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Vanadium Toxicological Potential Versus Its Pharmacological Activity: New Developments and Research

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Oxidative Medicine and Cellular Longevity Vanadium Toxicological Potential versus Its Pharmacological Activity: New Developments and Research Guest Editors: Agnieszka Ścibior, Juan Llopis, Alvin A. Holder, and Mario Altamirano-Lozano Vanadium Toxicological Potential versus Its Pharmacological Activity: New Developments and Research Oxidative Medicine and Cellular Longevity Vanadium Toxicological Potential versus Its Pharmacological Activity: New Developments and Research Guest Editors: Agnieszka Scibior, Juan Llopis, Alvin A. Holder, and Mario Altamirano-Lozano Copyright © 2016 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Oxidative Medicine and Cellular Longevity.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Mohammad Abdollahi, Iran Daniela Giustarini, Italy David Pattison, Australia Antonio Ayala, Spain Saeid Golbidi, Canada Serafina Perrone, Italy Neelam Azad, USA Tilman Grune, Germany Tiziana Persichini, Italy Peter Backx, Canada Hunjoo Ha, Republic of Korea Vincent Pialoux, France Damian Bailey, UK Nikolas Hodges, UK Chiara Poggi, Italy Consuelo Borrás, Spain Tim Hofer, Norway Aurel Popa-Wagner, Germany Vittorio Calabrese, Italy Silvana Hrelia, Italy Ada Popolo, Italy Angel Catalá, Argentina Maria G. Isaguliants, Sweden José L. Quiles, Spain Shao-Yu Chen, USA Vladimir Jakovljevic, Serbia Walid Rachidi, France Zhao Zhong Chong, USA Peeter Karihtala, Finland Kota V. Ramana, USA Giuseppe Cirillo, Italy Raouf A. Khalil, USA Pranela Rameshwar, USA Massimo Collino, Italy Kum Kum Khanna, Australia Sidhartha D. Ray, USA Mark J. Crabtree, UK Neelam Khaper, Canada Alessandra Ricelli, Italy Manuela Curcio, Italy Thomas Kietzmann, Finland Francisco J. Romero, Spain Andreas Daiber, Germany Mike Kingsley, UK Vasantha Rupasinghe, Canada Felipe Dal Pizzol, Brazil Ron Kohen, Israel Gabriele Saretzki, UK Francesca Danesi, Italy Werner Koopman, Netherlands Honglian Shi, USA Domenico D’Arca, Italy Jean-Claude Lavoie, Canada Cinzia Signorini, Italy Yolanda de Pablo, Sweden Christopher H. Lillig, Germany Dinender K. Singla, USA James Duce, UK Paloma B. Liton, USA Richard Siow, UK Grégory Durand, France Nageswara Madamanchi, USA Shane Thomas, Australia Javier Egea, Spain Kenneth Maiese, USA Rosa Tundis, Italy Amina El Jamali, USA Tullia Maraldi, Italy Giuseppe Valacchi, Italy Ersin Fadillioglu, Turkey Reiko Matsui, USA Jeannette Vasquez-Vivar, USA Qingping Feng, Canada Steven McAnulty, USA Victor M. Victor, Spain Giuseppe Filomeni, Italy Bruno Meloni, Australia Michal Wozniak, Poland Swaran J. S. Flora, India Trevor A. Mori, Australia Sho-ichi Yamagishi, Japan Rodrigo Franco, USA Ryuichi Morishita, Japan Liang-Jun Yan, USA José Luís García-Giménez, Spain A. Mouithys-Mickalad, Belgium Guillermo Zalba, Spain Janusz Gebicki, Australia Hassan Obied, Australia Jacek Zielonka, USA Husam Ghanim, USA Pál Pacher, USA Laura Giamperi, Italy Valentina Pallottini, Italy Contents Vanadium Toxicological Potential versus Its Pharmacological Activity: New Developments and Research Agnieszka &’Scibior, Juan Llopis, Alvin A. Holder, and Mario Altamirano-Lozano Volume 2016, Article ID 7612347, 2 pages In Vivo Effects of Vanadium Pentoxide and Antioxidants (Ascorbic Acid and Alpha-Tocopherol) on Apoptotic, Cytotoxic, and Genotoxic Damage in Peripheral Blood of Mice María del Carmen García-Rodríguez, Lourdes Montserrat Hernández-Cortés, and Mario Agustín Altamirano-Lozano Volume 2016, Article ID 6797851, 11 pages Role of Vanadium in Cellular and Molecular Immunology: Association with Immune-Related Inflammation and Pharmacotoxicology Mechanisms Olga Tsave, Savvas Petanidis, Efrosini Kioseoglou, Maria P. Yavropoulou, John G. Yovos, Doxakis Anestakis, Androniki Tsepa, and Athanasios Salifoglou Volume 2016, Article ID 4013639, 10 pages Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus Samuel Treviño, Denisse Velázquez-Vázquez, Eduardo Sánchez-Lara, Alfonso Diaz-Fonseca, José Ángel Flores-Hernandez, Aarón Pérez-Benítez, Eduardo Brambila-Colombres, and Enrique González-Vergara Volume 2016, Article ID 6058705, 14 pages Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae Amy T. Christensen, Craig C. McLauchlan, Anne Dolbecq, Pierre Mialane, and Marjorie A. Jones Volume 2016, Article ID 9025627, 12 pages Decavanadate Toxicology and Pharmacological Activities: V10 or V1, Both or None? M. Aureliano Volume 2016, Article ID 6103457, 8 pages Memory Deficit Recovery after Chronic Vanadium Exposure in Mice Oluwabusayo Folarin, Funmilayo Olopade, Silas Onwuka, and James Olopade Volume 2016, Article ID 4860582, 7 pages Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 7612347, 2 pages http://dx.doi.org/10.1155/2016/7612347 Editorial Vanadium Toxicological Potential versus Its Pharmacological Activity: New Developments and Research Agnieszka Ucibior,1 Juan Llopis,2 Alvin A. Holder,3 and Mario Altamirano-Lozano4 1 LaboratoryofOxidativeStress,CentreforInterdisciplinaryResearch,TheJohnPaulIICatholicUniversityofLublin, 20-708 Lublin, Poland 2InstituteofNutritionandFoodTechnology,BiomedicalResearchCenter,UniversityofGranada,18071Granada,Spain 3Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529-0126, USA 4Genetic and Environmental Toxicology Research Unit, FES-Zaragoza, UMIEZ Campus II, National Autonomous University of Mexico, 09230 Mexico´ City, Mexico Correspondence should be addressed to Agnieszka Scibior;´ [email protected] Received 23 May 2016; Accepted 23 May 2016 Copyright © 2016 Agnieszka Scibior´ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Vanadium, which arouses interest of many research centers thisresearchfieldmayhelptoestimatethebalancebetween worldwide, is a biologically essential redox-active metal with adverse effects of vanadium (which has a relatively narrow an ability to evoke diametrically opposite effects. Due to margin of safety) and its potential therapeutic properties its dual character and multidirectional action, vanadium and to determine better its toxicity and therapeutic intervals receives a great deal of attention of pharmacologists and which, in turn, allows us to devise and develop possible researchers from different scientific disciplines. procedures of treatment of certain illnesses. Despite the fact that extensive knowledge about vana- In this special issue, an attempt has been made to diumhasbeengathered,manyaspectsofitsactionstill include reports that update our knowledge about the role require to be clearly defined. At present, there is a lack of of vanadium in toxicological processes and pharmacological sufficient data about the mechanisms of absorption, trans- applications and identify gaps in this research field, which port, and excretion of this metal. Relatively little is also known would ensure better understanding of the specific behavior of about the consequences and mechanisms of mutual inter- this element. The special issue on vanadium compiles six (6) actions of vanadium with other elements, particularly those excellent manuscripts including reviews and research articles, that have antioxidant potential. The question of interactions which provide current and comprehensive knowledge about betweenelements,whichmaytakeplaceatdifferentlevels some aspects of the action of this metal. and can be used to elucidate the cellular mechanisms of The review article by M. Aureliano covers recent advances response to combinations of metals, is always up to date in the understanding of decavanadate toxicology and phar- and still an important issue in toxicology. The essentiality of macological applications. The Author (a) discusses in depth vanadium to humans and the mechanisms of its toxic action the modes of action of decavanadate (V10)throughoxidative also need to be elucidated. The above-mentioned aspects and stress, effects on mitochondria, sarcoplasmic reticulum, and likewise the pharmacological activity of vanadium, which cytoskeleton, (b) provides information about some aspects raises hopes for use thereof in the treatment of certain of action of decavanadate (V10)andvanadate(V1), and (c) diseases in humans, including diabetes, osteoporosis, and cer- highlights the significance of understanding the10 V toxicol- taintypesofcanceraswellasparasiticandinfectiousdiseases, ogy and pharmacological activities as important targets to need to be further studied in order to fully understand and elucidate the biological activities of several polyoxometalates elucidate the toxicology as well as the biological activity and in order to make them available and safe for clinical use. In pharmacological potential of this element. More details in turn, the review article by Tsave et al. focuses on the role 2 Oxidative Medicine and Cellular Longevity of vanadium in cellular and molecular immunology. The Authors nicely and concisely illustrate (a) the effects of selected vanadium species in the immune system processes, (b) forms of vanadium exhibiting immunogenic activity, and (c) the key role(s) of vanadium in promoting innate and adaptive
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