More than two million American men and their families are currently battling prostate cancer and three million more men will be compelled to join the battle in the coming decade. Our goal is to keep these families together. We are in a race against time. Prostate CancerKeeping Foundation Families | TogetherAnnual Report 2005 Headline to go here every time. More than 3 years ago, the Prostate Cancer Foundation (PCF) was founded with a single mission: to harness resources – both financial and human – to find better treatments and a cure for recurrent prostate cancer, a cancer that was little known at the time. Back then, who knew that prostate cancer would become the most common non-skin cancer in America? Who knew that prostate cancer would strike one in six men? Who knew that a man would be one-third more likely to develop prostate cancer than a woman is to develop breast cancer? Since then, the PCF has raised more than $260 million for prostate cancer research with the help of tens of thousands of generous supporters and corporate partners. We have funded hundreds of researchers in the United States and throughout the world in an effort to keep families together, longer. Despite the great progress, there is still much to do. In 2005, prostate cancer took the lives of more than 30,000 fathers, brothers, uncles and husbands. One of those men was Mickey Tarnopol, a stalwart supporter and a member of our Board of Directors for 0 years. He was a beloved husband, father and grandfather. It is with him in mind, along with the more than two million American men and their families currently battling this disease, that we move aggressively toward fulfilling our mission. And, there is no time to lose. In 2006, baby boomer men will begin turning 60. At this age, men are entering the highest-risk zone for prostate cancer. As a result, the number of new cases in the United States over the next decade is expected to increase from 232,000 to more than 300,000 annually. That’s one new case every 00 seconds. We’re in a race against time to keep these men and their families together. We can’t let time win. 2 Prostate Cancer Foundation | Annual Report 2005 Looking back, we have much to be proud of, including many new initiatives and a dramatic increase in the resources invested in research, such as: Aggressively advocating for increased federal Producing informational and educational and state funding of prostate cancer research, publications to increase knowledge about helping produce a 20-fold increase in annual prostate cancer nutrition and disease appropriations to $500 million. management for patients, physicians and other healthcare professionals. Funding ,200 medical and scientific research projects from the United States and around Working tirelessly with corporate partners the world through our Competitive Awards and other prostate cancer advocates to raise Program and Therapy Consortium. awareness about the risks of prostate cancer and what men can do to spare themselves Sponsoring a one-of-a-kind annual Scientific from suffering from this deadly disease. Retreat for thought leaders in prostate cancer research, making it possible for the brightest Perhaps most significantly, there are now 3 minds in the field from academia, government FDA-approved therapies for the treatment of and the biopharmaceutical industry to meet, prostate cancer, compared to the seven that share ideas and form new partnerships. were available when the PCF was founded 3 years ago. Pioneering a streamlined approach to grant making, dramatically slashing the time it takes for researchers to apply for funding. Keeping Families Together 3 FORTUNE magazine names the PCF its “Charity of the Year.” We would not have been able to Baume & Mercier, for its generous donation achieve our many goals without and public service announcements. the help of special individuals Hugo Boss and Armani, for continued support and businesses who provided through in-store events. extraordinary leadership in 2005: Esquire magazine, for including the PCF in its The PCF Board of Directors, friends and exclusive Esquire House activities in New York. donors who supported our biennial New York Dinner, which raised $4.7 million. Looking Ahead In 2006, we already know there will be more The 3,000 individuals who donated more innovative and promising prostate cancer research than $20 million. programs than we have resources to fund. We will Safeway, which raised a record $4.4 million need your help to provide as much support as from its annual point-of-purchase possible so we can keep families together. We hope donation program. you’re encouraged by our progress and will continue Neiman Marcus, which designated the PCF as to support the PCF generously. the beneficiary of its famed Christmas Book. FORTUNE magazine, for its donation in honor of the magazine’s 75th anniversary and naming the PCF its “Charity of the Year.” Arnold Palmer, who chairs Arnie’s Army Battles Prostate Cancer. Major League Baseball, which partnered with the PCF for the eighth annual Michael Milken Leslie D. Michelson Home Run Challenge. Founder and Chairman Chief Executive Officer The Republic of Tea, which developed a new product, MAN KIND TEA, in support of the PCF. 4 Prostate Cancer Foundation | Annual Report 2005 Prostate cancer is the most common non-skin cancer in the United States, striking one in six men. In 2005 alone, more than 232,000 men were diagnosed with prostate cancer and more than 30,000 died. Over the past decade, nearly 350,000 men have been lost to this disease. The Prostate Cancer Foundation will continue to harness every resource available to help find better treatments and a cure for recurrent prostate cancer. Risk Factors Early Prostate Cancer Detection We don’t know why this small organ, tucked inside Recognition of these risk factors enables men at each man’s pelvis just below the bladder, is so higher risk to be extra vigilant about detecting susceptible to cancer. But, research has shown that prostate cancer at its earliest and most treatable there are three major factors that increase a man’s stages. The PCF works tirelessly to identify other risk for developing prostate cancer – age, race and risk factors that might affect the risk of developing family history. prostate cancer, develop ways to distinguish aggressive from indolent disease and predict which • As men age, their risk of developing prostate men will respond to which treatments. cancer increases significantly, especially after age 60. Being diagnosed with prostate cancer can be a life-altering experience, affecting not only the man • African American men are 65% more likely diagnosed, but also his spouse, children, other family to develop prostate cancer compared with members and friends. That is why the PCF’s mission Caucasian men and are twice as likely to die to find better treatments and a cure for recurrent from the disease. prostate cancer is a means to achieve our even more • Men who have one first-degree relative – a profound goal: father, a brother or even a son – with prostate cancer are twice as likely to develop the disease, keeping families together. while those with two or more first-degree relatives are nearly four times as likely to be diagnosed. Keeping Families Together 5 David Koch – Prostate Cancer Survivor Diagnosed: 1992 Quality Time with Family This recent picture of my family demonstrates the full life I’ve been able to lead since being diagnosed. In May 1996 I was able to marry my beautiful wife, Julia, and soon thereafter, witness the birth of my two children, David Jr. and Mary Julia. And the family continues to grow! In this photo, Julia is carrying our third child, who is due in June 2006. 6 Prostate Cancer Foundation | Annual Report 2005 Just as no two men are alike, no two cases of prostate cancer are alike. Understanding how prostate cancer develops and spreads in each man remains one of the greatest research challenges. In 2005, the hard work and dedication of physicians and scientists around the world increased knowledge about this complex disease: • A greater understanding of the strengths • Recognition of the need for additional and weaknesses of the PSA (prostate-specific treatment options for men whose disease antigen) test as a marker for detecting prostate progresses despite treatment with existing cancer development and progression has drugs has led to the development of new underscored the need for better ways to chemotherapeutic agents that can destroy identify men at greatest risk for the disease, to tumor cells and improve quality of life. predict those who are likely to need aggressive Continued efforts by dedicated Prostate Cancer treatment and to assess the effectiveness of Foundation researchers and physicians will treatment strategies as the disease progresses. undoubtedly yield even greater advances in • A growing appreciation for the complexity understanding how prostate cancer develops of managing men with advanced disease has and spreads and will help countless men enjoy sparked the development of new and novel longer, more satisfying lives with their families treatment strategies, including therapeutic and loved ones. vaccines that boost the immune system’s ability to fight off prostate cancer cells. Keeping Families Together 7 Bob Each – Prostate Cancer Survivor Diagnosed: 1995 Climbing the Sky Tower in Auckland, New Zealand After my diagnosis more than 11 years ago, Joan, my wife, and I decided to fulfill some of our lifelong dreams of adventure. Our first trip was in 2001 to Africa, where we did valuable mission work for a children’s home. Following that, we visited Auckland, New Zealand, and climbed the Sky Tower, the highest freestanding building in the country.