View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Cell Host & Microbe Article Innate and Adaptive Immunity Interact to Quench Microbiome Flagellar Motility in the Gut Tyler C. Cullender,1,2 Benoit Chassaing,3 Anders Janzon,1,2 Krithika Kumar,1,2 Catherine E. Muller,4 Jeffrey J. Werner,5,7 Largus T. Angenent,5 M. Elizabeth Bell,1,2 Anthony G. Hay,1 Daniel A. Peterson,6 Jens Walter,4 Matam Vijay-Kumar,3,8 Andrew T. Gewirtz,3 and Ruth E. Ley1,2,* 1Department of Microbiology, Cornell University, Ithaca, NY 14853, USA 2Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA 3Center for Inflammation, Immunity and Infection, Georgia State University, Atlanta, GA 30303, USA 4Department of Food Science and Technology, University of Nebraska, Lincoln, NE 68583, USA 5Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA 6Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA 7Present address: Department of Chemistry, SUNY Cortland, Cortland, NY 13045, USA 8Present address: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA *Correspondence:
[email protected] http://dx.doi.org/10.1016/j.chom.2013.10.009 SUMMARY IgA’s role in barrier defense is generally assumed to be immune exclusion, in which the IgA binds microbial surface antigens and Gut mucosal barrier breakdown and inflammation promotes the agglutination of microbial cells and their entrap- have been associated with high levels of flagellin, ment in mucus and physical clearance (Hooper and Macpher- the principal bacterial flagellar protein.