Marcello Malpighi (1628-1694): Pioneer of Microscopic Anatomy and Exponent of the Scientific Revolution of the 17Th Century
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REVIEW Eur. J. Anat. 22 (5): 433-439 (2018) Marcello Malpighi (1628-1694): Pioneer of microscopic anatomy and exponent of the scientific revolution of the 17th Century Sanjib K. Ghosh, Ashutosh Kumar Department of Anatomy, All India Institute of Medical Sciences, Phulwarisharif, Patna, India SUMMARY jealousy and personal feuds. Nevertheless his ex- ploits were instrumental in understanding the hu- Marcello Malpighi (1628-1694) was an Italian man microscopic anatomy (histology) and his ac- anatomist and an eminent scientist who significant- complishments have etched his name in the pages ly contributed to the advancement of the anatomi- of medical science forever. cal sciences in the 17th century. Malpighi was one of the first to use the compound microscope (an Key words: Microscope – Capillaries – Circula- instrument designed by Galileo in 1609) and made tion – Embryology – Hepatic lobule – Glomerulus the most important discovery of his life in 1661 when he identified capillaries as connecting ves- INTRODUCTION sels between small arteries and veins in the lungs. Malpighi thus provided the missing link in William Marcello Malpighi (1628-1694) was an Italian Harvey’s theory of blood circulation. He made sig- anatomist and an eminent scientist (Fig. 1) who nificant contributions in the field of embryology significantly contributed to the advancement of the based on his observations on chick embryo, and anatomical sciences in the 17th century his efforts provided deep insights into the develop- (Adelmann, 1966). He successfully ventured into ment of the heart and the nervous system. His the unexplored domain of microscopic anatomy, communications based on microscopic studies and documented observations which revolution- scripted valuable details on the structural organiza- ized the understanding of the structural organiza- tion of organs like the liver, kidney and spleen. He tion of organs in the human body (Clendening, identified the hepatic lobule as the fundamental 1960). Malpighi’s findings heralded a new era in unit of the liver and noted that bile was being se- the progress of medical sciences as such, and set creted by these lobules and not from the gall blad- him in a different league altogether as compared to der (the popular belief then). In the kidney he dis- his illustrious predecessors such as Vesalius, Fab- covered the glomerulus (Malpighian Corpuscle), ricius, Veslingius and Harvey (Ghosh et al., 2014). and was the first to observe the convoluted tubules Although he was exceedingly successful in his sci- in the renal cortex. He was the first to describe the entific activities, his life was affected by unfortu- presence of lymphatic bodies (Malpighi’s Corpus- nate events and savage criticism from detractors cle) in the spleen. Although he was exceedingly arising out of professional jealousy and personal successful in his scientific activities, his life was feuds (Campieri et al., 2004; West, 2013). The fol- fraught with unfortunate events and savage criti- lowing words inscribed in his memorial plate ap- cism from detractors arising out of professional propriately describes the extraordinary life of this great anatomist in short (Bigoni et al., 2018): “Summum ingenium/ integerrimam vitam/ fortem Corresponding author: Dr. Sanjib Kumar Ghosh. Department strenuamque mentem/ audacem salutaris artis amorem” of Anatomy, All India Institute of Medical Sciences, [Great genius/ honest life/ strong and tough Phulwarisharif, Patna-801507, Bihar, India. Phone: +91- 8867502575 7 +91-8017541980; Fax : +91- 11- 4157-1111. E- mail: [email protected] Submitted: 28 April, 2018. Accepted: 24 May, 2018. 433 Marcello Malpighi and microscopic anatomy ever applicable have been appropriately refer- enced. The images used in the text were procured from the internet and it was ensured that all the figures included in this study are in public domain, i.e. free from copyright issues. EARLY LIFE AND CAREER Marcello Malpighi was born in the town of Crevalcore at the outskirts of Bologna, Italy, on 10 March 1628 (James, 1928). Interestingly in the same year, William Harvey published his ground- breaking findings on the circulation of blood in De Motu Cordis, and years later it was Malpighi that provided the missing link in Harvey’s observation through the discovery of capillaries (Lubitz, 2004). Malpighi was born to a family of small landowners and he was raised in the farm that his parents owned. In the early part of his life, he was engaged in grammatical studies mostly under the influence of his father. However by the tryst with destiny, he enrolled at the University of Bologna in 1646 to study medicine and philosophy (Adelmann, 1966). Unfortunately, his academic pursuits were inter- rupted by the sad demise of both his parents as well as his paternal grandfather when he was just 21 years old. He had to abandon his studies tem- porarily to take care of his family of eight brothers and sisters. He resumed his studies two years lat- Fig 1. A portrait of Marcello Malpighi from his text Opera Posthuma (1697). Image available online, and is in Pub- er and obtained doctorates in both medicine and lic Domain. philosophy in 1653 from Bologna (Motta, 1998). He displayed steely resolve as he withstood oppo- sition from University authorities while pursuing his mind/ daring love for the medical art] studies because he was not born in Bologna. This aspect of his character later served him well in his The present review was undertaken to chronicle defence against aggressive opposition to his aca- a brief outline of the life and achievements of Mar- demic exploits by his detractors. After completing cello Malpighi, regarded as the founder of micro- his graduation in medicine, Malpighi devoted him- scopic anatomy. We consider that this review self to anatomical studies and thus began his ex- would be relevant to anatomical sciences in the traordinary productive journey in the domain of present day, when scientists empowered with anatomy. His career was boosted by his appoint- technological advances are coming up with radical ment as Professor of Medicine at the University of revelations in relation to the orientation of human Bologna in 1656 (Nuland, 2008). During this time anatomy (Benias et al., 2018). he became a member of the anatomical society Coro Anatomico which was headed by Bartolomeo METHODS Massari, Professor of Anatomy in Bologna and Malpighi’s teacher. The society comprised of intel- An extensive literature search was undertaken lectuals devoted to anatomical studies on cadav- for this study and indexed databases such as Med- ers and the group met in Massari’s home to con- line, PubMed, Scopus, EMBASE, CINAHL, Google duct dissections and vivisection of animals (Porter Scholar as well as popular search platforms such 1996). These events were critical in shaping Mal- as Wikipedia and standard Google search engine pighi’s inclination towards rational experiment- were referred to for relevant published materials. based anatomical studies and his refusal to accept The following terms were used during literature Galen’s theories, which eventually made him un- search: “Marcello Malpighi”, “Malpighi”, “Biography popular among his contemporaries. Malpighi later of Malpighi”, “Malpighi and Anatomical Sciences”, married Francesca Massari (the daughter of his “Scientific discoveries of Malpighi”, “Microscopic teacher), who however died the following year, Anatomy and Malpighi”, “Capillaries”, bringing an unfortunate twist in his personal life “Communications of Malpighi”, “Published texts of (Malpighi, 1975). Towards the later part of 1656, Malpighi”, “Anatomy in 17th Century”, “Malpighi’s Malpighi (possibly compelled by the gloomy phase contributions in Embryology” and “Malpighi as Phy- in his personal life) accepted an offer from the sician”. Published texts of Malpighi and their trans- Archduke of Tuscany for the Chair of Theoretical lations in English were consulted from online librar- Medicine in the newly established University of ies while conducting the present study and wher- Pisa, which was specially created for him 434 S.K. Ghosh & A. Kumar (Bertoloni Meli, 1997). tions (Adelmann, 1966). He was successful in identifying the red blood cells and attributed the ACHIEVEMENTS AND TURBULENCES IN PRO- colour of blood to them. His communications with FESSIONAL LIFE his friends and colleagues during his stay in Messi- na underline the fact that he had to withstand a However, the stay in Pisa proved to be highly revolutionary environment of counter-opinion from productive from a professional point of view for the followers of Galenic traditions (Piccolino, Malpighi. Here he came across Giovanni Alfonso 1999). Subsequently he returned to Bologna in the Borelli (1608-1679), an eminent mathematician later part of 1667 and devoted himself to studies and naturalist, and this marked the beginning of a related to the subdivisions of specific organs like long association. Influenced by Borelli, Malpighi the brain, liver, spleen, kidney and the deeper lay- became a member of the Academia del Cimento, ers of the skin. His extraordinary exploits garnered one of the earliest scientific societies (Giglioni, the attention of the Royal Society of London, and 1997). As a member of the society, he was ex- his findings were serially published since 1668 in posed to the theory of iatromechanics, whereby the “Philosophical transactions”, a journal man- the human body is conceived as a set of machines aged by the Royal Society itself (Hall, 2002). Even- working independently