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(12) Patent Application Publication (10) Pub. No.: US 2017/0042958 A1 Du Et Al

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(12) Patent Application Publication (10) Pub. No.: US 2017/0042958 A1 Du Et Al US 20170042958A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0042958 A1 Du et al. (43) Pub. Date: Feb. 16, 2017 (54) METHODS OF REDUCING SKIN 46R 8/97 (2006.01) NFLAMMATION USING COMPOSITIONS A61O 19/08 (2006.01) COMPRISING AMPELOPSIS A6IR 36/48 (2006.01) GROSSEDENTATA AND ALBIZA JULIBRISSN EXTRACTS A6IR 9/00 (2006.01) (52) U.S. Cl. (71) Applicant: Johnson & Johnson Consumer Inc., CPC ............... A61K 36/87 (2013.01); A61K 36/48 Skillman, NJ (US) (2013.01); A61K 9/0014 (2013.01); A61K 8/97 (72) Inventors: Hua Du, Shanghai (CN); Yan Li, (2013.01); A61O 19/08 (2013.01); A61O Shanghai (CN); Tao Liu, Shanghai 19/007 (2013.01) (CN); Yingxin Ma, Shanghai (CN) (57) ABSTRACT (21) Appl. No.: 14/863,629 (22) Filed: Sep. 24, 2015 A composition for applying to skin in need of treatment for skin barrier restoration, hydration and moisturization, the (30) Foreign Application Priority Data composition comprising extracts of Ampelopsis grosseden tata and Albizia julibrissin. Also provided are methods for Aug. 14, 2015 (CN) ......................... 2O15105OO612.1 treating skin in need of skin barrier treatment, methods of Publication Classification treating skin to reduce the signs of aging and methods of (51) Int. Cl. treating skin to reduce the signs of inflammation with a A6 IK 36/87 (2006.01) composition comprising extracts of Ampelopsis grosseden A61O 19/00 (2006.01) tata and Albizia julibrissin. US 2017/0042958 A1 Feb. 16, 2017 METHODS OF REDUCING SKN activity of flavonoid-rich extracts from leaves of Ampelopsis NFLAMMATION USING COMPOSITIONS grossedentata. J. Food Biochem. 2009, 33, 808-820.). Mod COMPRISING AMPELOPSIS ern pharmacology studies have shown that it had activities GROSSEDENTATA AND ALBIZA Such as anticancer, liver protection, anti-oxidation, anti JULIBRISSN EXTRACTS inflammatory and so on (Xiao J. Zheng, Hao Xiao, Zhi Zeng, ZiW. Sun, Can Lei, Jing Z. Dong, Ying Wang. Composition CROSS REFERENCE TO RELATED and serum antioxidation of the main flavonoids from fer APPLICATION mented vine tea (Ampelopsis grossedentata) has also been 0001. This application claims priority of the benefits of shown. Journal of functional foods. 2 0 1 4, 9, 290–294.) Chinese Patent Application No. 201510500612.1, filed Aug. 0005 Albizia julibrissin is a species of tree from the 14, 2015, the complete disclosure of which is hereby incor Fabaceae family, native to Southwestern and eastern Asia. It porated herein by reference in its entirety. is known by a wide variety of common names such as “Persian silk tree' or "pink sins”. It is widely planted as an FIELD OF THE INVENTION ornamental plant in parks and gardens. The seeds of the plant are used as food for livestock and by wildlife. The extracts 0002 The present invention relates to compositions for of Albizia julibrissin are found to have anti-depressant treating the skin barrier and improving skin hydration com properties Kim, J H; Kim, SY; Lee, SY; Jang, C G (2007). prising plant extracts for use on skin. More specifically, the “Antidepressant-like effects of Albizzia julibrissin in mice: present invention relates to compositions comprising Involvement of the 5-HT1A receptor system’. Pharmacol extracts of Ampelopsis grossedentata and Albizia julibrissin ogy, Biochemistry, and Behavior 87 (1): 41-7. In traditional for improving the condition and appearance of the skin, Such Chinese medicine, Albizia julibrissin is used to nourish the as by improving skin barrier protection, improving hydra heart and calm the spirit. See http://www.acupuncture-and tion and moisturization of the skin and reducing inflamma chinese-medicine.com/albizza.html, accessed Jun. 15, 2015. tion of the skin, and providing anti-aging properties to the It is also used for treating insomnia, injuries due to falls and skin. removing carbuncles. “Shen Nong's Herbal Classic', a famous Chinese ancient book, teaches its medicinal use for BACKGROUND OF THE INVENTION mental diseases. Albizia julibrissin main constituents 0003) A wide variety of compositions intended for include triterpenoid saponins, lignanoids, phenolic glyco improving the appearance of skin, including improving skin sides, flavonoids, spermine macrocyclic alkaloids and so on. hydration and moisturization, are known in art. However, Among them, the triterpenoid Saponins have been proved to most of these moisturizing agents work either through be the main bioactive principles of this crude drug (Kokila formation of occlusive films on the skin that prevent tran K. Priyadharshini S. D. Sujatha V. Phytopharmacological Sepidermal water loss (e.g., mineral oil, petrolatum and other properties of Albizia species: a review. Int J Pharm Pharm oils), or through humectants that attract and retain moisture Sci 2013; 5(Suppl. 3):70-3.). Modern pharmacology studies on the skin Surface (e. g. glycerin, propylene glycol, buty have shown it possessed sedative, antidepressant, anti-oxi lene glycol and so on). There is a need for agents that protect dant, anti-tumor, immunomodulatory, anti-fertility and anti the skin barrier more holistically. platelet activating factor receptor activities. (Hongxiang 0004 Ampelopsis grossedentata or “Moyeam' is a spe Sun, Shuwang He, Minghua Shi. Adjuvant-active fraction cies of plant belonging to the Vitaceae family, genus: from Albizia julibrissin Saponins improves immune Ampelopsis Michx. The specific name grossedentata comes responses by inducing cytokine and chemokine at the site of from the plant's growing structure and leaves. It is mainly injection. International Immunopharmacology 22 (2014) distributed in middle and south of China. It also finds 346-355). presence in Some South-east Asian countries. Moyeam is 0006. The skin provides a vital barrier structure that generally grown in Zhang Jiajie, the famous mountain in protects human from environmental insults. The epidermis, Hunan province of China. The leaves and stems are used to where most of the skin barrier function resides, is highly make a herbal tea popular by the name “Moyearm in China. stratified and has an outermost layer that is cornified. Epi The tea is very popular among health-conscious consumers dermal barrier integrity disruption or dysfunction is patho for its high levels of flavonoids especially Dihydromyrice logically involved in a variety of compromised skin condi tin. Traditional uses include cure for respiratory diseases, tions, including dry skin, skin sensitization, atopic eliminating inflammation, as an anti-oxidant, regulating dermatitis, psoriasis and aging. To build a strong and blood Sugar and fat and as an anti-cancer agent. Ampelopsis improved skin barrier it is necessary to increase the thresh grossedentata is widely used as a medicinal plant. Its dried old to defend against extrinsic stimulates. Even for compro leaves and stems, also named as Vine Tea or Mao Yan Mei, mised skin conditions, the restoration of the skin barrier is have been consumed as a health tea and herbal medicine for also important for recovering and reducing appearance of hundreds of years. The chemical content of this plant dry, aging, inflammation and other pathological properties. includes flavonoids such as dihydromyricetin and myricetin (Du, Q.: Chen, P.; Jerz, G.; Winterhalter, P. Preparative 0007 Dry skin is a common skin condition that affects separation of flavonoid glycosides in leaves extract of almost all of people at Some times in their lives. Dry skin can Ampelopsis grossedentata using high-speed counter-current cause many skin problems including atopic dermatitis, chromatography. J. Chromatogr. A 2004, 1040, 147-149.). It eczema, psoriasis and pruritus. The moisturizing is also a was used as folk medicine or a daily drink for the treatment key step for an elastic and transparent skin condition, which of hepatitis, flu, hypertension, hyperglycemic and Sore makes skin look healthy, young and beautiful. throat. (Gao, J. H.; Liu, B. G.; Ning, Z. X. Zhao, R. X. 0008 Inflammatory skin conditions such as atopic der Zhang, A. Y.; Wu, Q. Characterization and antioxidant matitis, eczema and sensitive skin also have a close con US 2017/0042958 A1 Feb. 16, 2017 nection with the skin's barrier properties. Epidermal integ during epidermal differentiation. This function is catalyzed rity is necessary for the skin to defend against external by transglutaminase 1 (TGM 1). Most TGM1 is anchored to stimulants. the keratinocyte plasma membrane via fatty acyl linkages 0009 Filaggrin is an important protein involved in skin and can also function to crosslink lipids to the envelope. moisturizing and immune responses through its contribution Richard L. Eckert, Michael T Sturniolo, Ann-Marie to skin barrier structure and functions. Filaggrin can be Broome, Monica Ruse and Ellen A Rorke (2005)' Trans degraded to free amino acids forming a major component of glutaminase Function in Epidermis’ Journal of Investigative natural moisturizing factor (NMF), which serves as the Dermatology (2005) 124, 481-492 Mutation or reduced primary humectant of the stratum corneum (SC). 2-pyrroli amount of TGM 1 is associated with lamellar ichthyosis and done-5-carboxylic acid (PCA) and urocanic acid (UCA) are other skin problems with skin barrier dysfunction. Thus an two important NMF components, which bind water and increase of TGM 1 is beneficial for improving skin strength make the Surface of normal skin soft and flexible. Filaggrin, and preventing SC from coming off. together with NMF, contribute to stratum corneum (SC) 0013 Dry skin, aging, itching and other skin problems hydration and pH. Filaggrin is different from traditional are related to decreased differential ability and metabolism moisturizing ingredients which function to increase water of skin. Cell vitality is a basic source of skin physiological absorption. Filaggrin and NMF function to improve the skin properties. Recovery or improvement of skin cell vitality barrier function and water binding capability of the epider can provide a potential differential ability and metabolism of mis. Decreased filaggrin and NMF are mainly the key skin, which are important for skin regeneration and defend factors resulting in dry skin. Restoration or improvement of ing intrinsic and extrinsic stimulate.
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