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Book of Abstracts PEMED 2018 Personalized and Precision Medicine International Conference June 25-27, 2018 Paris BOOK OF ABSTRACTS premc.org Personalized and Precision Medicine International Conference 2018 Table of Contents Polypharmacology of Anti-Cancer Antibodies 1 Prof. Yosef Yarden Population-wide data and text mining of electronic health records 2 Prof. Lars Juhl Jensen DIAGENODE: Epigenomics Profiling Services 3 Dr. Matteo Tosolini Pharmacogenomics and Epigenetics: Update and Future Directions 4 Prof. Matthias Schwab How can dendrimers contribute to precision/personalized medicine? 5 Prof. Anne-marie Caminade Novel Hot Spot Mutations in BCR-ABL1: a Personalised Medicine Approach in Chronic Myeloid Leukaemia 7 Dr. Erik Laurini, Dr. Suzana Aulic, Dr. Domenico Marson, Prof. Maurizio Fermeglia, Prof. Sabrina Pricl Cluster analysis of oncogenes associated with colorectal cancer 8 Dr. Dmitriy Babenko, Mrs. Yelena Babenko Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients 10 Ms. Ibtissem Hannachi, Dr. Zohra CHADLI, Dr. Emna Kerkeni, Dr. Amel Chaabane, Dr. Nadia Ben Fredj, Prof. Naceur Boughattas, Prof. Karim Aouam Transient neonatal diabetes : multilocus methylation defects associated with novel ZFP57 mutation 11 Ms. Ameni Touati, Dr. Javier Errea, Prof. Sonia Nouri, Dr. Arreta Pereda, Dr. Aida Guith, Prof. Nabiha Mahd- haoui, Prof. Ali Saad, Prof. Guiomar Perez De Nanclares, Prof. Dorra H’mida Targeting the JNK-JUN pathway to reduce phenotypic plasticity and overcome therapy resistance in metastatic melanoma 12 Dr. Petranel Ferrao Pharmacogenomics of Sickle Cell Disease: Pain and Drug metabolism associated Gene Variants, and hydroxyurea-induced miRNAs 13 Ms. Khuthala Mnika, Prof. Wonkam Ambroise, Dr. Emile Chimusa, Prof. Collet Dandara, Dr. Shaheen Mowla The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F 14 Mrs. Vesna Gorenjak, Dr. Alex-Ander Aldasoro Arguinano, Dr. Sébastien Dadé, Dr. Maria Stathopoulou, Dr. Dwaine Vance, Ms. Christine Masson, Dr. Sophie Visvikis-Siest Development of microRNA biomarkers for predicting toxicities of selective COX-2 NSAIDs using Daphnia model 16 Mr. Myung-Gyun Kang, Dr. Bosun Kwon, Ms. Yoonjung Hong, Dr. Ryeo-ok Kim ii Personalized and Precision Medicine International Conference 2018 Pharmacogenetics of P450 CYP3A4 and CYP3A5 in the Tunisian population: Clinical application with tacrolimus 17 Ms. Ibtissem Hannachi, Dr. Zohra CHADLI, Dr. Emna Kerkeni, Dr. Amel Chaabane, Dr. Nadia Ben Fredj, Prof. Naceur Boughattas, Prof. Karim Aouam Analysis of the expression and colocalization study of CD44 And CD74 receptors expressed on human lung cancer derived cell. 18 Dr. Waleed Al abdulmonem, Dr. Hussain Alssadh The Diagenode Epigenetics Custom Service: Complete workflows for genome-scale DNA methylation and histone marks analysis 19 Dr. Matteo Tosolini How to Consider Rare Genetic Variants in Personalized Drug Therapy 20 Mr. Yitian Zhou, Dr. Souren Mkrtchian, Prof. Masahiro Hiratsuka, Prof. Magnus Ingelman-sundberg, Dr. Volker Lauschke Implementation of Pharmacogentics in clinical practice – The U-PGx project 22 Dr. Jesse Swen Pharmacogenomics of drug-induced liver injury 23 Prof. Ann Daly Genetic variability in organic cation transporter OCT1: a variance with clinical implication? 24 Prof. Mladen Tzvetkov Interindividual variability of hepatic membrane transporters and its impact on precision medicine 25 Prof. Anne Nies DNA Methyltransferases Expression in Triple-negative Breast Cancer Predicts Sensitivity to Decitabine 26 Dr. Liewei Wang, Dr. Jia Yu Liquid biopsy: A new diagnostic concept in oncology 28 Prof. Klaus Pantel Precision Medicine for Metastatic Breast Cancer Patients 30 Prof. Fabrice André The epigenetics of colon cancer & the GCAT |Genomes for Life: a cohort of the genomes of Catalonia 31 Prof. Manuel Perucho, Dr. Sonia Forcales, Dr. Gabrijela Dumbovic, Dr. Sergio Alonso, Dr. Rafael De Cid Preparation of functional nanogels for tumor imaging and therapy 32 Prof. Xiangyang Shi, Ms. Wenjie Sun, Mr. Jianzhi Zhu, Ms. Yiwei Zhou, Dr. Chen Peng, Prof. Mingwu Shen Development and clinical translation of a handheld imaging device for 5-ALA-induced fluorescence guided breast conserving surgery 33 Mr. Christopher Gibson, Dr. Kathryn Ottolino-Perry, Dr. Alexandra Easson, Dr. Wey Leong, Dr. Susan Done, Dr. Ralph DaCosta Genomic Association Study of Warfarin in Caribbean Hispanics. 35 Dr. Karla Claudio-Campos, Ms. Aurora Labastida, Dr. Alga S Ramos, Dr. Andrea Gaedigk, Mrs. Jessicca Y Renta, Ms. Dariana Padilla, Dr. Stuart Scott, Dr. Gualberto Ruano, Dr. Carmen Cadilla, Dr. Duconge Jorge iii Personalized and Precision Medicine International Conference 2018 Defining new strategies for therapy in PRKAG2 mutations and hypertrophic cardiomyopathy: implica- tions for personalised medicine in inherited cardiac disorders 37 Dr. Rameen Shakur, Mr. Juned Kadiwala, Dr. Robert Lowe Measurements of Heterotypic Associations Between Cluster of Differentiation CD74 and CD44 in Human Breast Cancer-Derived Cells 38 Dr. Hussain Alssadh, Dr. Patrick Spencer, Dr. Waleed Al abdulmonem, Dr. Rana Alghamdi, Dr. Inamul Hassan, Dr. Jose M. Miranda-sayago, Prof. Neslon Fernández Precision Medicine and immunomodulatory therapy for Stevens Johnson Syndrome/Toxic Epidermal Necrolysis. 40 Prof. Omer Iqbal Applications of artificial intelligence in precision medicine 41 Mr. Michal Madera, Prof. Jacek Kluska CDA status predicts life-threatening toxicities in AML patients treated with cytarabine 42 Dr. raphaelle fanciullino, Dr. Laure Flahault, Mrs. Melanie Donnette, Dr. Diane-charlotte Imbs, Dr. Vadim Ivanov, Dr. Geoffroy Venton, Dr. Ciccolini Joseph, Prof. L’houcine Ouafik, Prof. Bruno Lacarelle, Prof. Regis Costello Identifying Hyperphoria as a Leading Cause of Migraines and Linking Similarities to Seizures with Binoc- ular Exams and Prisms 43 Dr. David Chang An AI Enable Digital Physical Exam for the future of Precision Medicine 44 Mr. Mark Punyanitya, Dr. Girish Srinivasan, Mr. Zachary Rapp Detecting pre-cancers by liquid biopsy: The proof-of-principle and dilemma. 45 . John Martignetti, Mr. Deep Pandya, Dr. Nimesh Nagarsheth, Dr. Ying Chen, Dr. Olga Camacho-vanegas, Dr. Robert Sebra, Dr. Boris Reva, Dr. Peter Dottino New Key Questions and Tests to Precisely Identify Asthenopia Problems for Physicians, Parents and Pa- tients 47 Dr. David Chang Fluorescence-guided tumor surgery using a new RGD-based probe 48 Dr. Alessia Cordaro, Dr. Chiara Brioschi, Dr. Federica Chianale, Dr. Luigi Miragoli, Dr. Paolo Oliva, Dr. Giovanni Valbusa, Dr. Francesco Blasi, Dr. Federico Maisano, Prof. Enzo Terreno Methylation status of tumor suppressor genes in glioblastomas: evidence of survival correlation 49 Dr. Saoussen Trabelsi, Ms. Ameni Touati, Ms. Nesrine Ben Salah, Ms. Maroua Mastouri, Prof. Nadia Mama, Prof. Mohamed Ladib, Prof. Slim Ben Ahmed, Prof. Noureddine Bouaouina, Prof. Moncef Mokni, Prof. Hedi Krifa, Prof. Ali Saad, Prof. Kalthoum Tlili, Prof. Chris Jones, Prof. Dorra H’mida A novel predictor for stratifying pancreatic cancer patients to DNA damage checkpoint inhibitors 50 Dr. Dannel Yeo, Dr. Robert Jorissen, Prof. Mehrdad Nikfarjam, Dr. Petranel Ferrao Epigenetics for Precision Health and Performance 51 Dr. Mickra Hamilton A Multi-Omics approach to define the epigenetic profile of your model system 52 Dr. Sarantis Chlamydas iv Personalized and Precision Medicine International Conference 2018 Collaborations in Precision Medicine: Building the World’s First Data Commons in NAFLD/NASH 54 Dr. Diane Harbison Implementing Preemptive Clinical Pharmacogenomic Testing at an Institution-Wide Level 55 Dr. Cyrine Haidar, Dr. Mary Relling iASiS: Big Data to Support Precision Medicine and Public Health Policy 56 Dr. Anastasia Krithara, Dr. Maria-Esther Vidal, Prof. Ernestina Menasalvas, Dr. Alejandro Rodriguez-Gonzalez, Dr. Eleftherios Samaras, Prof. Peter Garrard, Dr. Maria Torrente, Mr. Anastasios Nentidis, Dr. Grigorios Tzortzis, Dr. Vassiliki Rentoumi, Dr. Benjamin Lang, Mr. Nikos Dimakopoulos, Dr. Rui Mauricio, Dr. Alison Evans, Dr. Louiqa Raschid, Dr. Jordi Rambla De Argila, Prof. Gian Gaetano Tartaglia, Prof. Mariano Provencio Pulla, Dr. Georgios Paliouras From cardiovascular genomics to interdisciplinary precision medicine 58 Prof. Anna Dominiczak Pharmacogenetics to Pharmaco-omics: Precision Medicine and Drug Response 60 Dr. Richard Weinshilboum Treatment and cure strategies for WHIM syndrome immunodeficiency 61 Dr. Philip Murphy Precision medicine, challenges and opportunities 62 Prof. Jacques S Beckmann Integrated analysis of transcriptome and DNA sequence variation identifies genetic variants associated with circular RNA expression and their potential to contribute to disease risk 63 Dr. Ikhlak Ahmed, Dr. Joel Malek Functional profiling of circular noncoding RNA circANKRD12 in cancer 64 Dr. Thasni Karedath, Dr. Ikhlak Ahmed, Ms. Fatima Al Dasim, Ms. Wafa Al Ameri, Dr. Joel Malek Global DNA (hydroxy)methylation is not associated to MTX response at 3 months in early RA patients. 65 Ms. Helen Gosselt, Mr. Bertrand Van Zelst, Prof. Mieke Hazes, Prof. Robert De Jonge, Dr. Sandra Heil Distribution of genetic polymorphisms of genes implicated in thiopurine drugs metabolism 66 Dr. Zohra CHADLI, Dr. Emna Kerkeni, Ms. Ibtissem Hannachi, Dr. Saoussen Chouchene, Dr. Nadia Ben Fredj, Dr. Amel Chaabane, Prof. Naceur Boughattas, Prof. Karim Aouam Regulatory considerations on the evaluation of companion diagnostics (CDx) in Japan
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