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1 CURRICULUM VITAE the Johns Hopkins University School Of CURRICULUM VITAE The Johns Hopkins University School of Medicine Hiroshi Ashikaga, M.D., Ph.D. Date: September 30, 2018 DEMOGRAPHIC AND PERSONAL INFORMATION Current Appointments University 2018-present Associate Professor of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine (https://www.hopkinsmedicine.org/profiles/results/directory/profile/2076821/hiroshi-ashikaga) Hospital 2012-present Attending Physician, Cardiac Arrhythmia Service, Johns Hopkins Hospital Other 2018-present Visiting Scholar, IHU Liryc, Electrophysiology and Heart Modeling Institute (L'institut de rythmologie et modélisation cardiaque), Université de Bordeaux, France (https://www.ihu-liryc.fr/) Personal Data Cardiac Arrhythmia Service, Division of Cardiology, Department of Medicine Carnegie 568, 600 N. Wolfe Street Baltimore, Maryland 21287 Tel: 410-955-7534 Fax: 443-873-5019 Email: [email protected] Education and Training Undergraduate 1992 Premedical course (no degree), University of Tokyo, College of Arts and Sciences, Tokyo, Japan Doctoral/graduate 1996 M.D., University of Tokyo, Faculty of Medicine, Tokyo, Japan 2007 Ph.D., University of Tokyo, Graduate School of Medicine, Japan Thesis advisor: Ryozo Nagai, M.D. (Present position: President, Jichi Medical University, Japan) Postdoctoral 1997 Intern in Medicine, University of Tokyo Hospital, Tokyo, Japan 2000 Resident in Medicine, Beth Israel Medical Center, New York, New York 2001 Chief Resident in Medicine, Beth Israel Medical Center, New York, New York 2004 Research Fellow in Bioengineering, Division of Cardiology, University of California, San Diego Primary Mentor: James W. Covell, M.D. (Present position: Professor Emeritus, University of California, San Diego) 2006 Research Fellow in Cardiovascular MRI, Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute (NHLBI), Bethesda, Maryland Primary Mentor: Elliot R. McVeigh, Ph.D. (Present position: Professor, University of California, San Diego) 2010 Clinical Fellow in Cardiovascular Disease, Johns Hopkins Hospital, Baltimore, Maryland 2012 Clinical Fellow in Clinical Cardiac Electrophysiology, Johns Hopkins Hospital, Baltimore, Maryland Professional Experience 2000-2001 Instructor of Medicine, Albert Einstein College of Medicine, Bronx, New York 2007-2008 Attending Physician, Cardiovascular Center, HIMEDIC Imaging Center, Lake Yamanaka, Japan 2007 Lecturer, Fukuoka School of Health Sciences, Japan (part-time) 2012-2018 Assistant Professor of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 2012-2017 Assistant Professor of Biomedical Engineering (secondary appointment), Department of Biomedical Engineering, Johns Hopkins University School of Medicine 1 2017-2018 Faculty, Malone Center for Engineering in Healthcare, Johns Hopkins University (https://malonecenter.jhu.edu/) 2018 Visiting Scholar, Kavli Institute of Theoretical Physics, University of California, Santa Barbara, California (https://www.kitp.ucsb.edu/) 2018-present Visiting Scholar, IHU Liryc, Electrophysiology and Heart Modeling Institute (L'institut de rythmologie et modélisation cardiaque), Université de Bordeaux, France (https://www.ihu-liryc.fr/) 2018-present Associate Professor of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland PUBLICATIONS Original Research [OR] 1. Ashikaga H, Criscione JC, Omens JH, Covell JW, Ingels NB, Jr. Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol. 2004;286:H640-H647. 2. Ashikaga H, Omens JH, Ingels NB, Jr, Covell JW. Transmural mechanics at left ventricular epicardial pacing site. Am J Physiol Heart Circ Physiol. 2004;286:H2401-H2407. 3. Ashikaga H, Omens JH, Covell JW. Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure. Am J Physiol Heart Circ Physiol. 2004;287:H1994- H2002. 4. Harrington KB, Rodriguez F, Cheng A, Langer F, Ashikaga H, Daughters GT, Criscione JC, Ingels NB, Jr., Miller DC. Direct measurement of transmural laminar architecture in the anterolateral wall of the ovine left ventricle: new implications for wall thickening mechanics. Am J Physiol Heart Circ Physiol. 2005;288:H1324- H1330. 5. Ashikaga H, Covell JW, Omens JH. Diastolic dysfunction in volume overload hypertrophy is associated with abnormal shearing of myolaminar sheets. Am J Physiol Heart Circ Physiol. 2005;288:H2603-H2610. 6. Ashikaga H, Mickelsen SR, Ennis DB, Rodriguez I, Kellman P, Wen H, McVeigh ER. Electromechanical analysis of infarct border zone in chronic myocardial infarction. Am J Physiol Heart Circ Physiol. 2005;289:H1099-H1105. 7. Mickelsen SR, Ashikaga H, Raval A, DeSilva R, McVeigh ER, Kusumoto FA. Transvenous access to the pericardial space: an approach to epicardial lead implantation for cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2005;28:1018-1024. 8. Moreau-Villéger V, Delingette H, Sermesant M, Ashikaga H, McVeigh ER, Ayache N. Building maps of local apparent conductivity of the epicardium with a 2-D electrophysiological model of the heart. IEEE Trans Biomed Eng. 2006;53:1457-1466. 9. Dickfeld T, Kato R, Zviman MM, Nazarian S, Dong J, Ashikaga H, Lardo AC, Berger RD, Calkins H, Halperin HR. Characterization of acute and subacute radiofrequencey ablation lesions with nonenhanced magnetic resonance imaging. Heart Rhythm. 2007;4:208-214. 10. Ashikaga H, Coppola BA, Hopenfeld B, Leifer ES, McVeigh ER, Omens JH. Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo. J Am Coll Cardiol. 2007;49:909-916. 11. Hopenfeld B, Ashikaga H, McVeigh ER. Geodesic based registration of sensor data and anatomical surface image data. Ann Biomed Eng. 2007;35:1771-1781. 12. Ciaccio EJ, Ashikaga H, Kaba RA, Cervantes D, Hopenfeld B, Wit AL, Peters NS, McVeigh E, Garan H, Coromilas J. Model of reentrant ventricular tachycardia based on infarct border zone geometry predicts reentrant circuit features as determined by activation mapping. Heart Rhythm. 2007;4:1034-1045. 13. Ashikaga H, Sasano T, Dong J, Zviman MM, Evers R, Hopenfeld B, Castro V, Helm RH, Dickfeld T, Nazarian S, Donahue JK, Berger RD, Calkins H, Abraham MR, Marbán E, Lardo AC, McVeigh ER, Halperin HR. Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res. 2007;101:939-947. 14. Jöbsis PD, Ashikaga H, Wen H, Rothstein EC, Horvath KA, McVeigh ER, Balaban RS. Visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle. Am J Physiol Heart Circ Physiol. 2007;293:H3379-H3387. 15. Ashikaga H, Coppola BA, Yamazaki KG, Villarreal FJ, Omens JH, Covell JW. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. Am J Physiol Heart Circ Physiol. 2008;295:H610-H618. 2 16. Sasano T, Abraham MR, Chang KC, Ashikaga H, Mills KJ, Holt DP, Hilton J, Nekolla SG, Dong J, Lardo AC, Helperin H, Dannals RF, Marbán E, Bengel FM. Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 2008;51:2266-2275. 17. Nazarian S, Kolandaivelu A, Zviman MM, Meininger GR, Kato R, Susil RC, Roguin R, Dickfeld TL, Ashikaga H, Calkins H, Berger RD, Blumke DA, Lardo AC, Halperin HR. Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studies. Circulation. 2008;118:223-229. 18. Ashikaga H, van der Spoel TIG, Coppola BA, Omens JH. Transmural myocardial mechanics during isovolumic contraction. JACC Cardiovasc Imaging. 2009;2:202-211. 19. Hopenfeld B, Ashikaga H. Origin of electrocardiographic U wave: Effects of M cells and dynamic gap junction coupling. Ann Biomed Eng. 2010;38:1060-1070. 20. Ashikaga H, Leclercq C, Wang J, Kass DA, McVeigh ER. Hemodynamic improvement in cardiac resynchronization does not require improvement in left ventricular rotation mechanics: three-dimensional tagged MRI analysis. Circ Cardiovasc Img. 2010;3:456-463. 21. Estner HL, Zviman MM, Herzka D, Miller F, Castro V, Nazarian S, Ashikaga H, Dori Y, Berger RD, Calkins H, Lardo AC, Halperin HR. The critical isthmus sites of ischemic ventricular tachycardia are in zones of tissue heterogeneity, visualized by magnetic resonance imaging. Heart Rhythm. 2011;8:1942-1949. 22. Ashikaga H, Omens JH. In vivo validation of longitudinal-circumferential area change ratio to estimate myofiber shortening in the heart. IEEE Trans Biomed Eng. 2012;59:1391-1397. 23. Ashikaga H, Arevalo H, Vadakkumpadan F, Blake RC, Bayer JD, Nazarian S, Zviman MM, Tandri H, Berger RD, Calkins H, Herzka DA, Trayanova NA, Halperin HR. Feasibility of image-based simulation to estimate ablation target in human ventricular arrhythmia. Heart Rhythm. 2013;10:1109-1116. 24. Yong Ji S, Dewire J, Barcelon B, Catanzaro J, Philips B, Nazarian S, Cheng A, Spragg DD, Tandri H, Bansal S, Ashikaga H, Rickard J, Kolandaivelu A, Sinha S, Marine JE, Calkins H, Berger RD. Phrenic nerve injury: an underrecognized and potentially preventable complication of pulmonary vein isolation using a wide area circumferential ablation approach. J Cardiovasc Electrophysiol. 2013;24:1086-1091. 25. Dewire J, Agarwal S, Khurram IK, Marine JE, Berger R, Spragg D, Ashikaga H, Rickard J, Nazarian S, Calkins H. Safety and efficacy of atrial fibrillation ablation in young patients.
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