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Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized with Acute Myocardial Infarction: a Randomized Clinical Trial

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Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized with Acute Myocardial Infarction: a Randomized Clinical Trial Supplementary Online Content O’Donoghue ML, Glaser R, Cavender MA, et al; LATITUDE-TIMI 60 Investigators. Effect of losmapimod on cardiovascular outcomes in patients hospitalized with acute myocardial infarction: a randomized clinical trial. JAMA . doi:10.1001/jama.2016.3609 eAppendix. LATITUDE-TIMI 60 Trial - Trial Leadership & Investigators eTable. Secondary Endpoints in LATITUDE-TIMI 60 This supplementary material has been provided by the authors to give readers additional information about their work. © 2016 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 eAppendix. LATITUDE-TIMI 60 Trial - Trial Leadership & Investigators LATITUDE Executive Steering Committee members Chairman: Marc S. Sabatine, MD, MPH (TIMI Study Group, Brigham and Women’s Hospital, Boston, MA, US) Global Principal Investigator: David A. Morrow, MD, MPH (TIMI Study Group, Brigham and Women’s Hospital, Boston, MA, US) Members: Prof. Philip Aylward (Flinders Medical Centre, Adelaide, South Australia) Prof. Keith Fox (University of Edinburgh, Edinburgh, Scotland) Prof. José López-Sendón (Hospital Universitario La Paz, Madrid, Spain) Prof. P. Gabriel Steg (Hôpital Bichat-CI. Bernard, Paris, France) Prof. Pierre Theroux (Montreal Heart Institure, Montreal, Quebec, Canada) GlaxoSmithKline members: Ian Laws (GlaxoSmithKline, London, UK) Ruchira Glaser (GlaxoSmithKline, King of Prussia, PA, US) Rich Davies (GlaxoSmithKline, King of Prussia, PA, US) LATITUDE-TIMI 60 Steering Committee Members & National Lead Investigators Prof. Diego Ardissino (Azienda Ospedaliero-Universitaria di Parma, Parma, Italy) Prof. Dan Atar (Oslo University Hospital, Ullevål, Oslo, Norway) Prof. Andrzej Budaj (Grochowski Hospital, Warsaw, Poland) Prof. Ramón Corbalán (Pontificia Universidad Católica de Chile, Santiago, Chile) Dr. Anthony J. Dalby (Milpark Hospital, Johannesburg, South Africa) Prof. Mikael Dellborg (COR Pulmonale AB, Goteborg, Sweden) Dr. Rafael Diaz (Estudios Clínicos Latino America, Rosario, Argentina) Prof. Maria Dorobantu (Emergency Clinical Hospital of Bucharest, Bucharest, Romania) Prof. Assen R Goudev (Queen Giovanna University Hospital, Sofia, Bulgaria) Prof. Christian Hamm (The Kerchoff Heart Center, Bad Nauheim, Germany) Prof. Yong Huo (Peking University First Hospital, Biejing, China) Prof. Robert Kiss (State Health Center, Budapest, Hungary) Dr. Frantisek Kovar (University Hospital Martin, Martin, Slovakia) © 2016 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 Prof. Basil Lewis (Lady Davis Carmel Medical Center, Haifa, Israel) Prof. Piera Merlini (Ospedale Niguarda Ca Granda, Milan, Italy) Prof. José C. Nicolau (Rua Aureliano Coutinho, São Paulo, BR) Dr. Ton Oude Ophuis (Canisius Wilhelmina Hospital, Nijmegan, Zetten, Netherlands) Prof. Alexander Parkhomenko (Institute of Cardiology, Kiev, Ukraine) Prof. Mikhail Ruda (Russian Cardiology Research and Prodaction Complex, Moscow, Russian Federation) Prof. Ki-Bae Seung (Kangnam St. Mary’s Hospital, Seoul, Korea) Prof. Peter Sinnaeve (University Hospitals Leuven, Leuven, Belgium) Prof. Jan Skov Jensen (Gentofte Hospital, Hellerup, Denmark) Prof. Jind řich Ŝpinar (University Hospital Brno, Brno, Czech Republic) Dr. Piyamitr Sritara (Ramathibodi Hospital, Mahidol University, Bangkok, Thailand) Prof. Jean-François Tanguay (Montreal Heart Institute, Montreal, QC, Canada) Prof. Dimitiros Tziakas (University General Hospital of Alexandroupolis, Alexandroupolis, Greece) Dr. Neal Uren (Royal Infirmary of Edinburgh, Edinburgh, United Kingdom) Prof. Harvey White (Auckland City Hospital, Auckland, New Zealand) Dr. Michelle O’Donoghue (Brigham and Women’s Hospital, Boston, MA, USA) Independent Data Monitoring Committee members (IDMC): Chairman: Dr. Jeffrey L. Anderson (Intermountain Medical Center, Murray, UT, US) Statistician: Dr. Kerry L. Lee (Duke University School of Medicine, Durham, NC, US) Additional Voting members: Dr. James de Lemos (UT Southwestern Medical Center, Dallas, TX, US) Prof. Freek W.A. Verheugt (Amsterdam, Netherlands) Dr. W. Douglas Weaver (Henry Ford Heart & Vascular Institute, Detroit, MI, US) Clinical Endpoint Committee (CEC) Chairman – Stephen Wiviott, MD (TIMI Study Group, Brigham and Women's Hospital, Boston, MA, US) Director – Cheryl Lowe, RN (TIMI Study Group, Boston, MA, US) Manager –Jessica Lamp, BA (TIMI Study Group, Boston, MA, US) © 2016 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 Team members: Mian Qasim Rehman, MD (Senior Medical Reviewer); Margarita Shimmer, MD (Medical Reviewer); Danielle Forni, RN (Senior Medical Reviewer), Ummi Khan, MD (Medical Reviewer); Arne Thompsen (CEC Coordinator) CEC adjudicators – Cardiology Eric Awtry, MD (Boston Medical Center, Boston, MA, US) Clifford J. Berger, MD (Boston Medical Center, Boston, MA, US) Kevin Croce, MD, PhD (Brigham and Women’s Hospital, Boston, MA, US) Akshay Desai, MD, MPH (Brigham and Women’s Hospital, Boston, MA, US) Eli Gelfand, MD (Beth Israel Deaconess Medical Center, Boston, MA, US) Carolyn Ho, MD (Brigham and Women’s Hospital, Boston, MA, US) David E. Leeman, MD (Beth Israel Deaconess Medical Center, Boston, MA, US) Mark S. Link, MD (New England Medical Center, Boston, MA, US) Ashvin Pande, MD (Boston Medical Center, Boston, MA, US) Frederick Ruberg, MD (Boston Medical Center, Boston, MA, US) CEC adjudicators – Neurology Andrew D. Norden, MD, MPH (Dana Farber Cancer Institute, Boston, MA, US) Natalia Rost, MD, MPH (Massachusetts General Hospital, Boston, MA, US) Scott Silverman, MD (Massachusetts General Hospital, Boston, MA, US) Aneesh Singhal, MD (Massachusetts General Hospital, Boston, MA, US) CEC adjudicators – Hepatic Specialists Wolfram Goessling, MD, PhD (Brigham and Women’s Hospital, Boston, MA, US) Anna Rutherford, MD, MPH (Brigham and Women’s Hospital, Boston, MA, US) Statistical Centers and involved statisticians: GlaxoSmitkKline Richard Davies, GlaxoSmithKline, Research Triangle Park, NC, US Jennifer Shannon, Parexel, Durham, NC, US Tim Rolfe, GlaxoSmithKline, Stockley Park, UK TIMI Study Group Naveen Deenadayalu, TIMI Study Group, Boston, MA KyungAh Im, TIMI Study Group, Boston, MA © 2016 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 Julia Kuder, TIMI Study Group, Boston, MA Sabina Murphy, TIMI Study Group, Boston, MA Central laboratory Quest Diagnostics Clinical Laboratories, Inc. (Valencia, CA, US) Data coordination: Data management: GlaxoSmithKline, R&D Projects Clinical Platforms & Sciences, King of Prussia, PA, US Registration and Medication Ordering System [RAMOS] interactive voice response system: GlaxoSmithKline, R&D Platform Technology & Science, Upper Providence, PA, US Web-based data capture vendor: Oracle Health Sciences, Boston, MA, US LATITUDE-TIMI 60 Investigators by Country Listed are investigators who recruited at least 1 patient. Number of patients included is listed in brackets. Argentina Alves de Lima, Alberto, Instituto Cardiovascular de Buenos Aires, Buenos Aires (12); Gomez Vilamajo, Oscar, Sanatorio San Martin S.A., Venado Tuerto, Sante Fe (3); Hrabar, Adrian, Sanatorio Modelo de Quilmes, Quilmes, Buenos Aires (1); Licheri, Alberto, Sanatorio Mayo S.A., Santa Fe, Santa Fe (4); Macin, Stella, Instituto de Cardiologia JF Cabral, Corrientes, Corrientes (15); Zapata, Gerardo, Instituto Cardiovascular de Rosario, Rosario, Santa Fe (7) Australia Amerena, John, Barwon Health, Geelong, Victoria (4); Hammett, Christopher, Royal Brisbane Hospital, Herston, Queensland (27); Lehman, Sam, Flinders Medical Centre, Bedford Park (18); Muhlmann, Michael, Sir Charles Gairdner Hospital, Nedlands (6); Nguyen, Michael, Fiona Stanley Hospital, Murdoch (12); Poulter, Rohan, Nambour General Hospital, Nambourm Queensland (9); Raffel, Christopher, The Prince Charles Hospital, Brisbane, Queensland (12); Roberts-Thomson, Philip, Royal Hobart Hospital, Hobart, Tasmania (7); Stramer, Gregory, Cairns Base Hospital, Cairns, Queensland (27): Van Gaal, William, Northern Hospital, Epping, Victoria (8) © 2016 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 Belgium Charlier, Filip, Imelda Ziekenhuis, Bonheiden (3); Cools, Frank, AZ Klina, Brasschaat (9); Dangoisse, Vincent, Cliniques Universitaires UCL de Mont Godinne, Yvoir (1); De Raedt, Herbert, Onze-Lieve-Vrouwziekenhuis - Campus Aalst, Aalst (8); Hermans, Kurt, AZ Sint-Lucas - Campus Sint-Lucas, Gent (6); Hoffer, Etienne, CHR La Citadelle, Liège (5); Missault, Luc, AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan, Brugge (6); Sinnaeve, Peter, UZ Leuven - Campus Gasthuisberg, Leuven (9); Verhaert, David, Ziekenhuis Oost-Limburg - Campus Sint- Jan, Namur (23); Vervoort, Geert, AZ Sint-Maarten - Campus Leopoldstraat, Mechelen (2) Bulgaria Atzev, Borislav, MHAT "Puls", Blagoevgrad (14); Draganov, Todor, Second Miltiprofile Hospital for Active Treatment – Sofia, Sofia (12); Gelev, Valeri, MHAT "Tokuda Hospital Sofia", Sofia (8); Goudev, Assen, MHAT "Tsaritsa Yoanna", Sofia (8); Lazov, Petar, MHAT “Pazardjik", Pazardjik (13); Mihov, Atanas, MHAT "Sveta Ekaterina", Dimitrovgrad (10); Petrov, Ivo, City Clinic, Sofia (8) Canada Billingsley, Ian, Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON (6); Cheung, Stephen, SMH Cardiology Clinical Trials Inc., Surrey, BC (9); Costa Vitali, Atilio, Health Sciences North (AMRIC), Sudbury, ON (14); Della Siega, Anthony, Victoria
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