Small-Bowel Capsule Endoscopy and Device-Assisted Enteroscopy For
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352 Guideline Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small- bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline Authors Marco Pennazio1, Cristiano Spada2, Rami Eliakim3, Martin Keuchel4, Andrea May5, Chris J. Mulder6, Emanuele Rondo- notti7, Samuel N. Adler8, Joerg Albert9, Peter Baltes4, Federico Barbaro2, Christophe Cellier10, Jean Pierre Charton11, Michel Delvaux12, Edward J. Despott13, Dirk Domagk14, Amir Klein15, Mark McAlindon16, Bruno Rosa17, Georgina Rowse18, David S. Sanders16, Jean Christophe Saurin19, Reena Sidhu16, Jean-Marc Dumonceau20, Cesare Hassan2,21, Ian M. Gralnek15 Institutions Institutions listed at end of article. Bibliography This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). DOI http://dx.doi.org/ The Guideline was also reviewed and endorsed by the British Society of Gastroenterology (BSG). It ad- 10.1055/s-0034-1391855 dresses the roles of small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and Endoscopy 2015; 47: 352–376 treatment of small-bowel disorders. © Georg Thieme Verlag KG Stuttgart · New York ISSN 0013-726X Main recommendations 1 ESGE recommends small-bowel video capsule ESGE does not recommend routine small-bowel Corresponding author endoscopy as the first-line investigation in pa- imaging or the use of the PillCam patency capsule Marco Pennazio, MD tients with obscure gastrointestinal bleeding prior to capsule endoscopy in these patients Division of Gastroenterology San Giovanni Battista University- (strong recommendation, moderate quality evi- (strong recommendation, low quality evidence). Teaching Hospital, dence). In the presence of obstructive symptoms or known Via Cavour 31 2 In patients with overt obscure gastrointestinal stenosis, ESGE recommends that dedicated small 10123 Turin bleeding, ESGE recommends performing small- bowel cross-sectional imaging modalities such as Italy bowel capsule endoscopy as soon as possible after magnetic resonance enterography/enteroclysis or Fax: +39-11-6333979 the bleeding episode, optimally within 14 days, in computed tomography enterography/enteroclysis [email protected] order to maximize the diagnostic yield (strong re- should be used first (strong recommendation, low commendation, moderate quality evidence). quality evidence). 3 ESGE does not recommend the routine perform- 6 In patients with established Crohn’s disease, ance of second-look endoscopy prior to small- based on ileocolonoscopy findings, ESGE recom- bowel capsule endoscopy; however whether to mends dedicated cross-sectional imaging for perform second-look endoscopy before capsule small-bowel evaluation since this has the potential endoscopy in patients with obscure gastrointesti- to assess extent and location of any Crohn’s disease nal bleeding or iron-deficiency anaemia should be lesions, to identify strictures, and to assess for ex- decided on a case-by-case basis (strong recom- traluminal disease (strong recommendation, low mendation, low quality evidence). quality evidence). 4 In patients with positive findings at small-bowel In patients with unremarkable or nondiagnostic capsule endoscopy, ESGE recommends device-as- findings from such cross-sectional imaging of the sisted enteroscopy to confirm and possibly treat small bowel, ESGE recommends small-bowel cap- lesions identified bycapsule endoscopy (strong re- sule endoscopy as a subsequent investigation, if commendation, high quality evidence). deemed to influence patient management (strong 5 ESGE recommends ileocolonoscopy as the first recommendation, low quality evidence). endoscopic examination for investigating patients When capsule endoscopy is indicated, ESGE re- with suspected Crohn’s disease (strong recom- commends use of the PillCam patency capsule to mendation, high quality evidence). confirm functional patency of the small bowel In patients with suspected Crohn’s disease and (strong recommendation, low quality evidence). negative ileocolonoscopy findings, ESGE recom- 7 ESGE strongly recommends against the use of mends small-bowel capsule endoscopy as the ini- small-bowel capsule endoscopy for suspected coe- tial diagnostic modality for investigating the small liac disease but suggests that capsule endoscopy bowel, in the absence of obstructive symptoms or could be used in patients unwilling or unable to known stenosis (strong recommendation, moder- undergo conventional endoscopy (strong recom- ate quality evidence). mendation, low quality evidence). Pennazio Marco et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment… Endoscopy 2015; 47: 352–376 Guideline 353 Abbreviations gastrointestinal bleeding (OGIB), iron-deficiency anaemia, sus- ! pected and known Crohn’s disease, tumours, polyposis syn- BSG British Society of Gastroenterology dromes, and coeliac disease. CECDAI Capsule Endoscopy Crohn’s Disease Activity Index This Guideline, commissioned by the European Society of Gastro- CECT contrast-enhanced computed tomography intestinal Endoscopy (ESGE) and endorsed by the British Society CI confidence interval of Gastroenterology (BSG), in addition to updating previous ESGE CT computed tomography guidelines [1,2], analyzes in detail the performance of VCE and CTA computed tomography-angiography device-assisted enteroscopy compared with nonendoscopic CTE computed tomography-enterography/enteroclysis methods for the investigation of the small bowel. The aim of this DBE double-balloon enteroscopy evidence-based and consensus-based Guideline, is to provide EATL enteropathy associated T-cell lymphoma caregivers with a comprehensive guide for the clinical applica- EMA endomysial antibodies tion of enteroscopy. FAP familial adenomatous polyposis FOBT faecal occult blood test GRADE Grading of Recommendations Assessment, Methods Development and Evaluation ! GIST gastrointestinal stromal tumour The ESGE commissioned this Guideline and appointed a guide- HLA human leukocyte antigen line leader (M.P.) who invited the listed authors to participate in IBD inflammatory bowel disease the project development. The key questions were prepared by IBDU inflammatory bowel disease-unclassified the coordinating team (M.P. and C.S.) and then approved by the ICCE International Conference on Capsule Endoscopy other members. The coordinating team formed task force sub- IDA iron-deficiency anaemia groups, each with its own coordinator, and divided the key topics MRE magnetic resonance enterography/enteroclysis amongst these task forces (see Appendix e1, available online). MRI magnetic resonance imaging Each task force performed a systematic literature search to pre- NPV negative predictive value pare evidence-based and well-balanced statements on their as- NSAIDs nonsteroidal anti-inflammatory drugs signed key questions. The coordinating team independently per- OGD oesophagogastroduodenoscopy formed systematic literature searches with the assistance of a li- OGIB obscure gastrointestinal bleeding brarian. The Medline, EMBASE and Trip databases were searched OR odds ratio including at minimum the following key words: video capsule PJS Peutz–Jeghers syndrome endoscopy (VCE), double-balloon enteroscopy (DBE), single-bal- PPV positive predictive value loon endoscopy (SBE), spiral enteroscopy, small-bowel, and en- RCD refractory coeliac disease teroscopy. All articles on the use of VCE and device-assisted en- RCT randomized controlled trial teroscopy in patients with OGIB, iron-deficiency anaemia, SBE single-balloon enteroscopy Crohn’s disease, small-bowel tumours, polyposis syndromes, SBFT small-bowel follow-through and coeliac disease were selected by title or abstract. All selected tTG tissue transglutaminase articles were graded by the level of evidence and strength of re- VCE (small-bowel) video capsule endoscopy commendation according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system [3,4]. Evidence tables and Recommendations for assessment of guide- Introduction line implementation are provided in Appendices e2 and e3 (avail- ! able online). The field of gastrointestinal endoscopy has made great strides Each task force proposed statements on their assigned key ques- over the past several decades, and endoscopists have mastered tions which were discussed and voted on during the plenary the art of advancing flexible video endoscopes in the upper and meeting held in November 2013.The literature searches were up- lower parts of the gastrointestinal tract. Endoscopic evaluation dated through to November 2014. In November 2014, a draft pre- of the small bowel (i.e., enteroscopy), on the other hand, poses a pared by the coordinating team was sent to all group members. unique challenge that has plagued physicians for decades. With After agreement on a final version, the manuscript was submit- the development of newer enteroscopic modalities, a more thor- ted to Endoscopy for publication. The journal subjected the ough evaluation is now possible. These new techniques comprise manuscript to peer review and the manuscript was amended to small-bowel video capsule endoscopy (VCE) and device-assisted take into account the reviewers’ comments. All authors agreed on enteroscopy; the latter includes double-balloon enteroscopy the final revised manuscript. The final revised manuscript was (DBE), single-balloon enteroscopy (SBE), spiral enteroscopy, and then reviewed and approved by the BSG. This Guideline was