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Figure 1

A

M7 M10M4 M2 M12 M11 M3 M1/ M8 M6 M9 M5 B CD Mesenchymal Basal

M1 M5 M8

M11 M9 M10

M6 M3 EF M7 Classical Atypical

M12

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G ME1 ME2 ME3 ME4 ME5

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Figure 2

A

T-cell signature corDeviance

r = 0.61, p < 2.2 x 10-16

Module membership: regulation of process (kME8) B

r = -0.86, p < 2.2 x 10-16 corDeviance

Myeloid signature

Module membership: leukocyte activation (kME1)

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ABC

M4

M3

M6

M1

M9

M5 M7 M8 M2

M10 DE

NES = -5.37, FDR > 0.001

| | 1.0 -1.0 k_cME6 Hypoxia signature eigengene signature Hypoxia

Leukocyte activation (meta_cME6)

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Upregulated glucose metabolism correlates inversely with CD8+ T cell infiltration and survival in squamous cell carcinoma

Christian H Ottensmeier, Kate L Perry, Elena L Harden, et al.

Cancer Res Published OnlineFirst May 20, 2016.

Updated version Access the most recent version of this article at: doi:10.1158/0008-5472.CAN-15-3121

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