TFAP2C Regulates Transcription in Human Naive Pluripotency by Opening Enhancers
UCLA UCLA Previously Published Works Title TFAP2C regulates transcription in human naive pluripotency by opening enhancers. Permalink https://escholarship.org/uc/item/03p035b0 Journal Nature cell biology, 20(5) ISSN 1465-7392 Authors Pastor, William A Liu, Wanlu Chen, Di et al. Publication Date 2018-05-01 DOI 10.1038/s41556-018-0089-0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Nat Cell Manuscript Author Biol. Author manuscript; Manuscript Author available in PMC 2018 October 25. Published in final edited form as: Nat Cell Biol. 2018 May ; 20(5): 553–564. doi:10.1038/s41556-018-0089-0. TFAP2C regulates transcription in human naive pluripotency by opening enhancers William A. Pastor1,8, Wanlu Liu1,2, Di Chen1, Jamie Ho1, Rachel Kim1, Timothy J. Hunt1, Anastasia Lukianchikov1, Xiaodong Liu3,4,5, Jose M. Polo3,4,5, Steven E. Jacobsen1,6,7, and Amander T. Clark1,6 1Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA 2Molecular Biology Institute, University of California, Los Angeles, CA 90095 3Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia 4Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Wellington Road, Clayton, VIC 3800, Australia 5Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, VIC 3800, Australia 6Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California 90095, USA 7Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, California 90095, USA Abstract Naïve and primed pluripotent hESCs bear transcriptional similarity to pre- and post-implantation epiblast and thus constitute a developmental model for understanding the earliest pluripotent stages in human embryo development.
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