C:\Documents and Settings\Babu\
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Serious Hazards of Transfusion (SHOT) Annual Report 2017
ANNUAL SHOT REPORT 2017 working with Affiliated to the Royal College of Pathologists DS OF ZAR TR A AN H S S F U U O S I I R O E N S A Y N R N A U S A R L E S YEARS IV H N O N T A RE T PORT 21S ANNUAL SHOT REPORT 2017 Serious Hazards of Transfusion (SHOT) Steering Group Chair Professor Mark Bellamy SHOT Medical Director Dr Paula Bolton-Maggs Operations Manager Ms Alison Watt Research Analyst Ms Debbi Poles Patient Blood Management Practitioner Mrs Jayne Addison Clinical Incidents Specialist Mr Simon Carter-Graham Mrs Ann Fogg Laboratory Incidents Specialist Mrs Hema Mistry National Coordinator for Mrs Rachael Morrison (Ms Dory Kovacs in 2018) Transfusion-Transmitted Infections (Public Health England) Working Expert Group (WEG) & Writing Group, on behalf of the SHOT Steering Group Chair: Dr Paula Bolton-Maggs Professor Mark Bellamy, Ms Alison Watt, Ms Debbi Poles, Mrs Hema Mistry, Mr Simon Carter-Graham, Mrs Ann Fogg, Mrs Jayne Addison, Mrs Rachael Morrison, Dr Tom Latham, Mrs Diane Sydney, Dr Helen New, Dr Megan Rowley, Dr Fiona Regan, Mr Chris Robbie, Dr Peter Baker, Dr Janet Birchall, Dr Jane Keidan, Mrs Terrie Perry, Mrs Katy Cowan, Dr Sharran Grey, Mrs Clare Denison, Dr Catherine Ralph, Dr Sarah Haynes, Mrs Pamela Diamond, Dr Anicee Danaee, Ms Tracey Tomlinson, Dr Shruthi Narayan, Mrs Heather Clarke. Steering Group (SG) during 2017 Chair: Professor Mark Bellamy Dr Shubha Allard British Society for Haematology Guidelines National Blood Transfusion Committee Dr Ganesh Suntharalingam Intensive Care Society, Faculty of Intensive Care Medicine -
HEMATOLOGY for THE.Pdf
HEMATOLOGY FOR THE UNDERGRADUATES By: Dr. Muhammad Saboor, PhD Assistant Professor, Baqai Institute of Hematology Director, Baqai Institute of Medical Technology Baqai Medical University and Dr. Moinuddin, FRCP(C), FRCP (E), PhD (Hons.) Professor of Hematology Director, Baqai Institute of Hematology Baqai Medical University HIGHER EDUCATION COMMISSION ISLAMABAD 1 Copyrights @ Higher Education Commission Islamabad Lahore Karachi Peshawar Quetta All rights are reserved. No part of this publication may be reproduced, or transmitted, in any form or by any means – including, but not limited to, electronic, mechanical, photocopying, recording, or, otherwise or used for any commercial purpose what so ever without the prior written permission of the publisher and, if publisher considers necessary, formal license agreement with publisher may be executed. Project: “Monograph and Textbook Writing Scheme” aims to develop a culture of writing and to develop authorship cadre among teaching and researcher community of higher education institutions in the country. For information please visit: www.hec.gov.pk HEC – Cataloging in Publication (CIP Data): Muhammad Saboor, Dr. Hematolog for Undergraduate I. Hematology 616.15 – dc23 2015 ISBN: 978-969-417-181-4 First Edition: 2015 Copies Printed: 500 Published By: Higher Education Commission – Pakistan Disclaimer: The publisher has used its best efforts for this publication through a rigorous system of evaluation and quality standards, but does not assume, and hereby disclaims, any liability to any person for any loss or damage caused by the errors or omissions in this publication, whether such errors or emissions result from negligence, accident, or any other cause. 2 PREFACE Hematology is one of the oldest specialties in conception yet it is the youngest in its inception. -
Postpartum Haemorrhage
Guideline Postpartum Haemorrhage Immediate Actions Call for help and escalate as necessary Initiate fundal massage Focus on maternal resuscitation and identifying cause of bleeding Determine if placenta still in situ Tailor pharmacological management to causation and maternal condition (see orange box). Complete a SAS form when using carboprost. Pharmacological regimen (see flow sheet summary) Administer third stage medicines if not already done so. Administer ergometrine 0.25mg both IM and slow IV (contraindicated in hypertension) IF still bleeding: Administer tranexamic acid- 1g IV in 10mL via syringe driver set at 1mL/minute administered over 10 minutes OR as a slow push over 10 minutes. Administer carboprost 250micrograms (1mL) by deep intramuscular injection Administer loperamide 4mg PO to minimise the side-effect of diarrhoea Administer antiemetic ondansetron 4mg IV, if not already given Prophylaxis Once bleeding is controlled, administer misoprostol 600microg buccal and initiate an infusion of oxytocin 40IU in 1L Hartmann’s at a rate of 250mL/hr for 4 hours. Flow chart for management of PPH Carboprost Bakri Balloon Medicines Guide Ongoing postnatal management after a major PPH 1. Purpose This document outlines the guideline details for managing primary postpartum haemorrhage at the Women’s. Where processes differ between campuses, those that refer to the Sandringham campus are differentiated by pink italic text or have the heading Sandringham campus. For guidance on postnatal observations and care after a major PPH, please refer to the procedure ‘Postpartum Haemorrhage - Immediate and On-going Postnatal Care after Major PPH 2. Definitions Primary postpartum haemorrhage (PPH) is traditionally defined as blood loss greater than or equal to 500 mL, within 24 hours of the birth of a baby (1). -
Ⅰ Obstetric Hemorrhage Safety Bundle Implementation in a Rural
Obstetric Hemorrhage Safety Bundle Implementation in a Rural CAH Dale C Robinson MD,FACOG Chief Ob/Gyn Grande Ronde Hospital La Grande Oregon S Planning for and Responding to Obstetric Hemorrhage California Maternal Quality Care Collaborative Obstetric Hemorrhage Version 2.0 Task Force This project was supported by Title V funds received from the California Department of Public Health; Maternal, Child and Adolescent Health Division 2 CMQCC S California Maternal Quality Care Collaborative S Multidisciplinary Task Force S Recommendations/ Obstetric Safety Bundle S Yellow/Blue Slides Maternal Mortality Rates, Moving Average, California Residents; 1999-2010 16 14 14.0 12.2 13.5 13.2 12 12.7 11.6 12.1 11.5 10 9.4 10.2 8 6 4 Maternal Deaths per 100,000 Live Births 2 0 1999-2001 2000-2002 2001-2003 2002-2004 2003-2005 2004-2006 2005-2007 2006-2008 2007-2009 2008-2010 Three-Year Moving Average SOURCE: State of California, Department of Public Health, California Birth and Death Statistical Master Files, 1999-2010. Maternal mortality for California (deaths ≤ 42 days postpartum) was calculated using ICD-10 cause of death classification (codes A34, O00-O95,O98-O99) for 1999-2010. On average, the mortality rate increased by 2% each year [(95% CI: 1.0%, 4.2%) p=0.06. Poisson regression] for a statistically significant increasing trend from 1999-2010 (p=0.001 one-sided Cochran-Armitage, based on individual year data). Produced by California Department of Public Health, Center for Family Health, Maternal, Child and Adolescent Health Division, December, 2012. North Carolina: Mortality Mostly Preventable Cause of Death (n=108) % of All Deaths % Preventable Cardiomyopathy 21% 22% Hemorrhage 14 93 PIH 10 60 CVA 9 0 Chronic condition 9 89 AFE 7 0 Infection 7 43 Pulmonary embolism 6 17 Berg CJ, Harper MA, Atkinson SM, et al. -
• Chapter 8 • Nursing Care of Women with Complications During Labor and Birth • Obstetric Procedures • Amnioinfusion –
• Chapter 8 • Nursing Care of Women with Complications During Labor and Birth • Obstetric Procedures • Amnioinfusion – Oligohydramnios – Umbilical cord compression – Reduction of recurrent variable decelerations – Dilution of meconium-stained amniotic fluid – Replaces the “cushion ” for the umbilical cord and relieves the variable decelerations • Obstetric Procedures (cont.) • Amniotomy – The artificial rupture of membranes – Done to stimulate or enhance contractions – Commits the woman to delivery – Stimulates prostaglandin secretion – Complications • Prolapse of the umbilical cord • Infection • Abruptio placentae • Obstetric Procedures (cont.) • Observe for complications post-amniotomy – Fetal heart rate outside normal range (110-160 beats/min) suggests umbilical cord prolapse – Observe color, odor, amount, and character of amniotic fluid – Woman ’s temperature 38 ° C (100.4 ° F) or higher is suggestive of infection – Green fluid may indicate that the fetus has passed a meconium stool • Nursing Tip • Observe for wet underpads and linens after the membranes rupture. Change them as often as needed to keep the woman relatively dry and to reduce the risk for infection or skin breakdown. • Induction or Augmentation of Labor • Induction is the initiation of labor before it begins naturally • Augmentation is the stimulation of contractions after they have begun naturally • Indications for Labor Induction • Gestational hypertension • Ruptured membranes without spontaneous onset of labor • Infection within the uterus • Medical problems in the -
Obstetrics Seventh Edition
PROLOGObstetrics seventh edition The American College of Obstetricians and Gynecologists WOMEN’S HEALTH CARE PHYSICIANS Obstetrics seventh edition Assessment Book The American College of Obstetricians and Gynecologists WOMEN’S HEALTH CARE PHYSICIANS ISBN 978-1-934984-22-2 Copyright 2013 by the American College of Obstetricians and Gynecologists. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, posted on the Internet, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. 12345/76543 The American College of Obstetricians and Gynecologists 409 12th Street, SW PO Box 96920 Washington, DC 20090-6920 Contributors PROLOG Editorial and Advisory Committee CHAIR MEMBERS Ronald T. Burkman Jr, MD Bernard Gonik, MD Professor of Obstetrics and Professor and Fann Srere Chair of Gynecology Perinatal Medicine Tufts University School of Medicine Division of Maternal–Fetal Medicine Division of General Obstetrics and Department of Obstetrics and Gynecology Gynecology Department of Obstetrics and Wayne State University School of Gynecology Medicine Baystate Medical Center Detroit, Michigan Springfield, Massachusetts Louis Weinstein, MD Past Paul A. and Eloise B. Bowers Professor and Chair Department of Obstetrics and Gynecology Thomas Jefferson University Philadelphia, Pennsylvania Linda Van Le, MD Leonard Palumbo Distinguished Professor UNC Gynecologic Oncology University of North Carolina School of Medicine Chapel Hill, North Carolina PROLOG Task Force for Obstetrics, Seventh Edition COCHAIRS MEMBERS Vincenzo Berghella, MD Cynthia Chazotte, MD Director, Division of Maternal–Fetal Professor of Clinical Obstetrics and Medicine Gynecology and Women’s Health Professor, Department of Obstetrics Department of Obstetrics and Gynecology and Gynecology Weiler Hospital of the Albert Einstein Thomas Jefferson University College of Medicine Philadelphia, Pennsylvania Bronx, New York George A. -
Filterability of Erythrocytes and Whole Blood in Preterm and Full-Term Neonates and Adults
003 1-3998/86/2012-1269$02.00/0 PEDIATRIC RESEARCH Vol. 20, No. 12, 1986 Copyright O 1986 International Pediatric Research Foundation, Inc. Printed in U.S. A. Filterability of Erythrocytes and Whole Blood in Preterm and Full-Term Neonates and Adults OTWIN LINDERKAMP, BERNHARD J. HAMMER, AND ROLF MILLER Department of Pediatrics, University of Heidelberg, Heidelberg, Federal Republic of Germany ABSTRACT. Filtration techniques are widely used to as- Hyperviscosity in neonates is a frequent and potentially serious sess red blood cell (RBC) deformability and flow behavior condition, which may cause circulatory failure and impaired of RBC in microcirculation. In this study filtration rates of microcirculation in various vital organs (1). Blood viscosity is RBC from 10 very low birth weight infants (24-30 wk mainly determined by hematocrit. However, decreased RBC gestation), 10 more mature preterm infants (31-36 wk deformability can also contribute to an increase in blood viscos- gestation), 10 full-term neonates, and 10 adults were meas- ity. At high hematocrit, the deformability of RBC is particularly ured by using Nucleopore filters with pore diameters of 5 crucial because blood viscosity exhibits a larger increase with pm and filtration pressures of 1, 2,5, and 10 cm H20.The increasing hematocrit when RBC deformability is impaired (2). major results follow: 1) At each of four filtration pressures, Moreover, decreased RBC deformability may hinder the entry filtration rates of washed RBC were significantly (p < of 8-pm diameter RBC into capillaries with diameters of 3-4 pm 0.05) lower in the preterm infants than in the term neonates (3), slow down oxygen uptake and release in capillaries (4), and who in turn showed lower values than adults. -
Safety Profile of Misoprostol for Obstetrical Indications
SAFETY PROFILE OF MISOPROSTOL FOR OBSTETRICAL INDICATIONS Lenita Wannmacher INTRODUCTION Cervical ripening, full‐term labour induction, and postpartum haemorrhage (PPH) are obstetric conditions that require proper and early interventions in order to save maternal and fetal lives. These interventions include pharmacological (uterotonic agents, mainly) and non‐pharmacological methods that have been tested and compared throughout the past decade. Regarding injectable uterotonic medicines (such as oxytocin, ergometrine, syntometrine, prostaglandins, and, more recently, carbetocin), factors limiting their use in low‐resource settings have been their cost, instability at high ambient temperatures, and difficult requirements of administration. In poor and rural settings, birth attendant skills are limited, transport facilities are inadequate, and injectable uterotonics and blood are hardly available. In contrast, misoprostol, a synthetic prostaglandin E1 analogue, presents low cost, storage at room temperature, and widespread availability. Misoprostol could also be easily administered by unskilled attendants or the women themselves, thus making them available for women giving birth at home or in isolated areas. These are benefits that make it particularly appealing for developing poor countries.1 Despite the built evidence of efficacy, induction of full‐term labour in women with a live fetus, as well as prevention and treatment of PPH, remains as a major challenge in modern obstetrics. Safety profile of misoprostol is still a matter of concern, especially relating to doses and routes used for the mentioned purposes.2 Misoprostol can be effectively administered vaginally, rectally, bucally, orally and sublingually. Pharmacokinetic studies have demonstrated the properties of misoprostol after various routes of administration. The rate of absorption varies considerably between routes, and care must be taken to use the correct dose and frequency for the specified route. -
History Midwives Representing MANA Statistics Project the Profession Data Collection Form Alliance of Midwifery of North America Revision 2.0 – Page 1 of 8
History Midwives Representing MANA Statistics Project the Profession Data Collection Form Alliance of Midwifery of North America Revision 2.0 – Page 1 of 8 Practice Code1 Y N Previous pregnancy and delivery history Midwife Code1 Number of previous: pregnancies Second Midwife Code1 (OPTIONAL) miscarriages5 Third Midwife Code1 (OPTIONAL) induced abortions Birth Code2 (MIDWIFE’S IDENTIFYING CODE) stillbirths5 live births Number of previous: History home births Client’s municipality: ___________________________ birth center births State or Province: ______________________________ Population: (CHOOSE ONLY ONE) caesarean sections | city | suburb | small town | rural VBACs Postal (ZIP) Code episiotomies Mother’s— postpartum hemorrhages age at booking Other previous pregnancy/delivery occurrences: last grade of high school completed gestation <37 weeks gestation >42 weeks post secondary formal education (YEARS) hypertension or pre/eclampsia6 3 Occupation : ___________________________________ breech Race/Ethnic origin: forceps/vacuum Caucasian IUGR/SGA7 African or Caribbean birth defect Native American shoulder dystocia Asian other: __________________________________ Hispanic none other4: _____________________________________ Mother’s height: (OR ESTIMATE) Special group: (CHECK ANY THAT APPLY) Amish feet inches OR Mennonite centimeters Francophone Mother’s prepregnancy weight: Immigrant of <10 years pounds OR kg Immigrant of >= 10 years Method of conception: (CHOOSE ONLY ONE) other group: ________________________________ | coitus Partner status -
Florida Obstetric Hemorrhage Initiative (Ohi) Tool Kit
FLORIDA OBSTETRIC HEMORRHAGE INITIATIVE (OHI) TOOL KIT A QUALITY IMPROVEMENT INITIATIVE FOR OBSTETRIC HEMORRHAGE MANAGEMENT Updated Version 10/2015 P a g e | 1 v. 10/2015 OHI Tool Kit Suggested Citation: Florida Perinatal Quality Collaborative (2015) Florida Obstetric Hemorrhage Initiative Toolkit: A Quality Improvement Initiative for Obstetric Hemorrhage Management. Acknowledgements: The FPQC gratefully acknowledges and thanks our partner organizations, including ACOG District XII, the Florida Chapter of AWHONN, the Florida Council of Nurse Midwives, the Florida Hospital Association, and the Florida Department of Health. The creation of this toolkit would not have been possible without the volunteer members of our Maternal Health Committee, including the members of the Obstetric Hemorrhage Advisory Team listed on page three of this toolkit, Washington Hill, MD and Karla Olson, as well as Kris-Tena Albers and Rhonda Brown from the Florida Department of Health. The FPQC would also like to thank the California Maternal Quality Care Collaborative, ACOG District II, and the Illinois Department of Public Health for sharing their materials, expertise, and time to assist the FPQC in the development of this Quality Improvement (QI) Initiative. This toolkit has been adapted and modeled from the California Improving Healthcare Response to Obstetric Hemorrhage Toolkit: The California Toolkit, IMPROVING HEALTHCARE RESPONSE TO OBSTETRICAL HEMORRHAGE, was developed through the California Maternal Quality Care Collaborative with leadership from the California Department of Public Health, Maternal Child and Adolescent Health (CDPH-MCAH), and is available through the California Maternal Quality Care Collaborative website: www.cmqcc.org/ob_hemorrhage. Funding for the development of the California toolkit was provided by: Federal Maternal & Child Health Title V block grant funding from the California Department of Public Health; Maternal, Child and Adolescent Health Division and Stanford University. -
Medicalverdicts
Medical Verdicts Notable judgmeNts aNd settlemeNts times she refused consent; her fam- Wrongful birth claim: Child has ily could not be contacted without her a chromosomal disorder authorization. Proper actions were A woman’S husband and an interpreter came to taken when consent was obtained. her first prenatal appointment at 10 weeks’ gesta- } VERDICT An Illinois defense verdict tion, as she spoke only Mandarin and the father’s was returned. English was limited. The ObGyn offered maternal serum sequential screening. At subsequent visits, Epidural pump stolen— with the husband and interpreter present, the mother saw a geneticist, genetic counselor, and nurse practitioner. At no time was additional while in use genetic testing offered. At the 23-week visit, the husband was present, but the interpreter had not yet arrived; the ObGyn attempted to communi- A WOMAN WAS GIVEN AN EPIDURAL cate through the husband. during labor. While she slept, a newly The baby was born at term with cri-du-chat syndrome. The child is hired physician assistant (PA) entered severely physically and mentally handicapped, and will require constant her room, disconnected the epidural medical and attendant care for life. pump, and stole it. The woman awoke but the PA assured her that every- } patient’S CLAIM The ObGyn did not offer amniocentesis or chorionic thing was fine. Soon, she experienced villus sampling (CVS), and failed to inform the parents that the chance significant labor pains and called the of a 37-year-old woman having a child with a chromosomal aberration nurses, who paged an anesthesiologist was 1.5%. -
Antepartum Care
Antepartum care (ch7) Preconception care: women’s health before pregnancy is really important, thus several models of preconception care have been developed … why we need it? - By the time the pregnant women have their first prenatal visit, it is too late to address and to reduce (how?? Our goals are assessing the risk + optimizing the health + medical intervention “in prenatal”) the risk of some birth defects like: Poor placental development (due to preeclampsia) low birth weight (<2500 grams) (seen in Preterm birth, and IUGR). * REMEMBER: Organogenesis begins early in pregnancy and placental development starts with implantation, about 7 days after conception. who7 days mostly after need conceptionit? - Women who are in high-risk are those with obesity, diabetes, or hypertension … etc. Preconception care in this type of women should be started 6 months to 1 year before conception is attempted. Examples of medical conditions: Affected by pregnancy: Affect the pregnancy: 1- SLE: 1- DM: Pregnancy should occur during disease quiescence, for less 6 months EGA The relationship between the hemoglobin If disease activate during pregnancy: adverse maternal and obstetrical A1C level and fetal malformation complication Risk: All SLE medication should be reviewed Hg A1c fetal Goal: maintain disease control with maximizing safety profile - Diabetic malformation 2- Hypertension: related fetal risk - Classification: malformation: Normal: Mild to moderate: 140- Severe: <7 Baseline CVS, CNS, <140/90 159/90-109 no benefit of >160/90 must 7.2-9.1 14% Gastric and treat it treat it 9.2- 23% genital - Treatment: methyldopa or labetalol 11.1 urinary, - Contraindication: ACE inhibitors, angiotensin II receptor blockers, direct >11.2 25% Skeleton renin inhibitors - Pregnancy risk: Superimposed preeclampsia, Placental abruption and Fetal - The relationship between the hemoglobin growth restriction.