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O F Ito T I F I!-X..5 HOT Z" /> eTable 1: Regular use of Acetaminophen and risk of ovarian cancer in the HOPE study No of Cases No. of Controls OR (95% CI)a Nonuserb 738 1,447 1.00 Regular usersc 164 355 0.98 (0.79, 1.23) Types of usersd Continuous 98 212 0.98 (0.74, 1.30) Current 9 24 0.81 (0.36, 1.83) Past 57 119 1.02 (0.72, 1.45) Standardized daily dosee Low 136 291 0.99 (0.77, 1.26) Moderate-High 28 64 0.98 (0.60, 1.60) Age at first use (years) < 45 86 175 1.02 (0.75, 1.37) ≥ 45 78 180 0.95 (0.70, 1.30) Age at last use (years) < 55 84 183 0.98 (0.72, 1.32) ≥ 55 80 172 0.99 (0.73, 1.35) Time since first use (years) < 10 82 167 1.05 (0.78, 1.43) ≥ 10 81 188 0.91 (0.68, 1.23) Time since last use (years) < 4 114 256 0.94 (0.72, 1.22) ≥ 4 49 99 1.08 (0.74, 1.56) a: ORs and p-values are adjusted by age at reference year, interview year, study center, race, education, breastfeeding, numbers of full-term, duration of oral contraception use (years), body mass index, postmenopausal hormone use, arthritis, diabetes, and prior tubal ligation. b: Non-user: Women who indicated that they had not used acetaminophen (but may or may not use aspirin or NA-NSAIDs) ≥ 2 tablets/per week for at least 6 months (“minimal level”). Reference category. c: Regular user: women who indicated that they had used acetaminophen (but may or may not use aspirin or NA-NSAIDs) ≥ 2 tablets/per week for at least 6 months d: Duration of use was defined by three indicators: (1) continuous (had used for at least 1 year and until or beyond the reference date); (2) current (used only less than a year and used on the reference date); (3) past users (discontinued use at least 1 year before the reference date). e: Only 6 cases and 9 controls used high standardized daily dose of acetaminophen, so we combined moderate- and high-standardized daily dose into one group (moderate-high) eTable 2: Regular use of NA-NSAIDs only or Acetaminophen by self-reported indications and risk of ovarian cancer in the HOPE study NA-NSAIDs only Acetaminophen No. Cases No. Controls OR (95% CI)a No. Cases No. Controls OR (95% CI)a Nonusers b 456 850 1.00 738 1447 1.00 Regular usersc by indicationsd Arthritis/bursitis, rheumatism 74 191 0.85 (0.59, 1.21) 62 161 0.88 (0.62, 1.25) Headache 16 38 0.99 (0.51, 1.91) 50 100 1.05 (0.72, 1.53) Other pain or injuries 85 127 1.33 (0.96, 1.85) 65 125 1.04 (0.73, 1.46) a: ORs and p-values were adjusted by age at reference year, interview year, region of residence, race, education, breastfeeding, numbers of full-term births, duration of oral contraception use (years), body mass index, postmenopausal hormone use, arthritis, diabetes, and prior tubal ligation. b: Non-user: for NA-NSAIDs only, women who indicated that they had not used aspirin or NA-NSAIDs ≥ 2 tablets/week for ≥ 6 months (“minimal level”); for acetaminophen, Women who indicated that they had not used acetaminophen (but may or may not use aspirin or NA-NSAIDs) ≥ 2 tablets/per week for at least 6 months. Reference category. c: Regular user: women who indicated that they had used aspirin≥ 2 tablets/week for ≥ 6 months d: If patients used NA-NSAIDs (or acetaminophen) for different major indications before the reference date, each episode (indication) was counted separately eTable 3: Regular use of Aspirin, NA-NSAID, Acetaminophen and Risk of Ovarian Cancer by Tumor Behaviors and Histologic Types in the HOPE study OR (95% CI)a among Regular usersb Aspirin only NA-NSAID only Aspirin plus NA-NSAID Nonusers c 1.00 1.00 1.00 Tumor Behaviors Borderline or low-malignant potential 0.66 (0.43, 1.02) 1.04 (0.60, 1.60) 0.74 (0.44, 1.24) Invasive 0.79 (0.62, 1.02) 1.06 (0.82, 1.39) 0.99 (0.73, 1.34) Histologic Types Serous 0.79 (0.59, 1.05) 0.95 (0.70, 1.30) 0.75 (0.52, 1.08) e Non-Serous 0.83 (0.58, 1.19) 1.27 (0.90, 1.78) 1.30 (0.87, 1.93) a: The ORs were adjusted by age at reference year, interview year, region of residence, race, education, breastfeeding, numbers of full-term births , duration of oral contraception use (years), body mass index, postmenopausal hormone use, arthritis, diabetes, and prior tubal ligation. b: Regular user: women who indicated that they had used aspirin/NA-NSAIDs/aspirin plus NA-NSAIDs ≥ 2 tablets/week for ≥ 6 months c: Non-user: Women who indicated that they did not use aspirin or NA-NSAIDs ≥ 2 tablets/week for ≥ 6 months (“minimal level”). Reference category e: Non-serous types include mucinous (n=66), endometrioid (n=100), clear cell (n=54), mixed cells (n=77), and other/unknown epithelial tumors (n=89). Except serous type, other histologic types had small sample sizes, resulting in imprecise estimates. eTable 4: Regular Use of Aspirin, NA-NSAID or Acetaminophen and Risks of Ovarian Cancer in the HOPE Study (Definition of non-users: without use any analgesics regularly) No. of No. of OR (95% CI)a Cases Controls Nonuserb 411 784 1.00 Regular users 491 1018 0.97 (0.81, 1.16) Aspirin only 136 285 0.79 (0.61, 1.04) Types of users c Continuous 102 234 0.73 (0.54, 0.98) Current 5 15 0.50 (1.18, 1.44) Past 29 36 1.43 (0.82, 2.51) SDDd Low 77 197 0.68 (0.49,0.94) Moderate 41 61 0.97 (0.62, 1.53) High 18 27 1.07 (0.54, 2.10) NA-NSAID only 119 232 1.13 (0.86, 1.49) Types of users c Continuous 65 131 1.14 (0.80, 1.62) Current 8 22 0.85 (0.35, 2.06) Past 46 79 1.30 (0.85, 2.01) SDDd Low 68 120 1.25 (0.88, 1.79) Moderate 24 58 0.96 (0.56, 1.65) High 27 54 1.19 (0.70, 2.02) Aspirin + NA-NSAID 72 146 1.09 (0.76, 1.55) c Types of users Continuous 61 125 1.07 (0.74, 1.57) Current 4 5 2.62 (0.63, 10.80) Past 7 16 0.82 (0.31, 2.16) d Standardized daily dose Low 42 94 0.89 (0.58, 1.38) Moderate 17 34 1.39 (0.72, 2.67) High 13 18 1.70 (0.78, 3.70) e Acetaminophen only 45 66 1.26 (0.81, 1.95) e Aspirin plus Acetaminophen 33 75 0.92 (0.58, 1.47) e Acetaminophen plus NA-NSAID 48 104 0.94 (0.62, 1.44) Aspirin plus Acetaminophen plus NA-NSAID 38 110 0.83 (0.53, 1.30) a: The ORs were adjusted by age at reference year, interview year, region of residence, race, education, breastfeeding, numbers of full-term births, duration of oral contraception use (years), body mass index, postmenopausal hormone use, arthritis, diabetes, and prior tubal ligation. b: Non-user: Women who indicated that they did not used any aspirin, NA-NSAIDs or acetaminophen ≥ 2 tablets/week for ≥ 6 months (“minimal level”). Reference category. c: Duration of use was defined by three indicators: (1) continuous (had used for at least 1 year and until or beyond the reference date); (2) current (used only less than a year and used on the reference date); (3) past users (discontinued use at least 1 year before the reference date). d: To examine dose-response effects, the average daily dose was converted to a standardized daily dose by dividing it minimal effective analgesic doses per day. Dosages were categorized into two clinically relevant categories: low-dose (≤ 0.5SDD), moderate -to-high dose (>0.5 SDD). e: Subgroup analyses of dose- and duration-effects were not shown due to relatively small sample size in cases. 10 No. CONTINUATION BOOK USED: 0 No 0 Yes HOPE (HORMONES AND OVARIAN CANCER PREDICTION) UNIVERSITY OF PITISBURGH CANCER INSTITUTE UNIVERSITY OF PITISBURGH, GRADUATE SCHOOL OF PUBLIC HEALTH AND MAGEE-WOMENS HOSPITAL Pis: Franoesmary Modugno, Ph.D., M.P.H. Roberta B. Ness, M.D., M.P.H. Revision: September 10, 2003 ...__._------­ .~ 6904 SECTION A:BEFORE AND AFTER INTERVIEW REVlSION 911012003 • A1. 10 Number IONU"" A2. case/Control Status \ -: 0 Case~ 0 Control c.. F\?E.c..OrJ A3. Area Code and Telephone Prefix A4. County _ [[] l-\G;hJ..<J tt - \ AS. Institutio" _ Code "99" for controls [[] \N~"TN c\:..\v...J,t- -, A6. Date of Interview OJ I OJ I [[IIJ INi'<'J DAlE. rna da yr -~J\.7. Reference MonthNear (REF MO YR*) -his is 9 months BEFORE todBy's Date. mo yr AS. Interviewer 10 [[] A9. Place of Interview \ N l" LDC. o o Home I 0 Wor!< 1. 0 Study Center ~ 0 HOBpitallClinic '\ 0 other Spe<IIy: 0.:0 First (initial) Interview A10. Interview Type I:: 0 Verification (second) Interview • Page 1 of 72 • ---------_.._. .~ 8904 SECTION B: DEMOGRAPHICS • First, I have some questions about your background. 81. Date of Birth 82. Age in 'REF MO YR' PTf\Eo", \'>II\TI\ In rn /rn /rnrn LU cI.~"']..
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