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Alzumab (Psoriasis) - Forecast and Market Analysis to 2022 REFERENCE CODE GDHC1176DFR | PUBLICATION DATE MAY 2013 ALZUMAB (PSORIASIS) - FORECAST AND MARKET ANALYSIS TO 2022 Alzumab (Psoriasis) - Forecast and Market Analysis to 2022 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form. ALZUMAB (PSORIASIS) - FORECAST AND MARKET ANALYSIS TO 2022 Executive Summary Table below presents key metrics for Alzumab Sales of Alzumab for Psoriasis Market in India, (itolizumab) in India. 2022 GlobalData expects Biocon to launch Alzumab in Alzumab: Key Metrics in the Psoriasis Market India in late 2013. We estimate the 2022 sales of 2022 Market Sales Alzumab will reach $34.0m in India. Key factors India $34.0m Total $34.0m affecting the uptake of Alzumab will include novel Key Events (2012–2022) Level of Impact mechanism of action and cost effectiveness of the Launch of Alzumab in India (2013) ↑↑ drug. Source: GlobalData Figure below presents sales for Alzumab by region in the PsO market, 2022 Alzumab Sales by Region, 2022 2022 Total: $34.0m 100% India Source: GlobalData Alzumab (Psoriasis) - Forecast and Market Analysis to 2022 2 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form. ALZUMAB (PSORIASIS) - FORECAST AND MARKET ANALYSIS TO 2022 Executive Summary What do the Physicians Think? The use of biosimilars has also been a hot topic among dermatologists and other physicians who Drug resistance and patients becoming refractory prescribe biologics for the warranted indications. to therapies in less than three years have become However, there is a misconception as to the pricing main issues of discussion in the PsO world. of these biologic generics; we discovered mixed “The resistance issue will be an issue in the five- feelings among physicians regarding their year [time] frame. We need alternative, possible presence due to manufacturing or pricing. alternative choices. The larger the number of “I think it’s an opportunity. This market is highly available drugs, the better.” price-sensitive...when they come to the market; [EU] key opinion leader, January 2013 they will completely grab the market of the anti- The upcoming launches of the IL-17 inhibitors have TNFs, provided the prices are 30 to 50%. It is very KOLs extremely excited, as they hope to be able to significant…If it’s 20%, then I’m disappointed.” put them to use early in the treatment paradigm. [EU] key opinion leader, January 2013 However, we encountered some physician experts who felt that the current pipeline would not unseat the established anti-TNF drugs. “I’m most excited about the antagonist IL-17. I find these drugs very effective and quite safe. I think they will probably have a role in the future.” [EU] key opinion leader, January 2013 “I don’t think [the] new biologics coming will have an impact on the use of TNF inhibitors.” [US] key opinion leader, December 2012 Alzumab (Psoriasis) - Forecast and Market Analysis to 2022 3 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form. ALZUMAB (PSORIASIS) - FORECAST AND MARKET ANALYSIS TO 2022 Table of Contents 1 Table of Contents 1 Table of Contents .......................................................................................................................... 4 1.1 List of Tables .......................................................................................................................... 7 1.2 List of Figures ......................................................................................................................... 8 2 Introduction ................................................................................................................................... 9 2.1 Catalyst .................................................................................................................................. 9 2.2 Related Reports ..................................................................................................................... 9 2.3 Upcoming Related Reports ................................................................................................... 11 3 Disease Overview ....................................................................................................................... 12 3.1 Etiology and Pathophysiology ............................................................................................... 12 3.1.1 Etiology ........................................................................................................................... 12 3.1.2 Pathophysiology ............................................................................................................. 14 3.2 Symptoms ............................................................................................................................ 17 4 Disease Management.................................................................................................................. 18 4.1 Treatment Overview ............................................................................................................. 19 5 Competitive Assessment ............................................................................................................. 23 5.1 Overview .............................................................................................................................. 23 5.2 Strategic Competitor Assessment ......................................................................................... 24 6 Opportunity and Unmet Need ...................................................................................................... 25 6.1 Overview .............................................................................................................................. 25 6.2 Unmet Needs ....................................................................................................................... 26 6.2.1 Improved Drug Safety and Efficacy Profiles .................................................................... 26 6.2.2 Biomarkers for Predicting Remission .............................................................................. 27 6.2.3 More Cost-Effective Therapies Through Oral Formulation and Biosimilars ..................... 27 Alzumab (Psoriasis) - Forecast and Market Analysis to 2022 4 © GlobalData. This report is a licensed product and is not to be copied, reproduced, shared or resold in any form. ALZUMAB (PSORIASIS) - FORECAST AND MARKET ANALYSIS TO 2022 Table of Contents 6.2.4 Education and Treatment of Psychological Factors Accompanying Psoriasis ................. 28 6.2.5 An Effective Biologic/Systemic Topical Therapy ............................................................. 28 6.2.6 More Effective Treatment for Mild Psoriasis, Specifically UV Therapies .......................... 29 6.2.7 Physician Education About the Different Types of Psoriasis, not Just Plaque Psoriasis .. 29 6.3 Opportunities ........................................................................................................................ 30 6.4 Unmet Needs Gap Analysis .................................................................................................. 30 6.4.1 Predictive Tools for Diagnosis and Treatment ................................................................. 31 6.4.2 Target Specificity ............................................................................................................ 31 6.4.3 Topical Biologic/Systemic Therapeutic Options .............................................................. 32 6.4.4 Helping Patients with Psychological Issues Associated with Psoriasis ............................ 32 7 Pipeline Assessment ................................................................................................................... 33 7.1 Overview .............................................................................................................................. 33 7.2 Promising Drugs in Clinical Development ............................................................................. 34 8 Alzumab (itolizumab) ................................................................................................................... 36 8.1 Overview .............................................................................................................................. 36 8.2 Efficacy ................................................................................................................................. 37 8.3 Safety ................................................................................................................................... 38 8.4 Dosing and Formulation ....................................................................................................... 38 8.5 Potential Clinical Positioning ................................................................................................. 38 8.6 Potential Commercial Positioning ......................................................................................... 38 8.7 Pricing and Reimbursement ................................................................................................. 38 8.8 SWOT Analysis .................................................................................................................... 39 8.9 Forecast ............................................................................................................................... 40 9 Appendix ....................................................................................................................................
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