THE JOURNAL OF CELL BIOLOGY
Cytoplasmic dyneinnomenclature which appeartobesharedamongsome,butnotall,cytoplasmic which Vallee, 1995).Threelightchain familieshavebeenidentified, 1993; Gilletal.,1994;Hughes1995;Vaughanand chain geneshavebeenfound(Mikamietal.,1993;Zhang dynein, buttwointermediatechainandlight been identifiedfortheinitiallydescribedformofcytoplasmic 2004; Pfisteretal.,2005).Onlyasingleheavychaingenehas plasmic dyneinshasemerged(forreviewseeValleeetal., 1987), furtherunderstandingofthesubunitcomplexitycyto- dynein wasfirstidentifiedandcharacterized(Paschaletal., gels intosubunitpolypeptidesof dyneincomplexisresolvedonSDS–polyacrylamide cytoplasmic lar processessuchasmembranetraffickingandmitosis.The motor proteinofthecell;itisinvolvedinmanyessentialcellu- Cytoplasmic dyneinisthemajormicrotubuleminusend–dire and isoforms. ofnewsubunits flexibility toaccommodatethediscovery two distinctcytoplasmicdyneincomplexesandhasthe of thepolypeptides.Thisnomenclaturerecognizes genes andthepublishedstudiesclarifyingfunctions teins thatreflectthephylogeneticrelationshipsof mammalian cytoplasmicdyneinsubunitgenesandpro- encoded bymultiplegenes.We proposenamesforthe malian cytoplasmicdyneins,manysubunitsofwhichare formam- on nomenclature.Thisisespeciallyimportant a strongneedformoredefinitiveconsensusstatement subunits ofcytoplasmicdyneincomplexes.Thus,thereis A varietyofnameshasbeenusedintheliteraturefor 11 10 9 8 7 6 5 4 3 2 1 E.Porter,Mary K. KevinPfister, and http://www.jcb.org/cgi/doi/10.1083/jcb.200508078 The JournalofCell Biology © Correspondence toK.KevinPfister:[email protected]
Department ofCellBiology,Department UniversityofVirginia SchoolofMedicine,Charlottesville, VA 22908 Department ofMolecular,Department Cellular, andDevelopmentalBiology, Berkeley, UniversityofCalifornia, Berkeley, CA94720 Department ofCellBiology,Department UniversityofMassachusettsMedicalSchool,Worcester, MA01655 ofBiology,Department JohnsHopkinsUniversity, Baltimore,MD21218 ofPhysiology,Department UniversityofPennsylvania,Philadelphia,PA 19104 Department ofBiologicalScience,UniversityNotreDame,IN46556 Department ofMolecular,Department Cellular, andDevelopmentalBiology, UniversityofColorado,Boulder, CO80309 ofGenetics,CellBiology,Department andDevelopment,UniversityofMinnesota,Minneapolis,MN55455 ofNeurodegenerativeDisease,InstituteNeurology,Department LondonWC1N3BG,UK
TeRceelrUiest rs $8.00 TheRockefellerUniversity Press
Department ofPathologyandCellBiology,Department ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork, NY10032 Department ofMolecular,Department Microbial,andStructuralBiology, UniversityofConnecticutHealthCenter, CT06030 Farmington, 74 (intermediatechains),