Curriculum Vitae

CURRICULUM VITAE

Name : Prof. Devrim GOZUACIK, MD PhD Address : Koç University, School of Medicine, KUTTAM Research Center for Translational Medicine, Topkapi 34010, Istanbul, TURKEY. Phone : +90 212 467 87 00 E-mail : [email protected] Orcid ID : https://orcid.org/0000-0001-7739-2346

EDUCATION 2001, Ph.D. of Molecular Cell Biology, Paris Pasteur Institute and Paris-Sud (XI) University. 1997, M.Sc. (French D.E.A. degree) of Biochemistry, Ecole Polytechnique and Paris-Sud University. 1995, Medical doctor (MD) degree, Hacettepe University, Faculty of Medicine (in English). 1994, Research fellow, Dept. of Tumor Biology, Rotterdam Erasmus Medical Center. 1989-1995, Student researcher, Hacettepe Children’s Hospital Medical Biology Dept. and Hacettepe Oncology Institute.

EMPLOYMENT June 2020-today, Professor, School of Medicine, KUTTAM Research Center for Translational Medicine, Koç University. 2018-today, Affiliate Member, Autophagy, Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, USA. 2018-today, Part-Time Senior Researcher, SUNUM Nanotechnology Research and Application Center. 2016-2020, Co-Founder and Board Member, EFSUN Nanodiagnostics Center of Excellence. 2018-2020, Professor, Molecular Biology Genetics and Bioengineering Program, Sabanci University. 2011-2018, Associate Professor, Molecular Biology Genetics and Bioengineering Program, Sabanci University. Sept. 2006-2011, Assistant Professor, Biological Sciences and Bioengineering Program, Sabanci University. 2001-2006, Postdoctoral fellow, Weizmann Institute of Science (Adi Kimchi Lab).

CITATIONS AND H-INDEX 8338 citations in the Science Citation Index (SCI, Thomson-Reuters), h-index: 25. 8710 citations in Scopus, h-index: 25 13670 citations in Google Scholar, h-index: 28. 11 publications with >100 citations.

1 AWARDS 2015, Elginkan Foundation Technology Award (with the SUTAB medical device team). 2014, Turkish Press Association, Sedat Simavi Health Sciences Award. 2014, Istanbul Kultur University, Prof. Onder Oztunali Science Award. 2008, Turkish Academy of Sciences Outstanding Young Scientist Award (TUBA-GEBIP Award). 2006, European Molecular Biology Organization, EMBO, Strategical Development and Installation Award. 2006, Selected by Hoffmann-La Roche Pharmaceuticals among the “Leading Bioscientists of the Next Decade” 2004-2006, European Union "Marie Curie Actions" Postdoctoral Fellowship. 2002-2004, Weizmann Institute Feinberg Graduate School Postdoctoral Fellowship. 2001-2002, French Organisation For Medical Research (FRM) Postdoctoral Fellowship. 1999-2001, French Cancer Research Association (ARC) PhD Scholarship. 1996-1999, TUBITAK / NATO A1 PhD Full Scholarship.

INTERNATIONAL AND NATIONAL PROFESSIONAL SERVICES A) International professional services, 2018-today, International Council Member, Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, USA (www.autophagy.center). 2010-today, Board of Directors Member, International Cell Death Society (ICDS) (Based in New York) (www.celldeath-apoptosis.org). 2016-today, Associate Editor, Autophagy journal (Taylor & Francis Group. SCI Impact Factor 2017: 11.1) 2017-today, Editorial Board Member, Cell Communication and Signaling journal (Springer Nature Publishing. SCI Impact Factor 2017: 3.94) 2010-2016, Editorial Board Member, Autophagy journal (SCI Impact Factor 2010-16: 9.1-12) 2007-2019, Referee, Nature Communications, PNAS, Autophagy, Cell Death and Differentiation, Cancer Research, Oncogene, Oncotarget, Human Molecular Genetics, Scientific Reports, Cell Death and Disease, Cell Signaling, Endocrine-Related Cancer, Molecular Cancer, , BMC Cell Biology, Biochimica Biophysica Acta (BBA), FEBS Letters, Experimental Biology and Medicine, Current Cancer Drug Targets, Biotechniques, Functional & Integrative Genomics Journal, Journal of Oncology, Turkish Journal of Biology, Turkish Journal of Medical Sciences, Frontiers in Anti-Cancer Drug Discovery. 2007-today: Grant or academic referee/advisor, Cancer Research, UK (United Kingdom), Wellcome Trust (United Kingdom), The Health Research Board, (Ireland) ve Research Foundation Flanders, FWO (Belgium), KU Leuven, (Belgium), Goethe University (Germany), University of Pretoria (South Africa), University of Florida (USA).

B) National professional services, 2018-today, Part-Time Senior Researcher, SUNUM Nanotechnology Research and Application Center. 2016-2020, Co-founder and Board Member, EFSUN Nanodiagnostics Center of Excellence. 2016-2019, Scientific Advisory Board Member, TUSEB Biotechnology Institute 2009-2018, Contributing Faculty, SUNUM Nanotechnology Research and Application Center. 2016-2017, Founding Member and Board Member, Turkish Cell Death Research Society (HOAD). 2011-2013, Founding Member and Board Member, Turkish Molecular Biology Society (MBD). 2018, TUBITAK Science Awards Referee, TUBITAK (Turkish Research Agency). 2018, TUSEB Aziz Sancar Science Awards Referee, TUSEB Ministry of Health of the Republic of Turkey (Equivalent of the NIH in the US). (Website: www.tuseb.gov.tr/english). 2013-today, TUBA GEBIP Awards Referee (7x), TUBA Academic Referee (2x) and Scientific Book Translation Award Referee (2x), Turkish Academy of Sciences (TUBA). 2014-today, Editorial Board Member, Turkish Journal of Biology (TUBITAK Publishing. SCI Impact Factor 2017: 1.04) 2014, Guest Co-Editor, Turkish Journal of Biology 2013, Academic Advisor, Izmir High Technology Institute, Gebze Technical University, Erciyes University, Acibadem University. 2012- today, Grant Referee, TUBITAK (National Science and Technology Council of Turkey), TR Ministry of Development, Hacettepe University, Uludag University, Ankara University, Gebze Technical University, Dokuz Eylul University.

C) Scientific Meeting Organization (As a primary organizer or co-organizer), 1) 1st International Cell Death Research Congress, 9 Eylul University, 4-7 May 2016, Izmir, Turkey. 2) 1st Autophagy Lab Techniques Practical Course, Sabanci University, 2 May 2016, Istanbul, Turkey. 3) 2nd Karakoy Autophagy Symposium, Karakoy Minerva Han, 3 May 2016, Istanbul, Turkey. 4) 1st Karakoy Autophagy Symposium, Karakoy Minerva Han, 22 October 2014, Istanbul, Turkey. 5) International Cell Death Society (ICDS) Conference on Multidisciplinary Approaches in Cell Death Research, 28-31 May 2010, Antalya, Turkey. 6) European Molecular Biology Organization (EMBO) International Forum, 20-22 February 2008, Bogazici University, Istanbul, Turkey. 7) International Cell Death Symposium, Cerrahpasa Medical Faculty, 9 April 2008, Istanbul, Turkey.

3 INVITED LECTURES

A) Keynote/Plenary Invited talks and/or Chairperson (International Meetings)

1) International Cell Death Society (ICDS) Conference on: "Cell Death through the Ages: 25th Anniversary Meeting", 27-30 June, 2019, New York, USA. 2) Annual Meeting and Symposium of the Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, 22 February, 2019, Albuquerque, New Mexico, USA. 3) Keystone Conference on Autophagy: From Model Systems to Therapeutic Opportunities, 17—21 February, 2019, Santa Fe, New Mexico, USA. 4) 4th INDERCOS Dermatology and Cosmetology Congress, 27-30 March 2019, Istanbul, Turkey. 5) European Federation For Pharmaceutical Sciences Annual Meeting, 24-26 May, 2018, Athens, Greece. 6) EMBO Young Scientist Forum, 5-6 January 2018, Istanbul, Turkey. 7) International Cell Death Society (ICDS) Conference on: "Cell Death in Development and Disease", June 18-20, 2017, Rehovot, Israel. 8) VI. International Congress of Molecular Medicine, 22-25 May 2017 Istanbul, Turkey. 9) 4rd General Assembly Meeting of HealthyMinorCereals, 11 – 12 May, 2017, Greece. 10) First Joint WGs Meeting of TRANSAUTOPHAGY (COST Action CA15138), 6-7 October 2016, Warsaw, Poland. 11) 41st FEBS Congress on "Molecular ans Systems Biology for a Better Life", 3-8 Spetember 2016, Ephesus, Turkey (Cancelled). 12) International Cell Death Society (ICDS) Conference on: "Cell Death and its Translational Ramification, 2-5 June, 2016, Cork, Ireland. 13) 3rd General Assembly Meeting of HealthyMinorCereals, 10-11 May 2016, Berlin, Germany. 14) 1st International Cell Death Research Congress, 04-07 May 2016, Izmir, Turkey. 15) 2nd Karakoy Autophagy Symposium and 1st Autophagy Practical Course, 3 May 2016, Istanbul, Turkey. 16) Black Forest Winter Conference on Autophagic Membrane Trafficking and Dynamics in Ageing and Disease, 29-31 January 2016, Freiburg, Germany. 17) 1st Pharmacogenomics Summit, 27-28 November 2015, Istanbul, Turkey. 18) International Cofactor Life Sciences Conference (ICLS), 21-22 November 2015, Istanbul, Turkey. 19) 1st Karakoy Autophagy Symposium, 22 October 2014, Istanbul, Turkey. 20) TUBITAK-USA Cancer and Cancer Stem Cells Workshop, 8-10 October 2015, Manisa, Turkey. 21) 3rd International BAU Drug Design Congress, 1-3 October 2015, Istanbul, Turkey. 22) 24th International Symposium on Morphological Sciences, 2-6 September 2015, Istanbul, Turkey. 23) EMBO (European Molecular Biology Organization)-Cancer YIP Sectoral Meeting 2-4 September 2015, Prague, Czech Republic.

4 24) International Cell Death Society (ICDS) Conference on: Implementation of Knowledge of Cell Death, 28-30 May 2015, Prague, Czech Republic. 25) 5th International Congress of Molecular Medicine: From Cell to Bedside, 20-22 May 2015, Izmir, Turkey. 26) The European Association for Cancer Research (EACR) Sponsored 3nd Anticancer Agents Development Congress, 18 - 19 May 2015, Izmir, Turkey. 27) Autophagy and Cancer Symposium, Centre de Recherches en Cancérologie de Toulouse, 15-19 September, 2014, France. 28) EMBO-Cancer YIP Sectoral Meeting, Institut Paoli-Calmettes/Centre de Recherche en Cancérologie de Marseille, 17-19 September, 2014, France. 29) International Cell Death Society (ICDS) Conference on: Cell Death and Diseases, 8-10 May 2014, Capetown, South Africa. 30) Istanbul Kultur University Nanotechnology and Tissue Engineering Conference, 20-21 December 2014, Istanbul, Turkey. 31) Federation of Biochemical Societies (FEBS) Advanced Lecture Course: 360° Degree Lysosome, 23- 28 October 2014, Izmir, Turkey. 32) EMBO-Cancer YIP Sectoral Meeting, 8-10 September 2013, Antalya, Turkey. 33) European Microscopy Society Conference 2013, 25-30 August 2013, Regensburg, Germany. 34) International Cell Death Society (ICDS) Conference on: “Mechanisms of cell death”, 6-9 June 2013, Malaga, Spain. 35) Bezmialem Medical Biology Annual Research Symposium, 14-15 May 2013, Istanbul, Turkey. 36) TUBITAK: The EMBO Meeting, 16 January 2013, Ankara, Turkey. 37) EMBO-Cancer YIP Sectoral Meeting, EMBL, 2-4 December 2012, Heidelberg, Germany. 38) International Cell Death Society (ICDS) Conference on: “Cell death: Ageing, Metabolism and Ramifications for Therapeutics and Drug Development”, 29 June-1 July 2012, Singapore. 39) EMBO Forum 2012. Yeditepe University, 2012, Istanbul, Turkey. 40) Keystone Symposium: Cell Death Pathways: Beyond Apoptosis, 19-24 March 2012, Banff, Alberta, Canada. 41) EMBO-Cancer YIP Sectoral Meeting, King’s College, 11-13 July 2011, London, United Kingdom. 42) 4th International Congress of Molecular Medicine, 27-30 June 2011, Istanbul, Turkey. 43) International Cell Death Society (ICDS) Conference on: “Multidisciplinary Approaches in Cell Death Research”, Kemer, 28-31 May 2010, Antalya, Turkey. 44) Genetics of Neurological Disorders Workshop, Bosphorus University, 15-17 October 2010, Istanbul, Turkey. 45) EMBO Conference on "Autophagy: Cell Biology, Physiology and Pathology", 18-21 October 2009, Ascona, Switzerland. 46) International Cell Death Society Conference on “Cell Death in Infectious Diseases and Cancer”, 5-9 June 2009, Johannesburg, South Africa. 47) European Workshop on Cell Death (EWCD), 1-6 June 2008, Hauenstein, Germany.

5 48) European Molecular Biology Organization (EMBO) International Forum, Bogazici University, 20- 22 February 2008, Istanbul, Turkey. 49) International Cell Death Symposium, 9 April 2008, Istanbul, Turkey. 50) Keystone Conference: Metabolomics: From Bioenergetics to Apoptosis (G5), 2-7 April 2006, Utah, USA. 51) Roche Symposium for "For leading scientists of the next decade”, 29-31 March 2006, Basel, Switzerland. 52) Gordon Research Conference (GRC) on "Autophagy in Stress, Development and Disease", 22-27 June 2003, Maine, USA. 53) International Conference on the Molecular Biology of Hepatitis B Virus, Pasteur Institute, 17-21 September 2000, Paris, France. 54) 47th Conference of French Association of Liver Research (AFEF), 27-29 September 2000, Paris, France.

B) Keynote/Plenary Invited talks (National Meetings)

55) ORPHEUS Approach: Graduate Mentorship Education in Biomedicine and in Health Sciences, Acibadem University, 24 December 2018, Istanbul, Turkey. 56) Istanbul Arel University Molecular Cancer Research Congress, 15-16 November 2018, Istanbul, Turkey. 57) 2nd National Hepatocellular Carcinoma Congress, 23-25 February 2018, Adana, Turkey. 58) 15th National Medical Biology and Genetics Congress, 26-29 October 2017, Mugla, Turkey. 59) 43rd National Physiology Congress, Denizli, Turkey. 60) 2nd Bioinformatics Forum, 26 May 2017, TUBITAK Marmara Research Center, Istanbul, Turkey. 61) Molecular Cancer Summit, 25-26 March 2017, Istinye University Istanbul, Turkey. 62) 1st Hepatocellular Carcinoma Symposium, 10-12 February 2017, Adana, Turkey. 63) Cell Death Research Association GTU Workshop, 9-11 February 2017, Kocaeli, Turkey. 64) Aziz Sancar DETEA Institute Symposium, 9-10 December 2017, Istanbul, Turkey. 65) 23rd National Pharmacology Congress, 7-10 September 2015, Ankara, Turkey. 66) Molecular Biology Association Winter Retreat (Chair), 16-17 January 2015, Ankara, Turkey. 67) Excellence Science: ERC Enables Young Researchers Joint Symposium of TUBA and TUBİTAK, 29 August 2014, Istanbul, Turkey. 68) 5th Multidisciplinary Cancer Research Congress, 23 - 27 April 2014, Mugla, Turkey. 69) Cell Death Research Association's First Conference with International Participation, 30 October- 03 November 2013, Izmir, Turkey. 70) National Cancer Conference, 19-23 April 2013, Antalya, Turkey. 71) 2nd Cell Death Research Techniques Course, 1-2 November 2012, Eskisehir, Turkey.

6 72) Current Approaches Symposium, Acıbadem University Medical Faculty, 28 December 2011, Istanbul Turkey. 73) Ist Theoretical Course on Cell Death Research Techniques, 24-25 November 2011, Izmir, Turkey. 74) 3rd DETEA Conference, 17-18 November 2011, Istanbul, Turkey. 75) Acıbadem University Mini Symposium: Fluorescence Techniques, Applications in Biology and Medicine, 5 November 2010, Istanbul, Turkey. 76) 3rd Multidisciplinary Cancer Research Symposium, 14-17 March 2010, Bursa, Turkey. 77) 20th National Immunology Congress, 19-22 November 2009, Girne, Northern Cyprus. 78) 19th National Electron Microscopy Congress, 22-25 June 2009, Trabzon, Turkey. 79) 25th Turkish National Gastroenterology Week, 12-16 November 2008, Adana, Turkey. 80) 10th Turkish National Medical Biology and Genetics Congress, Belek, 6-9 September 2007, Antalya, Turkey.

C) Invited Seminars in Universities, Institutes and Organizations Invited seminars in University of Nottingham (UK), DKFZ (Germany), ICGEB Trieste (Italy), University of Haifa (Israel), King's College (UK), Hacettepe Medical Faculty, Koç University (2x), Yeditepe University (3x), Boğaziçi University (2x), Bilkent University (2x), Istanbul University Science Faculty, Istanbul University DETAE/Aziz Sancar Institute (2x), Istanbul University Cerrahpaşa Faculty of Medicine, Istanbul Technical University, Ege University, Dokuz Eylul University (2x), Izmir Institute of Technology (IYTE), Yildiz Technical University, Acibadem University (2x), Biochemistry Association, Pharmacologists Association, IU Çapa DETAE (2x), Izmir International Biomedicine and Genome Institute (iBG), Arel University.

PATENTS AND INVENTIONS

1) Gozuacik D, Kutlu O, Akkoc Y, Akkiz H. IL as a novel biomarker and drug target in fatal liver cancer. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2019/051107. December 18, 2019. Pending. 2) Gozuacik D, Kutlu O, Kocaturk NM, Kilislioglu A, Karakus S, Kutlu M, Ilgar M, Ben Taleb AM, Tan E. Nano formulations comprizing Ceranib-2. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2019/050247. April 16, 2019. Pending. 3) Akgonul S, Zuvin M, Sevgen MI, Kosar A, Gozuacik D; Kutlu O, Yagci-Acar H. Rotary Magnetic Actuation System. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2019/050115. February 20, 2019. Pending. 4) Gozuacik D, Ozturk DG, Kocak M. Stress-Regulated Mirnas As Novel Cancer Biomarkers. WIPO- Patent Cooperation Treaty. Application Number: PCT/TR2019/050004. January 2, 2018. Pending. 5) Yagci-Acar H, Gozuacik D, Kosar A, Unal O, Kocak M, Akkoc Y, Zuvin M. Therapeutic nanoparticles containing a protein for microRNA delivery and compositions and methods using same. WIPO-Patent Cooperation Treaty. Application Number: PCT/TR2018/050094. March 10, 2018. Pending. 6) Kosar A, Gozuacik D, Sadaghiani AH, Motazakker A, Akkoc Y. Heat exchanger with enhanced heat transfer surfaces. Turkish Patent Institute. Application Number: 17T-10468. April 14, 2017. Pending. 7) Gozuacik D. Usage of FC for cancer diagnosis and treatment. European Patent Office Patent Application Number: EP3067422. March 13, 2013. Pending. 8) Cho YK, Bathany C, Kim JY, Gozuacik D. Device and method for single cell screening-based on inter- cellular communication. WIPO-Patent Cooperation Treaty. Patent Application Number: WO2016099207. June 23, 2016. Pending. USA Patent Office. Patent Number: 10385306. August 20, 2019. Approved. 9) Gozuacik D and Korkmaz G (PhD Student). Use of miRNAs for the diagnosis, propylaxis, treatment and follow-up of diseases involving macroautophagy abnormalities. European Patent Office Patent Number: EP10777121.4. April 05, 2012-2015. Approved.

8 SELECTED PUBLICATIONS

1) Unal O*, Akkoc Y*, Kocak M*, Nalbat E, Gulgun MA, Dogan-Ekici AI, Yagci-Acar Hx, Gozuacik Dx. Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles. Journal of Nanobiotechnology, DOI: 10.1186/s12951-020-00615-4. (SCI Impact factor: 5.34). 2) Ozturk DG, Kocak M, Akcay A, Kinoglu K, Buyuk Y, Kazan H and Gozuacik Dx. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy, 2019. 15(3): 375-390. (Top 5 percentile journal in the Cell Biology field) (SCI Impact factor: 11.1). 3) Onal G, Kutlu O, Ozere E, Gozuacik D, Karaduman A, Dokmeci-Emre Sx. Impairment of Lipophagy by PNPLA1 Mutations Cause Lipid Droplet Accumulation in Primary Fibroblasts of Autosomal Recessive Congenital Ichthyosis Patients. Journal of Dermatological Science, 2019, 93(1): 50-57. (Impact factor: 3.98). 4) Kocaturk N and Gozuacik Dx. Crosstalk between autophagy and the ubiquitin-proteasome system. Frontiers in Cell and Developmental Biology, 2018, 6(128), doi: 10.3389/fcell.2018.00128. (SCI Impact factor: 4.4) (SCI citations: 25). 5) Karakas HE, 1, Kim J, 1, Park J, Oh JM, Choi Y, Gozuacik Dx, Cho YKx. A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche. Scientific Reports, 2017, 7(1): 2050. DOI: 10.1038/s41598-017-02172-7. (SCI Impact factor: 5.2) (SCI citations: 9). 6) Gozuacik Dx, Akkoc Y, Ozturk DG and Kocak M. Autophagy, microRNAs and cancer. Frontiers in Oncology, 2017, 7:65. DOI: 10.3389/fonc.2017.00065.(SCI Impact Factor: 4.7) (SCI citations: 50). 7) Erbil S, Oral O*, Mitou G*, Cenk Kig, Durmaz-Timucin E, Guven-Maiorov E, Gulacti F, Gokce G, Dengjel J, Sezerman OU, Gozuacik Dx. RACK1 is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy. The Journal of Biological Chemistry (JBC), 2016, 291(32): 16753-65. (Eigenfactor: Ranked 2nd in Biochemistry) (SCI Impact Factor: 4.6) (SCI Citations: 15). 8) Bayraktar O, Oral O*, Kocaturk NM*, Akkoc Y, Eberhart K, Kosar A, Gozuacik Dx. IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation. PLOS ONE, 2016, 11(10): e0164864. DOI: 10.1371/journal.pone.0164864. (SCI Impact factor: 3.5) (SCI citations: 31). 9) Demir F, Hocaoglu I, Ozturk DG, Gozuacik D, Kiraz A, Yagci-Acar Hx. Highly Luminescent and Cytocompatible Cationic Ag2S NIR-emitting Quantum Dots for Gene Transfection and Optical Imaging. Nanoscale, 2015. 26: 11352-11362. (SCI Impact Factor: 6.7) (SCI Citations: 30). 10) Tekirdag KA, Korkmaz G, Ozturk DG, Agami R, Gozuacik Dx. MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy, 2013. 9(3): 374-85 (SCI Impact Factor: 12) (SCI citations: 103).

9 11) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacik Dx. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy, 2012. 8(2): 165-176. (SCI Impact Factor: 12) (SCI citations: 149). 12) Oral O*, Oz-Arslan D*, Zeynep Itah, Naghavi A, Deveci R, Karacali S, Gozuacik Dx. Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death. Apoptosis, 2012, Aug;17(8):810-20. (SCI Impact Factor: 4) (SCI citations: 79). 13) Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi Ax. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death and Differentiation, 2008. 15(12): 1875-86 (SCI Impact Factor: 8.4) (SCI citations: 167). 14) Llambi F, Calheiros F, Gozuacik D, Pays L, Del Rio G, Kimchi A, Mehlen Px. The dependence receptor UNC5H2 mediates apoptosis through DAP kinase. EMBO Journal, 2005 Mar 23;24(6): 1192-201 (SCI Impact Factor: 11.7) (SCI citations: 114). 15) Shani G, Marash L, Gozuacik, D, Bialik S, Teitelbaum L, Shohat G and Kimchi Ax. Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions. Molecular and Cellular Biology (MCB), 2004. 24(19): 8611-26. (SCI Impact Factor: 6) (SCI citations: 80). 16) Gozuacik D and Kimchi Ax. Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 2004 23(16): 2891-906. (Selected by Thomson Reuters as one of the 48 core papers on autophagy.) (SCI Impact Factor: 8.5) (SCI citations: 1048). 17) Gozuacik D, Chami M, Murakami Y, Faivre J, Lagorce D, Poch O, Biermann O, Knippers R, Bréchot C, Paterlini-Bréchot Px. Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. Nucleic Acids Research, 2003. 31(2): 570-9. (SCI Impact Factor: 8.8) (SCI citations: 68). 18) Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C, Paterlini-Brechot Px. Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging. Oncogene, 2001. 20(43): 6233-40. (SCI Impact Factor: 8.5) (SCI citations: 78). 19) Chami M*, Gozuacik D*, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Brechot C, Paterlini-Brechot Px. SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. Journal of Cell Biology (JCB), 2001. 153(6): 1301-14. (SCI Impact Factor: 10) (SCI citations: 54). 20) Chami M*, Gozuacik D*, Saigo K*, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Brechot C, Paterlini-Brechot Px. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. Oncogene, 2000. 19(25): 2877-86. (SCI Impact Factor: 8.5) (SCI citations: 44).

10 PUBLICATION LIST

ARTICLES UNDER REVISION, SUBMITTED OR IN PREPARATION 1) Ozturk DG, Kocak M, Yapici MK and Gozuacik Dx. Stress-related microRNAs are novel markers of colon cancer diagnosis. In preparation. 2) Akkoc Y, Tekirdag KA, Dogan-Ekici D and Gozuacik Dx. Overexpression of the autophagomir determines tumor size in breast cancer mice models and in patient samples. In preparation. 3) Pathak B, Christy J, Sefiane K, Gozuacik D. Study of Complex Pattern Formation in Solutions of Protein and Mixed Salts Using Dehydrating Sessile Droplets. Langmuir (SCI Impact factor: 3.68). Submitted. 4) Kutlu O, Kaleli HN, Yedier O, Kilic S, Yuce A, Dokmeci Sx, Gozuacik Dx. Lysosomal abnormalities in Gaucher Disease are significantly improved and the activity of mutant acid-β glucosidase restored using a gene therapy approach. Journal of Inherited Metabolic Disease (SCI Impact factor: 4). Submitted. 5) Akkoc Y*, Karakas HE*, Akkiz H, Dogan-Ekici D and Gozuacik Dx. Tumor-derived cytokine is an activator of autophagy in stroma fibroblasts and a critical mediator of stroma-assisted breast cancer cell migration, invasion and metastasis. Journal of Clinical Investigation (SCI Impact factor: 12.28). Submitted. 6) Kocaturk NM, Eberhart K and Gozuacik Dx. Direct interaction and coordination between UPS and autophagy components controls mitophagy. Autophagy (SCI Impact factor: 11.1). Under revision .

ORIGINAL RESEARCH AND REVIEW ARTICLES 7) Unal O*, Akkoc Y*, Kocak M*, Nalbat E, Gulgun MA, Dogan-Ekici AI, Yagci-Acar Hx, Gozuacik Dx. Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles. Journal of Nanobiotechnology, DOI: 10.1186/s12951-020-00615-4. (SCI Impact factor: 5.34). 8) Peker N and Gozuacik Dx. Autophagy as a cellular stress response mechanism in the nervous system. Journal of Molecular Biology, S0022-2836(20)30069-3. (SCI Impact factor: 5.06). 9) Akkoc Y and Gozuacik Dx. MicroRNAs and autophagy. Biochimica Biophysica Acta (BBA)- Molecular Cell, 1867(5):118662. (SCI Impact factor: F: 4.5). 10) Demir-Duman F, Akkoc Y, Demirci G, Bavili N, Kiraz,A, Gozuacik Dx, Yagci Acar Hx. Bypassing pro-survival and resistance mechanisms of autophagy in EGFR-positive lung cancer cells by targeted delivery of 5FU using theranostic Ag2S quantum dots. Journal of Materials Chemistry B, 2019, 7(46):7363-7376. (SCI Impact factor: 4.54). 11) Ozturk DG, Kocak M, Akcay A, Kinoglu K, Buyuk Y, Kazan H and Gozuacik Dx. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy, 2019. 15(3): 375-390. (Impact factor: 11.1). 12) Kocaturk NM, Akkoc Y, Kig C, Bayraktar O, Gozuacik D, Kutlu Ox. Autophagy as a molecular target for cancer treatment. European Journal of Pharmaceutical Sciences, 2019 Apr 11;134:116-137. (SCI Impact factor: 3.46).

11 13) Onal G, Kutlu O, Ozere E, Gozuacik D, Karaduman A, Dokmeci-Emre Sx. Impairment of Lipophagy by PNPLA1 Mutations Cause Lipid Droplet Accumulation in Primary Fibroblasts of Autosomal Recessive Congenital Ichthyosis Patients. Journal of Dermatological Science, 2019, 93(1): 50-57. (Impact factor: 3.98). 14) Akkoc Y, Lyubenova L, Grausgruber H, Janovská D, Yazici A, Cakmak Ix and Gozuacik Dx. Minor cereals exhibit superior antioxidant effects on human epithelial cells compared to common wheat cultivars. Journal of Cereal Science, 2019, 85: 143-152. (Impact factor: 2.45). 15) Ozturk DG, Kocak M, Gozuacik D. Cloning of Autophagy-Related MicroRNAs. Methods Mol Biol., 2019, 1854:131-146. doi: 10.1007/7651_2017_83. 16) Zuvin M, Kuruoglu E, Kaya VO, Unal O, Kutlu O, Yagci Acar H, Gozuacik D, Kosar Ax. Magnetofection of Green Fluorescent Protein Encoding DNA-Bearing Polyethyleneimine-Coated Superparamagnetic Iron Oxide Nanoparticles to Human Breast Cancer Cells. ACS Omega, 2019, 4(7): 12366-12374. 17) Zuvin M, Kocak M, Unal O, Akkoc Y, Kutlu O, Yagci-Acar H, Gozuacik D, Kosar Ax. Nanoparticle Based Induction Heating at Low Magnitudes of Magnetic Field Strengths for Breast Cancer Therapy. Journal of Magnetism and Magnetic Materials, 2019. 483: 169-177. (Impact factor: 3.04). 18) Ozbey A, Karimzadehkhouei M, Kocaturk NM, Erbil Bilir S, Kutlu O, Gozuacik D, Kosar Ax. Inertial focusing of Cancer Cell Lines in Curvilinear Microchannels. Micro and Nano Engineering, 2019. DOI: doi.org/10.1016/j.mne.2019.01.002. 19) Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Liu M, Hall P, Sklar LA, Allers L, Mariscal L, Garcia SA, Weaver J, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Chen GC, Elazar Z, Eskelinen EL, Fourie B, Gozuacik D, Hong W, Jo EK, Johansen T, Juhász G, Kimchi A, Ktistakis N, Kroemer G, Mizushima N, Münz C, Reggiori F, Rubinsztein D, Ryan K, Schroder K, Shen HM, Simonsen A, Tooze SA, Vaccaro M, Yoshimori T, Yu L, Zhang H, Klionsky DJ. Autophagy, Inflammation, and Metabolism (AIM) Center in its second year. Autophagy, 2019 Oct;15(10):1829-1833. (SCI Impact Factor: 11.1). 20) Yar Y, Khodadust R, Akkoc Y, Gozuacik D, Yagci Acar Hx. Development of PNIPAM/SPION nanoparticles by ATRP for dually responsive doxorubicin delivery and MR imaging. Journal of Materials Chemistry B, 2018, 6, 289-300. (SCI Impact factor: 4.54). 21) Boyd LS, Gozuacik D, Joubert Ax. The in vitro effects of a novel estradiol analogue on cell proliferation and cell morphology in human epithelial cervical carcinoma. Cellular and Molecular Biology Letters, 2018, 23(10). DOI: 10.1186/s11658-018-0079-z. (SCI Impact factor: 1.26). 22) Altun E, Aydogdu MO, Koc F, Kutlu O, Gozuacik D, Yucel S, Gunduz Ox. Amoxicillin Loaded Hollow Microparticles in the Treatment of Osteomyelitis Disease Using Single-Nozzle Electrospinning. BioNanoScience, 2018, p1-12, DOI: 10.1007/s12668-018-0539-y. 23) Kocaturk N and Gozuacik Dx. Crosstalk between autophagy and the ubiquitin-proteasome system. Frontiers in Cell and Developmental Biology, 2018, 6(128), doi: 10.3389/fcell.2018.00128. (SCI Impact factor: 4.4).

12 24) Vojo Dereticx, Eric Prossnitz, Mark Burge, Matthew J. Campen, Judy Cannon, Ke Jian Liu, Larry A. Sklar, Lee Allers, Sally Ann Garcia, Eric H. Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Gozuacik D, Wanjin Hong, Gökhan Hotamışlıgil, Marja Jäättelä, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru MIzushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Anne Simonsen, Sharon Tooze, Maria Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang & Daniel J. Klionsky. Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy, 2018. DOI: 10.1080/15548627.2018.1465784. (SCI Impact Factor: 11.1). 25) Akkoc Y, Gozuacik Dx. Autophagy and liver cancer. The Turkish Journal of Gastroenterology, 2018, DOI: 10.5152/tjg.2018.150318. Review. 26) Karakas HE, 1, Kim J, 1, Park J, Oh JM, Choi Y, Gozuacik Dx, Cho YKx. A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche. Scientific Reports, 2017, 7(1): 2050. DOI: 10.1038/s41598-017-02172-7. (SCI Impact factor: 5.2). 27) Motezakker A, Sadaghiani AK, Akkoc A, Semsari Parapari S, Gozuacik D, Kosar Ax. Surface modifications for phase change cooling applications via crenarchaeon Sulfolobus solfataricus P2 biocoatings. Scientific Reports, 2017, 7 (17891). doi:10.1038/s41598-017-18192-2. (SCI Impact factor: 5.2). 28) Elitas M, Sadeghi S, Karamahmutoglu H, Gozuacik D, Turhal NS. Microfabricated platforms to quantitatively investigate cellular behavior under the influence of chemical gradients. Biomedical Physics and Engineering Express, 2017, 3(3): 035023. doi.org/10.1088/2057-1976/aa7400. (Open Access Journal). 29) Akgönül S, Özbey A, Karimzadehkhouei M, Gozuacik Dx, Kosar Ax. The effect of asymmetry on micromixing in curvilinear microchannels. Microfluidics and Nanofluidics, 2017, 21: 118. DOI 10.1007/s10404-017-1952-1. (SCI Impact Factor: 2.34). 30) Erbil-Bilir S, Kocaturk NM, Yayli M, Gozuacik Dx. Study of protein-protein interactions in autophagy research. J. Vis. Exp. 2017, 127: e55881, doi:10.3791/55881 (2017). Technical Review. 31) Onal G, Kutlu O, Gozuacik D and Dokmeci S. Lipid droplets in health and disease. Lipids in Health and Disease, 2017, 16: 128. DOI: 10.1186/s12944-017-0521-7. Review. (IF: 2.1) 32) Gozuacik Dx, Akkoc Y, Ozturk DG and Kocak M. Autophagy, microRNAs and cancer. Frontiers in Oncology, 2017, 7:65. DOI: 10.3389/fonc.2017.00065.(Impact Factor: 4.7). 33) Tekirdag KA, Akkoc Y and Gozuacik Dx. MIR376 family and cancer. Histology and Histopathology, 2016, 4: 11752-11772. Review. (SCI Impact Factor: 2.1). 34) Ozbey A, Karimzadehkhouei M, Akgönül S, Gozuacik D, and Kosar Ax. Inertial Focusing of Microparticles in Curvilinear Microchannels (Circulating Tumor Cell (CTC) isolation biochip model). Scientific Reports, 2016, 6: 38809. DOI: 10.1038/srep38809. (SCI Impact factor: 5.2). 35) Bayraktar O, Oral O*, Kocaturk NM*, Akkoc Y, Eberhart K, Kosar A, Gozuacik Dx. IBMPFD Disease- Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation. PLOS ONE, 2016, 11(10): e0164864. DOI: 10.1371/journal.pone.0164864. (SCI Impact factor: 3.5).

13 36) Erbil S, Oral O*, Mitou G*, Cenk Kig, Durmaz-Timucin E, Guven-Maiorov E, Gulacti F, Gokce G, Dengjel J, Sezerman OU, Gozuacik Dx. RACK1 is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy. The Journal of Biological Chemistry, 2016, 291(32): 16753-65. (SCI Impact Factor: 4.6). 37) Ghorbani M, Oral O, Ekici S, Gozuacik D, Kosar Ax. Review on Lithotripsy and Cavitation in Urinary Stone Therapy. IEEE Rev Biomed Eng. 2016;9:264-83. DOI: 10.1109/RBME.2016.2573381. Review. (SCI Impact Factor: 5.7). 38) Oral Ox, Yedier O, Kilic S, Gozuacik D. Involvement of Autophagy in T cells Biology. Histology and Histopathology, 2016. May 26:11785. Review. (SCI Impact Factor: 2.1). 39) Klionsky DJ et al. (“International Autophagy Consortium” including Gozuacik D). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 2016, 12(1): 1-222. Review. (SCI Impact Factor: 12). 40) Ghorbani M, Yildiz M, Gozuacik D, Kosar Ax. Cavitating Nozzle Flow in Micro- and Minichannels under the Effect of Turbulence. Journal of Mechanical Science and Technology, 2016, 30(6): 2565–2581. (SCI Impact Factor: 1.13). 41) Ghorbani M, Alcan G, Unel M, Gozuacik D, Ekici S, Uvet H, Sabanovic A, Kosar Ax. Visualization of microscale cavitating flow regimes via particle shadow sizing imaging and vision-based estimation of the cone angle. Experimental Thermal and Fluid Science, 2016, 78: 322-333. (SCI Impact Factor: 2.83). 42) Oral Ox, Cıkım T, Zuvin M, Unal O, Yagci-Acar H, Gozuacik D, Kosar A. Effect of Varying Magnetic Fields on Targeted Gene Delivery of Nucleic Acid-based Molecules. Annals of Biomedical Engineering, 2015, pp 1-11, DOI: 10.1007/s10439-015-1331-6 (SCI Impact Factor: 3.2). 43) Demir F, Hocaoglu I, Ozturk DG, Kiraz A, Gozuacik D, Yagci-Acar Hx. Highly Luminescent and Cytocompatible Cationic Ag2S NIR-emitting Quantum Dots for Gene Transfection and Optical Imaging. Nanoscale, 2015. 26: 11352-11362. (SCI Impact Factor: 6.7). 44) Uzusen D, Demir E, Perk OY, Oral O, Ekici O, Unel M, Gozuacik D, Kosar Ax. Assessment of probe- to-specimen distance effect in kidney stone treatment with hydrodynamic cavitation. J. Med. Devices , 2015, doi: 10.1115/1.4030274. (SCI Impact Factor: 0.4). 45) Kucukgul C, Ozler SB, Inci I, Karakas E, Irmak S, Gozuacik D, Taralp A, Koc Bx. 3D Bioprinting of Biomimetic Aortic Vascular Constructs with Self-Supporting Cells. Biotechnology and Bioengineering, 2015. 112 (4): 811–821 (SCI Impact Factor: 4.2). 46) Ozlem Oralx, Yunus Akkoc, Gozuacik D. Physiological and Pathological Significance of Molecular Cross-talk Between Autophagy and Apoptosis. Histology and Histopathology, 2015, 18: 11714-11730. Review. (SCI Impact Factor: 2.1). 47) Ozbey A, Karimzadekhouie M, Yalcin SE, Gozuacik D, Kosar Ax. Modeling of ferrofluid magnetic actuation with dynamic magnetic fields in small channels. Microfluidics and Nanofluidics, March 2015, Volume 18, Issue 3, pp 447-460. (SCI Impact Factor: 2.34). 48) Gozuacik Dx, Yagci-Acar HF, Akkoc Y, Kosar A, Dogan-Ekici AI, Ekici S. Anticancer use of nanoparticles as nucleic acid carriers. Journal of Biomedical Nanotechnology, 2014. 10(9): 1751-1783. Review. (SCI Impact Factor: 7.6).

14 49) Karakas HE and Gozuacik Dx. Autophagy and cancer. Turkish Journal of Biology, 2014, 38: 720-739. Review. (SCI Impact Factor: 1.35). 50) Cıkım T, Gozuacik D, Kosar Ax. Power reclamation efficiency of a miniature energy harvesting device using external fluid flows. International Journal of Energy Research, 2014. Published online: DOI: 10.1002/er.3149. (SCI Impact Factor: 2.6). 51) Kurtoglu M, Kaya A, Gozuacik D, Yagci Acar HF, and Kosar Ax. Experimental study on convective heat transfer performance of iron oxide nanoparticle-based ferrofluids in microtubes. ASME Journal of Thermal Science and Engineering Applications, 2014. Published online: doi:10.1115/1.4026490. (SCI Impact Factor: 0.98). 52) Korkmaz G*, Tekirdag KA*, Ozturk DG, Kosar A, Sezerman OU and Gozuacik Dx. MIR376A is a regulator of starvation-induced autophagy. PLOS ONE, 2013. 8(12): e82556. DOI:10.1371/journal.pone. 0082556 (SCI Impact Factor: 3.5). 53) Tekirdag KA, Korkmaz G, Ozturk DG, Agami R, Gozuacik Dx. MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy, 2013. 9(3): 374-85 (SCI Impact Factor: 12). 54) Itah Z, Oral O, Perk OY, Sesen M, Demir E, Erbil S, Dogan-Ekici AI, Ekici S, Kosar A, Gozuacik Dx. Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue. Experimental Biology and Medicine, 2013. 238(11): 1242-50 (SCI Impact Factor: 2.8) 55) Erzurumlu Y, Kose FA, Gozen O, Gozuacik D, Eric A. Toth EA, Ballar Px. A unique IBMPFD-related p97/VCP mutation with differential binding pattern and subcellular localization. The International Journal of Biochemistry and Cell Biology, 2013, 45(4): 773-82 (SCI Impact Factor: 4.2). 56) Tekirdag KA and Gozuacik Dx. Role of miRNAs in the regulation of autophagy. Pakistan Journal of Clinical and Biomedical Research, 2013. Jul-Dec 1(2): 6-10. 57) Tekirdag AK, Ozturk DG and Gozuacik Dx. Alteration in autophagic-lysosomal potential during ageing and neurological diseases: The microRNA perspective. Current Pathobiology Reports, 2013. 1(4): 247- 261. Review. (Open Access Journal). 58) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacik Dx. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy, 2012. 8(2): 165-176. (SCI Impact Factor: 12). 59) Oral O*, Oz-Arslan D*, Zeynep Itah, Naghavi A, Deveci R, Karacali S, Gozuacik Dx. Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death. Apoptosis, 2012, Aug;17(8):810-20. (SCI Impact Factor: 4). 60) Kuzuoglu D, Cebeci-Yalcınkaya O, Akpinar BA, Mitou G, Korkmaz G, Gozuacık D, Budak Hx. Autophagy-related gene, TdAtg8, in wild emmer wheat plays a role in drought and osmotic stress response. Planta 2012, DOI: 10.1007/s00425-012-1657-3. (SCI Impact Factor: 3.4). 61) Perk OY, Sesen M, Gozuacik D, Kosar Ax. Kidney stone erosion by hydrodynamic cavitation and consequent kidney stone treatment. Annals of Biomedical Engineering, 2012. 40(9): 1895-902. (SCI Impact Factor: 2.4).

15 62) Klionsky DJ et al. (“International Autophagy Consortium” including Gozuacik D). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012 April; 8 (4): 1-100. Review. (SCI Impact Factor: 12). 63) Kosar Ax, Sesen M, Oral O, Itah Z and Gozuacik Dx. Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications. IEEE Transactions on Biomedical Engineering, 2011. 58(5): 1337-46. (SCI Impact Factor: 2.2). 64) Mitou G, Budak H, and Gozuacik Dx. Techniques to Study Autophagy in Plants. International Journal of Plant Genomics, 2009, Article ID 451357, 14 pages, 2009. doi:10.1155/2009/451357. Review (Scopus, Chemical Abstracts, PubMed, Google Scholar). 65) Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi Ax. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death and Differentiation, 2008. 15(12): 1875-86 (SCI Impact Factor: 8.4). 66) Gozuacik D and Kimchi Ax. Autophagy and cell death. Current Topics in Developmental Biology, 2007. 78: 217-45. Review. (SCI Impact Factor: 7.8). 67) Gozuacik D and Kimchi Ax. DAPk protein family and cancer. Autophagy, 2006 2(2): 74-79. Review. (SCI Impact Factor: 12). 68) Llambi F, Calheiros F, Gozuacik D, Pays L, Del Rio G, Kimchi A, Mehlen Px. The dependence receptor UNC5H2 mediates apoptosis through DAP kinase. EMBO Journal, 2005 Mar 23;24(6): 1192-201 (SCI Impact Factor: 11.7). 69) Shani G, Marash L, Gozuacik, D, Bialik S, Teitelbaum L, Shohat G and Kimchi Ax. Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions. Molecular and Cellular Biology, 2004. 24(19): 8611-26. (SCI Impact Factor: 6). 70) Gozuacik D and Kimchi Ax. Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 2004 23(16): 2891-906. Review. (Selected by Thomson Reuters as one of the 48 core papers on autophagy.).(SCI Impact Factor: 8.5). 71) Gozuacik D, Chami M, Murakami Y, Faivre J, Lagorce D, Poch O, Biermann O, Knippers R, Bréchot C, Paterlini-Bréchot Px. Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. Nucleic Acids Research, 2003. 31(2): 570-9. (SCI Impact Factor: 8.8). 72) Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Brechot Cx. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene, 2003 Jun 19;22(25):3911-6. (SCI Impact Factor: 8.5). 73) Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C, Paterlini-Brechot Px. Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging. Oncogene, 2001. 20(43): 6233-40. (SCI Impact Factor: 8.5). 74) Chami M*, Gozuacik D*, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Brechot C, Paterlini-Brechot Px. SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. Journal of Cell Biology, 2001. 153(6): 1301-14. (SCI Impact Factor: 10).

16 75) Chami M*, Gozuacik D*, Saigo K*, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Brechot C, Paterlini-Brechot Px. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. Oncogene, 2000. 19(25): 2877-86. (SCI Impact Factor: 8.5). 76) Brechot Cx, Gozuacik D, Murakami Y, Paterlini-Brechot P. Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Seminars in Cancer Biology, 2000. 10(3): 211-31. Review. (SCI Impact Factor: 9.1).

BOOK CHAPTERS 77) Bayraktar Ox and Gozuacik D. The crosstalk between miRNAs and autophagy in cancer progression. In the book: Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. In the book: Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Fayyaz S., Farooqi A. (Eds.) Springer Publishing 2018. ISBN: 978-3-319-71553-7 / 978-3-319-71552-0. 78) Erbil-Bilir S, Gozuacik D, Kutlu Ox. Autophagy as a physiological response of the body to starvation. In the book: Famine, Starvation, and Nutrient Deprivation: From Biology to Policy. Victor Preedy and Vinood B. Patel (Eds.) Springer Publishing 2017. ISBN: 978-3-319-55388-7. 79) Gozuacik Dx and Kig C. Cell death and autophagy: A historical perspective. In the book: Cell Death 1994-2014. Richard Lockshin and Zahra Zakeri (Eds.). An Anniversary Publication of the International Cell Death Society (ICDS). 2015. ISBN: 978-0-9894674-4-5. 80) Arachiche A and Gozuacik Dx. Autophagy in health and disease. In the book: Toxicity and autophagy in neurodegenerative disorders. Jose Manuel Fuentes (Ed.). Springer Publishing. 2015. ISBN: 978-3- 319-13938-8. 81) Tekirdag AK, Ozturk DG, Gozuacik Dx. Regulation of autophagy by miRNAs. Pages:. In the book: AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Hayat MA, (Ed). Elsevier Academic Press, 2015. ISBN: 9780128010327. 82) Eberhart K, Oral O, Gozuacik Dx. Induction of autophagic cell death by anticancer agents. Pages: 179- 202. In the book: AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Hayat MA, (Ed). Elsevier Academic Press 2013, ISBN: 978-012-405530-8 83) Paterlini-Brechot Px, Chami M and Gozuacik D. “Calcium ATPase Genes and Cell Transformation”. Pages 505-520. In the book: Calcium, The Molecular Basis of Calcium Action in Biology and Medicine. Pochet R, Donato R, Haiech J, Heizmann CW, Gerk V (Eds.). Springer Publishing, 2001. ISBN: 0-7923- 6421-X.

PUBLICATIONS IN TURKISH 84) Kocaturk NM and Gozuacik D. Hücre içi zar sistemleri (Intracellular membrane systems)(Translation to Turkish). In the book: Becker'in Hücre Dünyası (Translation of Becker's World of the Cell). Ali Osman Beldüz (Ed.), Palme Publishing, 2019. 85) Gozuacik Dx, Karakaş HE, Akkoç Y, Özata B. Otofaji ve kanser (Autophagy and cancer). In the book: Kanser Moleküler Biyolojisi. Yusuf Baran (Ed.), Nobel Publishing 2016.

17 86) Kocaturk NM and Gozuacik Dx. Otofaji ve Nörodejeneratif Hastalıklar (Autophagy and Neurodegenerative Diseases). Turkiye Klinikleri J Pharmacol-Special Topics 2017; 5(1): 11-20. 87) Oral O, Irmak S, Ekici S, Gozuacik Dx. Ürolojide otofaji (Autophagy in urology). Pages: 271-283. In the book: Moleküler Üroloji (Molecular Urology). Türkeri L, Ozer A, Narter F, (Eds). Urooncology Association Publishing. 2012. ISBN:978-975-01697-2-4. 88) Öz-Arslan D, Korkmaz G, Gozuacik Dx. Otofaji: Bir hücresel stres yanıtı ve ölüm mekanizması (Autophagy: A cellular stress and death mechanism). Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 2011 October; 2(4): 184-94. 89) Gozuacik Dx. Otofaji ve sinyal yolakları (Autophagy and signaling pathways). Pages 49-60. In the book: Hücre ölümü araştırma teknikleri. Kocturk S, Vatansever HS (Eds). Eskisehir Osmangazi University Press. 2012. ISBN No: 978-975-7936-95-4. 90) Gozuacik Dx. Otofaji analiz yöntemleri ve uygulama aşamaları (Autophagy analysis techniques and applications). Pages 133-146. In the book: Hücre ölümü araştırma teknikleri. Kocturk S, Vatansever HS (Eds). Eskisehir Osmangazi University Press. 2012. ISBN No: 978-975-7936-95-4. 91) Gozuacik Dx. Otofaji ve hücre ölümü. In the book: Programlı Hücre Ölümü Sempozyumu Kitabı. Editors: Öztürk M, Gozuacik D. İstabul Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri Dizisi, İstanbul 2008.

CONFERENCE PAPERS 92) Kim J, Karakaş Schüller HE, Choi Y, Gozuacik Dx, Cho YKx. Monitoring single tumor interactions with fibroblasts in autophagy activation. The 8th International Conference on Microtechnologies in Medicine and Biology (MMB), Seoul, S. Korea, 2016. 93) Kim J, Karakaş Schüller HE, Gozuacik Dx, Cho YKx. Single cell analysis on the role of TGF-β1 in autophagy of tumor cell-interacted stroma fibroblasts. 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Gyeongju, South Korea. MicroTAS 2015, pages: 358-360. 94) Kim J, Karakaş HE, Bathany C, Gozuacik Dx, Cho YKx. Screening chip for autophagy of fibroblast in tumor cell environment. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Antonio, USA. MicroTAS 2014, pages: 452-454. 95) Boyd LS, Gozuacik D, and Joubert AM. Antitumor signalling of a novel microtubule inhibitor in human epithelial cervical carcinoma. South African Journal of Science and Technology / Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie, 2014, 33 (1): 1. 96) Cikim T, Oral O, Unal O, Gozuacik D, Yagci Acar HF, Kosar Ax. Effect of varying magnetic fields on targeted gene delivery of nucleic acid-based molecules. 4th Micro Nano Flows Conference, UCL, London, UK, 2014. 97) Cıkım TA, Tatar O, Kaya, A, Gozuacik D and Kosar Ax. Power reclamation of a bio-inspired miniature device using internal flows. ASME, International Mechanical Engineering Conference Congress and Exhibition, Houston, Texas, USA. International Mechanical Engineering Congress and Exposition, 2013, 6 (PTS A and B): 195-205.

18 98) Kucukgul C, Ozler B, Karakas HE, Gozuacik D, Koc B. 3D hybrid bioprinting of macrovascular structures. 3rd ECCOMAS Thematic Conference on Tissue Engineering (ICTE), Leiria, Portugal. Procedia Engineering, 2013, Volume: 59 Pages: 183-192. 99) Kurtoglu E, Kaya A, Gozuacik D, Acar HFY, Kosar A. Heat Transfer Enhancement with Iron Oxide Nanoparticle Based Ferrofluids. 11th International Conference on Nanochannels, Microchannels and Minichannels , Sapporo, Japan. Proceedings of the 11th International Conference on Nanochannels, Microchannels and Minichannels, 2013, Article number V001T02A005: 1-7.

PUBLISHED ABSTRACTS 100) Gozuacik Dx. Autophagy: nobel prize and new results. Turkish Journal Of Molecular Biology and Biotechnology, 2 (Supplement 1): 17-17. 101) Yedier O, Kilic S, Gozuacik D, Kutlu Ox. PMA functions as an autophagy inhibitor through activation of a serine threonine kinase. Turkish Journal Of Molecular Biology and Biotechnology, 2(Supplement 1): 122-123. 102) Kilic S, Yedier O, Gozuacik D, Kutlu O. Identification of a serine-threonine kinase as a novel autophagic regulator. Turkish Journal Of Molecular Biology and Biotechnology, 2(Supplement 1): 113- 113. 103) Akkoc Y, Yar Y, Khodadust R, Gozuacik D, Yagci Acar H. Development of theranostic PNIPAM/SPION nanoparticles for cancer treatment. Turkish Journal Of Molecular Biology and Biotechnology, 2(Supplement 1): 47-48. 104) Karakas HE, Kim J, Park J, Oh JM, Choi Y, Gozuacik D, Cho YK. Autophagy analysis of tumor- fibroblast crosstalk on biochips. Turkish Journal Of Molecular Biology and Biotechnology, 2 (Supplement 1): 78-79. 105) Bayraktar O, Oral O, Kocaturk NM, Eberhart K, Kosar A, Gozuacik Dx. Autophagy targets an IBMPFD-related VCP/p97 mutant protein. Turkish Journal of Biochemistry, 2016, Volume 41, Special Issue 4, 185-185. 106) Kocaturk NM, Eberhart K, Gozuacik Dx. A novel regulator of mitophagy is a putative autophagy- UPS coordinator protein. Turkish Journal of Biochemistry, 2016, Volume 41, Special Issue 4, 184-184. 107) Akkoc Y, Tekirdag KA, Ekici-Dogan AI, Gozuacik Dx. miRNA 376 family and cancer. Turkish Journal of Biochemistry, 2016, Volume 41, Special Issue 4, 150-150. 108) Erbil S, Oral O, Mitou G, Cenk Kig, Durmaz-Timucin E, Guven-Maiorov E, Gulacti F, Gokce G, Dengjel J, Sezerman OU, Gozuacik Dx. A scaffold protein is an interaction partner of ATG5 and a novel regulator of autophagy. Turkish Journal of Biochemistry, 2016, Volume 41, Special Issue 4, 124-124. 109) Oral O, Bayraktar O, Yuce A, Dokmeci S, Gozuacik Dx. Molecular significance of autophagy in Gaucher disease. Turkish Journal of Biochemistry, 2016, Volume 41, Special Issue 4, 53-53. 110) Gozuacik Dx. Novel regulators of autophagy. Turkish Journal of Biochemistry, 2016, Volume 41, Special Issue 4, 18-18. 111) Akkoc Y, Tekirdag KA, Ekici-Dogan AI, Gozuacik Dx. miRNA 376 in breast cancer. Turkish Journal of Biochemistry, 2016, Volume 41, Special Issue 4, 185-185.

19 112) Gozuacik Dx. Novel ATG5 interactors in the control of basic autophagy and mitophagy. The FEBS Journal, 2016, Volume 283, Supplement 1: 30-30. 113) Onal G, Oral O, Taskiran EZ, Yuzbasioglu A, Karaduman A, Gozuacik Dx, Dokmeci Sx. The role of PNPLA1 protein in lipophagy mediated regulation of lipid droplets. The FEBS Journal, 2016, Volume 283, Supplement 1: 31-31. 114) Gozuacik Dx. Novel regulators of autophagy and relevance to human diseases Activity Name: XXIV International Symposium on Morphological Sciences, Anatomy, 2015, Volume 9, Suppl 2: 89-89.