Serious Hazards of Transfusion (SHOT) Annual Report 2017
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HEMATOLOGY for THE.Pdf
HEMATOLOGY FOR THE UNDERGRADUATES By: Dr. Muhammad Saboor, PhD Assistant Professor, Baqai Institute of Hematology Director, Baqai Institute of Medical Technology Baqai Medical University and Dr. Moinuddin, FRCP(C), FRCP (E), PhD (Hons.) Professor of Hematology Director, Baqai Institute of Hematology Baqai Medical University HIGHER EDUCATION COMMISSION ISLAMABAD 1 Copyrights @ Higher Education Commission Islamabad Lahore Karachi Peshawar Quetta All rights are reserved. No part of this publication may be reproduced, or transmitted, in any form or by any means – including, but not limited to, electronic, mechanical, photocopying, recording, or, otherwise or used for any commercial purpose what so ever without the prior written permission of the publisher and, if publisher considers necessary, formal license agreement with publisher may be executed. Project: “Monograph and Textbook Writing Scheme” aims to develop a culture of writing and to develop authorship cadre among teaching and researcher community of higher education institutions in the country. For information please visit: www.hec.gov.pk HEC – Cataloging in Publication (CIP Data): Muhammad Saboor, Dr. Hematolog for Undergraduate I. Hematology 616.15 – dc23 2015 ISBN: 978-969-417-181-4 First Edition: 2015 Copies Printed: 500 Published By: Higher Education Commission – Pakistan Disclaimer: The publisher has used its best efforts for this publication through a rigorous system of evaluation and quality standards, but does not assume, and hereby disclaims, any liability to any person for any loss or damage caused by the errors or omissions in this publication, whether such errors or emissions result from negligence, accident, or any other cause. 2 PREFACE Hematology is one of the oldest specialties in conception yet it is the youngest in its inception. -
Filterability of Erythrocytes and Whole Blood in Preterm and Full-Term Neonates and Adults
003 1-3998/86/2012-1269$02.00/0 PEDIATRIC RESEARCH Vol. 20, No. 12, 1986 Copyright O 1986 International Pediatric Research Foundation, Inc. Printed in U.S. A. Filterability of Erythrocytes and Whole Blood in Preterm and Full-Term Neonates and Adults OTWIN LINDERKAMP, BERNHARD J. HAMMER, AND ROLF MILLER Department of Pediatrics, University of Heidelberg, Heidelberg, Federal Republic of Germany ABSTRACT. Filtration techniques are widely used to as- Hyperviscosity in neonates is a frequent and potentially serious sess red blood cell (RBC) deformability and flow behavior condition, which may cause circulatory failure and impaired of RBC in microcirculation. In this study filtration rates of microcirculation in various vital organs (1). Blood viscosity is RBC from 10 very low birth weight infants (24-30 wk mainly determined by hematocrit. However, decreased RBC gestation), 10 more mature preterm infants (31-36 wk deformability can also contribute to an increase in blood viscos- gestation), 10 full-term neonates, and 10 adults were meas- ity. At high hematocrit, the deformability of RBC is particularly ured by using Nucleopore filters with pore diameters of 5 crucial because blood viscosity exhibits a larger increase with pm and filtration pressures of 1, 2,5, and 10 cm H20.The increasing hematocrit when RBC deformability is impaired (2). major results follow: 1) At each of four filtration pressures, Moreover, decreased RBC deformability may hinder the entry filtration rates of washed RBC were significantly (p < of 8-pm diameter RBC into capillaries with diameters of 3-4 pm 0.05) lower in the preterm infants than in the term neonates (3), slow down oxygen uptake and release in capillaries (4), and who in turn showed lower values than adults. -
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MME -303 Child Health Indira Gandhi National Open University School of Health Sciences Block 6 CHILDHOOD MORBIDITY UNIT 28 Common Paediatric Problems 5 UNIT 29 Cardiovascular, Haematological and Renal Disorders 24 UNIT 30 Gastrointestinal, Parasitic and Neurological Disorders 61 UNIT 31 Tuberculosis 90 UNIT 32 HIV/AIDS 106 UNIT 33 Common Paediatric Emergencies 119 UNIT 34 Common Paediatric Surgical Problems 130 PROGRAMMECORE TEAM Dr. I.C. Tiwari Dr. (Mrs.) Kamala Ganesh Dr. L.N. Balaji Dr. S.B. Arora Dr. Ruchika Kuba Sr. Consultant, UNICEF Director Professor and Head of Chief, Planning Division Course Coordinator Course Coordinator New Delhi O&G Deptt., MAMC, New Delhi UNICEF, New Delhi SOHS, IGNOU, New Delhi SOHS, IGNOU, New Delhi Dr. S.C. Chawla Dr. Sidharth Ramji Prof. (Col.) P.K. Dutta Dr. T.K. Jena Director Professor and Head of Professor, Deptt. of Paediatrics Programme Coordinator Course Coordinator PSM Deptt., LHMC, New Delhi MAMC, New Delhi SOHS, IGNOU, New Delhi SOHS, IGNOU, New Delhi COURSE REVISION TEAM (1st Revision) Dr. Neena Raina Dr. Harish Kumar Dr. M.S. Prasad Prof. A.K. Agarwal Dr. Ruchika Kuba Technical Officer, WHO Consultant Paediatrics, Head, Deptt. of Paediatrics Director, SOHS Sr. Lecturer and Course SEARO Office, New Delhi D.D.U. Hospital, New Delhi Safdarjang Hospital, IGNOU, New Delhi Coordinator New Delhi SOHS, IGNOU, New Delhi Dr. Siddharth Ramji Dr. A.K. Patwari Dr. T.K. Jena Professor, Deptt. of Peadiatrics National Professional Officer, Dr. Piyush Gupta Reader and Programme LNJP and MAMC, Delhi WHO Nirman Bhawan, Reader, Deptt. of Paediatrics Coordinator New Delhi GTB Hospital and UCMS SOHS, IGNOU, New Delhi New Delhi COURSE REVISION TEAM (2nd Revision) Dr. -
Copyrighted Material
Index Page numbers in italic refer to fi gures. Page numbers in bold refer to tables. -
UKOSS Vasa Praevia Form
ID Number: UK Obstetric Surveillance System Vasa Praevia in Pregnancy Study 02/14 Data Collection Form - CASE Please report any woman delivering on or after 1st December 2014 and before 1st December 2015 Case Definition: A case should meet at least one of the criteria below: 1. Suspected VP on antenatal U/S ≥18 weeks gestation, and confirmed on antenatal U/S ≥31 weeks gestation (if not delivered prior to 31 weeks) 2. Palpation or visualisation of the fetal vessels during labour 3. Rupture of membranes with bleeding associated with fetal death/exsanguination or severe neonatal anaemia 4. Antenatal or intrapartum bleeding of fetal origin with pathologic CTG and/or positive Apt6* test 5. VP documented in medical records as reason for admission and caesarean section And At least one of the following: • Clinical examination of the placenta confirming intact or ruptured velamentous vessels.These may be a velamentous insertion of the umbilical cord or exposed fetal vessels between placental lobes • Confirmation of VP on pathologcial examination of the placenta • Torn umbilical cord or placenta (not able to provide placental examination) Please return the completed form to: UKOSS National Perinatal Epidemiology Unit University of Oxford Old Road Campus Oxford OX3 7LF Fax: 01865 617775 CASEPhone: 01865 289714 Case reported in: *For guidance please see back cover Instructions 1. Please do not enter any personally identifiable information (e.g. name, address or hospital number) on this form. 2. Please record the ID number from the front of this form against the woman’s name on the Clinician’s Section of the blue card retained in the UKOSS folder. -
Hydroxyurea Enhances Fetal Hemoglobin Production in Sickle Cell Anemia
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. O S Platt, … , B Miller, D G Nathan J Clin Invest. 1984;74(2):652-656. https://doi.org/10.1172/JCI111464. Research Article Hydroxyurea, a widely used cytotoxic/cytostatic agent that does not influence methylation of DNA bases, increases fetal hemoglobin production in anemic monkeys. To determine its effect in sickle cell anemia, we treated two patients with a total of four, 5-d courses (50 mg/kg per d, divided into three oral doses). With each course, fetal reticulocytes increased within 48-72 h, peaked in 7-11 d, and fell by 18-21 d. In patient I, fetal reticulocytes increased from 16.0 +/- 2.0% to peaks of 37.7 +/- 1.2, 40.0 +/- 2.0, and 32.0 +/- 1.4% in three successive courses. In patient II the increase was from 8.7 +/- 1.2 to 50.0 +/- 2.0%. Fetal hemoglobin increased from 7.9 to 12.3% in patient I and from 5.3 to 7.4% in patient II. Hemoglobin of patient I increased from 9.0 to 10.5 g/dl and in patient II from 6.7 to 9.9 g/dl. Additional single-day courses of hydroxyurea every 7-20 d maintained the fetal hemoglobin of patient I t 10.8-14.4%, and the total hemoglobin at 8.7- 10.8 g/dl for an additional 60 d. The lowest absolute granulocyte count was 1,600/mm3; the lowest platelet count was 390,000/mm3. The amount of fetal hemoglobin per erythroid burst colony-forming unit (BFU-E)-derived colony cell was unchanged, but the number of cells per BFU-E-derived colony increased. -
Investigations of Kidney Dysfunction-Related Gene Variants in Sickle Cell Disease Patients in Cameroon (Sub-Saharan Africa)
fgene-12-595702 March 9, 2021 Time: 15:40 # 1 ORIGINAL RESEARCH published: 15 March 2021 doi: 10.3389/fgene.2021.595702 Investigations of Kidney Dysfunction-Related Gene Variants in Sickle Cell Disease Patients in Cameroon (Sub-Saharan Africa) Valentina J. Ngo-Bitoungui1,2,3, Suzanne Belinga4, Khuthala Mnika2, Tshepiso Masekoameng2, Victoria Nembaware1, René G. Essomba5,6, Francoise Ngo-Sack7, Gordon Awandare1, Gaston K. Mazandu2,8 and Ambroise Wonkam2* 1 West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon-Accra, Ghana, 2 Division of Human Genetics, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, Edited by: South Africa, 3 Department of Microbiology Haematology and Immunology, University of Dschang, Yaoundé, Cameroon, Maria G. Stathopoulou, 4 Centre Pasteur of Cameroon, Yaoundé, Cameroon, 5 National Public Health Laboratory, Yaoundé, Cameroon, 6 Department Institut National de la Santé et de la of Microbiology, Parasitology, Haematology, Immunology and Infectious Diseases, Faculty of Medicine and Biomedical Recherche Médicale (INSERM), Sciences, University of Yaounde 1, Yaounde, Cameroon, 7 Faculty of Medicine and Pharmaceutical Sciences, University France of Douala, Douala, Cameroon, 8 African Institute for Mathematical Sciences, Muizenberg, Cape Town, South Africa Reviewed by: Leon Mutesa, Background: Renal dysfunctions are associated with increased morbidity and mortality University of Rwanda, Rwanda Henu Verma, in sickle cell disease (SCD). Early detection -
Laboratory Medicine – Scope of Accreditation
DIAGNOSTIC ACCREDITATION PROGRAM College of Physicians and Surgeons of BC 300–669 Howe Street Telephone: 604-733-7758 Vancouver BC V6C 0B4 Toll free: 1-800-461-3008 (in BC) www.cpsbc.ca Fax: 604-733-3503 Laboratory Medicine – Scope of Accreditation Facility name Nanaimo Regional General Hospital Facility address 1200 Dufferin Crescent, Nanaimo, BC, V9S 2B7 Facility code 0711LM Corporate entity/health authority Island Health Accreditation Full Accreditation Effective date 2021-02-16 Expiry date 2023-03-14 Laboratory Standard Version 1.3 Services The College of Physicians and Surgeons of BC Diagnostic Accreditation Program accredits the capability of the named facility to perform the listed services and examinations/procedures. Examination – Other Examination Methodology/principle – Other Sample Type – Other DAP Scope Classification (Analyte/Procedure) Methodology/principle Sample Type (Analyte/Procedure) (Specify) (Specify) (Specify) Sample Collection Sample Collection Venous and Capillary Whole Blood Sample Collection Sample Processing Receipt, accessioning, storage, Blood, fluids, stool, tissues, swabs, transportation foreign bodies Anatomical Pathology Autopsy Fixation and gross examination Tissue - Fresh Anatomical Pathology Fixation and Gross examination Fixation and gross examination Tissue - Fresh Anatomical Pathology Intraoperative Consultations Frozen section prep and staining Tissue - Frozen Anatomical Pathology Microtomy Tissue processing (e.g.• block prep, Tissue - Formalin Fixed Paraffin embedding) Embedded Anatomical Pathology -
Lab Test Results to Albertans
Available Lab Tests 0-9 Apolipoprotein A1 Calcium, Stool 17-Hydroxyprogesterone Apolipoprotein B100 Calcium, Urine (Random and 24 Hr) 5-Hydroxyindoleacetic Acid (HIAA), Urine (Random And 24 Hour) Arginine Provocation Panel Calculus (Renal Stone) Arsenic Level, Blood Calprotectin, Stool Arsenic Level, Inorganic, Urine (Occupational) Canadian Blood Services Prenatal Testing A Arsenic Level, Urine (Random and 24 Hr) Cancer Antigen 125, Serum Acetaminophen Ascaris Serology Cancer Antigen 125 (CA 125), Body Fluid Acanthamoeba Culture ASO Titre Cancer Antigen 19-9 (CA 19-9), Body Fluid Acetylcholine Receptor Antibody Aspartate Aminotransferase (AST) Cancer Antigen 19-9, Serum Acetylcholinesterase Aspartate Aminotransferase (AST), Body Fluid Carbamazepine ACTH (Cortrosyn) Stimulation Selective Adrenal Vein Sampling Aspergillus Galactomannan Serology (Blood and Fluid) Carbapenemase Producing Organisms Screen ACTH (Cortrosyn) Stimulation, (1 And 250 Microgram Panels) Carbon Dioxide Content, Fluid Actin Antibody B Carboxyhemoglobin Activated Clotting Time Babesia Examinaon Carcinoembryonic Antigen (CEA), Body Fluid Activated Protein C Resistance Babesia Serology Carcinoembryonic Antigen (CEA), Serum Acylcarnitine Profile, Blood Bacterial Enteric Panel Carotene, Serum Acylcarnitine Profile, Dried Blood Spot Bacterial Vaginosis/Yeast Screen Catecholamines, Urine, Random And 24 Hour Adrenal Cortex Antibody Barium Level, Serum Catheter Tip Culture Adrenal Receptors Panel Barium Level, Urine (Random adnd 24 Hr) CBC and Differential Adrenal Vein Bleed -
Hematology. Spin the Tubes at 1(060 Rpm
DOCUMENT RESUME BD 200431 0 TITLE Medical. Service Climi Laboratory ProcedureHematologi INSTITUTION Department of the Air Force, Washingon,t, Department of the'Army,- Washington, D.C. EEPORT 110 AFM-150-51; -TH-B-227-4 PUN:. DATE 5 Dec 73 NOTE- 151p.; Contains colored pictures which may reproduce Well AVAILABLE FRO Superintendent of Documents, U' S . GovernmentPriatii Office, aashington, DC 20402 (Stock No. 00-020-00525-W; $3.55). IDES PRICE MF01/Pd07 Plus Postage. DESCRIPTORS , *Allied Health OCcupations: *Armed Forces;_Biology;-- Government Publications; Health Occupations; Higher Education; Instructional Materials; naberatory Manuals: *LaboratorY Procedures; 'Medical Education; *Medical. Technologists; riaterials-zr, Science IDENTIFIERS- *Hematology .ABSTRACT Presented are laboratory studies focusing onblood- cells and theomplete scheme of blood coagulation. Forked is'the basin for the following types :of laboratory operations: (1) distinguishi4.the morphology of normal and abnormal blood cells; (2) measuring theapcentrations or number of blood cells; (3) measuring concentration a** abnormalities'detecting of heloglobin; (4) . measuring defecesin coagulation; and (5) performing a few specific disease-related-tests which involve blood cells. Types, of equipment needed, actual stkavise perormance of tests, and reagents needed,= as well as established, minimum levels of accuracy are included. lAuthor/CS) ********************************* ****** -*4***** roductions dupplied by EDRS are the.best can be from th6 original docdment. ****************************************** -- D&;ARTM-ENTS. OF THEAIR FO10E_ AF MANUAL -160-51 _ . THE 'ARM TM- 8-227-4 Washington DC 20330_ 5 December 1973- Medical Service CLINICAL LABORATORY PROCEDURES-1 The purpose of this-manual is to present the laboratoi-y steadiesw concern the blood cells and the complete: scheme of blood coagulation. -
Annual Shot Report 2011
Affiliated to the Royal College of Pathologists AnnuAl The Steering Group includes members representing the following professional bodies: British Blood Transfusion Society Royal College of Nursing British Society for Haematology Royal College of Midwives SHOT British Society of Gastroenterology Royal College of Obstetricians and Gynaecologists Royal College of Physicians British Committee for Standards in Haematology Royal College of Surgeons Faculty of Public Health Report Royal College of Paediatrics and Child Health Institute of Biomedical Science Intensive Care Society Health Protection Agency Faculty of Intensive Care Medicine (Health Protection Services Division) The College of Emergency Medicine NHS Confederation Defence Medical Services Royal College of Anaesthetists UK Forum ANNUAL SHOT REPORT 2011 Serious Hazards of Transfusion (SHOT) Steering Group Chair Dr Hannah Cohen SHOT Medical Director Dr Paula Bolton-Maggs Operations Manager Ms Alison Watt Research Analyst Ms Debbi Poles Transfusion Liaison Practitioner Mr Tony Davies Clinical Incidents Specialist Mrs Julie Ball Laboratory Incidents Specialists Mrs Hema Mistry Mrs Christine Gallagher National Coordinator for Ms Claire Reynolds Transfusion Transmitted Infections Dr Su Brailsford (Health Protection Agency) Working Expert Group (WEG) & Writing Group, on behalf of the SHOT Steering Group Chair: Dr Paula Bolton-Maggs Dr Hannah Cohen, Ms Alison Watt, Ms Debbi Poles, Mr Tony Davies, Mrs Hema Mistry, Mrs Julie Ball, Mrs Christine Gallagher, Mrs Deborah Asher, Ms Claire Reynolds, -
Oxidative Stress in Newborn Erythrocytes
003 1-399819 1/2902-0119$03.00/0 PEDIATRIC RESEARCH Vol. 29, No. 2, 1991 Copyright O 199 1 International Pediatric Research Foundation, Inc. Printed in U.S. A. Oxidative Stress in Newborn Erythrocytes YAEL SHAHAL, ERIKA R. BAUMINGER, EHUD ZMORA, MIRIAM KATZ, DALIA MAZOR, SARAH HORN, AND NAOMI MEYERSTEIN Dr. Joseph Kaufmann Hematology Laboratory, Physiology Unit, Corob Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva and Racah Institute of Physics, Hebrew University, Jerusalem and Neonatal Department and Obstetrics and Gynecology Department, Soroka University Center, Ben Gurion University ofthe Negev, Beer Sheva, Israel ABSTRACT. Phenylhydrazine (PHZ) exposure is used to induced by low dose of PHZ, on neonatal erythrocytes, specifi- study in vitro red cell aging mechanisms dependent on Hb cally: 1) to study Hb oxidation in neonatal and adult cells by oxidation. The effect of PHZ on normal neonatal red blood two methods (measuring total oxidized Hb by spectrophotometry cells was studied in unseparated blood and after separation and identifying specific oxidation products by Mossbauer spec- into light and heavy cells. PHZ caused more extensive tra) and 2) to see whether neonatal heavy cells, enriched with morphologic changes in neonatal than in adult red blood old cells, are more sensitive to oxidation than lighter and younger cells. PHZ exposure of neonatal cells caused less reduced cells. glutathione depletion than in adult cells. Although we found the same total amount of oxidized Hb in both cells, a well- MATERIALS AND METHODS defined oxidation product of Hb was demonstrated by Mossbauer spectra only in neonatal cells.