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The Liryc Beat Electrophysiology and heart modeling institute THE LIRYC BEAT NEWSLETTER N° 12 /// 1ST HALF 2021 RESEARCH & INNOVATION: RESEARCH 20 MILLION EUROS FROM EXCELLENCE TO BENEFIT EUROPE TO FOSTER CARDIAC RESEARCH EDITORIAL PATIENTS. _ page 2 As the new Chief Executive Officer of the institute, I am INNOVATION pleased to lead Liryc to address the major cardiac challenges TIC EPAC : A HOPE FOR in electrophyisiology while keeping in mind our initial goal : NEW THERAPIES, FROM bringing major advances in medical technologies to the hospital, HEART FAILURE TO ATRIAL to improve patient care. FIBRILLATION _ page 3 y concern is to pursue the strategic orientations adopted in By Pierre PATIENT CARE Mresearch, innovation, care and education, focusing on the Jaïs, DATA MANAGEMENT : Chief scientific excellence of our teams that are recognized worldwide. OPTIMIZING CARE AND Executive This appointment is an opportunity to foster Liryc’s multidisciplinary RESEARCH Officer of Liryc approach, enhancing collaborations within the institute. I feel _ page strongly about the importance of a cross-disciplinary research for 4 the enrichment of Liryc’s ecosystem to make a real difference in patient care. This is TRAINING AND EDUCATION the whole point of the European projects and international collaborations that you A NEW LIRYC-EDUCATION can read in the following pages of this newsletter. I also want to boost synergies to PLATFORM respond to the urgency of cardiac rhythm diseases. Moreover, these collaborations are _ page an opportunity for researchers to obtain grants for their ambitious projects and to be 5 published in the best scientific journals. MANAGEMENT Innovation, both in terms of practices and approaches, will allow us to adress major A NEW CEO FOR LIRYC medical issues. We have already defined an ambitious roadmap for the future with the _ page 6 artificial intelligence and modeling tools, combining the expertise of our teams, in order to accelerate research and patient care. WOMEN AND MEN PORTRAIT OF A RESEARCH Finally, I which to focus on digitalization to be more flexible and to share knowledge in ASSOCIATE the current health context, which requires us to rethink our practice every day. _ page 7 RESEARCH 20 MILLION EUROS FROM EUROPE TO FOSTER CARDIAC RESEARCH The European Commission has is the selected three scientific projects number involving the Liryc teams as part of of its Horizon 2020 program. These 70 human hearts new grants are opening up new studied since the opportunities in terms of innovation, CADeNCE research by supporting collaborative and program based on interdisciplinary research to address organ donation was medical challenges. launched in March 2015. 6 year after the launch BEAT AF : a revolutionary treatment for of this successful atrial fibrillation program, the multi- The BEAT AF project coordinated by disciplinary teams met Pierre Jaïs, brings together 9 leading to review the results European clinical centers with the aim of and challenges ahead demonstrating the efficacy of Pulsed Electric during a workshop on Field, a new ablation method, supposedly March 26. more effective and safer than radio- frequency, the reference treatment to date. SIMCARDIOTEST : 21st century in-silico2 It will also help to reduce recurrences, which studies are common. This project has received 6 This project, coordinated by Maxime The program is a million euros funding from the EU’s Horizon Sermesant, is funded by the European great opportunity to 2020 program. Commission for 8 million euros. It will provide study human cardiac new insight into designing new predictive pathologies with tools in cardiac pathologies. It brings together MICROCARD : a more sophisticated advanced mapping and 10 international partners to develop a cardiac modeling tool high-resolution imaging The new European Project MICROCARD standardized and secure platform where in- tools that remain led by the IHU Liryc and coordinated by silico clinical trials run seamlessly in order to test currently unavailable in Mark Potse will develop a software able to drugs and medical devices. the clinic. simulate the electrical activity of an entire heart, cell by cell, on new ultra-powerful Pr Olivier Bernus, Scientific Director of the “Exascale”1 supercomputers. This project, 1Exascale computers perform one billion calculations IHU LIRYC involving multidisciplinary experts from 10 per second. partner centers received 6 million euros 2Research or a test performed using numerical funding from the EU. calculations or computer models. HIGHLIGHTS Two new international experts to guide Liryc’s major scientific orientations Liryc is honoured to host two new distinguished members on its Scientific Advisory Board, joining Pr. Barbara Casadei and Katja Zeppenfeld. Pr Srijoy Mahapatra will provide his expertise on new cardiac technologies. Professor of Medicine at the University of Minesota and Associate Dean for Clinical Innovation, he has held several strategics positions over the years within major international industral groups and startups. Pr Dobromir Dobrev will share his expertise on molecular mechanisms of cardiac arrhythmias. He is director of the institute for Pharmacology at the University of Duisburg-Essen in Germany. __ page page 2 2 INNOVATION HIGHLIGHTS Optimizing the ablation procedures : from the heart to the prostate Dr. Bruno Quesson’s imaging team has demonstrated the effectiveness of temperature mapping in cardiac MRI during radiofrequency ablation procedures in predicting the size of radiofrequency catheter-induced lesions, helping in improving both the efficacy and safety of treatments. This technique, which was originally developed for the heart, may benefit other organs. With this purpose, the Liryc teams are now working on the ThermoPro research protocol, coordinated by Dr. Clément Marcelin of the Bordeaux University Hospital. The protocol aims at evaluating this imaging method iorder to develop laser ablation of localized prostate tumors under MRI guidance. TIC EPAC: A HOPE FOR NEW THERAPIES, FROM A LOOK BACK AT HEART FAILURE TO ATRIAL AI : a new method to improve remote cardiac monitoring FIBRILLATION The IHU Liryc provides its potential in several experimental expertise to support and models of heart failure. This participate in the TIC EPAC compound is protected by a project coordinated by Dr. patent. Frank Lezoualc’h, Research Director at INSERM Unit 1048 The international recognition Different sources of noises, such in Toulouse, in collaboration of Liryc in preclinical models as artifacts due to movements, with INSERM Transfert and of atrial fibrillation and heart extra cardiac muscular activity or SATT Toulouse Tech Transfert. failure has aroused the interest interferences due electrical devices, The Institute is involved in of Dr. Lezoualc’h. This is how Dr. can modify the electrocardiogram transfering the first results Fabien Brette, also interested in (ECG) and affect the quality of cardiac on heart failure into atrial the EPAC protein’s involvement monitoring. fibrillation, paving the way for in arrhythmias, was asssociated new therapies. to the project. With the support The cardiac pacing team at the of Dr Alice Récalde, the team Bordeaux University Hospital launched conducts experiments to validate a machine learning challenge to the liryc he team led by Dr. Frank the inhibition of the EPAC protein community for which 4 teams accepted Lezoualc’h has developed with the AM-001 coumpound to participate. The objective was to Ta new promising molecule in atrial fibrillation. This project use clinical telecardiology databases for the treatment of heart failure. is also funded by the French to propose an artificial intelligence Their work first demonstrated National Research Agency algorithm that could identify relevant the involvement of the EPAC (ANR). Another example of the signals and differentiate them from protein (Exchange Protein importance of multidisciplinary noise. After careful analysis, the directly Activated by cAMP) in the scientific collaboration in order to researchers Narimane Gassa and Nejib disease. Toulouse researchers develop new therapies. Zemzemi presented the algorithm with then identified a pharmacological the lowest error rate of under 1%. inhibitor of EPAC1 called AM-001 Congratulations ! and demonstrated its therapeutic _ page 3 PATIENT CARE DATA MANAGEMENT: OPTIMIZING CARE AND RESEARCH The management of clinical data is essential for both research and care, and it requires tools to optimize data collection and manage the use of such data. In this context, clinical team of the Bordeaux University Hospital led by Dr Josselin Duchateau have set up the “DARE1” project. Medical examination results, clinical data… every year, e-health data are increasing considerably. Now, the challenge is to collect, store and analyze all this in information coming from heterogeneous sources. The DARE project has been developed to address this challenge with a double aim. Optimizing patient management Better data management will allow patients to have access The teams are working on a first phase of conversion to emerging medical technologies resulting from research and compilation of data to make them accessible after (AI, automatic analysis), but also to improve patient follow- pseudonymization in the next 6 to 12 months. This project has up (automated re-convocations, remote monitoring, practice a regional and national deployment objective. The availability evaluation, etc.). of these data will enrich research projects and allow progress in
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