Anne Buckingham Young
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TPWKY This Is Exactly Right
TPWKY This is Exactly Right. Jay My name is Jay and I am 34 years old and I was recently diagnosed with Huntington's disease. My grandfather was diagnosed with Huntington's in his 80s but I don't think he and my grandmother really understood the severity of the illness and its implications for their children and grandchildren. So they never really told us until my father started seeing some symptoms in his 50s. So that's when I found out, I guess I was 28, I'd just been married, you know there's so much optimism and then I find out from my parents that there's this terrible shadow, you know, that's going to be potentially hanging over my life. And it was definitely really, really hard, I'm not gonna lie. Your priorities sort of shift, just trying to maximize the years that you might have with a good quality of life, you know. So I didn't get tested right away, I really wasn't ready. But over the years I started to I guess come to a point of acceptance and I also started to see symptoms starting to appear. Things like coordination issues, balance issues also, difficulty swallowing and drinking. So that's how it's starting to affect me and it got to a point where I was ready to be tested. And so I did that I guess a few months ago actually and now I have the official results that I am positive for Huntington's disease. At that point I guess it wasn't as bad as I thought actually to get those words. -
An Interview with Dr. Nancy Wexler: Discovering the Huntington Disease Gene By: Kristin Darwin One Morning in 1968, Dr
InsightsTM HD periodical A Huntington disease research Issue No 3 -- Fall 2012 Research Round-Up Antisense Meet Isis HD Research in Chile Dr. Lise Munsie Oligoneucleotides Pharmaceuticals Dr. Claudio Hetz and overviews recent Dr. Emily Mitchell Senior Vice President Dr. Rene Vidal discuss developments in HD Sontag overviews the Dr. C. Frank Bennett interventions that may research. CHDI Highlights promises and discusses the company’s alleviate secretory Page 3 Notes on this year’s challenges of using drug development pathway stress in HD. presentations at the Status Report: ASOs for gene efforts using ASOs. Page 11 CHDI HD Clinical Trials silencing. Page 8 Therapeutics At a glance Page 6 Conference in Palm information on Springs, California. current clinical trials Page 4 in HD. Page 5 An Interview with Dr. Nancy Wexler: Discovering the Huntington Disease Gene By: Kristin Darwin One morning in 1968, Dr. Nancy Wexler’s mother, Leonore Wexler, had jury duty in downtown Los Angeles. As Leonore crossed the street on the way to the courthouse, a policeman yelled to her, “How can you be drunk so early in the morning?” Leonore realized that she had been staggering – an obvious sign that something was wrong. Soon after, Leonore was diagnosed with Huntington disease (HD). Nancy Wexler, who was pursuing a PhD in clinical psychology at the time of her mother’s diagnosis, devoted her life to the study of HD. In 1979, Wexler and her colleagues began a research project in Venezuela to search for the HD gene. They surmised that finding the gene was the most direct route to the development of treatments, even cures! They developed a pedigree of over 18,000 individuals and collected more than 4,000 blood samples from the largest extended family with HD ever to have been discovered. -
Bulletin Vol
american academy of arts & sciences winter 2006 Bulletin vol. lix, no. 2 Page 1 American Academy Welcomes the 225th Class of Members Page 2 Exhibit from the Archives Members’ Letters of Acceptance Page 26 Concepts of Justice Essays by Alan Brinkley, Kathleen M. Sullivan, Geoffrey Stone, Patricia M. Wald, Charles Fried, and Kim Lane Scheppele inside: Projects and Studies, Page 15 Visiting Scholars Program, Page 24 New Members: Class of 2005, Page 42 From the Archives, Page 60 Calendar of Events Thursday, Saturday, February 9, 2006 March 18, 2006 Stated Meeting–Cambridge Stated Meeting–San Francisco “Tax Reform: Current Problems, Possible “Innovation: The Creative Blending of Art Contents Solutions, and Unresolved Questions” and Science” Speaker: James Poterba, mit Speaker: George Lucas, Lucas½lm Ltd. Academy News Introduction and Response: Michael J. Introduction: F. Warren Hellman, Graetz, Yale University Hellman & Friedman, LLC Academy Inducts 225th Class 1 Location: House of the Academy Location: Letterman Digital Arts Center, The Presidio of San Francisco Major Funding from the Mellon Time: 6:00 p.m. Foundation 1 Time: 5:00 p.m. Exhibit from the Academy’s Archives 2 Wednesday, February 15, 2006 Tuesday, April 4, 2006 Challenges Facing the Regional Meeting–Chicago Intellectual Community 7 Stated Meeting and Joint Meeting with “America’s Greatest Lawyer: Abraham Lincoln the Boston Athenæum–Boston in Private Practice and Public Life” Projects and Studies 15 “Great Scienti½c Discoveries of the Twentieth Speaker: Walter E. Dellinger, Century” Duke University Visiting Scholars Program 24 Speaker: Alan Lightman, mit Introduction: Saul Levmore, Academy Lectures University of Chicago Law School Location: Boston Athenæum Location: University of Chicago Law School Time: 6:00 p.m. -
'Jfu: 'Jwenty C:::Mnth Florida, U.S.A
_J L m§ 15. Prof. David Bates (1995) Professor of Neurology University of Newcastle-upon- Tyne, U.K. 16. Prof. W.G. Bradley (1996) Chairman & Professor of Neurology, University of Miami School of Medicine, 'Jfu: 'Jwenty c:::Mnth Florida, U.S.A. 17. Prof. Robert C Griggs (1997) Chairman and Neurologist-in-Chief, University of Rochester, New York, U.S.A. 18. Prof. M.R. Trimble (1998) 'J ~ ~ilnlrJaian Raymond Way Professor of Behavioural Neurology, Institute of Neurology, Queen Square, London, U.K. 19. Prof. Sid Gilman (1999) Chairman & Professor of Neurology University of Michigan, Michigan, U.S.A. 20. Prof. Timothy A. Pedley (2000) Henry & Lucy Moses Professor of Neurology & Chairman, Dept. of Neurology, Columbia University New York, U.S.A. Prof. J.C. Morris 21. Prof. RSJ Frackowiak (2001) Professor of Neurology, National Hospital Dr. Morris received his B.A. from Ohio Wesleyan University. After receiving his MD from Queen Square, London, U.K the UniversiLy of Rochester School o( Medicine and Dentistry i;1 Rochester, NY, in 1974, he 22. Prof. Stanley Fahn (2002) completed his internship at San Francisco General Hospital before joining a private practice Houston Merritt Professor of Neurology as a family physidan in Fairbanks, Alaska (1975-76) and then directing the Emergency Columbia University, New York, U.S.A. Room at Carlsbad Regional Medical Cenb·e In New Mexi o (1976-77). Dr. Morris received 23. Prof. Jeffrey L. Cummings (2003) Augustus Rose Professor of Neurology, board ccrtliication in Internal Medicine and Neu,rology after returning to OJ1io to complete Psychiatry & Biobehavioral Sciences, UCLA residency programs in medicine (Akron General Medical Centre) and neurology School of Medicine, Los Angeles, CA,U.S.A. -
Hgpwexlertranscript.Pdf (121Kb)
GEORGETOWN UNIVERSITY Joseph and Rose Kennedy Institute of Ethics SUBJECT: Nancy Wexler DATE: INTERVIEWER: Robert Cook-Deegan Q: ...on the grounds of the Banbury Center at Cold Spring Harbor Laboratories, around 1:20 p.m., an interview on the Human Genome Project. I do have a standard set of questions. The first one is to ask you kind of the general context of how you became connected to the Genome Project, what was the first time you heard about it, and what were your responses to it the first time you did hear about it? WEXLER: Hmm. Q: Well, there's an alternative way to get at that, which is where would you trace the roots of the Genome Project, what would you see as the important early events, and how does that relate to your work? Either one of those. WEXLER: Well, there are really two things: one is my own personal involvement with genetic mapping activities that then became the Human Genome Project; and my awareness of Nancy Wexler - page 1 the Human Genome Project as an organized entity, which was rather much later. I think probably the first thing that crossed my awareness that using DNA markers was a possible strategy for finding genes was an incredible letter (which I have to try to find someday) written by Ray White and Arlene Wyman to Miss Alice Pratt, who is the head of the Wills Foundation, which I believe then was the Huntington's Chorea Foundation. It was an old typewriter that had letters missing and was truly hand-pecked out. -
Houses Undergoing Psychoanalysis: Gehry's Residence, Venturi's Mother's House and Johnson's Glass House
Houses Undergoing Psychoanalysis: Gehry's Residence, Venturi's Mother's House and Johnson's Glass House Ruth Palmon Bachelor of Architecture Bezalel Academy of Art and Design Jerusalem, Israel, 1997 - Submitted to the Department of Architecture in Partial Fulfillment of the requirements for the degree of Master of Science in Architecture Studies At the Massachusetts Institute of Technology June 2002 © 2002 Ruth Palmon. All Rights Reserved The Author hereby grants MIT permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part. Signature of Author: Department of Architecture May 23, 2002 Certified by: Julian Beinart Professor of Architecture Thesis Supervisor Accepted by: Julian Beinart Professor of Architecture MASSACHUSETTS INSTITUTE Chairman ,Department Committee on Graduate Students OF TECHNOLOGY JUN 2 4 2002 ROTCH LIBRARIES Mark M. Jarzombek, Associate Professor of History and Architecture, Reader. Beatriz Colomina, Professor of History and Theory of Architecture, Princeton University, Reader. 2 Houses Undergoing Psychoanalysis: Johnson's Glass House, Venturi's Mother's House, and Gehry's Residence. By Ruth Palmon Submitted to the Department of Architecture on May 23, 2002 in Partial Fulfillment of the requirements for the degree of Master of Science in Architecture Studies ABSTRACT The objective of this thesis is to explore the relationship between the self and the house. In approaching the subject, my assumptions were that the basic condition of the house-self relationship is of tension and animosity and that architectural design, following a psychoanalytical tendency to reduce tension, is used to improve this condition. When great amounts of energy and care are invested in this process, the narrative of tension and its resolution is brought to the surface through architectural drawings. -
0307.1.00.Pdf
testing knowledge Before you start to read this book, take this moment to think about making a donation to punctum books, an independent non-profit press @ https://punctumbooks.com/support If you’re reading the e-book, you can click on the image below to go directly to our donations site. Any amount, no matter the size, is appreciated and will help us to keep our ship of fools afloat. Contributions from dedi- cated readers will also help us to keep our commons open and to cultivate new work that can’t find a wel- coming port elsewhere. Our adventure is not possible without your support. Vive la Open Access. Fig. 1. Hieronymus Bosch, Ship of Fools (1490–1500) testing knowledge: toward an ecology of diagnosis, Preceded by the dingdingdong Manifesto. Copyright © 2021 by the authors. This work carries a Creative Commons BY-NC-sa 4.0 International li- cense, which means that you are free to copy and redistribute the mate- rial in any medium or format, and you may also remix, transform and build upon the material, as long as you clearly attribute the work to the authors (but not in a way that suggests the authors or punctum books endorses you and your work), you do not use this work for commercial gain in any form whatsoever, and that for any remixing and transfor- mation, you distribute your rebuild under the same license. http://cre- ativecommons.org/licenses/by-nc-sa/4.0/ First published in 2012 (The Dingdingdong Manifesto) and 2015 (Testing Knowledge) by Éditions Dingdingdong. -
MATHEW MARTOMA, Defendant. No. 12
Case 1:12-cr-00973-PGG Document 271 Filed 02/27/14 Page 1 of 45 UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF NEW YORK UNITED STATES OF AMERICA, No. 12-cr-00973 (PGG) -against- ECF Case MATHEW MARTOMA, ORAL ARGUMENT REQUESTED Defendant. DEFENDANT MATHEW MARTOMA’S MEMORANDUM OF LAW IN SUPPORT OF HIS RENEWED MOTION FOR A JUDGMENT OF ACQUITTAL OR, ALTERNATIVELY, FOR A NEW TRIAL GOODWIN PROCTER LLP Richard M. Strassberg (RS5141) John O. Farley (JF4402) Daniel Roeser (DR2380) The New York Times Building 620 Eighth Avenue New York, New York 10018 (212) 813-8800 Roberto M. Braceras (RB2470) 53 State Street Boston, Massachusetts 02109 (617) 570-1000 Attorneys for Defendant Mathew Martoma February 27, 2014 Case 1:12-cr-00973-PGG Document 271 Filed 02/27/14 Page 2 of 45 TABLE OF CONTENTS Page PRELIMINARY STATEMENT .................................................................................................... 1 BACKGROUND ............................................................................................................................ 3 ARGUMENT .................................................................................................................................. 4 I. THE COURT SHOULD ENTER A JUDGMENT OF ACQUITTAL ON ALL COUNTS PURSUANT TO FEDERAL RULE OF CRIMINAL PROCEDURE 29. ............................................................................................................... 4 A. This Court Should Enter A Judgment Of Acquittal On The Substantive Counts Of Insider Trading. .................................................................................... -
A Physician's Guide to the Management of Huntington's Disease
A Physician’s Guide to the Management of Huntington’s Disease Third Edition Martha Nance, M.D. Jane S. Paulsen, Ph.D. Adam Rosenblatt, M.D. Vicki Wheelock, M.D. Front Cover Image: Volumetric 3 Tesla MRI scan from an individual carrying the HD mutation, with full manifestation of the disease. The scan shows atrophy of the caudate. Acknowledgements: Images were acquired as part of the TRACK-HD study of which Professor Sarah Tabrizi is the Principal Investigator. TRACK-HD is funded by CHDI Foundation, Inc., a not-for-profit organization dedicated to funding treatments for Huntington¹s disease. A Physician’s Guide to the Management of Huntington’s Disease Third Edition Martha Nance, M.D. Director, HDSA Center of Excellence at Hennepin County Medical Center Medical Director, Struthers Parkinson’s Center, Minneapolis, MN Adjunct Professor, Department of Neurology, University of Minnesota Jane S. Paulsen, Ph.D. Director HDSA Center of Excellence at the University of Iowa Professor of Neurology, Psychiatry, Psychology, and Neuroscience, University of Iowa Carver College of Medicine, Iowa City, IA Principal Investigator, PREDICT-HD, Study of Early Markers in HD Adam Rosenblatt, M.D. Director, HDSA Center of Excellence at Johns Hopkins, Baltimore Maryland Associate Professor of Psychiatry, and Director of Neuropsychiatry, Johns Hopkins University School of Medicine Vicki Wheelock, M.D. Director, HDSA Center of Excellence at University of California Clinical Professor, Neurology, University of California, Davis Medical Center, Sacramento, CA Site Investigator, Huntington Study Group Editors: Debra Lovecky Director of Programs, Services & Advocacy, HDSA Karen Tarapata Designer: J&R Graphics Printed with funding from an educational grant provided by 1 Disclaimer The indications and dosages of drugs in this book have either been recommended in the medical literature or conform to the practices of physicians’ expert in the care of people with Huntington’s Disease. -
Scientific Advisory Board
SCIENTIFIC ADVISORY BOARD “The Hereditary Disease Foundation has long driven major pioneering discoveries in the field of Huntington’s disease. Its workshops and other programs promoting the research that led to these discoveries have had an immense and far broader impact, for example helping enable the Human Genome Project both intellectually and experimentally. I have had the tremendous privilege of being an adviser to the Hereditary Disease Foundation and a close friend of its president Nancy Wexler for many years. I have enormously enjoyed and learned from my interactions.” H. Robert Horvitz, Ph.D. Nobel Laureate Investigator, Howard Hughes Medical Institute Professor of Biology Massachusetts Institute of Technology Scientific Advisory Board Hereditary Disease Foundation SCIENTIFIC ADVISORY BOARD The Hereditary Disease Foundation’s Scientific Advisory Board is composed of distinguished scientists from around the world. The Board sets the scientific priorities of the Foundation, reviews grant and fellowship applications and selects the most innovative and promising research projects to fund. Anne B. Young, M.D., Ph.D. Chair, Scientific Advisory Board Chair Emerita, Department of Neurology Massachusetts General Hospital Distinguished Julieanne Dorn Professor of Neurology Harvard Medical School Royal College of Physicians, London American Academy of Arts and Sciences National Academy of Medicine With funding from the Hereditary Disease Foundation and the National Institutes of Health, Anne Young has been involved in HD research for four decades. Anne participated in the Hereditary Disease Foundation’s Venezuela Project from 1981 until 2002 when the team could no longer return because of Venezuelan President Hugo Chavez’s restrictions. In Venezuela, Anne focused on making accurate diagnoses, drawing blood for DNA, taking skin biopsies and helping collect tissue samples generously donated by the Venezuelan family members. -
Kaplan V. S.A.C. Capital Advisors, L.P. 12-CV-09350-Joint Consolidated
Case 1:12-cv-09350-VM-KNF Document 127 Filed 03/31/14 Page 1 of 185 UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF NEW YORK - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - - - - - - - - x : DAVID E. KAPLAN, MICHAEL S. ALLEN, CHI-PIN HSU, GARY W. MUENSTERMAN, FRED M. ROSS, MICHAEL CAHILL, JOHN P. CONNOLLY, JOHN M. GOULD, CAROLINE P. GOULD, GREG : KAPPES, DEEANN LEMMERLING, LUC : No. 12 Civ. 9350 (VM) (KNF) LEMMERLING, GARRY LEONARD, DAVID : (All Actions) LINDSAY, RICHARD LLOYD, GLEN LOCHMUELLER, STEPHEN W. MAMBER, JAMES C. MCGOWAN, CHRIS MITCHEM, BRIDGET : JURY TRIAL DEMANDED MONRAD, CHRISTIAN MONRAD, BENJAMIN MONRAD, JOSEPH F. MORGAN, JIM MOSER, STEVEN R. OLSON, LAWSON PHILLIPS, : ECF CASE SEYMOND PON, PAT A. SANYE, RONALD J. SANYE, PATRICIA TRACY, LINH TU, RAJ VADDI, JOHN WOLFF, and RHONDA WOLFF, Individually and on Behalf of All Others Similarly Situated, Plaintiffs, - against - S.A.C. CAPITAL ADVISORS, L.P., S.A.C. CAPITAL ADVISORS, INC., CR INTRINSIC INVESTORS, LLC, CR INTRINSIC INVESTMENTS, LLC, S.A.C. CAPITAL ADVISORS, LLC, S.A.C. CAPITAL ASSOCIATES, LLC, S.A.C. INTERNATIONAL EQUITIES, LLC, S.A.C. SELECT FUND, LLC, STEVEN A. COHEN, MATHEW MARTOMA, and SIDNEY GILMAN, Defendants. - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - - - - - - - - x (caption continued . ) JOINT CONSOLIDATED AMENDED CLASS ACTION COMPLAINT Case 1:12-cv-09350-VM-KNF Document 127 Filed 03/31/14 Page 2 of 185 (. caption continued) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - x : BIRMINGHAM RETIREMENT AND RELIEF : SYSTEM and KBC ASSET MANAGEMENT NV, : Individually and on Behalf of All Others Similarly : Situated, : No. 13 Civ. 2459 (VM) (KNF) Plaintiffs, : - against - : JURY TRIAL DEMANDED : S.A.C. CAPITAL ADVISORS, L.P., S.A.C. CAPITAL : ADVISORS, INC., CR INTRINSIC INVESTORS, : ECF CASE LLC, CR INTRINSIC INVESTMENTS, LLC, S.A.C. -
ACT-AD and FDA Focus on Evaluating Clinical Effectiveness in Early Alzheimer's Disease
ACT-AD and FDA Focus on Evaluating Clinical Effectiveness in Early Alzheimer’s Disease -- Scientists and FDA discuss options to guide research and drug availability -- Rockville, MD, July 21, 2009 – The ACT-AD (Accelerate Cure/Treatments for Alzheimer's Disease) Coalition today hosted the second in a series of defining meetings with a senior representative from the US. Food and Drug Administration (FDA), leading scientists, drug developers and AD advocates to address critical issues affecting the review and approval of new therapies for Alzheimer’s disease (AD). Participants focused on the FDA’s current standards for defining clinical meaningfulness, especially in Mild Cognitive Impairment/Early Alzheimer’s Disease (MCI/EAD); explored potential alternatives to global or functional assessments in these patients; reviewed the need for better trial design; and considered learnings on MCI/EAD from other regulatory agencies. The meeting was coordinated by ACT-AD, a coalition of national organizations seeking to accelerate development of potential cures and treatments for AD, and co-hosted by The Alzheimer’s Association and Leaders Engaged in Alzheimer’s Disease (LEAD). “Over the past three years, ACT-AD’s member organizations and our partners have coordinated a series of historic meetings with the FDA that have brought expert consensus on key Alzheimer’s issues to the Agency and built a momentum of collaboration that today resulted in concrete progress toward a workable definition of clinical effectiveness in early stages of the disease. And just in time,” said Daniel Perry, chair of the ACT-AD Coalition. “Literally each day brings greater hope for breakthroughs, but it also brings greater urgency as we continue to fight this disease individually and as a nation.