Volume 201, April-June, 1977 A-29981, Effects on Prostaglandin E2

INDEX

Volume 201, April-June, 1977

A-29981, effects on prostaglandin E2 bevels in in- levels in organ culture of mat superior cervical flammatory exudate, 769 ganglia, 298 Acetabdehyde, blood concentrations, role of liver cy- Amine(s) tosobic abdehyde dehydmogenase isozymes in biogenic, brain, in developing hyperthyroid mats, control of, 471 modification by lithium, 92 Acetazolamide alone and in combination with para- p-Aminohippurate, metabolism and transport in rat thyroid hormone, effect on HCO3 and P04 excre- kidney slices, effect of gentamycin, 233 tion, 243 d-Amphetamine, effects on behavior maintained Acetybcholine under various schedules of food presentation in effects on potassium movements in guinea-pig squirrel monkeys, 33 sinus node, 669 Analgesic properties of adizomorphine, 580 -induced contractions of dog tracheabis muscle, Analgesics, activity in man, bibiary colic as model robe of depolarization in, 199 for assessment of, 444 release from rat superior cervical ganglia elicited Androgen-dependent systems in rat, effects of nan- by extracts of black widow spider glands, 312 cotics, 76 y-Acetybenic y-aminobutynic acid (catalytic imne- Anesthetics, conduction-blocking concentrations of, vemsibbe inhibitor of y-aminobutynic acid trans- correlated with nerve axon diameter, 340 aminase), antiseizure activity in mice, 606 Antiamrhythmic drugs, effect on triggered sustained Adams, H. R. , Parker, J. L. and Mathew, B. P.: The rhythmic activity in cardiac Purkinje fibers, 689 influence of ketamine on inotmopic and chrono- Anticoagulant effect of warfarin in rats, inhibited tropic responsiveness of heart muscle, 171 by 6-mercaptopunine, 547 Adjuvant pobyarthnitis I, as modified model of adju- Anticoagubants, coumanin and indandione, mecha- vant arthritis that permits simultaneous mea- nism of action in rat, 541 surements of humoral and cellular immune me- Anticonvubsant agents, iontophoretic, (phenytoin sponse, 1 and medazepam), effect on hippocampab neu- Aldehyde dehydrogenase isozymes, liver cytosobic, rons in mat, 613 robe in control of blood acetabdehyde concentra- Antiepibeptic drug(s)

tions, 471 - cannabidob comparisons and interactions in ex- Adler, M. W. , Tabbarida, R. J., 587 pemimentally induced seizures in rats, 26 Adrenergic antagonists, beta, enhancement of nor- ethosuximide, effects on spinal monosynaptic epinephrine-induced contractions in rat veins transmission, 320 by, 406 Antihypertensive agent Admenergic function, investigation in organ culture prazosin, alpha blocking action, 747 of rat superior cervical gangbion, 298 steroidab, effects of mexrenoate potassium in dog Adrenergic receptor, and mat, 762 alpha, blocking properties of prazosin, 747 Anti-inflammatory agent(s) alpha, potency of methyldopa metabolites studied nonstemoidal, effects on prostagbandin E2 levels in by effects on mebanocyte function in frog, 622 inflammatory exudate, 769 beta, in vivo labeling with ‘25I-hydmoxybenzybpin- nonsteroid (subindac), 8 dobol, 644 Antimuscaminic properties of dicycbomine hydro- Alcohol chloride in human and rabbit bladder muscle, conduction-blocking concentrations of, correlated 662 with nerve axon diameter, 340 Antiseizure activity of y-acetybenic y-aminobutynic effects on hypothalamic-pituitary-gonadal axis in acid in mice, 606 rat, 427 Antitumor drug action potentiated by centrophen- Abdosterone antagonist, stemoidab, effects of mexmen- oxine, 518 oate potassium in dog and mat, 762 Apomorphine Abboxan diabetes, mechanism ofprotection provided effect on feeding in intact and 6-hydmoxydopa- by n-butanob, 450 mine-treated rats, 386

787 788 INDEX Vol. 201

-induced vasodilatation in dog hindleg, 738 Besse, J. C., see Fedan, J. S. , 285 Anachidonic acid, vascular responses in perfused ca- Bicarbonate excretion, effect of acetazolamide and nine lung to, comparison with dihomo-y-lino- parathymoid hormone, 243 benic acid, 417 Biggio, G., see Neckers, L. M. , 110 Amnsdorf, M. F.: The effect of antiannhythmic drugs Bile, mat, excretion of diphenylhydantoin, effects of on triggered sustained rhythmic activity in cam- diazepam, 14 diac Purkinje fibers, 689 Bile duct ligation, rat, effects on hexobarbitab phar- Amruda, J. A. L., see Nascimento, L., 243 macokinetics, 534 Artery Bishop, V. S. , see Newman, R. K. , 723 femorab, canine, vasodilation due to urokinase in, Blood 731 acetabdehyde concentrations, role ofbiver cytosobic femonab, canine, vasodibation produced by apo- abdehyde dehydrogenase isozymes in control of, morphine in, 738 471 Ascorbic acid deficiency, effect on extrahepatic mi- rats, effect of wamfarmn on kinetics of vitamin K- crosomab metabolism of drugs and carcinogens dependent clotting factors in, 507 in guinea pig, 527 Blood pressure, role of central and peripheral mech- Atrium, isolated, guinea-pig, inhibition of nomepi- anisms in effects of a-methyldopa on, 400 nephrine uptake by phenoxybenzamine and Bogaert, M. G. , see Buybaert, W. A., 738 desmethylimipramine in, 192 Bowman, R. , see Lapkin, R. , 233 Awad, S. A. , see Downie, D. A. S., 662 Brain Axon, giant, squid, mechanism ofketamine block of biogenic amines, in developing hyperthyroid rats, nerve conduction in, 156 modification by lithium, 92 Azidomorphine, investigation of analgesic and mom- cyclic guanosine 3’ :5’-monophosphate levels, al- phine-bike properties of, 580 tenations after acute and chronic ethanol treatment, 103 Badger, T. M. , see Cicero, T. J., 427 mouse, beta admenergic receptor labeling with I25I Baiter, N. J., Cowden, M. W. and Schwartz, S. L.: hydroxybenzylpindobol, 644 Induction of membrane alteration by norepi- rat, effect of 6-hydroxydopamine on food intact, nephnine: Studies with macrophages and phos- 386 phobipid monobayers, 627 rat, methamphetamine-induced changes in me- Babten, N. J. and Schwartz, S. L.: Accumulation of tabobite bevels in, studies based upon mitochon- norepinephrine by macrophages and relation- dniab respiratory state, 117 ships to known uptake processes, 636 striatum, mat, differential effects if reserpine and Banbieri, E. J., Orzechowski, R. F. and Rossi, G. V.: tetnabenazine on synaptosomal dopamine bio- Measurement of pnostagbandin E2 in an inflam- synthesis and pools in, 357 matory exudate: Effects of nonstenoidal anti- tryptophan content, modulation of tryptophan hy- inflammatory agents, 769 droxybase activity by, 110 Barbital, action on leech Retzius cell, effect of cab- Bnainstem, mat, binding ofstrychnine and analogs to cium, 332 synaptic membranes of, 326 Barbiturates, action on leech Ratzius cell, effect of Brass, D. A., Loh, H. H. and Way, E. L.: Compani- calcium, 332 son of the effects of morphine on locomotor ac- Behavior tivity, analgesia and primary and protracted changes, long-term, in rhesus monkey after mub- physical dependence in six mouse strains, 368 tiple daily injections ofd-amphetamine, 593 Bromo-LSD, blocking effect on serotonin and dopa- discriminative effects of morphine in mat, 55 mine in Mytilis muscle, 350 discriminative effects of morphine in squirrel Brown, J. H., Nelson, D. L. and Molinoff, P. B.: monkey, 67 Organ culture of the rat superior cervical gan- fixed-ratio operant in morphine-dependent mats, glia, 298 suppression by naboxone compared to weight Bryant, S. H. , see Morgan, K. G. , 138 loss, 44 Bueschen, H. , see Hill, R. C. , 580 in squirrel monkeys maintained under various Bumetanide, new diuretic agent, sites and mecha- schedules of food presentation, effects of cocaine nisms of action in man, 251 and d-amphetamine, 33 Burgschat, H. and Netter, K. J.: Application of ac.- mepenidine effects on schedule-controlled me- polarography in a study of p-nitmoanisole me- sponding in pigeon, 434 tabobism and its kinetic properties, 482 Bell, R. D., see Cicero, T. J. , 76 Burns, J. J., see Kuenzig, W. , 527 Bell, R. G. , see Ren, P., 541 n-Butanol, mechanism of protection from abloxan Benzbmomamone, effects on uric acid uptake by sepa- diabetes provided by, 450 rated renal tubules of rabbit, 226 Buylaert, W. A., Wibbems, J. L. and Bogaert, M. G.: 1977 INDEX 789

Vasodilatation produced by apomorphine in the izing hormone, testosterone and androgen-de- hindleg of the dog, 738 pendent systems, 76 Bylund, D. B. , Chamness, M. E. and Snyder, S. H.: Clotting factors, vitamin K-dependent, in mats, ef- Beta adrenengic receptor labeling in intact ani- fects of warfamin on kinetics of, 507 mals with ‘25I-hydnoxybenzylpindobol, 644 Cobumn, R. F. and Yamaguchi, T.: Membrane potential-dependent and -independent tension in the Calcium canine tracheal muscle, 276 antagonists, new (2-substituted 3-dimethylamino- Cocaine 5,6-methylenedioxyindenes), pharmacological effects on behavior maintained under various evaluation, 126 schedules of food presentation in squirrel mon- interaction with barbiturates on leech Retzius keys, 33 cell, 332 effects ofdrug-induced contractions of depolarized Calcium ipodate, effects on uric acid uptake by sepa- smooth muscle of rat and guinea-pig vas defer- mated renal tubules of rabbit, 226 ens, 267 Callahan, W., see Gunll, N. J., 731 effect on feeding in intact and 6-hydroxydopa- Cannabidol- antiepibeptic drug comparisons and in- mine-treated rats, 386 teractions in experimentally induced seizures in Cohen, J. B. , see Dubois, J. M. , 148 rats, 26 Cohen, M. L. and Wiley, K. S.: Specific enhance- apek, R. and Esplin, B. : Effects ofethosuximide on ment of nonepinephnine-induced contraction in transmission of repetitive impulses and appar- rat veins after beta adrenergic antagonists, 406 ent rates of transmitter turnover in the spinal Colic, biliary, as model for assessing activity of an- monosynaptic pathway, 320 algesics in man, 444 Caputo, G. , see Sacchetti, G. , 444 Collins, A. C. , see Petersen, D. R. , 471 Carbon dioxide tension, urinary, in lithium carbon- Conney, A. H. , see Kuenzig, W. , 527 ate-treated patients, 456 Connor, J. D. , see Matthews, W. D., 613 Carpenter, F. G. , see Fedan, J. S. , 285 Consmoe, P. and Wolkins, A.: Cannabidiol-antiepi- Castor oil (see Ricinoleic acid) leptic drug comparison and interactions in ex- Catecholamine-induced tachycardia in isolated nab- penimentaiby induced seizures in rat, 26 bit sinoatmial node, possible involvement of Contractility, drug-induced, of depolarized smooth cyclic adenosine 3’:S’-monophosphate, 678 muscle of guinea-pig and rat vas defemens, ef- Catmavas, G. N. , see Hunt, W. A., 103 fects of denervation, cocaine, 6-hydmoxydopa- Cats, effects of ethosuximide on transmission of me- mine and reserpine, 267 petitive impulses and apparent rate of trans- Cowdon, M. W. , see Baiter, N. J., 627 mitten turnover in spinal monosynaptic path- Cyclic adenosine 3’:S’-monophosphate, possible in- way of, 320 volvement in catecholamine-induced tachycar- Cell(s) dia in isolated rabbit sinoatnial node, 678 isolated intestinal epithelial, cytotoxicity of nicin- Cyclic guanosine 3’:5’-monophosphate levels, brain oleic acid and other intestinal secretogogues on, bevels, alterations after acute and chronic 259 ethanol treatment, 103 leech Retzius, relationship of calcium and barbit- Cytotoxic action of antitumon drugs potentiated by urates on, 332 centrophenoxine, 518 lymphatic leukemia, human, effect of aromatic Cytotoxicity of micinobeic acid and other intestinal diamidines on thymidylate synthetase in, 554 secretagogues on isolated intestinal epithelial Cefazolin nephrotoxicity, in newborn rabbits, mole of cells, 259 renal anionic transport system, 778 Centrophenoxine, potentiation of antitumor drug Dalton, T. K. , see Hunt, W. A. , 103 action by, 518 Danibo, P., Jr., Hordof, A. J. and Rosen, M. R.: Cephaloridine nephrotoxicity, in newborn rabbits, Effects of disopyramide on electrophysiobogic role of renal anionic transport system, 778 properties of canine cardiac Purkinje fibers, 701 Chang, Yi-han: Adjuvant polyarthnitis I: Incorpora- Dantrolene sodium, mechanism of action, 138 tion of quantitative measurements of humonal Davis, J. E. and Mende, T. J.: A study ofthe binding and cellular immune response, 1 of sulfur to rat liver microsomes which occurs Chamness, M. E. , see Bybund, D. B. , 644 concurrently with the metabolism of O,O-di- Cicero, T. J. and Badger, T. M.: Effects ofalcohoi on ethyl O-p-nitrophenyl phosphorothioate (pana- the hypothalamic-pituitary-gonadal axis in the thion) to 0,0-diethyl O-p-nitnophenyl phos- male rat, 427 phate (paraoxon), 490 Cicero, T. J. , Bell, R. D. , Meyer, E. R. and Deitnich, R. A. , see Petersen, D. R. , 471 Schweitzer, J.: Narcotics and the hypothalamic- Denenvation, effects on drug-induced contractions of pituitary-gonadal axis: Acute effects on leutein- depolarized smooth muscle of rat and guinea- 790 INDEX Vol. 201

pig vas deferens, 267 role ofprostaglandins in production of pulmonary Depolarization, role in acetylchobine-induced con- dysfunction during spbanchnic arterial occlu- tractions of dog trachealis muscle, 199 sion shock in, 753 desmethybimipnammne, inhibition of nonepinephnine trachealis muscle, membrane potential-depend- uptake in isolated guinea-pig left atrium by, 192 ent and -independent tension in, 276 Diabetes, induced by abboxan, mechanism of protec- tmacheabis muscle, robe ofdepolanization in acetyl- tion provided by n-butanol, 450 choline-induced contractions of, 199 Diamidines, aromatic, complex inhibition of thymi- Dopa, effect on feeding in intact and 6-hydmoxydopa- dylate synthetase by, 554 mine-treated rats, 386 Diazepam, effects on bibiary excretion of diphenyl- Dopamine hydantoin in mat, 14 as neutnotnansmitten, in Mytilis, blocked by Dicycbomine hydrochloride, antimuscarinic and mensabyb, 350 noncompetitive antagonist properties in human biosynthesis and bevels in rat stmiatum, diffemen- and rabbit bladder muscle, 662 tiab effects ofreserpine and tetmabenazine, 357 Dihomo-y-binolenic acid (monoenoic pnostaglandin metabolism, in rat superior cervical ganglion, precursor), vascular responses in perfused ca- trans-synaptic modulation of, 654 nine lung to, 417 Dopamine f3-hydroxylase, enzymatic and immuno- Dioctyb sodium sulfosuccinate, cytotoxicity on iso- reactive, in nat serum, changes during growth bated intestinal epitheliab cells, 259 and development, 375 Dipsogenic response in rats treated chronically with Dopaminemgic agonists and antagonists, effects on nonethynodrel, ethinyl estradiol and both com- feeding in intact and 6-hydroxydopamine- bined, 84 treated rats, 386 Disopyramide, effects on electrophysiobogic proper- Downie, J. W. , Twiddy, D. A. S. and Awad, S. A.: ties of canine cardiac Pumkinje fibers, 701 Antimuscaminic and noncompetitive antagonist Diuretic agent, new (bumetanide), sites and mecha- properties of dicycbomine hydrochloride in iso- nisms of action in man, 251 bated human and rabbit bladder muscle, 662 Diuretic drugs, effects on uric acid uptake by sepa- Dresel, P. E. , see Man, R. Y. K. , 184 rated renal tubules of rabbit, 226 Drew, R. , Priestly, B. G. and O’Reilly, W. J.: Hexo- Discriminative effects barbital pharmacokinetics in mats after ligation of morphine in rat, 67 of the common bile duct, 534 of morphine in squirrel monkey, 67 Drug interaction(s) Dog(s) cannabidol and antiepileptic drugs in expenimen- active form of sulindac (anti-inflammatory agent) tabby induced seizures in rats, 26 in, 8 inhibition of anticoagulant effects of warfanin by cardiac Puninje fibers, effects of disopyramide on 6-mencaptopunine, 547 ebectrophysiobogic properties of, 701 Dubois, J. M. and Cohen, J. B.: Effect of pabytoxin conscious, effect of verapamil on left ventricular on membrane and potential and current of frog performance in, 723 myelinated fibers, 148 digitalis-induced arrhythmias in glucose- and in- Duggan, D. E. , Hooke, K. F., Risley, E. A. , Shen, T. sulin-induced hypokalemia in, 711 Y. and Van Amman, C. G.: Identification of the effect of dihomo-y-linolenic acid on vascular me- biologically active form of subindac, 8 sponses in perfused lung of, 417 Duggan, D. E. , Hooke, K. F. , White, S. D. , Nobl, R. effect of bidocaine and methyl bidocaine on cardiac M. and Stevenson, C. R.: The effects of pmobene- conduction in, 184 cid upon the individual components of indo- effects of acetazobamide and panathyroid hormone methacin elimination, 463 in HCO3 and P04 excretion in, 243 Dunnette, J. , see Olukotun, A. , 375 effects of mexrenoate potassium on, 762 effects ofpnobenecid on indomethacin elimination Electromechanical coupling, properties in canine in, 463 trachealis muscle, 276 femomal circulation, vasodilation due to urokinase Electrophysiobogic properties of canine cardiac Pur- in, 731 kinje fibers, effects of disopymamide, 701 hindbeg, vasodibatation produced by apomorphine El-hawari, A. M. and Plaa, G. I.: Effects of diaze- in, 738 pam on the bibiary excretion of diphenylhydan- involvement of prostagbandin and histamine in tom in the rat, 14 gastric vasodilation action of pentagastnin in, 8,9-Epoxyhexahydrocannabinol, immunosuppres- 421 sive effects in mice, 573 robe of central and peripheral mechanisms in me- Esplin, B. , see apek, R. , 320 diating effects of a-methybdopa on blood pres- Estnogenic agent (ethinyb estmadiol), alone and in sure and menin secretion in, 400 combination with norethynodrel, effects on dip- 1977 INDEX 791

sogenic response in rats, 84 superior cervical, rat, trans-synaptic modulation Ethanol, acute and chronic treatment, alterations in of dopamine metabolism in, 654 brain cyclic guanosine 3’:S’-monophosphate 1ev- Ganong, W. F. , see Fnankel, R. J., 400 els after, 103 Garcia, A. G., see Sanchez-Garcia, P., 192 Ethinyl estradiol, alone and in combiantion with Garrison, C. K., see Kanoum, F., 654 nonethynodrel, effects on dipsogenic response in Gelbart, A. , see Hall, R. J., 711 rats, 84 Gelbert, V. F. and Spanber, S. B.: A comparison of Ethosuximide, effects on transmission of repetitive the effects of naloxone upon body weight loss impulses and apparent rates of transmitter and suppression of fixed-ratio operant behavior turnover in spinal monosynaptic pathway, 320 in morphine-dependent mats, 44 Eye, rabbit, effects of morphine and naboxone on Gentamycin, effect on p-aminohippumate metabo- miosis and fluctuation in pupil, 587 bism and transport in rat kidney slices, 233 Gerkins, J. F., Fbexner, C., Oates, J. A. and Shand, Farley, J. M. and Miles, P. R.: Role of depolarization D. G.: Prostaglandin and histamine involve- in acetybcholine-induced contractions ofdog tra- ment in the gastric vasodilator action of penta- chealis muscle, 199 gastnin, 421 Faust, M. M. , see Rahwan, R. G. , 126 Gland, submaxillary, mat, effects of neserpine pre- Fedan, J. S. , Besse, J. C. , Carpenter, F. G. and treatment on potassium release in vitro from, Teague, R. S.: Motor innervation of the smooth 206 muscle of the rat seminal vesicle, 285 Glucose and insulin infusion, digitalis-induced an- Fischer, L. J. , see Schaubenger, C. W. , 450 mhythmias in hypokabemia induced by, 711 Fischman, M. W. and Schuster, C. R.: Long-term Go, V. L. W. , see Gaginebba, T. S. , 259 behavioral changes in the rhesus monkey after Goats, skeletal muscle, mechanism of action of dan- multiple daily injections of d-methylampheta- troline sodium in, 138 mine, 593 Goldberg, S. R. , see Gonzalez, F. A. , 33 Flexner, C., see Gerkins, J. F. , 421 Goldman, R. H., see Hall, R. J., 711 Food intake, in intact and 6-hydroxydopamine- Gonzalez, F. A. and Goldberg, S. R.: Effects of co- treated rats, effects of dopaminergic agonists caine and d-amphetamine on behavior main- and antagonists, 386 tamed under various schedules offood presents- Formate metabolism, robe in methanol poisoning in tion in squirrel monkeys, 33 monkey, 564 Graham, R. M. , Oates, H. F., Stoker, L. M. and Fomnani, R. , see Sacchetti, G. , 444 Stokes, G. S.: Alpha blocking action of the an- Frankeb, R. J. , Reid, I. A. and Ganong, W. F.: Role tihypertensive agent, prazosin, 747 of central and peripheral mechanisms in the Guinea pig(s) action of a-methybdopa on blood pressure and depolarized smooth muscle, effects of denervation, renin secretion, 400 cocaine, 6-hydroxydopamine and reserpine on Fregly, M. J. , see Thrasher, T. N. , 84 drug-induced contractions of, 267 Frog effect of ascorbic acid deficiency on extrahepatic myebinated fibers, effect on pabytoxin on mem- microsomal metabolism of drugs and cancino- brane potential and current of, 148 gens in, 527 single myelinated fibers, conduction-blocking heart muscle, influence of ketamine on inotnopic concentrations of anesthetics correlated with and chronotropic responsiveness of, 171 nerve axon diameter in, 340 ibeum, pharmacological evaluation ofnew calcium skeletal muscle, mechanism of action of dantro- antagonists, 2-substituted 3-dimethylamino- line sodium in, 138 5,6-methylenedioxyindenes, in, 126 skin, effects of methyldopa metabolites on melan- isolated atrium, inhibition of nomepinephnine up- ocyte function in, 622 take by phenoxybenzamine and desmethybimip- Fugiwara, M. , see Taniguchi, T. , 678 namine in, 192 sinus node, effects of acetybcholine on potassium Gaginebla, T. S. , Haddad, A. C. , Go, V. L. W. and movements in, 669 Phillips, S. F.: Cytotoxicity of nicinoleic acid Gurbl, N. J., Zinner, M. J., Callahan, W. and Rey- (castor oil) and other intestinal secretagogues nobds, D. G.: Vasodilation due to urokinase in on isolated intestinal epithebial cells, 259 the canine femomab circulation, 731 Ganglia superior cervical, rat, investigation of adrenergic Haddad, A. C. , see Gaginella, T. S., 259 function in organ culture of, 298 Hall, R. J. , Gelbart, A. , Silverman, M. and Gold- superior cervical, rat, release of acetybcholine man, R. H.: Studies on digitalis-induced an- elicited by extracts ofbback widow spider glands mhythmias in glucose- and insulin-induced hy- from, 312 pokalemia, 711 792 INDEX Vol. 201

Habopemidol, effect on feeding in intact and 6-hy- Hypothalamic-pituitary-gonadal axis droxydopamine-treated rats, 386 effects of narcotics, 76 Hamster, isolated intestinal epithelial cells, cyto- rat, effects of alcohol, 427 toxicity of nicinobeic acid and other intestinal secretogogues on, 259 Immune response, humorab and cellular, simultane- Heart ous quantitative measurement of, in adjuvant conduction, effect of bidocaine and methyl bido- polyarthnitis I, 1 caine, 184 Immunosuppressive effects of 8,9-epoxyhexahydro- dog, effect of verapamil on left ventricular per- cannabinob in mice, 573 formance in, 723 Indomethacin mouse, beta adrenergic receptor labeling with 125I effects of probenecid on individual components of hydroxybenzybpindolol, 644 elimination of, 463 muscle influence of ketamine on inotnupic and effects on pmostagbandin E2 levels in inflammatory chronotropic responsiveness of, 171 exudate, 769 Punkinje fibers, canine, effects ofdisopyramide on Indoprofen, assessment ofanalgesic potency in man, electrophysiobogic properties of, 701 444 Purkinje fibers, effect of antiarnhythmic drugs on Innervation, motor, of smooth muscle of rat seminal triggered sustained rhythmic activity in, 689 vesicle, 285 Heffner, T. G. , Zigmond, M. J. and Stricken, E. M.: Insulin and glucose infusion, digitalis-induced am- Effects of dopaminergic agonists and antago- rhythmias in hypokalemia induced by, 711 nists on feeding in the intact and 6-hydroxydo- Intestine, guinea pig, effect of ascorbic acid defi- pamine-treated rats, 386 ciency on metabolism of drugs and carcinogens Hemoglobin-free perfused rat liver, kinetics of p- in, 527 nitroanisobe 0-demethylation in, 498 N-Isopropylmethoxamine, enhancement of norepi- Henshenson, F. M. , see Mackemer, C. R. , 326 nephrine-induced contractions in rat veins by, Hexobarbital, pharmacokinetics in rats, effects of 406 bile duct ligation, 534 Isozyrnes, liver cytosolic aldehyde dehydrogenase, Hill, R. C. , Roemer, D. and Bueschem, H.: Investiga- robe in control of blood acetabdehyde concentrations ofthe analgesic and morphine-bike proper- tions, 471 ties of azidomorphine, 580

Histamine, involvement in gastric vasodibator ac- J#{228}hnchen, E. , see Martini, A. , 547 tion of pentagastnin, 421 Jayakumam, S. and Puschett, J. B.: Study of the Hofmann, L. M. , Weien, R. M., Subeymanov, 0. D. sites and mechanisms of action of bumetanide and Pedera, H. A. : Mexrenoate potassium: A in man, 251 steriodal aldostenone antagonist and antihy- J#{246}bsis,F. F., see Sylvia, A. L. , 117 pertensive, 762 Johnson, R. L., see Ren, P., 541 Holtzman, S. G. , see Schaefer, G. J., 67 Jones, L. S. , see Thurman, R. G. , 498 Holtzman, S. G., see Shannon, H. E., 55 Joost, R. R. , see Wobd, J. S. , 778 Honda, S. , see Kippen, I. , 226 Jung, M. J., see Schechter, P. J. , 606 Hooke, K. F., see Duggan, D. E., 8 Hooke, K. F. , see Duggan, D. E. , 463 Kaboyanides, G. J., see Lapkin, R., 233 Hordof, A. J. , see Danibo, P. , Jr. , 701 Kamm, J. J., see Kuenzig, W. , 527 Horwitz, L. D. , see Newman, D. F., 723 Kaplan, Henry G. and Myers, C. E.: Complex inhi- Hunt, W. A., Redos, J. D. , Dalton, T. K. and Catna- bition of thymidylate synthetase by aromatic vas, G. N. : Alterations in brain cyclic guanosine diamidines: Evidence for both rapid, freely re- 3’ :S’-monophosphate bevels after acute and versibbe and slowly progressive, nonequibi- chronic treatment with ethanol, 103 brium inhibition, 554 ‘251-Hydroxybenzylpindolob, labeling of beta adre- Karoum, F., Garrison, C. K., Neff, N. and Wyatt, R. nergic receptor in mouse, 644 J.: Trans-synaptic modulation of dopamine me- 6-Hydroxydopamine, effects on drug-induced con- tabolism in the mat superior cervical gangbion, tractions of depolarized smooth muscle of rat 654 and guinea-pig vas deferens, 267 Kauffman, F. C., see Thurman, R. G. , 498 6-Hydnoxydopamine-treated mats, effects of dopami- Kester, R. A. , see Talbanida, R. J. , 587 nergic agonists and antagonists on feeding in, Ketamine 386 active form in squid giant axons, 156 Hyperthyroidism, neonatal, rat, effects of lithium, block of nerve conduction, mechanism, 156 92 influence on inotropic and chmonotropic respon- Hypokalemia, glucose- and insulin-induced, studies siveness of heart muscle, 171 on digitalis-induced arrhythmias, 711 Kidney 1977 INDEX 793

human, sites and mechanisms of action of new Lipsius, S. L. and Vassable, M.: Effects of acetylcho- diuretic agent, bumetanide, in, 251 line on potassium movements in the guinea-pig newborn rabbit, anionic transport system, robe in sinus node, 669 cephaboridine nephrotoxicity, 778 Lithium carbonate, urinary carbon dioxide tension separated cortical tubules, rabbit, characteristics ii, patients treated with, 456 of uric acid uptake by, 218 Lithium treatment in developing hyperthyroid mats, separated cortical tubules, rabbit, effects of drugs modification of behavioral activity and brain on uric acid uptake by, 226 biogenic amines by, 92 slices, rat, effect of gentamycin on p-aminohip- Liver purate metabolism and transport in, 233 cytosolic aldehyde dehydnogenase isozymes, role Kinetics in control of blood acetaldehyde concentrations, ofp-nitroanisobe O-demethybation in hemoglobin- 471 free perfused rat liven, 498 guinea pig, effect of ascorbic acid deficiency on of vitamin K-dependent clotting factors in rats, metabolism of drugs and carcinogens in, 527 effects of warfarmn, 507 microsomes, mat, study of sulfur binding which Kippen, I. , Nakata, N. , Honda, S. and Kbinenbemg, occurs concurrently with metabolism of pama- J. R.: Uptake of uric acid by separated renal thion to pamaoxon in, 490 tubules of the rabbit. II. Effects ofdrugs, 226 microsomes, rat, use ofa.c.-pobarography to study Kippen, I. , Nakata, N. and Kbinenberg, J. R.: Up- metabolism and kinetic properties ofp-nitmoani- take of uric acid by separated renal tubules of sole in, 482 the rabbit. I. Characteristics oftransport, 218 perfused, hemoglobin-free, mat, kinetics of p-ni- Klinenbeng, J. R. , see Kippen, I., 226 troanisole 0-dimethylation in, 498 Kbinenbemg, J. R. , see Kippen, I. , 218 Locomotor activity, in developing hyperthyroid mats, Kleinhaus, A. L. and Pnichard, J. W.: A calcium modification by lithium, 92 reversible action of barbiturates on the beech Loh, H. H., see Brase, D. A. , 368 retzius cell, 332 Lung Kbykken, P. C. , Smith, S. H. , Levy, J. A. , Razdan, guinea pig, effect of ascorbic acid deficiency on R. and Munson, A. E. : Immunosuppressive ef- metabolism of drugs and carcinogens in, 527 fects of 8,9-epoxyhexahydrocannabinol (EHHC), mouse, beta adnenemgic receptor labeling with hu5I 573 hydroxybenzylpindobol, 644 Kochman, R. L. , see Mackerer, C. R. , 326 perfused canine, vascular responses to dihomo-y-

Kot, P. A. , see Wicks, T. C. , 417 linobe. .- acid in, 417 Kramer, M. S. , see Tallanida, R. J., 587 Luteinizing hormone Kuczenski, R. : Differential effects of meserpine and levels in rat, effects of alcohol, 427 tetrabenazine on mat stniatal synaptosomab do- levels in mat, effects of narcotics, 76 pamine biosynthesis and synaptosomal dopamine pools, 357 Mackerer, C. R. , Kochman, R. L. , Shen, T. F. and Kuenzig, W. , Tkaczevski, V. , Kamm, J. J. , Conney, Hershenson, F. M.: The binding of strychnine A. H. and Burns, J. J. : The effect of ascorbic and strychnine analogs to synaptic membranes acid deficiency on extrahepatic microsomab me- of mat brainstem and spinal cord, 326 tabolism ofdrugs and carcinogens in the guinea Macrophages pig, 527 mouse, accumulation of norepinephnine by, rela- Kurtzman, N. A. , see Nascimento, L. , 243 tionship to known uptake processes, 636 mouse, membrane alterations by norepinephnine LaManna, J. C. , see Sylvia, A. L. , 117 in, 627 Lapkin, R. , Bowman, R. and Kaloyanides, G. J.: Magni, E. , see Sacchetti, G. , 444 Effect of gentamicin on p-aminohippumate me- Magninat, G. , see Perez, G. 0. , 456 tabolism and transport in mat kidney slices, 233 Markam, A. B. , see McMartin, K. E. , 564 Leander, J. D. and McMibban, D. E.: Meperidine Man effects on schedule-controlled responding, 434 biliamy colic as model for assessing activity of an- Ledgeme, M. , see Twanog, B. M. , 350 algesics in, 444 Leroux, E. J. , see Newman, R. K. , 723 bladder muscle, antimuscaminic and noncompeti- Levy, J. A. , see Klykken, P. C., 573 tive properties of dicycbomine hydrochloride in, Lidocaine 662 conduction-blocking concentrations of, correlated sites and mechanisms of action of bumetanide, with nerve axon diameter, 340 new diruetic agent, in, 251 effect on cardiac conduction, 184 urinary carbon dioxide tension with lithium cam- effect on triggered sustained rhythmic activity in bonate treatment in, 456 sheep cardiac Purkinje fibers, 689 Man, R. Y. K. and Dmesel, P. E.: Effect of bidocaine 794 INDEX Vol. 201

and methyl bidocaine on cardiac conduction, 184 of p-nitroanisole, studied by a.c.-pobarography, Mandelbi, V. , see Sacchetti, G. , 444 482 Manazzo, D. P. , see Thurman, R. G. , 498 of sulindac, 8 Martin-Amat, G., see McMartin, K. E., 564 Metabolite(s) Martinez, J. R. and Quissell, D. 0.: Potassium levels in rat brain, effects of methamphetamine, release from the rat submaxillary gland in vitro. studies based upon mitochondniab respiratory III. Effects of pretreatment with neserpine, 206 state, 117 Martinez-Sierra, R. , see Sanchez-GarcIa, P. , 192 methydopa, alpha adnenergic receptor potency on Martini, A. and Jahnchen, E.: Studies in rats on the melanocyte function, 622 mechanism by which 6-mencaptopurine inhibits Methamphetamine-induced changes in brain me- the anticoagulant effect of warfarin, 547 tabobite bevels, studies based upon mitochon- Mathew, B. P. , see Adams, H. R. , 171 dniab respiratory state, 117 Matthews, W. D. and Connon, J. D.: Actions of Methanol poisoning in monkey, robe of fommate me- iontophoretic phenytoin and medazepam on tabolism, 564 hippocampal neurons, 613 Methohexitab, action on leech Retzius cell, effect of Maturation, changes in enzymatic and immuno- calcium, 332 reactive rat serum dopamine 13-hydroxybase d-Methybamphetamine, multiple daily injections, during, 375 long-term behavioral changes in rhesus monkey McClure, W. 0. , see Pumplin, D. W., 312 after, 593 McMartin, K. E. , Martin-Amat, G., Makar, A. B. a-Methyldopa, effects on blood pressure and nenin and Tephly, T. R.: Methanol poisioning. V. Role secretion in mat, role of central and peripheral of formate metabolism in the monkey, 564 mechanisms, 400 McMiblan, D. E., see Leander, J. D., 434 Methyldopa, metabobites, alpha adrenergic potency Medazepam, iontophoretic, effect on hippocampal on melanocyte function, 622 neurons in rat, 613 Methyl bidocaine, effect on cardiac conduction, 184 Meek, J. L. , see Neckers, L. M. , 110 Methylphenidate, effect on feeding in intact and 6- Membrane potential hydroxydopamine-treated rats, 386 -dependent and -independent tension in canine Methysergide, blocking effect on serotonin and do- trachealis muscle, 276 pamine in Mytilis muscle, 350 in frog myelinated fibers, effect of pabytoxin, 148 a-Methyltyrosine, effect on feeding in intact and 6- Mende, T. J., see Davis, J. E. , 490 hydnoxydopamine-tmeated rats, 386 Mepenidme, effects on schedule-controlled respond- Mexrenoate potassium, stenoidal abdosterone antag- ing in pigeon, 434 onist and antihypertensive, 762 6-Mencaptopunine, inhibition of anticoagulant ef- Meyer, E. R., see Cicero, T. J. , 76 fects of warfanin in rats by, 547 Mice Mercuric chloride, nephmotoxicity in newborn nab- antiseizure activity of y-acetylenic y-aminobu- bits, mole of renal anionic transport system, 778 tyric acid in, 606 Mersalyl, blocking effect on senotonin and dopamine immunosuppressive effects of 8,9-epoxyhexahy- in Mytilis muscle, 350 drocannabinol in, 573 Metabolism investigation and analgesic and morphine-bike and transport ofp-aminohippurate in rat kidney properties of azidomorphine in, 580 slices, effect of gentamycin, 233 mechanism of protection from abboxan diabetes extrahepatic microsomal ofdrugs and carcinogens provided by n-butanol in, 450 in guinea pig, effect of ascorbic acid deficiency, Miles, P. R. , see Fanley, J. M., 199 527 Miosis, in rabbit pupil, effects of morphine and nab- of acetaldehyde, role of liver cystosobic aldehyde oxone, 587 dehydrogenase isozymes, 471 Mitochondniab respiratory state, as new approach to ofdiphenybhydantoin in rat, effect ofdiazepam, 14 study methamphetamine-induced changes in of dopamine in mat superior cervical ganglion, rat brain metabolite bevels, 117 trans-synaptic modulation, 654 Moja, E., see Neckers, L. M., 110 of formate, robe in methanol poisoning in monkey, Mobinoff, P. B., see Brown, J. H., 298 564 Monkey of hexobarbital in rats, effects of bile duct liga- investigation of analgesic and morphine-bike tion, 534 properties of azidomomphine in, 580 of indomethacin, effects of probenecid, 463 rhesus, bong-term behavioral changes after multi- of parathion to pamaoxon, study of sulfur binding pie daily injections ofd-methybamphetamine in, to rat liver microsomes which occurs concur- 593 mently, 490 robe of formate metabolism in methanol poision- 1977 INDEX 795

ing in, 564 choline-induced contractions of, 199 squirrel, discriminative effects of morphine in, 67 Myebinated fibers effects of probenecid on indomethacin elimination frog, conduction-blocking concentrations of anes- in, 463 thetics correlated with nerve axon diameter in, squirrel, effects of cocaine and d-amphetamine on 340 behavior maintained under various schedules of frog, effect of pabytoxin on membrane potential food presentation in, 33 and current of, 148 Monosynaptic pathway, spinal, effects of ethosux- Myers, C. E., see Kaplan, H. G. , 554 imide on transmission of repetitive impulses and apparent rates of transmitter turnover in, Nakata, N. , see Kippen, I. , 218 320 Nakata, N. , see Kippen, I. , 226 Morgan, K. G. and Bryant, S. H.: The mechanism of Naboxone action of dantrolene sodium, 138 effects on miosis and fluctuation in rabbit pupil, Morphine 587 discriminative effects in squirrel monkey, 67 effects upon body weight loss and suppression of -dependent rats, comparison of effects of naboxone fixed-ratio behavior in morphine-dependent upon body weight and suppression of fixed-ratio rats, 44 operant behavior in, 44 Narcotics, effects on hypothalamic-pituitary-gona- discriminative effects in rat, 55 dab axis, 76 effects on miosis and fluctuation in rabbit pupil, Nascimento, L. , Rademachem, D. R. , Amruda, J. A. 587 L. and Kurtzman, N. A.: Effect of acetazol- -bike properties, of adizomorphine, 580 amide and parathyroid hormone on HCO3 and Mouse P04 excretion, 243 accumulation of nomepinephnine by macmophages Neckems, L. M. , Biggio, G. , Moja, E. and Meek, J. and relationships to known uptake processes in, L.: Modulation ofbrain tryptophan hydroxylase 636 activity by brain tryptophan content, 110 ascites P388 lymphoma cells, potentiation of anti- Neff, N. , see Kanoum, F. , 654 tumor drug action by centrophenoxine on, 518 Nelson, D. L. , see Brown, J. H. , 298 beta adrenergic receptor labeling with ‘25I-hydrox- Nerve ybenzylpindobob in, 644 axon diameter, correlated with conduction-block- induction of membrane alterations by nomepi- ing concentrations of anesthetics, 340 nephnine in macmophages and phospholipid conduction, mechanism of ketamine block of, 156 monolayens in, 627 Nervous system, central and peripheral, roles in Muneoka, Y. , see Twamog, B. M., 350 mediating effects of a-methybdopa on blood Munson, A. E. , see Kbykken, P. C. , 573 pressure and menin secretion, 400 Murray, R. B. , see Talbanida, R. J., 587 Netter, K. J. , see Burgschat, H. , 482 Muscle Neurons bladder, human and rabbit, antimuscarinic and hippocampal, effects of iontophoretic phenytoin noncompetitive antagonist properties of dicy- and medazepam on, 613 cbomine hydrochloride in, 662 motor, characterization in rat seminal vesicle, 285 heart, influence of ketamine on inotropic and Neurotransmittems, serotonin and dopamine as, in chronotnopic responsiveness of, 171 Mytilus, effects of mersalyb, 350 Mytilu.s, serotonin and dopamine as neumotmans- Newman, R. K., Bishop, V. S. , Peterson, D. F., mittens in, effects of memsalyl, 350 Lemoux, E. J. and Horwitz, L. D.: Effect of vera- skeletal, frogs, rats and goats, mechanism of ac- pamil on left ventricular performance in con- tion of dantroline sodium in, 138 scious dogs, 723 smooth, depolarized, rat and guinea pig, effects of p-Nitmoanisobe denervation, cocaine, 6-hydmoxydopamine and metabolism and kinetic properties studied by ac.- meserpine on drug-induced contractions of, 267 pobamography, 482 smooth, preparations, pharmacological evabua- 0-demethylation, kinetics in hemoglobin-free tion of new calcium antagonists, 2-substituted perfused mat liven, 498 3-dimethylamino-S,6-methylenedioxyindenes, Nobi, R. M. , see Duggan, D. E. , 463 in, 126 Nomepinephrine smooth, rat seminal vesicbe, motor innervation, accumulation by macmophages and relationships 285 to known uptake processes, 636 trachealis, dog, membrane potential-dependent -induced contraction in rat veins, enhancement by and -independent tension in, 276 beta adrenengic antagonists, 406 tracheabis, dog, mole of depolarization in acetyb- induction of membrane alterations by, studies 796 INDEX Vol. 201

with macrophages and phospholipid monobay- ton potency of methybdopa metabobites on me- ens, 627 banocyte function, 662 uptake in isolated guinea-pig atrium, inhibition Pharmacological activity ofstrychnine and analogs, by phenoxybenzamine and desmethylimipra- correlation with binding site, 326 mine, 192 Pharmacological evaluation of new calcium antago- Norethynodnel, alone and in combination with ethi- nists, 2-substituted 3-dimethylamino-S,6-meth- nyb estradiob, effects on dipsogenic response in ylenedioxyindenes, 126 mats, 84 Phenobarbital, action on beech Retzius cell, effect of calcium, 332 Oates, H. F. , see Graham, R. M. , 747 Phenoxybenzamine, inhibition of nomepinephnine Oates, J. A., see Genkins, J. F., 421 uptake in isolated guinea-pig left atrium by, 192 Ohsumi, K. , see Taniguchi, T., 678 Phenybbutazone, effects on pmostaglandin E2 bevels Oleic acid, cytotoxicity on isolated intestinal epithe- in inflammatory exudate, 769 hal cells, 259 Phenytoin, iontophoretic, effect on hippocampal Olukotun, A. , Dunnette, J. and Weinshibboum, R.: neurons in rat, 613 Dissociation of changes in enzymatic and im- Phillips, S. F., see Gaginella, T. S. , 259 munoreactive rat serum dopamine f3-hydnox- Phosphate, excretion, effect of acetazolamide and ylase during growth and development, 375 parathyroid hormone, 243 O’Reilly, W. J., see Drew, R., 534 Pigeons, effects of meperidine on schedule-con- Organ culture, of rat superior cervical ganglia, in- tnolled responding in, 434 vestigation of adnenergic function in, 298 Plan, G. I., see El-hawani, A. M. , 14 Onzechowski, R. F., see Banbieri, E. J., 769 Pobarography, a.c., used to study metabolism and Osten, J. R. , see Perez, G. 0. , 456 kinetic properties ofp-nitmoanisobe, 482 Owen, N. V. , see Wobd, J. S., 778 Potassium movements in guinea-pig sinus node, effects of Pabytoxin, effect on membrane potential and cur- acetylchobine, 669 rent of frog myelinated fibers, 148 release from rat submaxillary gland in vitro, ef- Panaoxon (0,0-diethyl O-p-nitrophenyl phosphate), fects of reserpine pretreatment, 206 metabolism of parathion to, study of sulfur Pnactobob, enhancement of nomepinephrine-induced binding to rat liven microsomes which occurs contractions in mat veins by, 406 concurrently, 490 Prazosin (antihypertensive agent), alpha adrenengic Parathion (O,O-diethyl O-p-nitnophenyl phosphoro- blocking properties in vivo of, 747 thioate), metabolism to panaoxon, study of sub- Prichand, J. W., see Kbeinhaus, A. L. , 332 fun binding to mat liven microsomes which occurs Priestly, B. G., see Drew, R., 534 concurrently, 490 Probenecid, effects on indomethacin elimination, Parathynoid hormone, alone and in combination 463 with acetazobamide, effect on HCO3 and PO Procaine amide, effect on triggered sustained excretion, 243 rhythmic activity in sheep cardiac Purkinje fi- Parker, J. L., see Adams, H. R., 171 bens, 689 Pathological pain, model (bibiany colic) for assessing Propamidine, effect on thymidybate synthetase, 554 analgesic activity in man, 444 Propranobol, enhancement of norepinephnine-in- Pedera, H. A., see Hofmann, L. M., 762 duced contractions in rat veins by, 406 Pentagastnin, gastric vasodilator action in dog, in- Pmostagbandin(s) volvement of prostaglandin and histamine, 421 E2, involvement in gastric vasodilator action of Pentamidine, effect on thymidybate synthetase, 554 pentagastnin, 421 Pentazocine, assessment of analgesic potency in E2, bevels in inflammatory exudate, effects of non- man, 444 stemoidab anti-inflammatory agents, 769 Pentobarbital, action on leech Retzius cell, effect of precursors, vascular responses in perfused canine calcium, 332 lung to, 417 Perez, G. 0., Oster, J. R., Sonnebomn, R. E., Magni- robe in production of pulmonary dysfunction dun- nat, G. and Vaamonde, C. A. : Urinary carbon ing splanchnic arterial occlusion shock, 753 dioxide tension in lithium carbonate-treated pa- Pnothrombin, synthesis inhibition, correlation with tients, 456 regeneration of vitamin K, from vitamin K, Peterson, D. F. , see Newman, R. K. , 723 epoxide, as mechanism of action of anticoagu- Petersen, D. R. , Collins, A. C. and Deitmich, R. A.: bants, 541 Role of liver cytosolic abdehyde dehydrogenase Pulmonary dysfunction, during spbanchnic arterial isozymes in control of blood acetabdehyde con- occlusion shock, robe of prostaglandins, 753 centrations, 471 Pumplin, D. W. and McClure, W. 0.: The release of Pettingem, W. A. : Unusual alpha adrenengic necep- acetybcholine elicited by extracts ofbback widow 1977 INDEX 797

spider glands: Studies using rat superior cervi- cocaine, 6-hydroxydopamine and mesempine on cal ganglia and inhibitors of electrically stimu- drug-induced contractions of, 267 bated release, 312 developing hyperthyroid, modification of behav- Purkinje fibers ioral activity and brain biogenic amines by lith- cardiac, canine, effects ofdisopyramide on ebectro- ium in, 92 physiologic properties of, 701 differential effects of reserpine and tetmabenazine cardiac, sheep, effect of antiarrhythmic drugs on on straitab synaptosomab dopamine bio- triggered sustained rhythmic activity in, 689 syntheses and pools in, 357 Puschett, Jules B. , see Jayakumam, S. , 251 discriminative effects of morphine in, 55 effects of bile duct ligation on hexobarbitab phan- Quissebb, D. 0., see Martinez, J. it. , 206 macokinetics in, 534 effects of diazepam on biliary excretion of diphen- Rabbit ybhydantoin in, 14 bladder muscle, antimuscarinic and noncompeti- effects of iontophonetic phenytoin and medazepam tive properties of dicycbomine hydrochloride in, on hippocampab neurons in, 613 662 effects of mexmenoate potassium on, 762 effects of morphine and naboxone on miosis and effects of nonsteroidal anti-inflammatory agents fluctuation in pupil of, 587 on prostaglandin E2 levels in inflammatory exu- isolated sinoatrial node, possible involvement of date of, 769 cyclic adenosine 3’:S’-monophosphate in cate- effects of probenecid on indomethacin elimination cholamine-induced tachycandia in, 678 in, 463 newborn, role ofrenal anionic transport system in effect of warfarmn on kinetics of vitamin K-de- cephaboridine nephmotoxicity in, 778 pendent clotting factors in, 507 separated renal tubules, characteristics of uric hemoglobin-free perfused liver, kinetics of p-ni- acid uptake in, 218 troanisole 0-demethylation in, 498 separated renal tubules, effects of drugs on uric ibeum, pharmacological evaluation ofnew calcium acid uptake by, 226 antagonists, 2-substituted 3-dimethybamino- Rademacher, D. R. , see Nascimento, L. , 243 5,6-methybenedioxyindenes, in, 126 Rahwan, R. G. , Faust, M. M. and Witiak, D. T.: intact and 6-hydroxydopamine-treated, effects of Pharmacological evaluation of new calcium an- dopaminergic agonists and antagonists on feed- tagonists: 2-Substituted 3-dimethybamino-5,6- ing in, 386 methylenedioxyindenes, 126 investigation of analgesic and morphine-like Ramwell, P. W., see Wicks, T. C. , 417 properties of azidomorphine in, 580 Rastogi, R. B. and Singhab, R. L.: Lithium: Modifi- kidney slices, effect ofgentamycin onp-aminohip- cation of behavioral activity and brain biogenic pumate metabolism and transport in, 233 amines in developing hyperthyroid rats, 92 liver microsomes, study of sulfur binding which Rat(s) occurs concurrently with metabolism of para- active form of subindac (anti-inflammatory agent) thion to panaoxon in, 490 in, 8 male, effects of alcohol on hypothalamic-pitui- adjuvant pobyarthritis I in, simultaneous mea- tary-gonadab axis in, 427 surement of humorab and cellular immune me- male, effects of narcotics on hypothabamic-pitui- sponse in, 1 tary-gonadab axis in, 76 alpha blocking action of prazosin in, 747 mechanism by which 6-mencaptopunine inhibits application of a.c.-pobanography in study of p-ni- anticoagulant effects of warfanin in, 547 tmoanisobe metabolism and its kinetic properties mechanism of action of anticoagulants in, 541 in, 482 modulation of brain tryptophan hydmoxylase ac- brain cyclic guanosine 3’:S’-monophosphate 1ev- tivity by tryptophan content in, 110 ebs, alterations after acute and chronic ethanol morphine-dependent, comparison of effects of nal- treatment, 103 oxone upon body weight loss and suppression of brain, methamphetamine-induced changes in me- fixed-ratio operant behavior in, 44 tabolite levels in, studies based upon mitochon- role of liver cytosolic abdehyde dehydrogenase iso- dnial respiratory state, 117 zymes in control of blood acetaldehyde concen- brainstem and spinal cord, binding of strychnine trations in, 471 and strychnine analogs to synaptic membranes seminal vesicle smooth muscle, motor innerva- of, 326 tion, 285 cannabiodob-antiepileptic drug comparisons and serum, enzymatic and immunoreactive dopamine interactions in experimentally induced seizures f3-hydroxylase in, changes during growth and in, 26 development, 375 depolarized smooth muscle, effects of denervation, skeletal muscbe, mechanism of action of dantro- 798 INDEX Vol. 201

line sodium in, 138 Schaefer, G. J. and Hobtzman, S. G.: Discriminative submaxillary gland, effects of resenpine pretreat- effects ofmorphine in the squirrel monkey, 67 ment on potassium release in vitro from, 206 Schauberger, C. W. , Thies, R. L. and Fischer, L. J.: superior cervical ganglia organ culture, investi- Mechanism of protection from alboxan diabetes gation of adrenengic function in, 298 provided by n-butanob, 450 superior cervical ganglia, release of acetybchobine Schechten, P. J., Tranier, Y., Jung, M. J. and elicited by extracts ofbback widow spider glands Sjoemdsma, A.: Antiseizume activity of y-acety- from, 312 benic y-aminobutynic acid: A catalytic irreversi- superior cervical ganglion, trans-synaptic modu- ble inhibitor of y-aminobutynic acid transami- lation of dopamine metabolism in, 654 nase, 606 treated chronically with nonethynodrel, ethinyl Schuster, C. R. , see Fischman, M. W. , 593 estradiol and both combined, responsiveness to Schwartz, S. L. , see Baiter, N. J. , 636 dipsogenic stimuli in, 84 Schwartz, S. L., see Baiter, N. J., 627 uterus, pharmacological evaluation of new cal- Schweitzer, J. , see Cicero, T. J. , 76 cium antagonists, 2-substituted 3-dimethyba- Secobarbitab, action on leech Retzius cell, effect of mino-5,6-methybenedioxyindenes, in, 126 calcium, 332 veins, enhancement of norepinephrine-induced Seeman, P. , see Staiman, A. , 340 contractions after beta adrenengic antagonists Seizures in, 406 experimentally induced, in mice, effect of y-acety- Razdan, R., see Kbykken, P. C. , 573 lenic y-aminobutmyic acid, 606 Redos, J. D. , see Hunt, W. A., 103 experimentally induced, in rats, cannabidol- Reid, I. A. , see Frankel, R. J., 400 antiepibeptic drug comparisons and interactions Ren, P. , Stark, P. Y., Johnson, R. L. and Bell, R. G.: in, 26 Mechanism of action of anticoagubants: Correba- Seminal vesicbe, smooth muscle, rat, motor innervation between the inhibition ofprothmombin syn- tion, 285 thesis and the regeneration of vitamin K’ from Serotonin vitamin K, epoxide, 541 as neurotransmitter in Mytilis, blocked by memsa- Reserpine lyb, 350 differential effects on rat striatal synaptosomab synthesis, brain, relationship of tryptophan hy- dopamine biosynthesis and pools, 357 droxylase to, 110 effects on drug-induced contractions of depolar- Serum, mat, enzymatic and immunomeactive dopa- ized smooth muscle of mat and guinea-pig vas mine f3-hydroxylase in, changes during growth deferens, 267 and development, 375 pretreatment, effects on potassium release from Shand, D. G. , Genkins, J. F., 421 rat submaxillary gland in vitro, 206 Shannon, H. E. and Holtzman, S. G.: Further evalu- Renin secretion, mole of central and peripheral ation of the discriminative effects of morphine mechanisms in effects of a-methybdopa on, 400 in the rat, 55 Reynolds, D. G. , see Gunbb, N. J., 731 Sheep, cardiac Purkinje fibers, effect of antiar- Ricinobeic acid (castor oil) and other intestinal se- nythmic drugs on triggered sustained rhythmic cretogogues, cytotoxicity on isolated intestinal activity in, 689 epithelial cells, 259 Shen, T. F., see Mackerer, C. R. , 326 Risbey, E. A. , see Duggan, D. E., 8 Shen, T. Y., see Duggan, D. E., 8 Roemem, D., see Hill, R. C., 580 Shock, splanchnic arterial occlusion, mole of prosta- Rose, J. C., see Wicks, T. C., 417 gbandins in pulmonary dysfunction in, 753 Rosen, M. R. , see Danibo, P. , Jr., 701 Shnivastav, B. B.: Mechanism of ketamine block of Rosenthal, M. , see Sylvia, A. L., 117 nerve conduction, 163 Rossi, G. V. , see Barbieri, E. J., 769 Shrivastav, B. B.: Active form ofketamine in squid Roy, J. W. , see Tablanida, R. J. , 587 giant axons, 156 Silverman, M. , see Hall, R. J., 711 Sacchetti, G. , Caputo, G., Mandebbi, V. , Fornami, R. Singhab, R. L. , see Rastogi, R. B., 92 and Magni, E.: Biliary colic as a model for as- Sinoatniab node, isolated, rabbit, possible involve- sessing analgesic activity in man, 444 ment ofcycbic adenosine 3’:S’-monophosphate in Sanchez-Garcia, P. , Garcia, A. G., Martinez-Sierra, catecholamine-induced tachycardia in, 678 R. and Vebasco-Martin, A.: Inhibition of nomepi- Sinus node, guinea pig, effects of acetybcholine on nephnine uptake by phenoxybenzamine and potassium movements in, 669 desmethylimipramine in the isolated guinea- Sjoemdsma, A. , see Schechter, P. J. , 606 pig atrium, 192 Skeletal muscle (see Muscle, skeletal) SC-19220, effects on measurement of prostaglandin Skin frog, effects of methybdopa metabolites on me- E2 in inflammatory exudate, 769 lanocyte function in, 622 1977 INDEX 799

Sladek, N. E.: Potentiation ofantitumom drug action Taniguchi, T. , Fujiwara, M. and Ohsumi, K.: Possi- by centrophenoxine: Specificity, 518 bbe involvement of cyclic adenosine 3’ :S’-mono- Small intestine, isolated epithelial cells, cytotoxic- phosphate in the genesis of catechobamine-in- ity of ricinoleic acid and other intestinal ser- duced tachycardia in isolated rabbit sinoatnial cretogogues on, 259 node, 678 Smith, S. H. , see Kbykken, P. C. , 573 Teague, R. S. , see Fedan, J. S. , 285 Smooth muscle (see Muscle, smooth) Tephbey, T. R., see McMartin, K. E., 564 Snyder, S. H. , see Bylund, D. B. , 644 Testosterone Sodium, permeability in frog myelinated fibers, ef- levels in mat, effects of alcohol, 427 fect of palytoxin, 148 levels in mat, effects of narcotics, 76 Sodium cholate, cytotoxicity on isolated intestinal Tetrabenazine, differential effects on rat stniatal epithelial cells, 259 synaptosomal dopamine biosynthesis and pools, Sodium deoxycholate, cytotoxicity on isolated intes- 357 tinal epithebial cells, 259 Tetrodotoxin, conduction-blocking concentrations Sonnebomn, R. E. , see Perez, G. 0. , 456 of, correlated with nerve axon diameter, 340 Spambem, S. B. , see Gellert, V. F. , 44 Thies, R. L. , see Schauberger, C. W. , 450 Spinal cord, rat, binding of strychnine and analogs Thiopentab, action on leech Retzius cell, effect of to synaptic membranes of, 326 calcium, 332 Spiropemidob, effect on feeding in intact and 6-hy- Thirst, responsiveness in rats treated chronically droxydopamine-treated rats, 386 with norethynodmel and ethinyl estradiol and Squid both combined, 84 giant axon, mechanism ofketamine block of nerve Thrasher, T. N. and Fregly, M. J.: Responsiveness conduction in, 156 to various dipsogenic stimuli in rats treated Staiman, A. and Seeman, P.: Conduction-blocking chronically with norethynodreb, ethinyl estra- concentrations of anesthetics increase with diol and both combined, 84 nerve axon diameter: Studies with alcohol, bido- Thurman, R. G. , Mamazzo, D. P. , Jones, L. S. and caine and tetrodotoxin on single myebinated fi- Kauffman, F. C.: The continuous kinetic deter- bers, 340 mination of p-nitroanisole O-demethylation in Stark, P. Y. , see Ron, P. , 541 hemoglobin-free perfused rat liver, 498 Stevenson, C. R. , see Duggan, D. E. , 463 Thymidylate synthetase, effect of aromatic diami- Stibbamidine, effect on thymidylate synthetase, 554 dines, 554 Stoker, L. M. , see Graham, R. M. , 747 Tkaczevski, V. , see Kuenzig, W., 527 Stokes, G. S. , see Graham, R. M. , 747 Tolamobol, effect on triggered sustained rhythmic Stricken, E. M. , see Heffner, T. G. , 386 activity in cardiac Purkinje fibers, 689 Strychnine and analogs, binding to synaptic analogs Tranier, Y. , see Schechter, P. J. , 606 membranes of rat brainstem and spinal cord, Tryptophan content, brain, modulation of brain 326 tryptophan hydroxylase activity by, 110 2-Substututed 3-dimethybamino-5,6-methylenediox- Tryptophan hydroxylase activity, in brain, modu- yindenes, as calcium antagonists, pharmacobog- bated by brain tryptophan content, 110 ical evaluation, 126 Twarog, B. M. , Muneoka, Y. and Ledgeme, M.: Sero- Suieymanov, 0. D. , see Hofmann, L. M. , 762 tonin and dopamine as neurotmansmittems in Subfinpyrazone, effect on uric acid uptake by sepa- mytilus: Block of serotonin receptors by an on- mated renal tubules of rabbit, 226 ganic mercurial, 350 Sulfur, binding to rat liven microsomes which occurs Twiddy, D. A. S. , see Downie, J. W. , 662 concurrently with metabolism of parathion to paraoxon, 490 Unicosumic drugs, effects on uric acid uptake by sep- Subindac, identification ofbioiogically active form, 8 amated renal tubules of rabbit, 226 Sylvia, A. L., LaManna, J. C., Rosenthal, M. and Uric acid J#{246}bsis, F. F.: Metabobite studies of metham- uptake by separated renal tubules of rabbit, char- phetamine effects based upon mitochondnial acteristics, 218 respiratory state in rat brain, 117 uptake by separated renal tubules of rabbit, effects of drugs, 226 Tachycardia, catechobamine-induced, in isolated Urine, man, carbon dioxide tension with lithium rabbit sinoatrial node, possible involvement of carbonate treatment, 456 cyclic adenosine 3’:S’-monophosphate in, 678 Urokinase-induced vasodilation in canine femoral Tailanida, R. J. , Kramer, M. S., Roy, J. W. , Kestem, circulation, 731 R. A. , Murray, R. B. and Adler, M. W.: Miosis and fluctuation in the rabbit pupil: Effects of Vaamonde, C. A. , see Perez, G. 0. , 456 morphine and naloxone, 587 Vainiemi, H. and Wingand, L. B. , Jr.: Effect of war- 800 INDEX Vol. 201

farm on the kinetics of the vitamin K-depend- captopurine, 547 ent clotting factors in rats, 507 Way, E. L., see Brase, D. A. , 368 Van Arman, C. G., see Duggan, D. E., 8 Weien, R. M., see Hofmann, L. M. , 762 Vascular responses to dihomo-a-linolenic acid in Weinshibboum, R. , see Obukotun, A. , 375 perfused canine lung, 417 Westfalb, D. P. : The effects of denervation, cocaine, Vas defenens, depolarized smooth muscle, rat and 6-hydroxydopamine and mesenpine on the char- guinea pig, effects of denervation, cocaine, 6- acteristics of drug-induced contractions of the hydroxydopamine and nesenpine on drug-in- depolarized smooth muscle of the rat and duced contractions of, 267 guinea-pig vas deferens, 267 Vasodilation due to urokinase in canine femoral White, S. D. , see Duggan, D. E., 463 circulation, 731 Wicks, T. C. , Ramwebb, P. W. , Rose, J. C. and Kot, Vasodiltation, apomorphine-induced, in dog hind- P. A. : Vascular responses to the monoenoic leg, 738 pnostagbandin precursor dihomo-y-binolenic acid Vasodibator action of pentagastrin, involvement of in the perfused canine lung, 417 prostaglandin and histamine, 421 Wiley, K. S., see Cohen, M. L., 406 Vassalle, M. , see Lipsius, S. L., 669 Wilkenson, R. D.: Possbile role for prostaglandins in Veins, rat, enhancement of nonepinephnine-induced the production of alterations in pulmonary contraction after beta adrenergic antagonists function during splanchnic arterial occlusion in, 406 shock, 753 Venom, black widow spider, release of acetyicholine Wibbems, J. L., see Buybaert, W. A. , 738 from rat Superior cervical gangbia elicited by, Wingard, L. B. , Jr. , see Vainieni, H. , 507 312 Witiak, D. T., see Rahwan, R. G. , 126 Velasco-Martin, A., see Sanchez-Garcia, P. , 192 Withdrawal, induced by naboxone in morphine-de- Venapamil, effect on left ventricular performance in pendent rats, comparison between body weight conscious dogs, 723 loss and suppression of fixed-ratio operant be- Vitamin K-dependent clotting factors in mats, effects havion, 44 of wanfanin on kinetics of, 507 Woid, J. S. , Joost, R. R. and Owen, N. V.: Nephno- Vitamin K,, regeneration from vitamin K, epoxide, toxocity of cephabomidine in newborn rabbits: correlation with prothnombin synthesis inhibi- Role of the renal anionic transport system, 778 tion, as mechanism of action of anticoagulants, Wolkin, A. , see Consroe, P., 26 541 Wyatt, R. J., see Karoum, F., 654

Warfarmn Yamaguchi, T., see Coburn, R. F. , 276 effect on kinetics of vitamin k-dependent clotting factors in rats, 507 Zigmond, M. J., see Heffner, T. G. , 386 anticoagulant effects in rats, inhibition by 6-men- Zinnen, M. J., see Gurlb, N. J. , 731