaria di Parma, Parma (14); Cavallini, Claudio, Azienda Ospedaliera di Perugia-Ospedale S. Maria della Misericordia, Perugia, Umbria (9); Maria De Biase, Anna, Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milano, Lombardia (6); Morocutti, Giorgio, Azienda Ospedaliero-Universitaria di Udine, Udine (1); Musumeci, Giuseppe, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Lombardia (10); Pirelli, Salvatore, Istituti Ospitalieri, Cremona, Lombardia (13); Salvioni, Alessandro, Milano, Lombardia (3)

Korea Hong, Bum Kee, Gangnam Serverance Hospital, Seoul (3); Jeong, Jin-Ok, Chungnam National University Hospital, Daejeon (11); Jeong, MyungHo, Chonnam National University Hospital, Gwangju (8); Kim, Chong-Jin, Kyung-Hee University Hospital at Gangdong, Seoul (5); Kim, Hyo-Soo, Seoul National University Hospital - Department of Medicine, Seoul (7); Rha, SeungWoon, Korea University Guro Hospital, Seoul (10); Seung, Ki-Bae, The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul (4); Yoon, Junghan, Wonju Severance Christian Hospital, Ganwon-do (14)

Mexico Carrillo-Calvillo, Jorge, Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosi (6); Esturau-Santalo, Ramon-Miguel, Hospital Civil “Fray Antonio Alcalde”, Guadalajara, Jalisco (6)

Netherlands Dirksen, Maurits, MC Alkmaar, Alkmaar (16); Gosselink, Antonius, Isala Klinieken, Zwolle (10); Hamer, Barnabas J.B., Meander MC, Amersfoort (32); Magro, Michael, Tweesteden Ziekenhuis, Tilburg (27); Nierop, Pieter, St. Fransiscus Gasthuis, Rotterdam (14); Oude Ophuis, Canisius Wilhemina Ziekenhuis, Nijmegen (44); Perik, Patrick J., Deventer Ziekenhuis, Deventer (19); Prins, Fransisco J., Elkerliek Ziekenhuis, Helmond (5); Rensing, Bernard J.W.M., St. Antonius Ziekenhuis, Nieuwegein (10); Ronner, Eelko, Reinier de Graaf Groep, Delft (10); Slagboom, Ton, Onze Lieve Vrouwe Gasthuis, Amsterdam (6); Troquay, Roland, Vie-Curie MC,

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Venlo (6); van Daele, Marcus, Orbis Medisch Centrum, Sittard- Geleen (12); van der Heijden, Robert, Vlietland Ziekenhuis, Schiedam (12)

New Zealand Devlin, Gerard, Waikato Hospital, Hamilton (23); Elliott, John, Christchurch Hospital, Canterbury DHB, Christchurch (10); Harding, Scott, Wellington Hospital, Wellington South (9); Scott, Douglas, Middlemore Hospital, Otahuhu, Auckland (3); Stewart, Ralph, Auckland City Hospital, Grafton, Auckland (5); Ternouth, Ian, Taranaki Base Hospital, New Plymouth (17)

Norway Atar, Dan, Oslo Universitetssykehus HF, Ullevål, Oslo (2); Høgalmen, Geir, Sykehuset Innlandet Lillehammer, Lillehammer (10); Hysing, Jan, Sykehuset i Telemark, Skien (11); Larsen, Alf, Stavanger Universitetssykehus, Stavanger (15); Trovik, Thor, Universitetssykehuset i Nord- Norge HF, Tromsø (1)

Philippines Añonuevo, John, Philippine General Hospital, Manila (2); Hay, Eduardo Tin, Philippine Heart Center, Quezon City (8); Marañon, Donato, The Medical City, Pasig City (4); Miranda, Ariel, Cardinal Santos Hospital, San Juan (2)

Poland Budaj, Andrzej, Szpital Grochowski, Warszawa (20); Gessek, Jacek, Specjalistyczny Szpital Miejski im. M. Kopernika, Torun (17); Jaworska, Krystyna, Wojewódzki Szpital Zespolony im. Rydygiera, Torun (14); Kubica, Jacek, Szpital Uniwersytecki Nr 1 im. dr A. Jurasza w Bydgoszczy, Bydgoszcz (12); Miekus, Pawel, Szpitale Wojewodzkie w Gdyni spo ka z ograniczona odpowiedzialno cia z siedziba w Gdyni, Gdynia (23); Mysiak, Andrzej, Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu, Wroclaw (10); Przewlocki, Tadeusz, Krakowski Szpital Specjalistyczny im. Jana Pawla II w Krakowie, Krakow (22); Raczak, Grzegorz, Uniewrsyteckie Centrum Kliniczne, Gdansk (7); Serafin, Ryszard, Specjalistyczny Szpital im. dr A. Sokolowskiego, Walbrzych (8); Trebacz, Jaroslaw, Krakowski Szpital Specjalistyczny im. Jana Pawla II, Krakow (35); Tyllo, Mateusz, Wojewodzki Szpital Specjalistyczny w Olsztynie, Olsztyn (5); Wlodarczak, Adrian, Miedziowe Centrum Zdrowia, Lubin (27); Wojcik, Jaroslaw, SPSK nr 4 w Lublinie, Lublin (15)

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Romania Cinteza, Mircea, Spitalul Universitar de Urgenta Bucuresti, Bucharest (35); Dorobantu, Maria, Emergency Hospital of Bucharest, Bucharest (4); Musetescu, Rodica, Ionescu, Dan (FPI), Center of Cardiovascular Diseases, Craiova (19)

Russia Aksentyev, Sergey, Ryazan Regional Clinical Hospital, Ryazan (15); Apartsin, Konstantin, East- Siberian Scientific Centre Reconstructive and Plastic Surgery, Irkutsk (19); Barbarash, Olga, RAMS SRI of Complex Problems of CV Diseases, Kemerovo (10); Berns, Svetlana, City Clinical Hospital #71, Moscow (3); Bessonova, Nina, City Hospital #28 "Maksimilianovskaya", St. Petersburg (10); Duda, Alexey, Altai Regional Cardiology Dispenser, Barnaul (26); Duplyakov, Dmitry, Samara Regional Clinical Cardiology Centre, Samara (9); Ermoshkina, Lyudmila, Gatchina Central Region Clinical Hospital, Gatchina (19); Gordeev, Ivan, Moscow Clinical Hospital #15, Moscow (16); Kobalava, Zhanna, City Clinical Hospital #64, Moscow (32); Kostenko, Victor, Scientific Research Centre of Emergency n.a Dzhanelidze, St. Petersburg (9); Lapin, Oleg, City Clinical Hospital #4, Perm (8); Markov, Valentin, Scientific Research Center of Cardiology, Tomsk (14); Orlikova, Olga, Saratov Research Cardiology Institute of Roszdrav, Saratov (1); Rebrov, Andrey, Saratov Regional Medical Hospital, Saratov (6); Ruda, Mikhail, Russian Cardiology Research-Industrial Complex of RosMedTechnology, Moscow (4); Shalaev, Sergey, South-Ural Scientific Centre, Tuymen Affiliate, Tyumen (3); Tsyba, Larisa, Municipal Institution of healthcare “Novosibirsk’s municipal clinical hospital of Emergency Call Ser, Novosibirsk (8); Vishnevsky, Alexander, Pokrovskaya city hospital, St-Petersburg (17); Yakushin, Sergey, Ryazan Regional Clinical Cardiology Dispensary, Ryazan (4)

Slovakia Hranai, Marian, Kardiocentrum Nitra, Nitra (141); Hricak, Vasil, Narodny ustav srdcovych a cievnych chorob, Bratislava (47); Juhas, Stanislav, Vychodoslovensky ustav srdcovych a cievnych chorob, a.s., Kosice (35); Kovar, Frantisek, Univerzitna nemocnica Martin, Martin (8)

South Africa Abelson, Mark, Vergelegen Medi Clinic, Somerset West (3); Basson, Matthys, Tiervlei Trial Centre, Bellville (6); Cyster, HP, Tygerberg Hospital, Cape Town (8); Dalby, Anthony, Millpark Hospital, Parktown West (2); Dawood, Saleem, Vincent Pallotti Hospital, Pinelands (2); Horak, Adrian, Vincent Pallotti Hospital, Pinelands (3); Saaiman, Jan, Kuils River, Private Hospital, Kuils River (1)

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Spain Barrabes Riu, José Antonio, Hospital Vall De Hebron, Barcelona (12); Cequier Fillat, Angel, Ciudad Sanitaria y Universitaria de Bellvitge, Barcelona (56); Delia, Manuel Almendro, Hospital Virgen de la Macarena, Sevilla (15); Fernández-Avilés Díaz, Francisco, Hospital Gregorio Marañón, Madrid (27); Genover, Xavier Bosch, Hospital Clinic i Provincial, Barcelona (10); González Juanatey, José Ramón, Hospital Clínico Universitario de Santiago, Santiago De Compostela, (9); Lekuona Goya, Iñaki, Hospital de Galdakano, Galdakano (6); López de Sa, Esteban, Hospital La Paz, Madrid (38); Macaya, Carlos, Hospital Clinico San Carlos, Madrid (12); Navarro, Manuel Jiménez, Hospital Clinico Universitario Virgen Victoria, Malaga (8); Ortega Marcos, Javier, Hospital Puerta de Hierro, Majadahonda (Madrid) (11); Zamorano, Jose Luis, Hospital Ramón y Cajal , Madrid (25)

Sweden Bandh, Stellan, Västmanlands Sjukhus Västerås, Västerås (28); Boberg, Gunnar, Södersjukhuset, Stockholm (6); Christensen, Kjeld, Universitetssjukhuset Örebro, Örebro (12); Holmgren, Christina, Länssjukhuset Ryhov, Jönköping (9); Hornestam, Björn, SU Östra Sjukhuset, Götenborg (13); Mooe, Thomas, Östersunds Sjukhus, Östersund (5); Råmunddal, Truls, Sahlgrenska Universitetssjukhuset, Götenborg (11); Wagner, Henrik, Helsingborgs lasarett, Helsingborg (8)

Taiwan Chiang, Chern-En, Taipei Veterans General Hospital, Taipei (11); Hou, Jia-Yin, Mackay Memorial Hospital, Taipei City (8); Hsia, Chien-Hsun, Changhua Christian Hospital, Changhua (15); Huang, Wei-Chun, Kaohsiung Veterans General Hospital, Kaohsiung (10); Wang, Ji-Hung, Buddhist Tzu Chi General Hospital, Hualien (10)

Thailand Chotinaiwattarakul, Chiangmai (15); Suithichaiyakul, Taworn, Chulalongkorn Hospital, Bangkok (2); Yamwong, Sukit, Ramathibodi Hospital, Mahidol University, Bangkok (8) Chunhakasem, Siriraj Hospital, Bangkok (5); Kuanprasert, Srun, Maharajnakorn Chiangmai Hospital,

Ukraine Kraiz, Igor, Kharkiv Central Clinical Hospital of Ukrzaliznytsia, Kharkiv (21); Malynovsky, Yaroslav, Municipal Institution Regional Cardiology Dispensary, Zaporizhzhya (1); Parkhomenko, Oleksandr, National Scientific Centre “M.D. Strazhesko Institute of Cardiology”,

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Kyiv (19); Pavlyk, Stepan, Lviv Regional Cardiology Centre, Lviv (6); Rishko, Mykola, Transcarpathian Regional Clinical Cardiology Clinic, Uzhhorod (9); Vakaliuk, Igor, Ivano- Frankivsk State Medical University, Ivano-Frankivsk (20); Zhurba, Svitlana, Cherkassy Regional Cardiology Center, Cherkassy (14)

United Kingdom Glover, Jason, Basingstoke and North Hampshire Hospital, Basingstoke (10); Irving, Robert, Ninewells Hospital & Medical School, Dundee (12); Levy, Terry, Royal Bournemouth Hospital, Bournemouth (10); Purcell, Ian, Freeman Hospital, Newcastle-upon-Tyne (13); Pye, Maurice, York Hospital, York (10); Uren, Neal, Royal Infirmary of Edinburgh, Edinburgh (7)

United States Albirini, Abdulhay, Genesis Healthcare System, Zaneville, Ohio (5); Aycock Jr., George, Cardiology Consultants, Pensacola, Florida (1); Bach, Richard, Washington University, St. Louis, Missouri (6); Banerjee, Subhash, Dallas, V.A. Medical Center, Dallas, Texas (7); Barr, Lawrence, Midwest Heart Foundation, Oakbrook Terrace, Illinois (1); Bernstein, Marc, Louisiana Heart Center, Slidell, Louisiana (3); Brechtken, Johannes, Regions Hospital, Saint Paul, Minnesota (9); Burchenal, Joseph, South Denver Cardiology, Littleton, Colorado (7); Burke, Martin, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota (19); Chan, Michael, St. Joseph Heritage Medical Group, Orange, California (1); Chandler, Bleakley, Chandler Cardiovascular Clinical Research LLC, Augusta, Georgia (7); Chandna, Harish, Victoria Heart and Vascular Center, Victoria, Texas (8); Chane, Majed, California Heart Specialist, Inc, Huntington Beach, California (2); Conn, Eric, Chattanoga Heart Institute, Chattanooga, Tennessee (3); Dodds, Al, Michigan Heart PC, Ypsilanti, Michigan (6); Duffy, Brendan, Aultman Hospital, Canton, Ohio (13); Eaton, Gregory, Mid Ohio Heart Clinic, Mansfield, Ohio (7); Ferrier, L., Black Hills Cardiovascular Research Group Cardiology Associates, P.C., Rapid City, North Dakota (4); French, William, Harbor - UCLA Medical Center, Torrance, California (1); Gammon, Roger, Austin Heart, Austin, Texas (7); Gessler, Jr., Carl, The Heart Center, Huntsville, Alabama (39); Ginete, Wilson, Essentia Health, Duluth, Minnesota (3); Graham, Bruce, Medical Consultants, Muncie, Indiana (20); Gray, Richard, Community Hospital of the Monterey Peninsula, Monterey, California (3); Gruberg, Luis, Stony Brook University Medical Center, Stony Brook, New York (2); Guidera, Steven, Doylestown Hospital, Doylestown, Pennsylvania (5); Henderson, David A., Cardiology Physicians PA, Daytona Beach, Florida (3); Hill, Roger, Cardiology Associates of Northeast Arkansas, Jonesboro, Arkansas (7); Hoang, Kheit, MemorialCare Medical Group, Long

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Beach, California (6); Jackson, Charles, Redmond Regional Medical Center, Rome, Georgia (2); Jaffrani, Naseem, Alexandria Cardiology Clinic, Alexandria, Louisiana (16); Katopodis, John, Tallahassee Research Institute, Tallahassee, Florida (5); Kavanaugh, Kevin, Kootenai Heart Clinics, Coeur D Alene, Idaho (8); Kazziha, Samer, Crittenton Hospital Medical Center, Rochester, Michigan (2); Klugherz, Bruce, Abington Memorial Hospital, Abington, Pennsylvania (1); Kraft, Philip, William Beaumont Hospital, Troy, Michigan (3); Laddu, Abhay, St. Louis University, St. Louis, Missouri (3); Lambert Jr., Charles, University Community Hospital, Tampa, Florida (1); Larrain, German, Cardiovascular Research and Education Foundation, Wausua, Wisconsin (12); Lee, Kwan, University of Arizona Medical Center, Tucson, Arizona (7); Lotun, Kapildeo, Univeristy of Arizona Sarver Center, Tucson, Arizona (3); Loussararain, Arthur, St Joseph Heritage Healthcare, Mission Viejo, California (3); Mansouri, Vafa, Saints Thomas Hospital, Nashville, Tennessee (2); McCullum, Kevin, York Hospital Wellspan, York, Pennsylvania (14); McLaurin, Brent, AnMed Health, Anderson, South Carolina (4); Mulkay, Angel, Holy Name Hospital, Teaneck, New Jersey (6); Nahhas, George, Oakwood Hospital & Medical Center, Dearborn, Michigan (3); Othman, Islam, Raleigh Cardiology Associates, Raleigh, North Carolina (2); Pap, John, DLP Marquette Physician Practices, Inc., Marquette, Michigan (2); Pasquini, John, Mid Carolina Cardiology, Charlotte, North Carolina (9): Perlman, Richard, Associated Cardiovascular Consultants PA, Cherry Hill, New Jersey (5); Prashad, Rakesh, Ocala Research Institute, Ocala, Florida (2); Rao, Vijay, Indiana Heart Physician, Indianapolis, Indiana (4); Rosenberg, Michael, Holy Family Memorial Clinical Research, Manitowoc. Wisconsin (4); Ruff, Christian, Brigham and Women’s Hospital, Boston, Massachusetts (3); Sane, David, Carilion Medical Center, Roanoke, Virginia (3); Secaira, Roberto, Franciscan Research Center, Tacoma, Washington (2); Sharma, Sanjiv, Central Cardiology Medical Clinic, Bakersfield, California (4); Siegel, Craig, Austin Heart, Round Rock, Texas (18); Stuckey, Thomas, Moses H. Cone Memorial Hospital, Greensboro, North Carolina (17); Tahirkheli, Naeem, South Oklahoma Heart Research, LLC, Oklahoma City, Oklahoma (10); Tang, Aylmer, Summit Health, Chambersburg, Pennsylvania (3); Uretsky, Barry, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas (6); Warden, Bradford, West Virginia University Hospital, Morgantown, West Virginia (5); Webber, Jeffrey, Columbia, Medical Group, Nashville, Tennessee (5); Weiss, Robert, Central Marine Heart and Vascular Institute, Lewiston, Maine (5); Wickemeyer, William, Iowa Heart Center, PC, West Des Moines, Iowa (3); Zahr, Firas, University of Iowa Hospitals and Clinics, Iowa City, Iowa (2); Zenni, Martin, University of Florida Health Science Center, Jacksonville, Florida (2); Zidar, David, University Hospitals of Cleveland, Cleveland, Ohio (1)

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eTable. Secondary Endpoints in LATITUDE-TIMI 60

• The composite of CV death, MI, or hospitalization for heart failure.

• The composite of arterial CV events, defined as CV death, MI, SRI-UR, or stroke.

• The composite of coronary events, defined as CHD death, MI, SRI-UR, or any unplanned

coronary artery revascularization (planned revascularizations are those initial or staged

interventions performed based on the initial qualifying ACS).

• The composite of CV death or hospitalization for heart failure

• The composite of CV death, MI or stroke.

• The composite of CV death, MI, SRI-UR, stroke or hospitalisation for heart failure

• The primary and principal secondary endpoints will be evaluated replacing CV death

separately with CHD death and all-cause death.

• The primary and principal secondary endpoints will be evaluated replacing all MI with Type

1 (spontaneous) MI.

• Individual components of the composite endpoints (including all-cause mortality).

• Definite or probable stent thrombosis.

• Any re-hospitalization within 30 days of discharge.

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