Received: 10 January 2017 | Accepted: 26 February 2017 DOI: 10.1111/liv.13408 GENETIC AND METABOLIC LIVER DISEASE Binge drinking and the risk of liver events: A population- based cohort study Fredrik Åberg1 | Jaana Helenius-Hietala2 | Pauli Puukka3 | Antti Jula3 1Transplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki Abstract University, Helsinki, Finland Background & Aims: Binge drinking or heavy episodic drinking is increasingly preva- 2 Department of Oral and Maxillofacial lent, but the health effects are incompletely understood. We investigated whether Diseases, Helsinki University Hospital, Helsinki University, Helsinki, Finland binge drinking increases the risk for liver disease above and beyond the risk due to 3Department of Health, National Institute for average alcohol consumption. Health and Welfare, Turku, Finland Methods: 6366 subjects without baseline liver disease who participated in the Finnish Correspondence population- based Health 2000 Study (2000- 2001), a nationally representative cohort. Fredrik Åberg, MD, PhD, Transplantation Follow- up data from national registers until 2013 were analysed for liver- related ad- and Liver Surgery Clinic, Helsinki University Hospital, Helsinki University, Helsinki, Finland. missions, mortality and liver cancer. Binge drinking (≥5 drinks per occasion, standard Email:
[email protected] drink 12 g ethanol) was categorised as weekly, monthly, or as less often or none. Funding information Multiple confounders were considered. FÅ received research grants from Wilhelm and Else Stockmanns Foundation, Liv och Hälsa, Results: Eighty- four subjects developed decompensated liver disease. Binge drinking and Finska Läkaresällskapet. frequency showed a direct association with liver- disease risk after adjustment for aver- Handling Editor: Helena Cortez-Pinto age daily alcohol intake and age.