Downloaded from http://perspectivesinmedicine.cshlp.org/ on October 1, 2021 - Published by Cold Spring Harbor Laboratory Press History of the Discovery of Hepatitis A Virus Stephen M. Feinstone Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine, Washington, D.C. 20037 Correspondence:
[email protected] Disease outbreaks resembling hepatitis A have been known since antiquity. However, it was not until World War II when two forms of viral hepatitis were clearly differentiated. After the discovery of Australia antigen and its association with hepatitis B, similar method- ologies were used to find the hepatitis A virus. The virus was ultimately identified when investigators changed the focus of their search from serum to feces and applied appropriate technology. iseases resembling hepatitis A, both in DIFFERENTIATION OF TWO FORMS OF Dindividuals and in outbreaks involving VIRAL HEPATITIS groups, were reported in China as early as 5000 years ago. Hippocrates noted a disease Viral hepatitis was a major problem for both the he called benign epidemic jaundice in “De Allies and the Axis during World War II. Early Morbis Internis” that certainly resembled hep- in the war, an outbreak of hepatitis related to atitis A. More accurate descriptions of hepatitis yellow fever vaccine, stabilized with human se- A began appearing in the 17th century often rum involving 49,233 clinically apparent cases associated with military campaigns. The first (Seeff et al. 1987), prompted a major hepatitis outbreak recorded in the United States was research effort. As the records on the vaccinees in 1812 in Norfolk, VA, and the disease was were very good, the incubation period was de- common among the Union troops during fined accurately as between 60 and 154 days.