Seton Hall University eRepository @ Seton Hall Seton Hall University Dissertations and Theses (ETDs) Seton Hall University Dissertations and Theses Spring 5-4-2020 Chemical tools for Residue-Specific and Secondary Amine Selective Petasis (SASP) bioconjugation of Peptides and Proteins Yonnette Sim
[email protected] Follow this and additional works at: https://scholarship.shu.edu/dissertations Part of the Biochemistry Commons Recommended Citation Sim, Yonnette, "Chemical tools for Residue-Specific and Secondary Amine Selective Petasis (SASP) bioconjugation of Peptides and Proteins" (2020). Seton Hall University Dissertations and Theses (ETDs). 2776. https://scholarship.shu.edu/dissertations/2776 Chemical tools for Residue-Specific and Secondary Amine Selective Petasis (SASP) bioconjugation of Peptides and Proteins A dissertation submitted to Seton Hall University in partial fulfillment for the Doctor of Philosophy Degree By: Yonnette E. Sim May 2020 Department of Chemistry and Biochemistry Seton Hall University South Orange, NJ. 07079 USA © 2020 Yonnette E. Sim DocuSign Envelope ID: 9EF6018D-72DB-4316-B86E-3A103260E910 We certify that we have read this dissertation and in our opinion it is adequate in scientific scope and quality as dissertation for the degree of Doctor of Philosophy Dr. Gregory R. Wiedman Mentor Dr. Monika Raj Co-Mentor (No Longer SHU Faculty) Dr. Joseph Badillo Member of Dissertation Committee Dr. Stephen Kelty Department Chair Seton Hall University I dedicate this thesis to my husband, Ebo, my children Ebony and Ethan for their tremendous love and support & My late parents Rupert and Theresa for their love and wisdom. “The only limit to the height of your achievements is the reach of your dreams and your willingness to work for them” – Michelle Obama i ACKNOWLEDGEMENTS First I would like to express my appreciation and thanks to my research mentor, Dr.