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Cshperspect-CAL-Index 491-500 491..500 This is a free sample of content from Calcium Signaling. Click here for more information or to buy the book. Index A nitric oxide, 447–448 Adenylate cyclases, phosphorylation of, 306 testosterone, 446–447 2þ Adenylyl cyclases, 273–290 Arachidonate-regulated Ca (ARC) channels, STIM1 activity at single cell level, 290 roles in regulation, 74 overview, 273–275 Asthma, 474–475 phylogenetic tree, 276 Atherosclerosis, 472 physiological roles for Ca2þ-dependency of, ATP, ryanodine receptor (RyR) activation and, 285–287 105–106 2þ regulation by Ca2þ-signaling pathways, 278–290 ATPase. See Plasma membrane Ca ATPase (PMCA); by agonist-triggered Ca2þ release, 288 SERCA (sarco/endoplasmic reticulum 2þ by Ca2þ entry, 287 Ca ATPase); SPCA (secretory pathway 2þ compartments for Ca2þ and cAMP, 288–289 Ca ATPase) direct regulation by Ca2þ, 278–279 Atypical periodic paralyses (APP), role of ryanodine evidence for, 285, 286 receptors (RyRs) in, 101 indirect regulation by PKC, 281, 282–283 Autophagy, 452–455 indirect regulation via CaMKII, CaMKIV, and induction by ER stress pathways, 453 CaN, 279–280, 282 overview, 452–453 indirect regulation via GBg, 283–285 regulation by calcium signaling, 453–454 regulatory susceptibilities of, 275–278 regulation by IP3Rs, 454–455 structural domains of, 275 T-cell activation, 454 Aequorin, 361–362 Autosomal centronuclear myopathy, 475 A kinase anchoring protein (AKAP), 9–11 Axon outgrowth and pathfinding, regulation of, 345–346 Anesthesia, IP3R activity and, 472 Angiotensins, apoptosis regulation by, 446, 447 Apoptosis, 443–452 ER stress and, 464–467 B overview, 443–444 Bak, calcium regulation by, 451 regulation by anti-apoptotic Bcl-2 family proteins, Bax, calcium regulation by, 451 449–451 Bcl-2 family proteins IP3 receptor interaction, 449–450 apoptosis regulation by anti-apoptotic, 449–451 IP3R phosphorylation, 450 apoptosis regulation by proapoptotic, 451–452 2þ mitochondrial cross-talk, 450 regulation of ER Ca pump, 236 regulation of luminal calcium, 450–451 BH3-only proteins, calcium regulation by, 451–452 regulation of prosurvival calcium signals, 451 Bik, 452 regulation by antigen receptors, 444–445 Bim, 452 regulation by pharmacological agents, 448 BiP (immunoglobulin bonding protein), 199–200 cisplatin, 448 BKCa channels, in smooth muscle, 436, 437 staurosporine, 448 Brody disease, 475 2þ thapsigargin, 448 Buffers. See Calcium (Ca ) buffers, cytosolic; 2þ regulation by proapoptotic Bcl-2 family proteins, Calcium (Ca ) buffers, organellar 451–452 Burn injury, 475 calcium regulation by Bax and Bak, 451 calcium regulation by BH3-only proteins, 451–452 C regulation by signaling molecules, 445–448 Ca2þ current types, 2–4 angiotensins, 446, 447 Ca2þ-dependent inactivation (CDI), 68–69 corticosteroids, 445–446 Ca2þ homeostasome, 188–191 491 © 2011 by Cold Spring Harbor Laboratory Press This is a free sample of content from Calcium Signaling. Click here for more information or to buy the book. Index Ca2þ-induced Ca2þ release (CICR), in cardiac endoplasmic reticulum Golgi intermediate myocytes, 404–405, 407–409 complex, 206 Ca2þ sensors, as buffers, 177 Golgi Ca2þ stores, 205–206 Cab45, 205 mitochondria, 206 CaBPs. See Calcium-binding proteins peroxisomes, 206 Cadmium toxicity, 475 sarcoplasmic reticulum Ca2þ stores, 201–205 Calbindin-D9K (CB-D9K), 184–185 Calcium channels. See Store-operated calcium channels properties of, 178 (SOCs); Transient receptor potential structure, 181 (TRP) channels; Voltage-gated calcium Calbindin-D28K (CB-D28K), 185–186 channels functional aspects, 185–186 Calcium oscillations, 159–171 properties of, 178 computational models for, 160–167 structural aspects, 185 classifications, 162 structure, 181 InsP3 oscillations and, 161–164 Calcineurin (CaN) perspectives, 166–167 adenylyl cyclase regulation, 277, 282 stochastic aspects, 164–165 cardiac RyRs and, 409 interplay between Ca2þ entry and Ca2þ release Calcium-binding proteins during, 167–171 histidine-rich and regulation of ER Ca2þ pump, 238 overview, 159–160 neuronal function, regulation of, 262–266 store-operated calcium (SOC) channels, 168–171 voltage-gated calcium channels Calcium signaling CaV2 channels in synaptic transmission, autophagy regulation by, 453–454 14–15 in cardiac myocytes, 403–418 excitation-contraction coupling, 11 during mammalian fertilization, 313–328 Calcium (Ca2þ) buffers, cytosolic, 177–191 in neuronal development, 337–348 Ca2þ homeostasome and, 188–191 in smooth muscle, 423–438 Ca2þ sensors as, 177 in synapse-to-nucleus communication, 371–392 calbindin-D9K (CB-D9K), 184–185 visualization during embryonic skeletal muscle calbindin-D28K (CB-D28K), 185–186 formation in vertebrates, 351–366 functional aspects, 185–186 Caldendrin, 265, 266 structural aspects, 185 Calmodulin (CaM) calretinin, 186 Ca2þ channels, 11, 14–15 defined, 177–179 IP3 receptor regulation, 126 mitochondrial Ca2þ buffering compared, neuronal functions of, 255–257 187–188 ryanodine receptor (RyR) regulation, 106, 408 parameters to characterize, 179–186 as sensor for CDI (Ca2þ-dependent inactivation), intracellular concentration, 179 69, 407 ligand interaction, 182 Calneurons, 263, 265–266 metal-binding affinities, 179–180 Calnexin, regulation of ER Ca2þ pump and, metal-binding kinetics, 180, 182 236–237 mobility, 182 CALNUC (nucleobindin), 205 parvalbumins, 182–184 Calreticulin functional aspects, 183–184 gain-of-function (overexpression), 199 structured aspects, 182–183 loss-of-function (deficiency), 198–199 pH buffers compared, 178 organellar calcium buffering, 198–199 properties of, 178 regulation of ER Ca2þ pump, 236–237 structure, 181 structure, 198 Calcium (Ca2þ) buffers, organellar, 197–207 Calretinin endolysosomal compartment, 206 properties of, 178 endoplasmic reticulum, 197–201 structural and functional aspects, 186 calreticulin, 198–199 Calsequestrin, 201–203 ERp72, 200–201 in cardiac myocytes, 408 GRP94, 200 ryanodine receptor (RyR) regulation, 106–107, 408 immunoglobulin bonding protein Calumenin, regulation of ER Ca2þ pump and, (BiP/GRP78), 199–200 237–238 protein disulfide isomerase (PDI), 200 CaM. See Calmodulin (CaM) 492 © 2011 by Cold Spring Harbor Laboratory Press This is a free sample of content from Calcium Signaling. Click here for more information or to buy the book. Index CaM kinase (CaMK) nephropathy, 470 adenylyl cyclase regulation, 277, 279–280, 282 sensory neuropathy, 470 CaMKII vascular disease, 469–470 dendritic arborization and, 344–345 Diacylglycerol kinases (DGK), phosphorylation of, 306 ryanodine receptor (RyR) phosphorylation, 108 Dihydropyridine receptors (DHPRs), 104 CaN. See Calcineurin (CaN) Cancer, 476–477 anticancer drugs, 476–477 E malignant transformation, 476 EF-hand proteins Cardiac cycle, overview of, 403–404 calcium-binding proteins (CaBPs), 262–264 Cardiac myocytes cytosolic calcium buffers, 177, 181 adaptation to disease, 414–417 neuronal calcium sensor (NCS) proteins, 257, 258 calcium signaling, 403–418 Endolysosomal compartment Ca2þ efflux, 410–412 calcium buffers, 206 contraction, 409–410 NAADP and physiology of, 152–153 excitation-contraction coupling, 404–406, 413 transient receptor potential (TRP) channels, L-type VOCCs, regulation of, 406–407 41–44 RyRs and CICR, regulation of, 407–409 Endoplasmic reticulum 2þ cardiac cycle, 403–404 Ca homeostasis in, 462–464 2þ subcellular organization, 412–414 Ca pumps of, 229–245 Cardiomyopathy, diabetic, 468–469 calcium buffers, 197–201 Cardiovascular diseases, 472–473 calreticulin, 198–199 Catecholaminergic polymorphic ventricular tachycardia ERp72, 200–201 (CPVT), 408 GRP94, 200 Cation channels, nonselective immunoglobulin bonding protein calcium signaling in smooth muscle, 429–431 (BiP/GRP78), 199–200 receptor-activated channels, 430–431 protein disulfide isomerase (PDI), 200 CB-D9K. See Calbindin-D9K (CB-D9K) calcium depletion and disease, 461–477 CB-D28K. See Calbindin-D9K (CB-D28K) asthma, 474–475 CDI (Ca2þ-dependent inactivation), 68–69 atherosclerosis, 472 Central core disease, 101, 475 autosomal centronuclear myopathy, 475 Channels. See specific channel types Brody disease, 475 Cholestatic liver disease, 475 burn injury, 475 Chronic heart failure, 472–473 cadmium toxicity, 475 CICR (Ca2þ-induced Ca2þ release), in cardiac cancer, 476–477 myocytes, 404–405, 407–409 cardiovascular diseases, 472–473 Cisplatin, apoptosis regulation by, 448 central core disease, 475 Corticosteroids, apoptosis regulation by, 445–446 chronic heart failure, 472–473 CPVT (catecholaminergic polymorphic ventricular diabetes mellitus, 467–471 tachycardia), 408 liver diseases, 475 CRAC (Ca2þ release-activated Ca2þ) channels lung diseases, 474–475 accumulation/activation at ER-PM junctions, neural ischemia, 471 64–66 neurodegeneration, 471–472 overview, 58 neurological diseases, 471–472 properties, 68–69 neuropathic pain, 472 Ca2þ-dependent inactivation (CDI), 68–69 skeletal muscle diseases, 475 ion selectivity and permeation, 68 skin disease, 475–476 CSQ. See Calsequestrin virus infection, 473–474 Cytosolic calcium buffers, 177–191 conduit from synapse to nucleus, 390–391 ER-PM junctions CRAR channel accumulation/activation at, D 64–66 Dendritic arborization, 344–345 formation and function of, 71–72 DHPRs (dihydropyridine receptors), 104 STIM accumulation at, 63–64 Diabetes mellitus, 467–471 NAADP and lysosomal-ER interactions, 150–151 cardiomyopathy, 468–469 transient receptor potential (TRP) channels, 38–41 493 © 2011 by Cold Spring Harbor Laboratory Press This is a free sample of content from Calcium Signaling. Click here for more information or to buy the book. Index
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