Sebastien Hillaire Epic Games
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V2a Neurons Pattern Respiratory Muscle Activity in Health and Disease
V2a Neurons Pattern Respiratory Muscle Activity in Health and Disease by Victoria N. Jensen A dissertation submitted to the University of Cincinnati in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Cincinnati College of Medicine Neuroscience Graduate Program December 2019 Committee Chairs Mark Baccei, Ph.D. Steven Crone, Ph.D. i Abstract Respiratory failure is the leading cause of death in in amyotrophic lateral sclerosis (ALS) patients and spinal cord injury patients. Therefore, it is important to identify neural substrates that may be targeted to improve breathing following disease and injury. We show that a class of ipsilaterally projecting, excitatory interneurons located in the brainstem and spinal cord – V2a neurons – play key roles in controlling respiratory muscle activity in health and disease. We used chemogenetic approaches to increase or decrease V2a excitability in healthy mice and following disease or injury. First, we showed that silencing V2a neurons in neonatal mice caused slow and irregular breathing. However, silencing V2a neurons in adult mice did not alter the regularity of respiration and actually increased breathing frequency, suggesting that V2a neurons play different roles in controlling breathing at different stages of development. V2a neurons also pattern respiratory muscle activity. Our lab has previously shown that increasing V2a excitability activates accessory respiratory muscles at rest in healthy mice. Surprisingly, we show that silencing V2a neurons also activated accessory respiratory muscles. These data suggest that two types of V2a neurons exist: Type I V2a neurons activate accessory respiratory muscles at rest whereas Type II V2a neurons prevent their activation when they are not needed. -
Shipbreaking Bulletin of Information and Analysis on Ship Demolition # 60, from April 1 to June 30, 2020
Shipbreaking Bulletin of information and analysis on ship demolition # 60, from April 1 to June 30, 2020 August 4, 2020 On the Don River (Russia), January 2019. © Nautic/Fleetphoto Maritime acts like a wizzard. Otherwise, how could a Renaissance, built in the ex Tchecoslovakia, committed to Tanzania, ambassador of the Italian and French culture, carrying carefully general cargo on the icy Russian waters, have ended up one year later, under the watch of an Ukrainian classification society, in a Turkish scrapyard to be recycled in saucepans or in containers ? Content Wanted 2 General cargo carrier 12 Car carrier 36 Another river barge on the sea bottom 4 Container ship 18 Dreger / stone carrier 39 The VLOCs' ex VLCCs Flop 5 Ro Ro 26 Offshore service vessel 40 The one that escaped scrapping 6 Heavy load carrier 27 Research vessel 42 Derelict ships (continued) 7 Oil tanker 28 The END: 44 2nd quarter 2020 overview 8 Gas carrier 30 Have your handkerchiefs ready! Ferry 10 Chemical tanker 31 Sources 55 Cruise ship 11 Bulker 32 Robin des Bois - 1 - Shipbreaking # 60 – August 2020 Despina Andrianna. © OD/MarineTraffic Received on June 29, 2020 from Hong Kong (...) Our firm, (...) provides senior secured loans to shipowners across the globe. We are writing to enquire about vessel details in your shipbreaking publication #58 available online: http://robindesbois.org/wp-content/uploads/shipbreaking58.pdf. In particular we had questions on two vessels: Despinna Adrianna (Page 41) · We understand it was renamed to ZARA and re-flagged to Comoros · According -
Good Game Game Idea Development Knowledge Value Creation Unique
57-я научная конференция аспирантов, магистрантов и студентов БГУИР, 2021 г CUTTING-EDGE GAME CREATION Maglich I.M. Belarusian State University of Informatics and Radioelectronics, Minsk, Republic of Belarus Liakh Y. V. – Lecturer Annotation. The main features of cutting-edge game creation and several examples of such games are given in this thesis. The terms of idea and imagination and the role of them in game development, as well as the main game development tools are explained. Keywords. Game, idea, imagination, graphics, game engine, soundtrack, mechanics. This thesis demonstrates how a combination of unique value characteristics can be used to create games which stand out from the mass. The most important aspect in creating of a cutting-edge game is an idea. In the dictionary term “idea” is referred to as the ability or gift of forming such conscious ideas or mental images, especially for the purposes of artistic or intellectual creation. The initial idea for a game in an individual’s mind is often brought to the organization as a collection of thoughts untouched, not yet contested via idea sharing practices. The resulting evolving idea moves through organizational knowledge boundaries to which individuals contribute by adding value [1]. The market of computer games is really huge now and the competition is only increasing. That’s why you need good imagination to create an exclusive idea. So, what is your imagination? Imagination is the ability of a person to spontaneously create or deliberately construct images, representations, ideas of objects, which in the life experience of the imagining in a holistic form were not previously perceived or cannot be perceived at all through the senses. -
Numerical Technique for Calculation of Radiant Energy Flux to Targets from Flames
iiii«jiiiin«iitfftaw « ^»gJ>^ j rü t 5wr!TKg t‘‘3v>g>!eaBggMglMgW8ro?ftanW This dissertation has been microfilmed exactly as received 66-1874 I SHAHROKHI, Firouz, 1938- NUMERICAL TECHNIQUE FOR CALCULATION OF RADIANT ENERGY FLUX TO TARGETS FROM FLAMES. The University of Oklahoma, Ph.D., 1966 Engineering, mechanical University Microfilms, Inc., Ann Arbor, Michigan j THE UNIVERSITY OF OKLAHOMA GRADUATE COLLEGE NUMERICAL TECHNIQUE FOR CALCULATION OF RADIANT ENERGY FLUX TO TARGETS FROM FLAMES A DISSERTATION SUBMITTED TO THE GRADUATE FACULTY in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY BY FIROUZ SHAHROKHI Norman, Oklahoma 1965 NUMERICAL TECHNIQUE FOR CALCULATION OF RADIANT ENERGY FLUX TO TARGETS FROM FLAMES DISSERTATION COMMITTEE ABSTRACT This is a study to predict total flux at a given surface from a flame which has a specified shape and. dimen sion. The solution to the transport equation for an absorbing and emitting media has been calculated based on a thermody namic equilibrium and non-equilibrium flame. In the thermodynamic equilibrium case, it is assumed that the cir cumstances are such that at each point in the flame a local temperature T is defined and the volume emission coefficient at that point is given in terms of volume absorption coeffi cient by the Kirchhoff's Law. The flame's monochromatic intensity of volume emission in a thermodynamic equilibrium is assumed to be the product of monochromatic volume extinction coefficient and the black body intensity. In the non-equilibrium case, a measured monochromatic intensity of volume emission of a given flame is used as well as the measured monochromatic volume extinction coefficient. -
Decima Engine: Novità Riguardanti Il Motore Grafico
Decima Engine: novità riguardanti il motore grafico Durante la conferenza intitolata “Decima Engine: Advances in Lighting and AA” avvenuta durante l’annuale manifestazione Siggraph nella città di Los Angeles,Carpentier (Guerrilla Games) e Ishiyama (Kojima Productions) hanno sviscerato alcune novità dietro il motore grafico proprietario chiamato appunto Decima Engine. Inizialmente sviluppato dai Guerrilla Games per la serie Killzone, esteso e migliorato per supportare nuovi giochi tra cuiHorizon: Zero Dawn il motore grafico viene oggi condiviso con lo studio Kojima Production – studio di cui il famosissimo Hideo Kojima, sviluppatore e mente della saga Metal Gear Solid, è a capo – che sta in questo momento sviluppando Death Stranding. Gioco che sarà ovviamente (ed è appunto il motivo della condivisione del motore grafico targato Guerrilla) esclusiva Playstation. La sessione di conferenza ricopre vari punti tra cui due in particolare hanno suscitato l’interesse di tutti i partecipanti e sviluppatori di videogiochi. GGX Spherical Area Light e Height Fog. Senza scendere in complicatissime formule matematiche (di cui la conferenza ovviamente era piena zeppa) il primo tratterebbe, per la prima volta in un motore grafico, un nuovo sistema di riflessione della luce che riuscirebbe rispetto al passato a migliorarne l’efficacia dando risultati più naturali specialmente durante rendering effettuati da certe angolazioni. Per i più tecnici ci sarebbero riusciti aggiungendo micro-facet shaders GGX alle AREA Light di forma sferica. L’Height Fog sarebbe invece il risultato della collaborazione con lo studioKojima Production. Questa nuova tecnologia è una customizzazione avvenuta per una esigenza da parte dello studio per il nuovo titolo Death Stranding. Il Decima Engine possedeva già un flessibile sistema di dispersione particellare e atmosferico ma lo studio chiedeva esplicitamente un sistema atmosferico ottimizzato per il rendering fotorealistico. -
Trident Technical College Transparency Report February
Trident Technical College Transparency Report February 2020 Identification # Check Date Payee Category Object Department Source of Funds Total 03*0460665 02/05/20 AAA Business Travel Contractual Services Other Contractual Services Accreditations Unrestricted Funds $ 160.00 03*0460665 02/05/20 AAA Business Travel Travel - Out of State Out-Of-State - Air Transp. Achieving The Dream Unrestricted Funds $ 364.10 03*0460666 02/05/20 Adams Outdoor Advertising S.C. Contractual Services Prtg.Bndg.Adv.-Commercial Marketing Services Unrestricted Funds $ 825.00 03*0460667 02/05/20 Adorama Supplies & Materials Education Supplies Foundation Mini Grants Unrestricted Funds $ 4,398.70 03*0460668 02/05/20 Aircraft Technical Publishers Contractual Services Data Processing Serv.-Other IT Software Unrestricted Funds $ 4,872.00 03*0460669 02/05/20 Alternative Staffing Contractual Services Temporary Services Bookstore - Operating Overhead Unrestricted Funds $ 6,306.72 03*0460670 02/05/20 Apple Computer, Inc. Supplies & Materials Data Processing Supplies Foundation Mini Grants Unrestricted Funds $ 4,490.80 03*0460671 02/05/20 Atlantic Electric LLC Contractual Services Other Contractual Services Plant Oper & Maint-M Unrestricted Funds $ 5,605.79 03*0460672 02/05/20 Berkeley County Water & Sanitation Authority Contractual Services Utilities Plant Oper & Maint-B Unrestricted Funds $ 221.71 03*0460673 02/05/20 Berkeley Propane Company Contractual Services Utilities Plant Oper & Maint-M Unrestricted Funds $ 235.48 03*0460674 02/05/20 Berlin's Restaurant Supply, Inc. -
The Thickening Web of Asian Security Cooperation: Deepening Defense
The Thickening Web of Asian Security Cooperation Deepening Defense Ties Among U.S. Allies and Partners in the Indo-Pacific Scott W. Harold, Derek Grossman, Brian Harding, Jeffrey W. Hornung, Gregory Poling, Jeffrey Smith, Meagan L. Smith C O R P O R A T I O N For more information on this publication, visit www.rand.org/t/RR3125 Library of Congress Cataloging-in-Publication Data is available for this publication. ISBN: 978-1-9774-0333-9 Published by the RAND Corporation, Santa Monica, Calif. © Copyright 2019 RAND Corporation R® is a registered trademark. Cover photo by Japan Maritime Self Defense Force. Limited Print and Electronic Distribution Rights This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited. Permission is given to duplicate this document for personal use only, as long as it is unaltered and complete. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial use. For information on reprint and linking permissions, please visit www.rand.org/pubs/permissions. The RAND Corporation is a research organization that develops solutions to public policy challenges to help make communities throughout the world safer and more secure, healthier and more prosperous. RAND is nonprofit, nonpartisan, and committed to the public interest. RAND’s publications do not necessarily reflect the opinions of its research clients and sponsors. Support RAND Make a tax-deductible charitable contribution at www.rand.org/giving/contribute www.rand.org Preface Since the turn of the century, an important trend toward new or expanded defense cooperation among U.S. -
WOLF 359 "BRAVE NEW WORLD" by Gabriel Urbina Story By: Sarah Shachat & Gabriel Urbina
WOLF 359 "BRAVE NEW WORLD" by Gabriel Urbina Story by: Sarah Shachat & Gabriel Urbina Writer's Note: This episode takes place starting on Day 1220 of the Hephaestus Mission. FADE IN: On HERA. Speaking directly to us. HERA So here's a story. Once upon a time, there lived a broken little girl. She was born with clouded eyes, and a weak heart, not destined to beat through an entire lifetime. But instead of being wretched or afraid, the little girl decided to be clever. She got very, very good at fixing things. First she fixed toys, and clocks, and old machines that no one thought would ever run again. Then, she fixed bigger things. She fixed the cold and drafty orphanage where she grew up; when she went to school, she fixed equations to make them more useful; everything around her, she made better... and sharper... and stronger. She had no friends, of course, except for the ones she made. The little girl had a talent for making dolls - beautiful, wonderful mechanical dolls - and she thought they were better friends than anyone in the world. They could be whatever she wanted them to be - and as real as she wanted them to be - and they never left her behind... and they never talked back... and they were never afraid of her. Except when she wanted them to be. But if there was one thing the girl never felt like she could fix, it was herself. Until... one day a strange thing happened. The broken girl met an old man - older than anyone she had ever met, but still tricky and clever, almost as clever as the girl. -
Avid Maestro | Virtual Set User Guide V2019.8
Avid® Maestro | Virtual Set User Guide Version 2019.8 Legal Notices Product specifications are subject to change without notice and do not represent a commitment on the part of Avid Technology, Inc. This product is subject to the terms and conditions of a software license agreement provided with the software. The product may only be used in accordance with the license agreement. This product may be protected by one or more U.S. and non-U.S patents. Details are available at www.avid.com/patents. This document is protected under copyright law. An authorized licensee of may reproduce this publication for the licensee’s own use in learning how to use the software. This document may not be reproduced or distributed, in whole or in part, for commercial purposes, such as selling copies of this document or providing support or educational services to others. This document is supplied as a guide for . Reasonable care has been taken in preparing the information it contains. However, this document may contain omissions, technical inaccuracies, or typographical errors. Avid Technology, Inc. does not accept responsibility of any kind for customers’ losses due to the use of this document. Product specifications are subject to change without notice. Copyright © 2019 Avid Technology, Inc. and its licensors. All rights reserved. The following disclaimer is required by Epic Games, Inc.: Unreal® is a trademark or registered trademark of Epic Games, Inc. in the United States of America and elsewhere. Unreal® Engine, Copyright 1998 - 2019 Epic Games, Inc. All rights reserved." The following disclaimer is required by Apple Computer, Inc.: APPLE COMPUTER, INC. -
Alexandria Gazette Packet 25 Cents Serving Alexandria for Over 200 Years • a Connection Newspaper June 18, 2015 Page 14 Once a Titan
Alexandria Gazette Packet 25 Cents Serving Alexandria for over 200 years • A Connection Newspaper June 18, 2015 Page 14 Once a Titan ... A Party Divided Parents and students from the Class of 2015 Democratic unity in Alexandria remember successes and struggles. uncertain as Euille weighs options. By Vernon Miles Silberberg immediately received By Vernon Miles Gazette Packet the vocal support of opponent Gazette Packet Kerry Donley, who said the party ne week after the Demo- needed to remain united for uch of the cratic primary, questions November’s election. However, an Robinson fam- O linger about whether or endorsement from Euille was not M ily pointed out not incumbent William Euille will as forthcoming, and the incum- every girl en- challenge Democratic candidate bent mayor announced that he tering the floor of the Patriot Allison Silberberg as a write-in. would take the weekend to delib- Center, trying to determine at While on the surface local Demo- erate on whether or not to orches- a distance which was McKayla crats have rallied behind trate a write-in campaign. Robinson. It wasn’t an easy Silberberg’s nomination as Demo- The Alexandria Democratic task, and each one of the par- cratic candidate for mayor, Euille’s Committee (ADC) released a state- ents filling the 10,000 seat reluctance to yield the position ment of unity on June 16, includ- sports center at George Mason casts doubts. ing comments from both University was attempting to On June 9, Silberberg won the Silberberg and Euille. Silberberg accomplish. More than 700 stu- three-way Democratic primary by thanked her opponents and em- dents were gathered at the Pa- 312 votes over Euille. -
Real-Time Procedural Risers in Games: Mapping Riser Audio Effects to Game Data
Real-Time Procedural Risers in Games: Mapping Riser Audio Effects to Game Data S. de Koning* Breda University of Applied Sciences, Monseigneur Hopmansstraat 2, 4817 JS Breda, the Netherlands Abstract The application of audio to a nonlinear context causes several issues in the game audio design workflow. Mainly, industry standard software is not optimised for creating nonlinear audio, and a disconnect exists between the game’s timeline and the audio timeline or grid. Standard middleware solutions improve the audio development workflow, but also cause new issues, such as requiring users to switch back and forth between different software before being able to test a sound in its context. This research applied procedural riser audio effects to a walking simulator horror game to explore an alternative to game audio development. The research investigated which are the essential parameters of the riser, and how they can be implemented in Unreal Engine based on the game’s state and events. Interviews have been done with game audio designers, programmers, and leads/directors. The interviewees were shown a prototype, developed for this research, that allows the user to design a riser, control how it should adapt, and implement it in Unreal Engine. Analysis of the interviews indicates that modulating the volume and pitch of the riser over multiple layers are the most essential parameters. These parameters can best be modulated based on the player’s current position, the elapsed time, and the amount of action over time. Furthermore, the data indicates that the approach put forward in the research is a viable and relevant solution to the stated issues and worth further investigation. -
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