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[email protected]) Title page Evaluating the biological effects of electronic cigarettes using a novel in-house designed aerosol delivery system and an in-vitro co-culture model of the human airways Pranav Vasanthi Bathrinarayanan Doctor of Philosophy Aston University June 2018 ©Pranav Vasanthi Bathrinarayanan, 2018 Pranav Vasanthi Bathrinarayanan asserts his moral right to be identified as the author of this thesis This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without proper acknowledgement. 1 Aston University Evaluating the biological effects of electronic cigarettes using a novel in-house designed aerosol delivery system and an in-vitro co-culture model of the human airways Pranav Vasanthi Bathrinarayanan Doctor of Philosophy June 2018 Summary Although electronic cigarettes (ECs) have been widely promoted as safer alternatives to tobacco cigarettes, limited scientific data is currently available on their possible health effects. The current study aims to investigate the potential effects of ECs using a novel in- house designed cigarette/EC aerosol delivery system and physiologically relevant 2D and 3D in-vitro human airway models.