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CAN2019 Program The Canadian Association Meeting Program for Neuroscience presents 13th Annual Canadian Neuroscience Meeting May 22–25, 2019 Sheraton Centre Toronto Hotel @CAN_ACN #CAN2019 CAN.ACN Toronto City Hall can-acn.org Catalyzes formation of oligomers Fibril Elongation Alpha Synuclein Alpha Synuclein Alpha Synuclein Alpha Synuclein Monomer Oligomer Protofibril Oligomer Preformed Fibril Tau PFFs Tau Fibrils Paired Helical Neurofibrillary Tau Monomers Filaments Tangles Alpha Synuclein & Tau Preformed fibrils (PFFs) for neurodegeneration research Alpha Synuclein Proteins for Tau Proteins for Alzheimer’s Parkinson’s Disease Research Disease Research Alpha synuclein PFFs seed the formation of new New tau PFFs cause tau monomers to aggregate into fibrils from a pool of active monomers, inducing Lewy neurofibrillary tangles, leading to the tau pathology body pathology in neurons. A53T mutant monomers seen in Alzheimer’s Disease. Monomers, PFFs, and and PFFs are available. filaments are available. ICC/IF of primary rat neurons IHC of rat brain treated with TEM of Tau 2N4R PFFs TEM of Tau 2N4R Filaments treated with alpha synuclein PFFs alpha synuclein PFFs Alpha synuclein pathology Booth #1 Find out more: www.stressmarq.com/PFFs | [email protected] | 1.250.294.9065 TABLE OF CONTENTS Letter from the president page 1 Program-at-a-glance page 3 About CAN-ACN page 4 CAN-ACN leadership page 5 Executive Committee page 5 Membership information page 5 General conference information page 6 Award winners page 9 2019 Young investigator awardee page 9 Advocacy award presentations page 10 Special meetings & social events page 11 CAN-ACN pre-conference events page 12 Annual conference schedule page 15 Keynote sessions & plenary symposia overviews page 24 Parallel symposia overviews page 30 CAN-ACN exhibitors page 49 Poster author index page 55 Poster sessions page 68 Session 1 – Thursday, May 23 page 68 Session 2 – Friday, May 24 page 81 Session 3 – Saturday, May 25 page 94 Poster & exhibitor floor plans page 107 Poster session 1 page 108 Poster session 2 page 109 Poster session 3 page 110 Thanks to our exhibitors page 112 The Canadian Association for Neuroscience | 13th Annual Meeting 2019 | can-acn.org 3 LETTER FROM THE PRESIDENT Dear Colleagues and Friends Welcome to the 13th annual Canadian Neuroscience Meeting. The Scientific Program Committee, chaired by Dr. Paul Frankland and co-chair Dr. Ruth Slack, along with local chair Dr. Julie Lefebvre, have put together an exciting roster of scientific presentations, community building events and opportunities for networking and career development. The CAN meeting, as always, aims to be a safe and welcoming environment for all our attendees, guests and staff. This year, with guidance from our Equity, Diversity and Inclusion committee and the Board of Directors, we have generated a statement that encapsulates the values of CAN and will help ensure a safe and positive meeting environment for all. The full statement is available on our website (https://can-acn.org/can-meeting-value-statement). We will be hosting a luncheon on Equity, Diversity and Inclusion, and are excited to welcome Dr. Imogen Coe as expert speaker on this topic. This important event will help inform the action CAN will take to address EDI issues in coming years. Scientific highlights of the 2019 meeting include the Presidential lecture by Dr. Robert Malenka, Keynote address by Dr. Michelle Monje and plenary lectures by Drs. Jeffrey Mogil, Florian Engert and Guo-Li Ming. The plenary symposia, featuring prominent Canadian and international speakers, and the diverse parallel symposia proposed by our members complete the CAN scientific program. I want to warmly congratulate this year’s Young Investigator laureate, Dr. Blake Richards, from the University of Toronto at Scarborough. Dr. Richards’ research explores the neural basis of deep learning. The goal of this work is to better understand the neurobiological basis of animal and human intelligence and provide new insights to help guide AI development. His laboratory has made several important contributions to mathematical models of learning and memory in the brain. Don’t miss the CAN Young Investigator award lecture to learn more about these exciting discoveries. Dr. Richards will also host the CAN public lecture, which this year features a Canadian pioneer in Artificial Intelligence, Dr. Geoffrey Hinton, from the University of Toronto. This event will explore the use of artificial intelligence to understand how the brain computes. CAN has developed important partnerships over the years which help support and expand our meeting. IBRO has been a consistent supporter of our meeting, and this year will help facilitate our efforts to increase the participation of trainees from underrepresented groups in our meeting. We are grateful for their commitment to increasing the diversity of our attendees and for expanding the range of research presented at our meeting. I also wish to thank the International Society for Developmental Neuroscience for their important support as platinum sponsors. Finally, we are excited to welcome the Lundbeck Foundation, which awards the annual Brain Prize to honour scientists who have made outstanding contributions to neuroscience. This year we will host the Brain Prize lecture by 2016 awardee Dr. Graham Collingridge from the University of Toronto. I hope you enjoy the meeting and look forward to meeting many of you during the week. Jaideep Bains, PhD President of the Canadian Association for Neuroscience 1 back to Table of Contents The Canadian Association for Neuroscience | 13th Annual Meeting 2019 | can-acn.org Chers collègues et amis Bienvenue au 13e congrès canadien annuel des neurosciences. Le comité du programme scientifique, présidé par Dr Paul Frankland, co-présidé par Dre Ruth Slack, et la présidente du comité local d’organisation Dre Julie Lefebvre, ont monté un programme passionnant combinant présentations scientifiques et événements de réseautage et de développement de carrière. Comme toujours, le congrès de l’ACN vise à créer un environnement sûr et accueillant pour tous nos participants, invités et membres du personnel. Cette année, grâce aux conseils de notre comité sur l’équité, la diversité et l’inclusion et du conseil d’administration, une déclaration de valeurs de l’ACN a été rédigé pour contribuer à garantir un environnement de congrès positif et sans danger pour tous. La déclaration complète est disponible sur notre site web (https://can-acn. org/fr/declaration-de-valeurs). Nous organisons un atelier-lunch sur l’équité, la diversité et l’inclusion (EDI), et nous sommes ravis d’accueillir la Dre Imogen Coe en tant que conférencière experte sur ce sujet. Cet événement important aidera à informer l’action que l’ACN entreprendra pour répondre aux questions portant sur l’EDI dans les années à venir. Les points forts scientifiques du congrès 2019 incluent la conférence présidentielle du Dr. Robert Malenka, la conférence principale de la Dre Michelle Monje et les conférences plénières des Drs Jeffrey Mogil, Florian Engert et Guo-Li Ming. Les colloques pléniers réunissant des conférenciers canadiens et internationaux éminents, ainsi que les divers symposiums parallèles proposés par nos membres complètent le programme scientifique de cette année. Je tiens à féliciter chaleureusement le lauréat du prix Jeune chercheur de l’ACN 2019, le Dr Blake Richards, de l’Université de Toronto à Scarborough. Les recherches du Dr Richards explorent les bases neuronales de l’apprentissage en profondeur (deep learning). Le but de ce travail est de mieux comprendre la base neurobiologique de l’intelligence animale et humaine et de fournir de nouvelles informations pour aider à guider le développement de l’Intelligence Artificielle (IA). Son laboratoire a fait des contributions importantes aux modèles mathématiques d’apprentissage et de mémoire dans le cerveau. Ne manquez pas la conférence du jeune chercheur de l’ACN pour en savoir plus sur ces découvertes passionnantes. Le Dr Richards animera également la conférence publique de l’ACN, avec un pionnier canadien en intelligence artificielle, le Dr Geoffrey Hinton, de l’Université de Toronto. Cet événement explorera l’utilisation de l’IA pour comprendre le fonctionnement du cerveau. L’ACN a développé d’importants partenariats au fil des ans, qui aident à soutenir et à élargir notre congrès. L’IBRO soutient cette année la participation des stagiaires des groupes sous-représentés à notre congrès grâce à l’attribution de bourses de voyage. Nous leur sommes reconnaissants de leur engagement à accroître la diversité de nos participants et à élargir l’éventail des recherches présentées lors de notre congrès. Je souhaite également remercier l’International Society for Developmental Neuroscience pour son soutien important en tant que commanditaire platine. Enfin, nous sommes ravis d’accueillir la Fondation Lundbeck, qui décerne le Brain Prize annuellement à des scientifiques ayant fait une contribution exceptionnelle aux neurosciences. Cette année, le Dr Graham Collingridge de l’Université de Toronto, récipiendaire du Brain Prize 2016, donnera une conférence Brain Prize à notre congrès. J’espère que vous apprécierez le congrès et je me réjouis de pouvoir rencontrer nombre d’entre vous au cours de la semaine. Jaideep Bains, PhD Président de l’Association canadienne des neurosciences The Canadian Association for Neuroscience | 13th Annual Meeting 2019 | can-acn.org back to Table of Contents 2 PROGRAM-AT-A-GLANCE TIME Wednesday, May
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