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Growth Abnormalities of Fetuses and Infants BioMed Research International Growth Abnormalities of Fetuses and Infants Lead Guest Editor: Erich Cosmi Guest Editors: Enrico Grisan, Vassilios Fanos, Giuseppe Rizzo, Shanthi Sivanandam, and Silvia Visentin Growth Abnormalities of Fetuses and Infants BioMed Research International Growth Abnormalities of Fetuses and Infants Lead Guest Editor: Erich Cosmi Guest Editors: Enrico Grisan, Vassilios Fanos, Giuseppe Rizzo, and Shanthi Sivanandam Copyright © 2017 Hindawi. All rights reserved. This is a special issue published in “BioMed Research International.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Contents Growth Abnormalities of Fetuses and Infants Erich Cosmi, Enrico Grisan, Vassilios Fanos, Giuseppe Rizzo, Shanthi Sivanandam, and Silvia Visentin Volume 2017, Article ID 3191308, 4 pages DNA Damage as a Driver for Growth Delay: Chromosome Instability Syndromes with Intrauterine Growth Retardation Benilde García-de Teresa, Mariana Hernández-Gómez, and Sara Frías Volume 2017, Article ID 8193892, 14 pages A Psychological Perspective on Preterm Children: The Influence of Contextual Factors on Quality of Family Interactions Michela Gatta, Marina Miscioscia, Lorenza Svanellini, Chiara Peraro, and Alessandra Simonelli Volume 2017, Article ID 9152627, 10 pages Echocardiographic Techniques of Deformation Imaging in the Evaluation of Maternal Cardiovascular System in Patients with Complicated Pregnancies Silvia Visentin, Chiara Palermo, Martina Camerin, Luciano Daliento, Denisa Muraru, Erich Cosmi, and Luigi P. Badano Volume 2017, Article ID 4139635, 10 pages Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe? Flaminia Bardanzellu, Paola Neroni, Angelica Dessì, and Vassilios Fanos Volume 2017, Article ID 1438038, 25 pages Metabolomics and Cardiology: Toward the Path of Perinatal Programming and Personalized Medicine Roberta Pintus, Pier Paolo Bassareo, Angelica Dessì, Martino Deidda, Giuseppe Mercuro, and Vassilios Fanos Volume 2017, Article ID 6970631, 8 pages Parental Genetic Variants, MTHFR 677C>TandMTRR66A>G, Associated Differently with Fetal Congenital Heart Defect Qian-nan Guo, Hong-dan Wang, Li-zhen Tie, Tao Li, Hai Xiao, Jian-gang Long, and Shi-xiu Liao Volume 2017, Article ID 3043476, 7 pages Postnatal Growth in a Cohort of Sardinian Intrauterine Growth-Restricted Infants Maria Grazia Clemente, Giampiero Capobianco, Paolo Mattia Galasso, Francesco Dessole, Giuseppe Virdis, Maria Grazia Sanna, Mauro Giorgio Olzai, Lino Argiolas, Salvatore Dessole, and Roberto Antonucci Volume 2017, Article ID 9382083, 5 pages The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor- in Pregnancy Complicated by Placental Insufficiency Dorota Darmochwal-Kolarz, Magdalena Michalak, Bogdan Kolarz, Monika Przegalinska-Kalamucka, Agnieszka Bojarska-Junak, Dariusz Sliwa, and Jan Oleszczuk Volume 2017, Article ID 6904325, 5 pages Does Chemotherapy for Gynecological Malignancies during Pregnancy Cause Fetal Growth Restriction? Nabil Abdalla, Magdalena Bizoń, Robert Piórkowski, Paweł Stanirowski, Krzysztof Cendrowski, and Włodzimierz Sawicki Volume 2017, Article ID 7543421, 7 pages Scientific Evidence for Different Options for GDM Screening and Management: Controversies and Review of the Literature Claudia Caissutti and Vincenzo Berghella Volume 2017, Article ID 2746471, 12 pages Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort Stephen Norda, Tanja K. Rausch, Thorsten Orlikowsky, Matthias Hütten, Sören Schulz, Wolfgang Göpel, and Ulrich Pecks Volume 2017, Article ID 2837027, 8 pages Care-Related and Maternal Risk Factors Associated with the Antenatal Nondetection of Intrauterine Growth Restriction: A Case-Control Study from Bremen, Germany Sinja Alexandra Ernst, Tilman Brand, Anna Reeske, Jacob Spallek, Knud Petersen, and Hajo Zeeb Volume 2017, Article ID 1746146, 10 pages Do miRNAs Play a Role in Fetal Growth Restriction? A Fresh Look to a Busy Corner Benito Chiofalo, Antonio Simone Laganà, Alberto Vaiarelli, Valentina Lucia La Rosa, Diego Rossetti, Vittorio Palmara, Gaetano Valenti, Agnese Maria Chiara Rapisarda, Roberta Granese, Fabrizio Sapia, Onofrio Triolo, and Salvatore Giovanni Vitale Volume2017,ArticleID6073167,8pages First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural Congenital Abnormalities Measured in Virtual Reality: An Observational Study L.Baken,B.Benoit,A.H.J.Koning,P.J.vanderSpek,E.A.P.Steegers,andN.Exalto Volume 2017, Article ID 1953076, 6 pages Suspected Fetal Growth Restriction at 37 Weeks: A Comparison of Doppler and Placental Pathology William M. Curtin, Karmaine A. Millington, Tochi O. Ibekwe, and Serdar H. Ural Volume 2017, Article ID 3723879, 10 pages Hindawi BioMed Research International Volume 2017, Article ID 3191308, 4 pages https://doi.org/10.1155/2017/3191308 Editorial Growth Abnormalities of Fetuses and Infants Erich Cosmi,1 Enrico Grisan,1 Vassilios Fanos,2 Giuseppe Rizzo,3 Shanthi Sivanandam,4 and Silvia Visentin1 1 University of Padua, Padua, Italy 2University of Cagliari, Cagliari, Italy 3University of Rome Tor Vergata, Rome, Italy 4University of Minnesota, Minneapolis, MN, USA Correspondence should be addressed to Erich Cosmi; [email protected] Received 27 September 2017; Accepted 27 September 2017; Published 22 November 2017 Copyright © 2017 Erich Cosmi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The objective of this special issue is to address recent highest rates of infant mortality in the early 20th century research trends and developments about the advancements also had the highest rates of mortality from coronary heart of image processing and vision in healthcare. A substantial disease decades later. As the most commonly registered cause number of papers were submitted, and after a thorough peer of infant death at the start of 20th century was low birth reviewprocess,someofthesewereselectedtobeincluded weight, these observations led to the hypothesis that low birth in this special issue. Growth abnormalities (either growth weightbabieswhosurvivedinfancyandchildhoodmightbe restriction or large for gestational age) during perinatal and at increased risk of coronary heart disease in later life. There postnatal life are a hot topic issue, since they are often linked is an increased evidence of the link between intrauterine and to alteration of uterine environment caused by placental perinatal alterations and adult diseases. Although the main insufficiency, maternal metabolic syndrome, and in general focussofarhasbeenthetimingofdeliveryandfollow-up, under- or overnutrition of the fetus. These fetal abnormalities thestudyofthepathophysiologyandofpossiblerecoveryisof account for the leading causes of perinatal morbidity and paramount importance and needs the contributions of physi- mortality. Moreover, under the hypothesis of developmental cians from several fields, biologists, bioinformaticians, and origin of adult diseases, they bear consequences in later life, programming the infant physiology for a higher risk engineers. of noncommunicable diseases, cardiovascular adult diseases, The paper by C. Caissutti and V. Berghella presents and neurodevelopment delay. Low birth weight, caused either a comprehensive review about the most important and by preterm birth and/or by intrauterine growth restriction, employed guidelines about screening and management of isrecentlyknowntobeassociatedwithincreasedratesof gestational diabetes (GDM) that affects up to 7% of pregnant cardiovascular disease and noninsulin dependent diabetes women and is associated with several maternal and perinatal in adult life. The “developmental origins of adult disease” morbidities. It is well known that GDM represents over hypothesis, often called “the Barker hypothesis,” proposes time a risk factor of type 2 diabetes, for both the mother that these diseases originate through adaptations of the fetus and the fetus. Nowadays, there are many unsolved questions when it is undernourished. These adaptations may be cardio- concerning the indications of screening, the timing and type vascular, metabolic, or endocrine and they may permanently of screening, the criteria for diagnosis, and the population change the structure and function of the body, increasing to screen. The correct identification of universally approved coronary heart disease risk factors, such as hypertension, type andsharedrecommendationsshouldimprovetheGDM 2 diabetes mellitus, insulin resistance, and hyperlipidaemia. pregnancy outcomes (gestational hypertension, prematurity, This hypothesis originally involved from observation by cesarean deliveries, number of large for gestational age and Barker and colleagues that the regions in England with the small for gestational age fetuses, and 1-minute Apgar scores 2 BioMed Research International < 7), improving the health care and maintaining a cost- IUGR in our series showed significant postnatal catch-up effective benefit. growth essentially during the first 12 months of life. The The paper by B. Chiofalo et al. takes into account modern research describes a new personalized medicine the role of microRNAs (miRNAs) of the placenta
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